GREMLIN Database
AROC - Chorismate synthase
UniProt: Q980I7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (351)
Sequences: 3226 (1551)
Seq/√Len: 82.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_E85_R4.8711.00
230_M289_T3.6411.00
215_A345_V3.2511.00
40_D144_K3.2481.00
314_D319_E3.2441.00
246_G253_F3.2051.00
44_E143_K3.1821.00
84_V133_V3.1231.00
251_L280_Y2.9841.00
205_D261_S2.9831.00
218_P294_L2.9131.00
145_L350_V2.7131.00
233_E352_H2.5451.00
203_E259_K2.3791.00
253_F299_A2.3391.00
71_F121_Y2.3121.00
30_V80_I2.2961.00
184_A193_Y2.2751.00
216_K293_D2.2711.00
234_L345_V2.2711.00
101_P111_I2.2631.00
238_I296_V2.2341.00
246_G299_A2.1791.00
12_I25_V2.1601.00
309_P322_Y2.1231.00
27_I141_V2.1191.00
159_S257_K2.1101.00
215_A349_I2.1041.00
248_E297_R2.0781.00
64_P82_V2.0751.00
37_T40_D2.0381.00
15_F81_A2.0011.00
156_H185_S1.9891.00
238_I345_V1.9851.00
176_C179_Y1.9751.00
153_I346_A1.9621.00
199_K203_E1.9601.00
61_K87_T1.9591.00
228_D236_K1.9311.00
35_P74_R1.9291.00
180_S190_E1.8881.00
162_P196_L1.8591.00
106_A286_G1.8581.00
296_V345_V1.8371.00
266_E311_K1.8341.00
277_K311_K1.8301.00
159_S162_P1.8161.00
25_V82_V1.8131.00
189_L192_K1.8001.00
268_I277_K1.7941.00
159_S164_E1.7621.00
196_L200_A1.7611.00
233_E236_K1.7481.00
131_E135_R1.7461.00
309_P324_S1.7341.00
212_E297_R1.7241.00
22_A83_I1.7061.00
200_A207_Y1.7001.00
241_I341_V1.6701.00
269_R320_E1.6621.00
255_A263_A1.6611.00
214_I293_D1.6391.00
181_P194_E1.6321.00
36_L141_V1.6321.00
42_K46_E1.6201.00
22_A67_L1.5921.00
5_S13_T1.5811.00
233_E355_R1.5521.00
191_E194_E1.5371.00
15_F24_G1.5130.99
284_I294_L1.4620.99
82_V137_I1.4600.99
210_I297_R1.4570.99
209_G334_A1.4570.99
158_R212_E1.4560.99
41_I140_A1.4490.99
258_M263_A1.4480.99
300_F341_V1.4480.99
298_C341_V1.4450.99
30_V141_V1.4320.99
264_N310_Q1.4320.99
10_F30_V1.4290.99
238_I298_C1.4240.99
254_I257_K1.4230.99
108_L267_I1.3950.99
21_P65_E1.3880.99
96_E326_I1.3870.99
268_I275_G1.3870.99
178_K183_R1.3840.99
160_L332_A1.3800.99
147_M152_W1.3750.99
237_A348_T1.3650.99
213_V341_V1.3570.99
267_I276_W1.3560.99
284_I289_T1.3560.99
143_K342_E1.3400.99
238_I247_F1.3350.99
25_V138_A1.3290.99
34_L145_L1.3280.99
101_P315_L1.3250.99
70_I80_I1.3220.99
152_W216_K1.3150.98
235_A239_M1.3130.98
36_L75_T1.3100.98
99_Y316_R1.3080.98
247_F296_V1.3010.98
311_K322_Y1.2950.98
198_K201_T1.2930.98
182_V197_I1.2900.98
314_D321_S1.2880.98
275_G292_E1.2820.98
174_V177_S1.2750.98
225_P288_L1.2710.98
8_K11_R1.2650.98
100_K321_S1.2630.98
155_G338_V1.2570.98
44_E140_A1.2400.98
129_A333_V1.2300.98
244_V300_F1.2300.98
195_A199_K1.2290.98
47_F342_E1.2280.98
25_V134_S1.2280.98
205_D259_K1.2240.98
239_M249_Y1.2230.98
111_I315_L1.2200.98
232_A236_K1.2080.97
154_A177_S1.2060.97
159_S210_I1.2060.97
21_P85_R1.2050.97
243_A333_V1.2000.97
149_T353_A1.1990.97
10_F347_L1.1880.97
251_L255_A1.1850.97
54_Y198_K1.1840.97
151_T353_A1.1820.97
35_P148_L1.1800.97
163_E189_L1.1800.97
10_F27_I1.1800.97
27_I82_V1.1750.97
37_T144_K1.1700.97
204_G307_R1.1680.97
256_S299_A1.1640.97
352_H355_R1.1630.97
215_A294_L1.1600.97
222_L353_A1.1590.97
215_A218_P1.1560.97
143_K346_A1.1490.96
224_E352_H1.1430.96
104_G285_L1.1400.96
266_E277_K1.1150.96
196_L259_K1.1100.96
40_D43_F1.1070.96
90_I93_F1.1050.96
261_S306_I1.1050.96
300_F337_G1.0980.95
154_A174_V1.0960.95
251_L258_M1.0950.95
186_K189_L1.0930.95
36_L40_D1.0890.95
196_L199_K1.0850.95
74_R116_Y1.0800.95
305_S325_V1.0790.95
166_S189_L1.0760.95
300_F333_V1.0750.95
57_G88_D1.0730.95
194_E198_K1.0730.95
210_I253_F1.0640.94
49_R61_K1.0620.94
285_L290_N1.0600.94
10_F142_A1.0580.94
142_A347_L1.0560.94
176_C187_K1.0530.94
99_Y314_D1.0520.94
218_P222_L1.0470.94
40_D147_M1.0430.94
312_T323_I1.0390.94
206_S303_T1.0380.94
312_T321_S1.0350.94
244_V298_C1.0340.94
311_K320_E1.0280.93
203_E308_K1.0270.93
164_E257_K1.0200.93
276_W292_E1.0150.93
159_S256_S1.0140.93
270_K275_G1.0140.93
211_A341_V1.0000.92
135_R344_M1.0000.92
345_V349_I0.9940.92
112_M220_I0.9930.92
108_L112_M0.9880.92
17_E76_T0.9880.92
212_E295_I0.9790.92
237_A344_M0.9770.92
241_I344_M0.9760.92
163_E192_K0.9730.91
109_P267_I0.9720.91
57_G201_T0.9700.91
11_R28_D0.9680.91
42_K45_L0.9630.91
184_A190_E0.9530.91
109_P288_L0.9430.90
234_L296_V0.9410.90
30_V34_L0.9390.90
190_E194_E0.9300.89
192_K195_A0.9300.89
251_L254_I0.9290.89
211_A300_F0.9260.89
49_R59_R0.9170.89
191_E195_A0.9130.89
97_I121_Y0.9120.88
33_G74_R0.9110.88
92_S95_D0.9070.88
236_K240_S0.9040.88
95_D121_Y0.8970.88
23_V134_S0.8960.88
23_V133_V0.8950.88
213_V296_V0.8940.87
163_E196_L0.8940.87
188_D192_K0.8930.87
157_L334_A0.8920.87
150_D217_N0.8890.87
200_A259_K0.8880.87
182_V190_E0.8880.87
154_A216_K0.8870.87
258_M262_E0.8860.87
157_L160_L0.8850.87
144_K147_M0.8850.87
189_L193_Y0.8850.87
161_G207_Y0.8840.87
266_E278_Y0.8780.87
268_I320_E0.8750.86
210_I246_G0.8740.86
25_V81_A0.8700.86
156_H212_E0.8690.86
163_E193_Y0.8680.86
269_R274_I0.8680.86
303_T331_P0.8680.86
196_L207_Y0.8640.86
229_K242_P0.8640.86
9_L355_R0.8630.86
104_G281_A0.8600.85
100_K312_T0.8580.85
316_R319_E0.8540.85
71_F122_R0.8420.84
131_E226_V0.8390.84
154_A214_I0.8370.84
161_G196_L0.8370.84
213_V298_C0.8330.84
274_I313_I0.8320.83
66_I70_I0.8280.83
65_E83_I0.8280.83
155_G213_V0.8240.83
307_R326_I0.8230.83
303_T333_V0.8220.83
270_K273_R0.8200.83
180_S187_K0.8200.83
230_M352_H0.8170.82
234_L348_T0.8120.82
215_A296_V0.8110.82
32_A359_I0.8100.82
334_A337_G0.8090.82
109_P285_L0.8080.82
84_V134_S0.8060.81
205_D308_K0.8040.81
17_E20_G0.8020.81
251_L263_A0.7990.81
190_E193_Y0.7980.81
184_A189_L0.7970.81
276_W290_N0.7940.80
70_I144_K0.7940.80
231_K245_M0.7920.80
34_L350_V0.7920.80
80_I141_V0.7920.80
66_I137_I0.7910.80
135_R240_S0.7880.80
231_K235_A0.7880.80
95_D98_K0.7860.80
5_S11_R0.7860.80
281_A285_L0.7850.80
304_S340_V0.7850.80
41_I66_I0.7840.80
67_L83_I0.7800.79
207_Y259_K0.7790.79
96_E100_K0.7780.79
228_D233_E0.7780.79
222_L349_I0.7760.79
157_L335_I0.7720.79
42_K63_E0.7700.78
204_G308_K0.7680.78
175_L179_Y0.7650.78
224_E228_D0.7650.78
165_L189_L0.7640.78
14_T135_R0.7590.77
14_T131_E0.7590.77
30_V142_A0.7550.77
47_F339_T0.7520.77
63_E87_T0.7510.77
337_G341_V0.7510.77
160_L197_I0.7490.76
356_A359_I0.7480.76
348_T351_D0.7470.76
238_I341_V0.7400.76
231_K249_Y0.7380.75
6_F347_L0.7370.75
23_V84_V0.7370.75
26_V81_A0.7360.75
45_L133_V0.7310.75
233_E348_T0.7290.75
109_P290_N0.7290.75
198_K202_Q0.7270.74
24_G67_L0.7260.74
8_K355_R0.7260.74
314_D317_N0.7250.74
210_I299_A0.7250.74
356_A360_P0.7240.74
38_V42_K0.7230.74
210_I256_S0.7230.74
197_I332_A0.7200.74
129_A242_P0.7200.74
20_G122_R0.7150.73
193_Y197_I0.7150.73
255_A281_A0.7150.73
239_M296_V0.7110.73
289_T294_L0.7100.73
162_P257_K0.7090.72
228_D355_R0.7050.72
42_K49_R0.7030.72
38_V65_E0.7030.72
10_F350_V0.7010.72
199_K202_Q0.7000.72
131_E134_S0.6980.71
254_I258_M0.6960.71
300_F340_V0.6950.71
267_I274_I0.6950.71
261_S308_K0.6940.71
27_I142_A0.6940.71
153_I349_I0.6940.71
13_T26_V0.6930.71
195_A198_K0.6930.71
135_R226_V0.6910.71
12_I347_L0.6900.70
46_E49_R0.6900.70
218_P353_A0.6880.70
55_V197_I0.6870.70
42_K64_P0.6830.70
66_I82_V0.6770.69
91_S122_R0.6770.69
200_A203_E0.6770.69
15_F26_V0.6760.69
6_F344_M0.6710.68
32_A356_A0.6710.68
75_T144_K0.6690.68
259_K262_E0.6690.68
104_G304_S0.6670.68
67_L81_A0.6670.68
55_V182_V0.6650.68
166_S186_K0.6640.67
55_V194_E0.6640.67
89_V93_F0.6610.67
218_P288_L0.6570.67
267_I285_L0.6550.66
110_F127_A0.6540.66
211_A337_G0.6530.66
12_I138_A0.6510.66
82_V141_V0.6470.65
239_M247_F0.6460.65
6_F237_A0.6440.65
284_I290_N0.6430.65
213_V345_V0.6430.65
231_K247_F0.6420.65
229_K232_A0.6410.65
192_K196_L0.6400.65
170_T173_E0.6390.65
158_R164_E0.6390.65
41_I82_V0.6350.64
224_E355_R0.6350.64
269_R313_I0.6350.64
152_W174_V0.6330.64
281_A294_L0.6320.64
67_L85_R0.6310.64
59_R88_D0.6300.63
88_D92_S0.6290.63
129_A340_V0.6270.63
165_L185_S0.6250.63
14_T229_K0.6250.63
248_E252_G0.6230.63
49_R52_R0.6230.63
268_I311_K0.6230.63
111_I121_Y0.6210.62
44_E47_F0.6210.62
14_T126_R0.6200.62
143_K153_I0.6190.62
171_F175_L0.6190.62
38_V63_E0.6190.62
14_T134_S0.6110.61
197_I200_A0.6110.61
354_M357_G0.6090.61
126_R131_E0.6080.61
333_V340_V0.6070.61
214_I295_I0.6070.61
75_T141_V0.6060.60
294_L349_I0.6050.60
24_G81_A0.6050.60
269_R272_N0.6030.60
255_A258_M0.6020.60
71_F120_D0.6000.60
152_W217_N0.6000.60
234_L238_I0.5990.60
156_H214_I0.5980.59
241_I340_V0.5960.59
268_I274_I0.5950.59
228_D352_H0.5950.59
156_H165_L0.5950.59
33_G116_Y0.5940.59
27_I30_V0.5930.59
12_I344_M0.5910.59
232_A240_S0.5900.58
98_K121_Y0.5890.58
166_S171_F0.5890.58
144_K148_L0.5880.58
78_S110_F0.5870.58
156_H174_V0.5860.58
234_L247_F0.5840.58
158_R210_I0.5830.58
12_I27_I0.5830.58
47_F178_K0.5820.57
164_E254_I0.5820.57
72_N121_Y0.5800.57
204_G324_S0.5800.57
97_I323_I0.5780.57
165_L184_A0.5770.57
243_A337_G0.5760.57
35_P144_K0.5750.56
304_S325_V0.5750.56
36_L144_K0.5740.56
151_T218_P0.5740.56
155_G342_E0.5730.56
344_M348_T0.5730.56
350_V354_M0.5720.56
333_V337_G0.5720.56
205_D262_E0.5710.56
37_T43_F0.5690.56
90_I95_D0.5690.56
38_V144_K0.5690.56
158_R295_I0.5690.56
307_R325_V0.5680.56
158_R297_R0.5660.55
243_A300_F0.5650.55
27_I140_A0.5650.55
32_A360_P0.5630.55
249_Y296_V0.5600.55
155_G341_V0.5600.55
34_L144_K0.5600.55
36_L43_F0.5570.54
197_I201_T0.5550.54
71_F76_T0.5550.54
36_L66_I0.5550.54
53_L180_S0.5540.54
227_F242_P0.5540.54
39_E43_F0.5530.54
76_T122_R0.5530.54
248_E253_F0.5520.53
81_A134_S0.5520.53
201_T204_G0.5510.53
215_A234_L0.5490.53
111_I116_Y0.5470.53
156_H172_E0.5440.52
165_L186_K0.5440.52
52_R56_S0.5440.52
304_S307_R0.5440.52
72_N95_D0.5440.52
192_K199_K0.5430.52
44_E136_V0.5400.52
30_V347_L0.5380.52
163_E200_A0.5380.52
269_R273_R0.5360.51
8_K228_D0.5360.51
45_L137_I0.5350.51
17_E122_R0.5350.51
41_I144_K0.5340.51
82_V134_S0.5340.51
267_I313_I0.5330.51
131_E240_S0.5330.51
138_A347_L0.5330.51
226_V229_K0.5320.51
15_F67_L0.5310.51
285_L305_S0.5300.51
263_A281_A0.5280.50
30_V145_L0.5280.50
45_L219_P0.5270.50
43_F46_E0.5270.50
12_I82_V0.5270.50
242_P337_G0.5270.50
25_V242_P0.5260.50
10_F354_M0.5260.50
193_Y196_L0.5250.50
20_G76_T0.5250.50
155_G211_A0.5220.50
293_D296_V0.5210.49
52_R55_V0.5210.49
226_V240_S0.5200.49
127_A131_E0.5200.49
219_P353_A0.5200.49
126_R135_R0.5190.49
281_A290_N0.5180.49
222_L352_H0.5180.49
64_P70_I0.5160.49
305_S340_V0.5160.49
182_V194_E0.5160.49
113_K224_E0.5150.49
173_E176_C0.5140.48
94_Y327_G0.5130.48
149_T350_V0.5120.48
244_V247_F0.5100.48
210_I295_I0.5100.48
331_P337_G0.5070.48
59_R87_T0.5050.47
215_A222_L0.5050.47
281_A284_I0.5030.47
38_V73_N0.5030.47
96_E99_Y0.5030.47
55_V160_L0.5020.47
32_A78_S0.5010.47
38_V66_I0.5010.47
156_H177_S0.5010.47
68_S81_A0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r53A 4 0.7059 100 0.084 Contact Map
2o11A 4 0.9207 100 0.088 Contact Map
4ob9A 2 0.7954 100 0.09 Contact Map
1q1lA 4 0.8363 100 0.091 Contact Map
1sq1A 4 0.7366 100 0.092 Contact Map
4ecdA 3 0.6829 100 0.095 Contact Map
1qxoA 4 0.9386 100 0.098 Contact Map
1um0A 4 0.9156 100 0.099 Contact Map
4wdcA 1 0.3964 29.1 0.98 Contact Map
2ekmA 3 0.1381 22 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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