GREMLIN Database
AROE - Shikimate dehydrogenase (NADP(+))
UniProt: Q980I8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (252)
Sequences: 6317 (4702)
Seq/√Len: 296.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_E224_K4.6981.00
17_K45_D4.1671.00
83_D101_Y3.2111.00
92_V100_G2.9611.00
246_K252_S2.9251.00
106_L243_E2.8731.00
207_V219_L2.6881.00
243_E246_K2.5701.00
73_D134_K2.5461.00
123_E147_S2.4191.00
79_L95_I2.3561.00
125_Y183_N2.2351.00
136_A210_F2.2161.00
79_L100_G2.2111.00
218_E222_N2.2031.00
27_I241_A2.1971.00
10_K63_E2.1931.00
216_E221_K2.1791.00
96_Y247_I2.1011.00
86_S92_V2.0591.00
126_I137_A2.0581.00
108_I208_I2.0491.00
74_E77_K2.0181.00
155_K159_Y1.9651.00
113_R143_L1.9501.00
11_L42_L1.9461.00
66_N244_A1.9391.00
124_C145_C1.8721.00
65_L95_I1.8691.00
110_N113_R1.8551.00
134_K164_L1.8521.00
207_V223_A1.8501.00
17_K47_D1.8271.00
220_I230_Y1.8241.00
17_K48_E1.8131.00
16_G68_T1.8051.00
76_M82_T1.7761.00
13_G44_F1.7751.00
108_I136_A1.7531.00
84_T87_T1.7421.00
75_V79_L1.7171.00
75_V95_I1.7111.00
53_R56_S1.7111.00
123_E184_I1.6581.00
202_K205_D1.6561.00
32_F39_A1.6501.00
101_Y247_I1.6461.00
110_N239_N1.6331.00
12_F39_A1.6291.00
71_Y74_E1.6071.00
15_I65_L1.5881.00
79_L92_V1.5701.00
82_T87_T1.5621.00
12_F32_F1.5611.00
125_Y151_V1.5591.00
159_Y163_E1.5581.00
41_Y66_N1.5531.00
129_A152_N1.5201.00
132_A210_F1.5071.00
149_S183_N1.4861.00
123_E149_S1.4801.00
89_I105_Y1.4781.00
94_T103_T1.4771.00
111_L208_I1.4561.00
154_T157_R1.4391.00
85_H101_Y1.4341.00
18_N21_Y1.4331.00
57_G60_E1.4251.00
52_K56_S1.4081.00
69_I191_P1.4011.00
111_L235_E1.3911.00
12_F63_E1.3861.00
58_I62_A1.3811.00
50_K53_R1.3811.00
59_L97_K1.3811.00
30_F34_T1.3781.00
221_K225_K1.3651.00
14_L43_V1.3441.00
11_L40_V1.3431.00
85_H142_E1.3401.00
17_K71_Y1.3271.00
46_L54_S1.3261.00
152_N191_P1.3151.00
88_R142_E1.3061.00
14_L19_I1.3021.00
122_Y184_I1.2921.00
20_K45_D1.2731.00
205_D228_I1.2681.00
47_D50_K1.2461.00
13_G65_L1.2371.00
224_K230_Y1.2221.00
96_Y101_Y1.2141.00
133_A189_S1.2071.00
11_L61_I1.1991.00
206_L231_I1.1901.00
105_Y139_A1.1871.00
57_G61_I1.1861.00
239_N255_D1.1831.00
58_I65_L1.1741.00
82_T100_G1.1691.00
81_N98_K1.1681.00
124_C140_L1.1651.00
114_K239_N1.1531.00
138_F142_E1.1491.00
137_A165_L1.1461.00
32_F245_E1.1451.00
15_I67_V1.1431.00
245_E249_F1.1401.00
82_T86_S1.1331.00
223_A228_I1.1321.00
145_C148_I1.1211.00
222_N225_K1.1101.00
59_L80_D1.1031.00
123_E146_S1.0891.00
19_I45_D1.0841.00
140_L187_V1.0811.00
34_T257_K1.0801.00
26_Y30_F1.0771.00
106_L110_N1.0771.00
51_F75_V1.0511.00
222_N226_Y1.0511.00
29_N40_V1.0471.00
88_R138_F1.0451.00
30_F33_R1.0431.00
256_E260_E1.0411.00
160_E164_L1.0401.00
253_V258_I1.0301.00
82_T92_V1.0291.00
37_I249_F1.0281.00
52_K78_Y1.0261.00
108_I187_V1.0241.00
49_M74_E1.0211.00
126_I133_A1.0131.00
115_K231_I0.9871.00
117_K206_L0.9841.00
44_F62_A0.9801.00
189_S210_F0.9721.00
19_I22_T0.9701.00
75_V92_V0.9671.00
162_A166_N0.9641.00
254_A257_K0.9611.00
110_N243_E0.9581.00
52_K74_E0.9551.00
218_E221_K0.9541.00
76_M79_L0.9531.00
194_S197_P0.9491.00
109_K113_R0.9461.00
238_V242_V0.9411.00
23_L26_Y0.9301.00
79_L82_T0.9291.00
242_V255_D0.9291.00
137_A148_I0.9291.00
51_F78_Y0.9271.00
55_I78_Y0.9261.00
35_L251_K0.9241.00
211_V217_T0.9241.00
46_L71_Y0.9241.00
16_G19_I0.9161.00
235_E239_N0.9151.00
257_K261_Y0.9011.00
35_L245_E0.9001.00
54_S61_I0.9001.00
48_E74_E0.8941.00
131_G135_A0.8901.00
129_A150_I0.8841.00
109_K139_A0.8831.00
194_S222_N0.8681.00
31_S35_L0.8641.00
29_N33_R0.8631.00
111_L239_N0.8451.00
140_L145_C0.8401.00
73_D157_R0.8391.00
84_T88_R0.8371.00
152_N157_R0.8331.00
54_S57_G0.8271.00
132_A189_S0.8261.00
110_N114_K0.8251.00
67_V71_Y0.8251.00
123_E182_N0.8241.00
91_A102_N0.8191.00
109_K142_E0.8161.00
173_S176_E0.8141.00
31_S245_E0.8101.00
186_I205_D0.8071.00
107_A236_I0.8051.00
65_L97_K0.8021.00
15_I54_S0.8011.00
27_I237_L0.8001.00
28_H241_A0.7950.99
81_N87_T0.7940.99
152_N158_A0.7880.99
216_E220_I0.7810.99
166_N169_G0.7810.99
198_E222_N0.7810.99
20_K43_V0.7750.99
215_V232_N0.7700.99
201_V228_I0.7690.99
30_F257_K0.7680.99
243_E247_I0.7670.99
12_F249_F0.7640.99
201_V207_V0.7600.99
65_L75_V0.7580.99
73_D77_K0.7580.99
192_N195_V0.7580.99
125_Y186_I0.7540.99
89_I138_F0.7530.99
157_R160_E0.7530.99
119_V122_Y0.7510.99
37_I245_E0.7480.99
56_S59_L0.7440.99
216_E230_Y0.7440.99
11_L44_F0.7350.99
114_K235_E0.7340.99
211_V232_N0.7310.99
127_Y190_T0.7300.99
44_F54_S0.7290.99
31_S258_I0.7280.99
34_T254_A0.7240.99
206_L229_Q0.7240.99
111_L115_K0.7210.99
23_L213_R0.7200.99
210_F236_I0.7200.99
55_I75_V0.7180.99
193_S218_E0.7180.99
231_I235_E0.7140.99
197_P200_C0.7120.99
15_I46_L0.7080.99
21_Y69_I0.7070.99
137_A150_I0.7060.99
51_F74_E0.7040.99
91_A135_A0.6970.99
185_L206_L0.6960.99
207_V220_I0.6860.98
133_A137_A0.6850.98
55_I59_L0.6830.98
119_V145_C0.6830.98
160_E163_E0.6820.98
198_E226_Y0.6780.98
204_S228_I0.6770.98
75_V78_Y0.6760.98
53_R57_G0.6760.98
243_E252_S0.6760.98
13_G43_V0.6720.98
188_N219_L0.6720.98
51_F71_Y0.6710.98
202_K228_I0.6700.98
89_I135_A0.6650.98
47_D71_Y0.6570.98
156_S160_E0.6560.98
198_E225_K0.6560.98
94_T244_A0.6520.98
105_Y138_F0.6500.98
122_Y146_S0.6500.98
30_F258_I0.6500.98
28_H32_F0.6490.98
165_L168_N0.6440.98
41_Y94_T0.6390.98
235_E259_I0.6380.98
28_H94_T0.6380.98
201_V222_N0.6370.98
110_N246_K0.6340.97
234_L238_V0.6310.97
37_I251_K0.6280.97
127_Y186_I0.6280.97
69_I211_V0.6270.97
126_I150_I0.6260.97
158_A162_A0.6250.97
13_G62_A0.6240.97
109_K143_L0.6220.97
117_K185_L0.6210.97
186_I207_V0.6200.97
88_R164_L0.6190.97
112_V140_L0.6180.97
124_C185_L0.6160.97
115_K235_E0.6160.97
199_D226_Y0.6160.97
127_Y151_V0.6140.97
112_V231_I0.6130.97
154_T191_P0.6120.97
188_N211_V0.6120.97
14_L66_N0.6120.97
95_I100_G0.6110.97
15_I71_Y0.6100.97
52_K77_K0.6100.97
84_T142_E0.6080.97
111_L231_I0.6050.97
114_K259_I0.6040.97
141_S148_I0.6020.97
125_Y180_I0.6000.97
105_Y142_E0.5980.96
180_I183_N0.5970.96
17_K21_Y0.5970.96
89_I102_N0.5940.96
220_I232_N0.5910.96
107_A111_L0.5900.96
83_D247_I0.5890.96
105_Y109_K0.5890.96
183_N186_I0.5890.96
187_V210_F0.5870.96
115_K229_Q0.5860.96
123_E183_N0.5830.96
192_N218_E0.5790.96
53_R60_E0.5790.96
165_L169_G0.5760.96
190_T211_V0.5750.96
141_S165_L0.5740.96
244_A248_W0.5730.95
26_Y43_V0.5710.95
67_V95_I0.5710.95
126_I189_S0.5670.95
166_N170_Y0.5670.95
139_A143_L0.5670.95
155_K173_S0.5660.95
11_L57_G0.5650.95
133_A152_N0.5650.95
56_S60_E0.5640.95
254_A258_I0.5640.95
63_E98_K0.5640.95
76_M86_S0.5610.95
58_I97_K0.5600.95
245_E253_V0.5600.95
118_N122_Y0.5600.95
14_L22_T0.5580.95
62_A65_L0.5550.95
120_S144_G0.5540.95
30_F261_Y0.5540.95
138_F165_L0.5510.94
126_I140_L0.5510.94
215_V234_L0.5510.94
15_I51_F0.5490.94
213_R237_L0.5490.94
129_A154_T0.5480.94
121_G146_S0.5440.94
18_N71_Y0.5430.94
81_N84_T0.5410.94
124_C187_V0.5400.94
85_H138_F0.5400.94
156_S159_Y0.5390.94
85_H105_Y0.5380.94
66_N94_T0.5380.94
19_I213_R0.5360.94
115_K208_I0.5330.93
171_N176_E0.5320.93
257_K260_E0.5320.93
127_Y196_V0.5310.93
178_C181_T0.5290.93
169_G176_E0.5270.93
31_S253_V0.5260.93
24_S212_Y0.5250.93
40_V43_V0.5240.93
132_A135_A0.5230.93
11_L43_V0.5220.93
112_V206_L0.5200.93
255_D259_I0.5190.92
169_G172_A0.5190.92
19_I68_T0.5180.92
242_V258_I0.5180.92
246_K253_V0.5160.92
216_E232_N0.5160.92
113_R119_V0.5150.92
162_A165_L0.5140.92
163_E167_K0.5130.92
88_R141_S0.5120.92
69_I213_R0.5100.92
169_G175_K0.5100.92
91_A132_A0.5100.92
201_V223_A0.5090.92
105_Y136_A0.5070.92
54_S58_I0.5060.92
32_F248_W0.5050.91
29_N38_N0.5030.91
136_A187_V0.5030.91
201_V226_Y0.5020.91
129_A133_A0.5020.91
85_H89_I0.5020.91
194_S198_E0.5010.91
232_N235_E0.5000.91
105_Y111_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1npyA 1 0.948 100 0.224 Contact Map
4xijA 1 0.948 100 0.23 Contact Map
3t4eA 2 0.9703 100 0.247 Contact Map
3tnlA 2 0.9777 100 0.278 Contact Map
2o7sA 2 0.9442 100 0.279 Contact Map
3phhA 1 0.9033 100 0.282 Contact Map
3jyoA 2 0.9628 100 0.297 Contact Map
3pwzA 1 0.9554 100 0.297 Contact Map
2d5cA 2 0.9405 100 0.298 Contact Map
3fbtA 2 0.9591 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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