GREMLIN Database
Q980J0 - Phospho-2-dehydro-3-deoxyheptonate aldolase /chorismate mutase (AroG)
UniProt: Q980J0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (255)
Sequences: 2160 (1123)
Seq/√Len: 70.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
296_H299_K5.0171.00
101_E146_R4.9281.00
177_I191_V3.9021.00
174_M227_V3.4551.00
91_V317_M3.4301.00
261_C288_M3.1671.00
78_N81_D3.0541.00
78_N83_E2.8541.00
145_R149_D2.7051.00
268_A277_L2.6741.00
219_L226_T2.6501.00
113_R314_E2.6501.00
323_L327_L2.5931.00
252_A256_T2.5301.00
254_L272_E2.4861.00
139_E142_K2.4781.00
157_T172_V2.4331.00
163_R190_E2.4201.00
118_L174_M2.3651.00
279_L319_R2.3461.00
89_V282_V2.2981.00
107_T295_P2.2771.00
304_S307_Q2.2691.00
182_A206_N2.2621.00
246_I277_L2.2281.00
271_R312_S2.2271.00
104_V143_I2.2191.00
211_W252_A2.0711.00
200_L218_I2.0471.00
145_R148_G1.9551.00
109_K150_E1.9251.00
159_I175_I1.9221.00
89_V324_A1.8811.00
111_V116_A1.8791.00
249_M262_A1.8761.00
324_A328_G1.8571.00
157_T168_F1.7901.00
168_F172_V1.7671.00
244_L262_A1.7461.00
192_G221_E1.6971.00
105_L151_V1.6961.00
100_N103_Q1.6681.00
114_A314_E1.6540.99
76_V83_E1.6320.99
251_A273_L1.6260.99
142_K171_Y1.6140.99
252_A260_I1.6000.99
124_Y164_D1.5920.99
164_D186_S1.5580.99
323_L326_A1.5360.99
148_G155_I1.5250.99
271_R298_E1.5160.99
146_R150_E1.5110.99
159_I165_S1.5050.99
84_I174_M1.4930.99
98_V144_L1.4920.99
271_R309_T1.4910.99
160_M186_S1.4830.99
148_G151_V1.4650.99
275_H319_R1.4510.99
309_T312_S1.4280.98
110_A311_E1.4280.98
92_A118_L1.4170.98
84_I90_I1.3930.98
291_I316_L1.3830.98
191_V198_V1.3690.98
162_T165_S1.3620.98
105_L150_E1.3420.98
93_A293_V1.3350.98
92_A261_C1.3300.98
226_T258_L1.3270.98
237_E243_T1.3170.97
106_T109_K1.3140.97
235_T243_T1.3110.97
138_E167_I1.3070.97
119_L174_M1.2960.97
218_I223_N1.2900.97
145_R171_Y1.2800.97
109_K151_V1.2710.97
75_T257_H1.2700.97
111_V313_F1.2580.97
143_I147_V1.2450.96
193_K221_E1.2390.96
101_E105_L1.2260.96
277_L284_A1.2200.96
82_V90_I1.1660.95
190_E193_K1.1560.94
314_E318_N1.1560.94
195_G225_N1.1550.94
138_E142_K1.1490.94
104_V147_V1.1470.94
159_I177_I1.1470.94
313_F317_M1.1420.94
267_P277_L1.1400.94
189_K221_E1.1300.94
161_D186_S1.1100.93
247_G267_P1.1040.93
165_S191_V1.1000.93
322_T326_A1.1000.93
165_S194_L1.0850.92
77_V227_V1.0800.92
92_A156_V1.0770.92
253_K287_D1.0750.92
167_I171_Y1.0730.92
106_T295_P1.0670.92
79_V84_I1.0380.91
134_Q189_K1.0330.90
274_V308_L1.0290.90
219_L258_L1.0220.90
198_V218_I1.0210.90
156_V199_L1.0150.90
103_Q295_P1.0140.90
219_L224_G1.0050.89
279_L320_I0.9990.89
208_V251_A0.9980.89
278_A320_I0.9970.89
102_E106_T0.9810.88
112_K153_L0.9790.88
103_Q107_T0.9770.88
105_L109_K0.9770.88
86_S287_D0.9760.88
148_G154_P0.9670.87
208_V248_G0.9670.87
192_G218_I0.9650.87
167_I170_Q0.9600.87
191_V194_L0.9560.87
144_L155_I0.9430.86
169_S175_I0.9430.86
138_E170_Q0.9390.86
279_L323_L0.9380.85
239_S251_A0.9330.85
80_K154_P0.9330.85
136_L143_I0.9320.85
79_V82_V0.9290.85
112_K151_V0.9270.85
160_M164_D0.9210.84
315_V319_R0.9200.84
262_A277_L0.9190.84
215_A219_L0.9160.84
148_G171_Y0.9150.84
140_G144_L0.9070.84
209_E239_S0.9050.83
188_L218_I0.9000.83
191_V221_E0.8980.83
87_K287_D0.8950.83
319_R322_T0.8820.82
321_R325_R0.8810.82
278_A289_L0.8800.82
117_S154_P0.8790.82
108_A144_L0.8770.81
205_G242_F0.8770.81
107_T310_P0.8750.81
77_V174_M0.8740.81
244_L249_M0.8690.81
118_L156_V0.8690.81
136_L140_G0.8690.81
315_V318_N0.8690.81
110_A310_P0.8660.81
105_L146_R0.8660.81
244_L277_L0.8650.81
230_E233_I0.8630.80
84_I118_L0.8620.80
162_T186_S0.8580.80
166_N170_Q0.8580.80
233_I248_G0.8550.80
102_E109_K0.8500.79
197_P225_N0.8480.79
172_V175_I0.8450.79
215_A258_L0.8440.79
179_A204_M0.8440.79
278_A290_L0.8430.79
206_N214_A0.8430.79
84_I119_L0.8430.79
82_V117_S0.8400.79
308_L316_L0.8390.78
215_A228_L0.8380.78
118_L154_P0.8340.78
293_V313_F0.8330.78
116_A317_M0.8270.77
105_L147_V0.8230.77
249_M284_A0.8220.77
247_G250_V0.8190.77
77_V225_N0.8120.76
92_A227_V0.8100.76
118_L153_L0.8100.76
138_E171_Y0.8080.76
322_T325_R0.8040.75
165_S169_S0.8000.75
270_K273_L0.8000.75
131_Y216_E0.7970.75
291_I313_F0.7950.75
108_A153_L0.7860.74
182_A203_G0.7850.74
169_S195_G0.7840.74
166_N190_E0.7830.74
282_V320_I0.7810.73
300_A304_S0.7780.73
84_I92_A0.7780.73
246_I262_A0.7750.73
105_L148_G0.7750.73
197_P229_C0.7730.73
147_V151_V0.7720.72
92_A154_P0.7700.72
155_I172_V0.7700.72
136_L139_E0.7640.72
80_K148_G0.7640.72
119_L147_V0.7590.71
204_M236_F0.7570.71
100_N104_V0.7560.71
96_C302_S0.7560.71
142_K145_R0.7550.71
101_E104_V0.7430.70
159_I168_F0.7410.69
239_S242_F0.7400.69
169_S194_L0.7370.69
209_E213_Q0.7360.69
283_A323_L0.7350.69
101_E143_I0.7290.68
216_E219_L0.7260.68
112_K152_G0.7190.67
107_T110_A0.7140.66
273_L276_S0.7120.66
86_S90_I0.7110.66
301_L307_Q0.7100.66
110_A114_A0.7090.66
131_Y220_L0.7090.66
320_I323_L0.7050.65
159_I191_V0.7040.65
137_G186_S0.7030.65
162_T190_E0.6990.65
88_K117_S0.6970.65
199_L290_L0.6880.64
179_A302_S0.6860.63
159_I169_S0.6850.63
143_I146_R0.6840.63
93_A116_A0.6840.63
268_A273_L0.6820.63
114_A310_P0.6810.63
161_D164_D0.6800.63
239_S255_M0.6750.62
74_P86_S0.6720.62
189_K193_K0.6720.62
132_S209_E0.6720.62
77_V84_I0.6690.61
207_T210_E0.6690.61
144_L147_V0.6670.61
237_E247_G0.6660.61
186_S189_K0.6660.61
78_N225_N0.6640.61
302_S307_Q0.6620.61
92_A174_M0.6600.60
97_A301_L0.6580.60
148_G152_G0.6580.60
124_Y161_D0.6580.60
233_I243_T0.6550.60
112_K150_E0.6540.60
79_V174_M0.6520.59
293_V307_Q0.6520.59
149_D171_Y0.6510.59
139_E143_I0.6500.59
246_I268_A0.6490.59
175_I194_L0.6480.59
119_L197_P0.6470.59
216_E258_L0.6450.59
246_I267_P0.6390.58
90_I117_S0.6390.58
84_I288_M0.6380.58
169_S172_V0.6370.58
79_V197_P0.6350.57
175_I191_V0.6340.57
137_G160_M0.6330.57
275_H315_V0.6310.57
92_A288_M0.6310.57
133_F136_L0.6310.57
136_L301_L0.6300.57
124_Y167_I0.6290.57
251_A270_K0.6210.56
282_V324_A0.6190.56
106_T110_A0.6190.56
204_M242_F0.6170.55
79_V225_N0.6150.55
189_K220_L0.6140.55
127_R266_H0.6110.55
287_D328_G0.6080.54
110_A314_E0.6070.54
108_A151_V0.6030.54
130_P133_F0.6020.53
104_V119_L0.6010.53
100_N301_L0.5980.53
89_V328_G0.5980.53
196_K225_N0.5970.53
79_V118_L0.5960.53
104_V302_S0.5900.52
146_R149_D0.5880.52
218_I226_T0.5870.52
165_S175_I0.5870.52
174_M197_P0.5850.51
278_A316_L0.5830.51
275_H291_I0.5830.51
179_A290_L0.5810.51
145_R168_F0.5810.51
97_A133_F0.5790.51
129_S213_Q0.5780.51
79_V154_P0.5770.50
212_L256_T0.5770.50
137_G164_D0.5760.50
124_Y168_F0.5750.50
279_L284_A0.5720.50
98_V122_G0.5720.50
107_T120_R0.5710.50
247_G281_A0.5700.50
165_S190_E0.5700.50
106_T149_D0.5700.50
322_T328_G0.5690.49
98_V140_G0.5680.49
249_M286_A0.5670.49
264_P316_L0.5670.49
295_P310_P0.5650.49
316_L320_I0.5630.49
113_R254_L0.5610.49
228_L252_A0.5600.48
267_P302_S0.5590.48
75_T258_L0.5580.48
168_F175_I0.5570.48
106_T142_K0.5570.48
111_V118_L0.5550.48
79_V92_A0.5540.48
212_L216_E0.5540.48
208_V239_S0.5510.47
280_A284_A0.5490.47
209_E238_K0.5480.47
166_N193_K0.5470.47
76_V85_G0.5450.47
262_A267_P0.5450.47
230_E248_G0.5450.47
195_G221_E0.5450.47
145_R170_Q0.5440.46
163_R166_N0.5430.46
145_R172_V0.5420.46
188_L192_G0.5420.46
90_I288_M0.5400.46
118_L290_L0.5400.46
91_V313_F0.5400.46
170_Q196_K0.5370.46
250_V254_L0.5370.46
109_K112_K0.5340.45
250_V253_K0.5330.45
92_A199_L0.5330.45
159_I186_S0.5330.45
97_A104_V0.5290.45
211_W228_L0.5290.45
264_P274_V0.5270.44
247_G268_A0.5270.44
87_K324_A0.5260.44
147_V153_L0.5260.44
246_I284_A0.5240.44
98_V133_F0.5230.44
253_K286_A0.5230.44
103_Q143_I0.5220.44
97_A302_S0.5190.43
175_I196_K0.5170.43
179_A211_W0.5160.43
274_V316_L0.5160.43
148_G173_D0.5160.43
238_K247_G0.5150.43
241_R244_L0.5130.43
198_V229_C0.5120.43
91_V116_A0.5110.42
164_D167_I0.5100.42
274_V304_S0.5090.42
168_F171_Y0.5090.42
254_L273_L0.5080.42
251_A255_M0.5060.42
215_A226_T0.5060.42
292_E302_S0.5050.42
173_D196_K0.5050.42
282_V289_L0.5050.42
200_L226_T0.5030.42
125_K134_Q0.5030.42
289_L323_L0.5010.41
89_V117_S0.5000.41
156_V229_C0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vr6A 4 1 100 0.253 Contact Map
3nvtA 4 0.9456 100 0.386 Contact Map
1vs1A 4 0.8187 100 0.427 Contact Map
4c1lA 4 0.7915 100 0.429 Contact Map
4lu0A 4 0.7402 100 0.452 Contact Map
2qkfA 4 0.7402 100 0.462 Contact Map
3tmlA 4 0.7251 100 0.465 Contact Map
1o60A 4 0.7674 100 0.465 Contact Map
3fs2A 4 0.7462 100 0.468 Contact Map
3sz8A 4 0.7613 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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