GREMLIN Database
AROB - 3-dehydroquinate synthase
UniProt: Q980I9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (322)
Sequences: 4430 (3039)
Seq/√Len: 169.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_S282_D4.3121.00
329_T333_S3.1041.00
113_N151_S3.0981.00
75_V107_I2.9331.00
69_S72_I2.8741.00
222_E230_I2.8431.00
106_S146_T2.8251.00
166_E256_Y2.7351.00
89_I101_A2.7031.00
236_F262_M2.6171.00
71_V104_L2.3481.00
276_E279_V2.3451.00
272_L343_T2.3431.00
247_G311_A2.3401.00
340_P343_T2.3001.00
164_P167_E2.2671.00
225_R228_K2.2211.00
329_T335_K2.2161.00
271_E346_G2.2051.00
178_Y212_S2.1751.00
306_K345_K2.1691.00
270_E280_V2.1371.00
269_A328_P2.1371.00
34_A38_S2.1261.00
78_L89_I2.1111.00
103_F107_I2.0891.00
183_D211_R2.0711.00
30_D61_D2.0281.00
98_T127_A2.0171.00
78_L83_F2.0151.00
210_F214_L2.0141.00
214_L218_S2.0031.00
211_R214_L1.9981.00
55_Y81_K1.9941.00
230_I233_V1.9781.00
68_L135_V1.8901.00
32_N61_D1.8791.00
176_I290_Y1.8681.00
38_S56_F1.8661.00
165_I169_K1.8591.00
57_I77_K1.8561.00
83_F87_D1.8451.00
182_L215_D1.8221.00
180_L283_V1.8081.00
140_I143_L1.7881.00
77_K81_K1.7771.00
76_E139_N1.7681.00
218_S222_E1.7581.00
137_F144_I1.7461.00
180_L328_P1.7351.00
266_A283_V1.7211.00
233_V334_W1.7181.00
165_I200_K1.7171.00
34_A58_P1.7161.00
71_V75_V1.7141.00
26_S78_L1.7031.00
28_I101_A1.7011.00
275_A279_V1.6931.00
252_V260_V1.6701.00
71_V107_I1.6561.00
149_Q224_E1.6241.00
184_K188_D1.6071.00
59_I97_V1.5991.00
86_G319_R1.5931.00
330_R333_S1.5881.00
182_L218_S1.5851.00
304_D307_L1.5691.00
91_G101_A1.5481.00
267_K284_L1.5381.00
29_K34_A1.5371.00
193_N196_K1.5341.00
262_M287_L1.5331.00
219_I233_V1.5231.00
313_N341_L1.5211.00
240_I264_C1.5031.00
270_E277_E1.4861.00
328_P334_W1.4861.00
26_S83_F1.4671.00
68_L72_I1.4441.00
24_K53_N1.4301.00
71_V134_G1.4241.00
187_Y331_I1.4231.00
189_Y208_I1.4101.00
185_E188_D1.4041.00
129_I213_T1.3961.00
277_E281_E1.3801.00
263_V284_L1.3681.00
259_S287_L1.3671.00
70_S73_S1.3671.00
77_K80_E1.3661.00
268_M325_I1.3651.00
31_N60_N1.3501.00
39_R45_D1.3491.00
76_E80_E1.3481.00
74_L100_V1.3441.00
195_E289_I1.3331.00
74_L104_L1.3311.00
59_I65_T1.3291.00
125_V175_V1.3231.00
194_K290_Y1.3181.00
170_K253_P1.3161.00
307_L310_N1.3111.00
279_V330_R1.3091.00
322_V338_E1.3081.00
181_T236_F1.3021.00
246_A311_A1.2971.00
189_Y193_N1.2941.00
157_L209_I1.2891.00
98_T116_N1.2841.00
178_Y215_D1.2771.00
327_F337_V1.2571.00
71_V135_V1.2531.00
341_L345_K1.2501.00
309_L345_K1.2471.00
124_M160_L1.2371.00
207_D211_R1.2331.00
71_V100_V1.2291.00
42_S56_F1.2231.00
87_D112_L1.1991.00
309_L313_N1.1991.00
57_I74_L1.1971.00
217_L221_K1.1961.00
31_N61_D1.1871.00
204_A207_D1.1851.00
172_L175_V1.1791.00
180_L187_Y1.1751.00
26_S77_K1.1731.00
279_V331_I1.1731.00
161_E202_K1.1721.00
120_T123_G1.1681.00
247_G307_L1.1661.00
76_E137_F1.1631.00
106_S148_Y1.1581.00
82_N314_M1.1541.00
305_L345_K1.1441.00
155_S213_T1.1421.00
28_I89_I1.1331.00
189_Y207_D1.1281.00
167_E253_P1.1221.00
236_F283_V1.1211.00
284_L288_Q1.1101.00
197_I208_I1.0991.00
281_E285_W1.0991.00
29_K33_A1.0931.00
25_L88_Y1.0931.00
187_Y282_D1.0761.00
186_L189_Y1.0721.00
29_K97_V1.0691.00
39_R42_S1.0681.00
34_A56_F1.0641.00
107_I146_T1.0611.00
65_T70_S1.0560.99
241_G257_A1.0510.99
296_I308_A1.0500.99
26_S57_I1.0470.99
236_F266_A1.0450.99
253_P256_Y1.0430.99
84_D87_D1.0420.99
157_L206_E1.0420.99
265_E326_P1.0410.99
28_I104_L1.0410.99
114_L148_Y1.0410.99
268_M347_F1.0400.99
167_E170_K1.0380.99
25_L90_I1.0310.99
89_I112_L1.0270.99
31_N35_V1.0240.99
263_V287_L1.0240.99
270_E278_G1.0200.99
267_K270_E1.0170.99
305_L349_E1.0150.99
90_I117_V1.0110.99
186_L208_I1.0090.99
259_S292_L1.0040.99
240_I265_E1.0020.99
309_L341_L1.0000.99
232_I324_L0.9910.99
267_K347_F0.9830.99
260_V263_V0.9720.99
76_E138_N0.9690.99
29_K58_P0.9650.99
22_L113_N0.9630.99
168_L200_K0.9610.99
345_K349_E0.9610.99
41_I92_V0.9560.99
175_V190_L0.9530.99
266_A275_A0.9520.99
27_K42_S0.9480.99
218_S221_K0.9470.99
169_K291_G0.9440.99
65_T96_T0.9420.99
68_L75_V0.9420.99
148_Y225_R0.9400.99
326_P336_K0.9380.99
196_K204_A0.9380.99
68_L71_V0.9350.99
73_S77_K0.9330.99
248_S252_V0.9300.99
267_K271_E0.9280.99
274_Y335_K0.9280.99
60_N70_S0.9240.99
59_I100_V0.9240.99
65_T97_V0.9220.99
343_T346_G0.9200.99
158_E161_E0.9200.99
55_Y83_F0.9130.98
59_I70_S0.9130.98
201_D204_A0.9110.98
80_E139_N0.9100.98
269_A275_A0.9090.98
79_F137_F0.9040.98
184_K330_R0.9020.98
88_Y113_N0.9020.98
184_K331_I0.9000.98
241_G258_I0.8960.98
33_A37_Y0.8940.98
342_D346_G0.8920.98
188_D192_L0.8920.98
27_K38_S0.8920.98
214_L217_L0.8910.98
30_D65_T0.8900.98
26_S55_Y0.8870.98
194_K289_I0.8860.98
272_L340_P0.8840.98
38_S42_S0.8810.98
176_I287_L0.8790.98
37_Y162_T0.8780.98
30_D33_A0.8720.98
178_Y186_L0.8700.98
24_K87_D0.8640.98
155_S209_I0.8620.98
133_N146_T0.8570.98
91_G116_N0.8550.98
121_F168_L0.8460.98
226_E232_I0.8450.97
181_T233_V0.8440.97
92_V159_F0.8410.97
182_L230_I0.8390.97
269_A327_F0.8350.97
325_I339_V0.8280.97
179_G186_L0.8210.97
176_I286_L0.8180.97
206_E210_F0.8170.97
288_Q294_Y0.8140.97
92_V117_V0.8070.97
278_G281_E0.8070.97
271_E343_T0.8070.97
84_D318_H0.8050.97
89_I105_A0.8040.97
23_S84_D0.8010.97
268_M343_T0.7970.96
57_I73_S0.7970.96
42_S54_A0.7930.96
269_A274_Y0.7930.96
265_E269_A0.7900.96
263_V294_Y0.7870.96
28_I74_L0.7840.96
180_L236_F0.7820.96
61_D65_T0.7820.96
136_N167_E0.7800.96
129_I217_L0.7780.96
191_S285_W0.7760.96
40_K45_D0.7740.96
96_T136_N0.7650.96
118_P123_G0.7640.95
37_Y92_V0.7620.95
166_E253_P0.7620.95
169_K198_L0.7620.95
267_K280_V0.7600.95
125_V212_S0.7580.95
32_N65_T0.7580.95
173_A259_S0.7570.95
67_E70_S0.7560.95
207_D214_L0.7550.95
32_N120_T0.7540.95
280_V284_L0.7540.95
148_Y151_S0.7490.95
190_L286_L0.7440.95
175_V178_Y0.7440.95
84_D321_D0.7440.95
266_A328_P0.7430.95
275_A283_V0.7420.95
182_L219_I0.7410.95
207_D210_F0.7400.95
339_V344_V0.7350.94
172_L290_Y0.7320.94
281_E284_L0.7320.94
275_A328_P0.7310.94
265_E325_I0.7310.94
188_D282_D0.7290.94
109_L143_L0.7270.94
284_L295_D0.7260.94
79_F108_Y0.7250.94
266_A280_V0.7240.94
116_N127_A0.7240.94
72_I76_E0.7220.94
188_D191_S0.7200.94
274_Y329_T0.7160.94
264_C347_F0.7120.93
29_K38_S0.7110.93
265_E327_F0.7100.93
140_I250_F0.7050.93
195_E199_N0.7020.93
168_L205_L0.6990.93
306_K341_L0.6970.93
346_G349_E0.6930.93
235_N316_K0.6910.92
170_K256_Y0.6900.92
260_V264_C0.6880.92
187_Y286_L0.6850.92
231_R235_N0.6840.92
79_F143_L0.6820.92
109_L134_G0.6810.92
196_K201_D0.6800.92
83_F108_Y0.6800.92
98_T123_G0.6750.92
327_F335_K0.6750.92
32_N35_V0.6730.91
271_E347_F0.6710.91
208_I212_S0.6690.91
69_S73_S0.6690.91
189_Y204_A0.6630.91
270_E275_A0.6610.91
187_Y283_V0.6600.91
272_L338_E0.6560.90
65_T100_V0.6550.90
285_W288_Q0.6520.90
285_W289_I0.6510.90
75_V144_I0.6510.90
191_S286_L0.6500.90
67_E136_N0.6500.90
194_K197_I0.6490.90
232_I319_R0.6470.90
236_F328_P0.6460.90
29_K62_G0.6400.89
263_V267_K0.6400.89
276_E330_R0.6360.89
297_S303_V0.6350.89
24_K55_Y0.6330.89
270_E276_E0.6320.89
263_V280_V0.6320.89
212_S215_D0.6320.89
41_I90_I0.6240.88
115_I152_M0.6240.88
244_I252_V0.6220.88
40_K46_K0.6210.88
181_T215_D0.6200.88
137_F140_I0.6190.88
247_G308_A0.6180.88
90_I115_I0.6170.87
244_I260_V0.6150.87
218_S230_I0.6130.87
31_N65_T0.6110.87
86_G320_K0.6100.87
109_L314_M0.6100.87
274_Y337_V0.6100.87
85_R147_F0.6090.87
91_G98_T0.6090.87
224_E228_K0.6090.87
288_Q295_D0.6080.87
42_S45_D0.6070.87
181_T262_M0.6050.86
79_F139_N0.6050.86
31_N58_P0.6050.86
26_S87_D0.6030.86
32_N36_I0.6030.86
82_N310_N0.6020.86
183_D215_D0.6020.86
67_E71_V0.6010.86
187_Y191_S0.6000.86
114_L149_Q0.5990.86
189_Y211_R0.5980.86
274_Y327_F0.5960.86
260_V293_P0.5940.85
109_L112_L0.5940.85
55_Y77_K0.5940.85
130_G235_N0.5930.85
231_R316_K0.5900.85
222_E229_G0.5900.85
200_K205_L0.5900.85
324_L338_E0.5890.85
210_F218_S0.5880.85
184_K282_D0.5870.85
98_T128_A0.5860.85
248_S251_N0.5860.85
342_D345_K0.5850.85
308_A312_I0.5850.85
78_L104_L0.5850.85
169_K256_Y0.5850.85
67_E100_V0.5850.85
23_S88_Y0.5840.84
246_A250_F0.5800.84
252_V256_Y0.5800.84
88_Y151_S0.5790.84
113_N148_Y0.5790.84
328_P335_K0.5770.84
125_V209_I0.5770.84
262_M283_V0.5750.84
24_K83_F0.5730.83
88_Y115_I0.5720.83
194_K198_L0.5720.83
198_L291_G0.5700.83
59_I74_L0.5700.83
27_K41_I0.5690.83
131_G235_N0.5680.83
37_Y159_F0.5680.83
191_S289_I0.5680.83
109_L318_H0.5670.83
131_G231_R0.5660.83
29_K56_F0.5650.82
125_V155_S0.5650.82
86_G228_K0.5640.82
175_V208_I0.5620.82
311_A314_M0.5600.82
165_I291_G0.5590.82
124_M155_S0.5580.82
246_A314_M0.5570.82
29_K92_V0.5550.81
27_K56_F0.5540.81
40_K158_E0.5520.81
108_Y143_L0.5470.80
268_M272_L0.5450.80
37_Y40_K0.5450.80
272_L337_V0.5450.80
119_T159_F0.5440.80
27_K54_A0.5440.80
173_A262_M0.5430.80
137_F143_L0.5430.80
25_L29_K0.5430.80
283_V287_L0.5420.80
127_A241_G0.5410.80
307_L311_A0.5400.80
24_K84_D0.5390.79
41_I47_I0.5380.79
282_D285_W0.5370.79
241_G262_M0.5350.79
184_K279_V0.5340.79
193_N204_A0.5340.79
344_V347_F0.5330.79
23_S87_D0.5320.79
286_L289_I0.5310.78
57_I81_K0.5300.78
203_Q207_D0.5300.78
23_S320_K0.5300.78
121_F175_V0.5270.78
168_L172_L0.5270.78
306_K310_N0.5260.78
118_P122_L0.5260.78
172_L176_I0.5260.78
117_V154_I0.5250.78
87_D113_N0.5250.78
268_M339_V0.5240.78
235_N317_K0.5240.78
34_A120_T0.5230.77
225_R230_I0.5210.77
100_V104_L0.5190.77
121_F209_I0.5180.77
274_Y330_R0.5170.77
41_I159_F0.5170.77
67_E135_V0.5160.76
305_L348_A0.5150.76
114_L128_A0.5150.76
123_G127_A0.5130.76
163_L167_E0.5120.76
244_I264_C0.5120.76
166_E252_V0.5120.76
196_K199_N0.5110.76
165_I168_L0.5110.76
182_L233_V0.5100.76
107_I134_G0.5090.76
70_S100_V0.5090.76
147_F153_I0.5090.76
155_S178_Y0.5080.75
216_K315_D0.5070.75
68_L107_I0.5070.75
35_V61_D0.5060.75
41_I117_V0.5060.75
318_H323_I0.5040.75
21_S88_Y0.5040.75
83_F109_L0.5030.75
175_V212_S0.5020.75
141_K242_H0.5010.74
96_T100_V0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gruA 2 0.9746 100 0.284 Contact Map
3zokA 4 0.9802 100 0.285 Contact Map
3okfA 3 0.9802 100 0.297 Contact Map
3qbeA 1 0.9576 100 0.313 Contact Map
1sg6A 1 0.952 100 0.315 Contact Map
4p53A 2 0.9633 100 0.317 Contact Map
1ujnA 2 0.904 100 0.327 Contact Map
1xahA 1 0.8983 100 0.332 Contact Map
3clhA 2 0.839 100 0.365 Contact Map
3ce9A 3 0.904 100 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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