GREMLIN Database
AROA - 3-phosphoshikimate 1-carboxyvinyltransferase
UniProt: Q980I5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (387)
Sequences: 7885 (4795)
Seq/√Len: 243.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_G277_F4.3501.00
13_I244_T4.0921.00
341_G352_F3.8501.00
38_H217_Q3.5741.00
242_T277_F3.4141.00
240_G279_K3.3831.00
399_N402_Q3.1131.00
171_G209_N3.1001.00
38_H219_E2.9801.00
198_D209_N2.8371.00
15_K244_T2.7961.00
235_L267_A2.7061.00
397_N403_D2.6801.00
192_F197_S2.6601.00
105_D111_R2.6421.00
36_Y217_Q2.6301.00
128_S139_T2.6071.00
311_T352_F2.5811.00
363_V388_T2.5081.00
236_V378_A2.4911.00
283_K309_E2.4511.00
268_S279_K2.4441.00
334_I337_L2.4071.00
42_L47_I2.4021.00
51_K54_R2.3291.00
232_L304_L2.3121.00
241_I407_L2.3111.00
272_K275_R2.2961.00
154_S157_Y2.1761.00
345_K348_S2.1411.00
121_A161_L2.1181.00
380_A386_V2.0761.00
101_E137_T2.0731.00
42_L62_N2.0601.00
162_I189_I2.0291.00
307_I382_V2.0291.00
36_Y66_F2.0181.00
288_K315_I1.9891.00
171_G207_H1.9881.00
11_S240_G1.9811.00
354_I357_G1.9731.00
358_M384_G1.9711.00
334_I376_S1.9501.00
313_E350_L1.9261.00
30_S35_V1.8971.00
61_K68_P1.8961.00
23_A40_L1.8871.00
335_L340_V1.8021.00
116_N120_Q1.8011.00
28_F49_A1.7731.00
36_Y68_P1.7711.00
38_H66_F1.7701.00
248_E274_G1.7691.00
242_T275_R1.7591.00
144_S168_L1.7561.00
242_T272_K1.7341.00
285_S309_E1.7331.00
134_L140_G1.7321.00
93_P160_G1.7181.00
303_G375_M1.6971.00
197_S213_L1.6941.00
143_S169_N1.6761.00
334_I367_L1.6591.00
52_S79_I1.6531.00
343_E352_F1.6531.00
26_L191_L1.6351.00
311_T350_L1.6341.00
338_Y386_V1.6341.00
338_Y362_P1.6241.00
343_E350_L1.6211.00
120_Q124_N1.6181.00
270_E277_F1.6091.00
130_S139_T1.5981.00
228_S297_L1.5951.00
59_K70_E1.5931.00
50_I60_V1.5521.00
340_V359_L1.5221.00
13_I242_T1.4961.00
329_E344_V1.4861.00
288_K313_E1.4851.00
404_L409_A1.4841.00
193_K202_Y1.4831.00
200_K209_N1.4751.00
272_K277_F1.4651.00
231_A259_V1.4631.00
377_S400_Y1.4571.00
27_I53_V1.4461.00
364_T376_S1.4421.00
111_R133_S1.4261.00
202_Y206_I1.4181.00
130_S137_T1.4171.00
146_E172_S1.4111.00
260_K263_S1.4051.00
78_F103_T1.4031.00
109_S112_R1.3891.00
403_D406_S1.3771.00
54_R60_V1.3761.00
63_N68_P1.3731.00
338_Y379_L1.3581.00
148_K176_L1.3581.00
306_A340_V1.3531.00
247_W250_K1.3531.00
100_G139_T1.3421.00
286_P312_S1.3391.00
221_A251_E1.3381.00
233_S381_L1.3331.00
310_G353_G1.3251.00
326_D329_E1.3211.00
195_F216_F1.3211.00
286_P311_T1.3201.00
231_A243_I1.3181.00
305_S312_S1.3151.00
329_E333_K1.3121.00
187_L218_G1.3101.00
227_A246_L1.3001.00
37_L220_V1.2961.00
47_I62_N1.2961.00
127_I142_L1.2941.00
119_V131_S1.2931.00
26_L220_V1.2921.00
135_P138_I1.2891.00
89_R159_S1.2871.00
302_A314_I1.2861.00
132_Y137_T1.2821.00
146_E177_P1.2751.00
232_L258_I1.2711.00
51_K55_A1.2621.00
16_A243_I1.2571.00
27_I50_I1.2521.00
231_A262_F1.2441.00
189_I199_V1.2411.00
61_K70_E1.2341.00
40_L46_V1.2311.00
194_R216_F1.2211.00
193_K198_D1.2161.00
262_F267_A1.2111.00
84_S87_T1.2101.00
270_E279_K1.2101.00
162_I208_V1.2091.00
14_I407_L1.2011.00
63_N66_F1.2001.00
265_M287_I1.1951.00
23_A46_V1.1931.00
345_K350_L1.1851.00
62_N67_I1.1841.00
134_L138_I1.1821.00
330_S367_L1.1761.00
123_S128_S1.1751.00
291_I316_G1.1731.00
101_E139_T1.1731.00
50_I67_I1.1721.00
142_L168_L1.1711.00
373_A393_V1.1701.00
88_L134_L1.1661.00
200_K207_H1.1661.00
380_A387_I1.1611.00
183_S190_D1.1591.00
261_I289_I1.1571.00
15_K245_N1.1531.00
35_V191_L1.1501.00
136_L140_G1.1471.00
76_E101_E1.1471.00
125_Y145_N1.1431.00
231_A278_V1.1411.00
230_Y397_N1.1381.00
262_F304_L1.1231.00
307_I354_I1.1151.00
24_I49_A1.1031.00
52_S81_L1.1011.00
44_E394_G1.1001.00
236_V382_V1.0991.00
399_N403_D1.0961.00
176_L179_I1.0951.00
233_S378_A1.0951.00
290_D316_G1.0931.00
302_A331_I1.0871.00
33_T215_E1.0841.00
181_S204_S1.0801.00
373_A392_C1.0731.00
54_R59_K1.0691.00
303_G379_L1.0681.00
328_I349_I1.0681.00
120_Q123_S1.0671.00
402_Q405_L1.0671.00
342_S349_I1.0551.00
119_V123_S1.0491.00
247_W251_E1.0481.00
261_I301_I1.0481.00
364_T386_V1.0461.00
48_D82_K1.0401.00
229_F374_M1.0391.00
263_S271_Y1.0391.00
12_G407_L1.0371.00
169_N212_N1.0371.00
235_L282_D1.0351.00
100_G137_T1.0281.00
311_T353_G1.0251.00
35_V216_F1.0251.00
265_M308_A1.0201.00
244_T275_R1.0171.00
149_I161_L1.0151.00
48_D51_K1.0051.00
331_I372_V1.0041.00
228_S300_T1.0021.00
248_E271_Y0.9891.00
159_S188_T0.9861.00
128_S141_K0.9831.00
383_N386_V0.9771.00
305_S314_I0.9771.00
37_L69_P0.9741.00
10_I233_S0.9721.00
261_I264_E0.9711.00
336_G341_G0.9661.00
337_L362_P0.9641.00
189_I202_Y0.9621.00
184_Y224_Y0.9611.00
232_L297_L0.9611.00
226_L403_D0.9541.00
224_Y258_I0.9501.00
362_P386_V0.9481.00
166_H213_L0.9481.00
146_E176_L0.9461.00
314_I349_I0.9421.00
354_I358_M0.9401.00
286_P310_G0.9391.00
53_V58_V0.9381.00
54_R62_N0.9331.00
50_I54_R0.9251.00
297_L300_T0.9221.00
389_S392_C0.9171.00
232_L262_F0.9171.00
314_I317_I0.9141.00
134_L141_K0.9141.00
238_G281_K0.9111.00
26_L37_L0.9061.00
368_N389_S0.9051.00
25_R28_F0.9021.00
172_S207_H0.8981.00
317_I348_S0.8901.00
192_F213_L0.8901.00
147_I150_S0.8881.00
78_F105_D0.8871.00
172_S205_K0.8831.00
118_I160_G0.8810.99
108_E370_H0.8810.99
202_Y205_K0.8780.99
170_G210_P0.8780.99
103_T137_T0.8760.99
218_G221_A0.8760.99
119_V129_F0.8750.99
280_A284_Y0.8740.99
219_E245_N0.8710.99
302_A330_S0.8690.99
366_C373_A0.8670.99
117_R151_G0.8650.99
263_S268_S0.8620.99
286_P308_A0.8610.99
150_S261_I0.8610.99
381_L409_A0.8550.99
265_M284_Y0.8520.99
284_Y308_A0.8500.99
193_K201_F0.8500.99
361_S386_V0.8480.99
328_I344_V0.8470.99
39_N219_E0.8470.99
58_V69_P0.8470.99
16_A230_Y0.8460.99
360_N384_G0.8450.99
306_A335_L0.8440.99
191_L195_F0.8430.99
234_A237_S0.8370.99
166_H197_S0.8330.99
55_A78_F0.8330.99
171_G210_P0.8280.99
308_A312_S0.8230.99
190_D194_R0.8230.99
28_F94_I0.8190.99
306_A354_I0.8180.99
120_Q150_S0.8180.99
93_P163_Y0.8180.99
95_L127_I0.8170.99
194_R218_G0.8150.99
193_K199_V0.8150.99
10_I239_G0.8140.99
302_A349_I0.8120.99
81_L110_L0.8040.99
233_S409_A0.8040.99
231_A234_A0.8000.99
267_A284_Y0.7980.99
391_E394_G0.7970.99
236_V307_I0.7960.99
88_L115_L0.7960.99
238_G280_A0.7900.99
135_P140_G0.7880.99
22_L191_L0.7850.99
271_Y276_W0.7810.99
16_A227_A0.7790.99
380_A404_L0.7770.99
253_F260_K0.7750.99
390_A393_V0.7740.99
236_V303_G0.7720.99
234_A241_I0.7710.99
302_A351_I0.7710.99
23_A220_V0.7710.99
230_Y403_D0.7700.99
315_I348_S0.7690.99
29_L191_L0.7680.99
129_F136_L0.7660.99
307_I357_G0.7660.99
117_R150_S0.7640.99
271_Y275_R0.7620.99
32_F94_I0.7600.99
50_I62_N0.7590.99
300_T378_A0.7550.98
265_M304_L0.7550.98
258_I297_L0.7540.98
164_A168_L0.7500.98
39_N245_N0.7490.98
110_L324_E0.7490.98
209_N212_N0.7460.98
190_D193_K0.7430.98
22_L187_L0.7420.98
34_R214_V0.7410.98
191_L216_F0.7400.98
26_L218_G0.7390.98
361_S383_N0.7390.98
265_M305_S0.7380.98
227_A243_I0.7380.98
193_K200_K0.7380.98
340_V357_G0.7350.98
377_S393_V0.7350.98
344_V348_S0.7340.98
72_L98_I0.7330.98
134_L137_T0.7330.98
54_R61_K0.7320.98
17_P226_L0.7310.98
81_L104_I0.7310.98
44_E48_D0.7300.98
31_L53_V0.7240.98
333_K367_L0.7230.98
92_I138_I0.7230.98
338_Y364_T0.7210.98
394_G401_W0.7210.98
15_K39_N0.7190.98
78_F111_R0.7180.98
182_K186_L0.7140.98
108_E112_R0.7140.98
75_K100_G0.7130.98
125_Y147_I0.7130.98
359_L383_N0.7120.98
338_Y383_N0.7120.98
149_I176_L0.7100.98
95_L102_V0.7090.98
259_V263_S0.7090.98
312_S351_I0.7080.98
235_L262_F0.7080.98
10_I409_A0.7080.98
75_K98_I0.7070.98
17_P403_D0.7070.98
299_M372_V0.7060.98
14_I243_I0.7050.98
315_I345_K0.7040.98
162_I206_I0.7010.97
96_A127_I0.7000.97
287_I312_S0.7000.97
19_S23_A0.6970.97
129_F138_I0.6970.97
291_I298_A0.6960.97
151_G322_I0.6950.97
195_F213_L0.6950.97
27_I67_I0.6940.97
53_V91_L0.6930.97
229_F300_T0.6920.97
187_L190_D0.6880.97
77_R80_K0.6870.97
231_A235_L0.6850.97
92_I118_I0.6830.97
201_F204_S0.6800.97
268_S281_K0.6790.97
23_A41_V0.6790.97
144_S169_N0.6790.97
280_A283_K0.6780.97
366_C387_I0.6750.97
238_G282_D0.6720.97
198_D211_N0.6710.97
91_L122_L0.6700.97
366_C389_S0.6700.97
87_T395_K0.6680.97
269_S278_V0.6680.97
18_Q220_V0.6670.97
31_L58_V0.6670.97
235_L278_V0.6670.97
77_R111_R0.6630.97
103_T132_Y0.6610.96
198_D212_N0.6590.96
53_V60_V0.6570.96
328_I348_S0.6560.96
89_R156_Q0.6520.96
303_G376_S0.6510.96
92_I104_I0.6500.96
327_R369_D0.6470.96
259_V271_Y0.6460.96
9_K239_G0.6450.96
131_S136_L0.6420.96
123_S129_F0.6410.96
234_A243_I0.6400.96
134_L139_T0.6380.96
88_L104_I0.6380.96
44_E47_I0.6370.96
290_D315_I0.6360.96
190_D218_G0.6350.96
62_N65_E0.6350.96
156_Q185_I0.6350.96
122_L127_I0.6340.96
269_S276_W0.6340.96
291_I294_A0.6340.96
235_L284_Y0.6320.95
381_L404_L0.6320.95
117_R153_E0.6300.95
22_L25_R0.6290.95
228_S258_I0.6280.95
299_M330_S0.6250.95
401_W405_L0.6240.95
115_L119_V0.6220.95
234_A280_A0.6210.95
74_I132_Y0.6180.95
95_L122_L0.6180.95
222_G243_I0.6170.95
230_Y404_L0.6160.95
313_E345_K0.6160.95
233_S404_L0.6140.95
263_S269_S0.6140.95
317_I328_I0.6140.95
201_F206_I0.6130.95
35_V215_E0.6110.95
232_L300_T0.6110.95
261_I287_I0.6100.94
30_S69_P0.6080.94
186_L189_I0.6080.94
95_L104_I0.6080.94
117_R120_Q0.6060.94
366_C392_C0.6050.94
104_I136_L0.6050.94
14_I403_D0.6030.94
81_L87_T0.6030.94
377_S401_W0.6030.94
393_V401_W0.6010.94
113_R371_R0.6010.94
197_S211_N0.5980.94
25_R89_R0.5970.94
123_S131_S0.5950.94
303_G306_A0.5940.94
234_A239_G0.5940.94
81_L88_L0.5920.94
338_Y359_L0.5910.93
14_I230_Y0.5900.93
191_L218_G0.5900.93
246_L276_W0.5900.93
248_E276_W0.5880.93
331_I375_M0.5860.93
113_R327_R0.5860.93
336_G342_S0.5850.93
197_S212_N0.5850.93
142_L170_G0.5840.93
193_K197_S0.5820.93
56_L95_L0.5820.93
306_A382_V0.5810.93
52_S91_L0.5810.93
259_V269_S0.5760.93
24_I28_F0.5740.92
340_V379_L0.5740.92
230_Y400_Y0.5740.92
175_I206_I0.5740.92
47_I51_K0.5730.92
237_S280_A0.5730.92
261_I294_A0.5720.92
237_S381_L0.5710.92
136_L139_T0.5710.92
286_P309_E0.5670.92
66_F69_P0.5670.92
390_A401_W0.5660.92
165_L192_F0.5660.92
303_G335_L0.5640.92
24_I87_T0.5630.92
74_I101_E0.5630.92
337_L376_S0.5610.92
231_A269_S0.5610.92
333_K336_G0.5600.92
97_A167_I0.5600.92
368_N392_C0.5600.92
373_A401_W0.5590.92
286_P353_G0.5580.91
142_L164_A0.5570.91
374_M400_Y0.5570.91
331_I376_S0.5560.91
264_E293_D0.5550.91
234_A238_G0.5550.91
189_I206_I0.5530.91
314_I351_I0.5530.91
72_L75_K0.5520.91
93_P96_A0.5520.91
236_V304_L0.5520.91
267_A278_V0.5510.91
160_G164_A0.5500.91
110_L134_L0.5500.91
186_L201_F0.5480.91
313_E348_S0.5480.91
110_L323_K0.5480.91
123_S130_S0.5470.91
50_I69_P0.5470.91
298_A328_I0.5470.91
35_V195_F0.5420.90
17_P398_P0.5420.90
187_L221_A0.5410.90
58_V72_L0.5410.90
242_T274_G0.5410.90
336_G343_E0.5390.90
190_D202_Y0.5370.90
92_I160_G0.5360.90
246_L275_R0.5350.90
234_A267_A0.5350.90
186_L206_I0.5340.90
36_Y63_N0.5340.90
156_Q159_S0.5320.89
305_S351_I0.5300.89
225_G370_H0.5300.89
330_S372_V0.5300.89
149_I206_I0.5300.89
337_L367_L0.5290.89
287_I308_A0.5290.89
165_L170_G0.5290.89
298_A314_I0.5280.89
29_L213_L0.5270.89
20_K113_R0.5270.89
118_I121_A0.5270.89
248_E275_R0.5260.89
135_P141_K0.5260.89
192_F195_F0.5250.89
56_L75_K0.5230.89
74_I100_G0.5230.89
52_S90_M0.5230.89
283_K357_G0.5230.89
42_L67_I0.5220.89
341_G357_G0.5220.89
316_G324_E0.5200.88
40_L67_I0.5190.88
124_N147_I0.5170.88
83_G107_D0.5170.88
33_T195_F0.5160.88
302_A342_S0.5160.88
19_S221_A0.5140.88
402_Q406_S0.5140.88
330_S392_C0.5140.88
89_R323_K0.5140.88
359_L362_P0.5140.88
27_I49_A0.5130.88
336_G340_V0.5130.88
41_V226_L0.5120.88
189_I193_K0.5120.88
16_A246_L0.5100.87
147_I176_L0.5100.87
121_A125_Y0.5100.87
291_I301_I0.5090.87
101_E135_P0.5080.87
77_R81_L0.5070.87
268_S282_D0.5070.87
16_A222_G0.5050.87
361_S385_G0.5040.87
166_H211_N0.5040.87
331_I334_I0.5030.87
177_P205_K0.5030.87
265_M312_S0.5030.87
86_T90_M0.5020.87
306_A357_G0.5020.87
89_R324_E0.5020.87
59_K62_N0.5020.87
341_G354_I0.5010.86
289_I301_I0.5010.86
159_S187_L0.5010.86
362_P385_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.971 100 0.142 Contact Map
2pqcA 1 0.9734 100 0.174 Contact Map
2o0bA 1 0.9734 100 0.183 Contact Map
1rf6A 1 0.9638 100 0.186 Contact Map
3slhA 4 0.971 100 0.193 Contact Map
3nvsA 1 0.9783 100 0.209 Contact Map
3r38A 2 0.9565 100 0.277 Contact Map
4fqdA 2 0.9469 100 0.277 Contact Map
3zh4A 1 0.942 100 0.282 Contact Map
2yvwA 1 0.9517 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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