GREMLIN Database
Q980I6 - Shikimate kinase
UniProt: Q980I6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (227)
Sequences: 3797 (3078)
Seq/√Len: 204.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_N204_L5.3061.00
195_L198_M3.5991.00
105_I108_P3.2651.00
195_L199_K3.1441.00
200_M204_L2.9361.00
200_M203_I2.7941.00
157_L239_V2.5171.00
174_N177_R2.3301.00
109_I113_I2.2631.00
48_E57_N2.2621.00
45_Y69_E2.2501.00
185_E189_I2.2351.00
158_S240_S2.1891.00
240_S248_I2.1481.00
37_E69_E2.1271.00
57_N61_E2.1051.00
206_A213_L2.1021.00
196_T199_K2.0531.00
107_P111_S1.9611.00
107_P113_I1.8791.00
59_F93_I1.8761.00
108_P111_S1.8661.00
194_Y199_K1.8381.00
108_P113_I1.8381.00
194_Y198_M1.8161.00
212_S229_I1.7881.00
47_Q71_D1.7431.00
181_H184_E1.7331.00
187_F190_A1.7201.00
39_R69_E1.7081.00
159_I237_F1.6911.00
31_N34_V1.6841.00
159_I235_S1.6591.00
170_P173_L1.6571.00
185_E188_K1.6531.00
186_I190_A1.6491.00
52_I72_I1.6101.00
150_L153_L1.5991.00
127_D143_K1.5741.00
42_K46_S1.5721.00
176_L179_Y1.5651.00
109_I112_A1.5621.00
37_E71_D1.5531.00
177_R180_S1.5051.00
217_E221_K1.5051.00
186_I189_I1.4901.00
169_K173_L1.4651.00
58_Y62_K1.4601.00
182_V185_E1.4431.00
209_L212_S1.4361.00
205_I209_L1.4231.00
93_I109_I1.4021.00
34_V38_I1.3951.00
56_L60_K1.3801.00
32_L35_K1.3621.00
228_G237_F1.3561.00
96_I100_Y1.3491.00
103_R107_P1.3451.00
80_S161_I1.3421.00
104_N108_P1.3331.00
176_L180_S1.3261.00
35_K73_E1.3061.00
62_K113_I1.2921.00
30_I34_V1.2831.00
31_N38_I1.2821.00
178_K181_H1.2821.00
110_L134_C1.2811.00
47_Q69_E1.2791.00
103_R111_S1.2711.00
109_I114_L1.2631.00
166_G232_N1.2591.00
104_N109_I1.2351.00
105_I113_I1.2351.00
176_L181_H1.2351.00
218_I222_K1.2241.00
227_A238_A1.2151.00
184_E188_K1.2071.00
219_A238_A1.2051.00
177_R181_H1.2011.00
107_P112_A1.2001.00
187_F191_L1.1981.00
30_I82_L1.1941.00
185_E190_A1.1741.00
205_I212_S1.1721.00
206_A212_S1.1591.00
209_L229_I1.1561.00
188_K192_K1.1531.00
213_L217_E1.1421.00
97_A104_N1.1381.00
103_R109_I1.1371.00
104_N113_I1.1351.00
103_R106_N1.1341.00
189_I192_K1.1301.00
59_F100_Y1.1301.00
180_S184_E1.1281.00
52_I92_L1.1211.00
53_K57_N1.1061.00
33_K73_E1.1051.00
249_Y253_K1.1041.00
219_A224_A1.1021.00
29_A33_K1.0971.00
193_D197_A1.0931.00
98_K102_L1.0921.00
193_D196_T1.0851.00
33_K38_I1.0811.00
248_I252_L1.0771.00
103_R113_I1.0761.00
94_A133_Y1.0701.00
176_L185_E1.0701.00
183_F189_I1.0611.00
177_R190_A1.0541.00
166_G171_V1.0511.00
220_L227_A1.0471.00
56_L70_V1.0461.00
76_L87_A1.0361.00
183_F190_A1.0341.00
179_Y182_V1.0341.00
218_I221_K1.0281.00
184_E187_F1.0281.00
183_F186_I1.0271.00
59_F96_I1.0251.00
243_G246_G1.0251.00
104_N112_A1.0141.00
180_S183_F1.0061.00
92_L96_I1.0051.00
182_V189_I0.9981.00
110_L113_I0.9891.00
146_R149_K0.9881.00
93_I107_P0.9851.00
205_I208_I0.9811.00
34_V91_A0.9761.00
60_K100_Y0.9741.00
180_S185_E0.9711.00
107_P114_L0.9701.00
167_R170_P0.9671.00
180_S190_A0.9651.00
164_K211_Y0.9500.99
106_N109_I0.9500.99
180_S189_I0.9470.99
51_L89_S0.9380.99
182_V188_K0.9380.99
48_E53_K0.9330.99
176_L184_E0.9270.99
45_Y71_D0.9170.99
199_K203_I0.9130.99
97_A102_L0.9060.99
168_Q172_N0.9060.99
108_P112_A0.9010.99
182_V186_I0.8970.99
104_N107_P0.8960.99
130_V138_A0.8950.99
29_A32_L0.8910.99
94_A98_K0.8900.99
177_R182_V0.8890.99
43_R46_S0.8860.99
156_N243_G0.8850.99
58_Y61_E0.8850.99
185_E192_K0.8840.99
198_M203_I0.8830.99
181_H185_E0.8790.99
145_F148_V0.8720.99
108_P114_L0.8680.99
30_I33_K0.8600.99
145_F149_K0.8590.99
176_L182_V0.8580.99
211_Y214_E0.8470.99
44_V67_D0.8470.99
176_L187_F0.8400.99
183_F187_F0.8400.99
110_L114_L0.8350.99
182_V190_A0.8310.99
194_Y197_A0.8310.99
97_A103_R0.8290.98
32_L36_V0.8060.98
59_F63_Y0.8030.98
79_K234_P0.8030.98
103_R112_A0.8030.98
32_L38_I0.8010.98
174_N180_S0.8000.98
193_D198_M0.7930.98
82_L159_I0.7900.98
179_Y183_F0.7890.98
90_V133_Y0.7870.98
216_I236_Y0.7870.98
175_E179_Y0.7870.98
219_A227_A0.7860.98
141_Y148_V0.7830.98
55_I92_L0.7820.98
194_Y204_L0.7800.98
43_R69_E0.7770.98
156_N262_R0.7710.98
97_A101_D0.7670.97
53_K70_V0.7660.97
179_Y184_E0.7630.97
246_G250_E0.7560.97
29_A34_V0.7550.97
181_H190_A0.7530.97
206_A209_L0.7510.97
180_S188_K0.7470.97
106_N111_S0.7460.97
79_K165_G0.7460.97
214_E217_E0.7450.97
102_L107_P0.7430.97
250_E254_K0.7430.97
180_S187_F0.7430.97
177_R184_E0.7400.97
251_S254_K0.7380.97
177_R188_K0.7350.97
87_A132_S0.7340.97
166_G205_I0.7330.97
257_D260_I0.7290.97
212_S216_I0.7280.97
29_A38_I0.7280.97
34_V76_L0.7250.96
40_E43_R0.7230.96
163_A257_D0.7160.96
177_R185_E0.7150.96
249_Y260_I0.7100.96
70_V92_L0.7100.96
86_S132_S0.7080.96
238_A252_L0.7060.96
39_R71_D0.7040.96
177_R183_F0.7040.96
175_E184_E0.7010.96
36_V95_E0.7010.96
161_I235_S0.7000.96
216_I227_A0.6980.96
174_N184_E0.6960.96
222_K248_I0.6920.95
175_E185_E0.6910.95
230_S235_S0.6890.95
35_K71_D0.6870.95
174_N188_K0.6840.95
249_Y252_L0.6840.95
249_Y258_V0.6830.95
209_L213_L0.6830.95
36_V56_L0.6820.95
179_Y185_E0.6820.95
40_E46_S0.6810.95
55_I58_Y0.6800.95
111_S114_L0.6720.95
241_K245_E0.6710.95
105_I111_S0.6680.94
161_I259_I0.6670.94
56_L96_I0.6670.94
251_S255_F0.6650.94
32_L39_R0.6610.94
181_H189_I0.6600.94
102_L109_I0.6590.94
44_V53_K0.6590.94
250_E253_K0.6550.94
105_I109_I0.6530.94
184_E190_A0.6470.93
39_R43_R0.6450.93
58_Y110_L0.6450.93
41_G45_Y0.6440.93
83_K132_S0.6430.93
151_E154_E0.6420.93
244_E247_P0.6410.93
252_L255_F0.6400.93
182_V187_F0.6390.93
104_N111_S0.6370.93
178_K184_E0.6370.93
188_K191_L0.6320.93
220_L224_A0.6240.92
166_G234_P0.6240.92
101_D108_P0.6240.92
193_D199_K0.6240.92
157_L237_F0.6220.92
158_S238_A0.6210.92
178_K182_V0.6210.92
178_K183_F0.6190.92
103_R114_L0.6160.92
126_L140_T0.6140.92
57_N60_K0.6130.92
247_P251_S0.6120.91
218_I255_F0.6110.91
184_E189_I0.6090.91
240_S245_E0.6050.91
180_S186_I0.6000.91
205_I210_G0.5990.91
156_N245_E0.5960.90
181_H188_K0.5950.90
102_L108_P0.5920.90
74_S88_V0.5920.90
214_E218_I0.5900.90
86_S131_A0.5890.90
174_N183_F0.5860.90
183_F188_K0.5860.90
101_D109_I0.5850.90
175_E182_V0.5810.89
176_L189_I0.5790.89
171_V205_I0.5760.89
41_G44_V0.5760.89
63_Y100_Y0.5740.89
195_L204_L0.5730.89
194_Y201_N0.5720.89
179_Y189_I0.5710.88
225_L241_K0.5710.88
212_S236_Y0.5700.88
160_L238_A0.5690.88
55_I93_I0.5610.88
148_V153_L0.5600.87
125_A128_D0.5600.87
79_K235_S0.5580.87
195_L203_I0.5540.87
171_V208_I0.5540.87
246_G249_Y0.5530.87
195_L202_G0.5520.87
197_A201_N0.5520.87
228_G235_S0.5490.86
192_K198_M0.5490.86
59_F92_L0.5460.86
175_E181_H0.5450.86
215_P236_Y0.5440.86
104_N114_L0.5420.86
174_N178_K0.5390.85
36_V70_V0.5300.84
130_V134_C0.5300.84
105_I112_A0.5290.84
196_T201_N0.5270.84
247_P250_E0.5250.84
170_P208_I0.5250.84
65_I100_Y0.5230.84
82_L230_S0.5220.84
174_N181_H0.5210.83
177_R187_F0.5200.83
199_K202_G0.5180.83
140_T147_I0.5160.83
44_V47_Q0.5140.83
114_L124_G0.5130.83
30_I35_K0.5110.82
158_S260_I0.5100.82
35_K38_I0.5090.82
128_D205_I0.5070.82
198_M201_N0.5070.82
128_D131_A0.5030.81
220_L226_A0.5020.81
242_N245_E0.5010.81
217_E220_L0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h72C 2 0.9636 100 0.391 Contact Map
3hulA 4 0.9018 100 0.407 Contact Map
4p52A 2 0.9818 100 0.41 Contact Map
4rpfA 2 0.9745 100 0.414 Contact Map
3pyfA 1 0.9273 100 0.455 Contact Map
4hacA 2 0.9673 100 0.477 Contact Map
3qt5A 2 0.9491 100 0.49 Contact Map
2ww4A 2 0.9236 100 0.496 Contact Map
1uekA 1 0.8727 100 0.501 Contact Map
2v8pA 1 0.8909 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.