GREMLIN Database
AROD - 3-dehydroquinate dehydratase
UniProt: Q980I4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (206)
Sequences: 1367 (1074)
Seq/√Len: 74.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_I110_I4.2601.00
187_S203_V3.4611.00
156_L164_V3.2211.00
6_V184_L3.1891.00
33_L60_V3.1721.00
115_Y118_Y2.9831.00
125_I141_I2.6881.00
145_S166_P2.6811.00
178_G211_N2.2561.00
163_T184_L2.2251.00
9_L17_L2.1711.00
25_D56_K2.1321.00
122_L158_E2.1181.00
186_Y193_L2.0631.00
62_L71_N2.0231.00
114_H167_M1.9021.00
74_A77_L1.8871.00
60_V85_L1.8821.00
64_D78_K1.8791.00
108_N137_F1.8481.00
142_A165_I1.8451.00
122_L154_L1.8081.00
59_I91_L1.8021.00
91_L110_I1.7951.00
147_K157_L1.7891.00
139_V160_E1.7691.00
111_V136_A1.7521.00
156_L165_I1.7411.00
133_S160_E1.7381.00
116_F167_M1.7301.00
199_Y202_K1.7201.00
116_F144_P1.6961.00
194_A197_Q1.6841.00
122_L151_E1.6531.00
14_I50_F1.6341.00
67_E97_S1.6121.00
125_I155_P1.5970.99
145_S149_Y1.5910.99
61_T114_H1.5850.99
52_D90_Y1.5750.99
202_K205_Q1.5740.99
167_M194_A1.5730.99
114_H194_A1.5600.99
206_I209_Y1.5360.99
149_Y166_P1.5310.99
177_V182_S1.5250.99
57_K138_S1.5050.99
113_V128_I1.4700.99
28_L184_L1.4410.99
11_I20_I1.4240.99
154_L158_E1.4210.99
114_H197_Q1.4200.99
96_V111_V1.4100.99
61_T93_D1.4090.99
14_I47_Y1.4070.99
129_V164_V1.3930.99
114_H174_R1.3740.98
11_I16_D1.3660.98
20_I190_I1.3460.98
14_I36_L1.3380.98
143_V152_V1.3350.98
93_D114_H1.3340.98
149_Y173_E1.3300.98
166_P173_E1.3190.98
126_K155_P1.3130.98
14_I18_K1.3120.98
13_K37_R1.3070.98
26_A56_K1.2860.98
85_L89_Q1.2790.97
91_L138_S1.2750.97
156_L162_V1.2680.97
125_I143_V1.2520.97
35_Y70_I1.2500.97
82_L92_Y1.2440.97
76_E80_K1.2420.97
126_K158_E1.2130.96
175_I206_I1.2070.96
26_A200_Y1.2030.96
21_E54_Y1.2010.96
13_K16_D1.2010.96
152_V166_P1.1930.96
61_T167_M1.1710.96
61_T95_E1.1670.96
142_A167_M1.1560.95
83_N106_Y1.1500.95
85_L92_Y1.1460.95
86_Y94_I1.1430.95
150_K157_L1.1400.95
7_A189_A1.1310.95
10_P193_L1.1280.95
198_L203_V1.1270.95
48_Y88_R1.1120.94
65_K72_Q1.1010.94
96_V132_F1.0980.94
83_N103_D1.0970.94
20_I24_L1.0930.94
152_V164_V1.0920.94
78_K98_F1.0760.93
57_K161_N1.0740.93
25_D204_I1.0620.93
177_V193_L1.0610.93
125_I129_V1.0500.92
32_R61_T1.0490.92
121_T124_K1.0460.92
174_R194_A1.0460.92
111_V132_F1.0400.92
4_L78_K1.0380.92
7_A200_Y1.0350.92
153_L180_L1.0320.92
75_D78_K1.0250.91
10_P35_Y1.0200.91
36_L47_Y1.0180.91
31_L48_Y1.0130.91
33_L82_L1.0090.91
28_L57_K1.0060.91
8_S186_Y1.0050.91
26_A189_A1.0040.91
26_A204_I0.9900.90
142_A194_A0.9690.89
131_K147_K0.9540.88
31_L36_L0.9530.88
100_Q131_K0.9490.88
91_L108_N0.9400.87
119_L148_G0.9380.87
73_L77_L0.9340.87
83_N87_E0.9330.87
93_D194_A0.9330.87
84_E87_E0.9300.87
167_M174_R0.9260.87
7_A24_L0.9250.87
4_L35_Y0.9130.86
60_V82_L0.9110.86
144_P167_M0.9090.86
67_E113_V0.9000.85
130_S133_S0.8970.85
65_K70_I0.8960.85
93_D197_Q0.8920.84
171_S175_I0.8910.84
7_A26_A0.8910.84
12_K37_R0.8860.84
167_M196_G0.8830.84
95_E114_H0.8800.84
116_F195_Q0.8760.83
8_S193_L0.8720.83
137_F161_N0.8680.83
125_I151_E0.8650.83
205_Q209_Y0.8640.83
113_V141_I0.8620.82
45_S84_E0.8600.82
77_L80_K0.8510.82
172_L176_A0.8500.81
22_N54_Y0.8470.81
69_G95_E0.8240.79
63_R95_E0.8130.79
5_I203_V0.8070.78
116_F142_A0.8060.78
207_F210_I0.8060.78
176_A207_F0.8020.78
153_L156_L0.7990.77
156_L182_S0.7970.77
30_E34_D0.7940.77
97_S128_I0.7900.77
148_G151_E0.7860.76
20_I23_F0.7830.76
64_D67_E0.7830.76
78_K82_L0.7740.75
126_K130_S0.7710.75
152_V173_E0.7650.74
9_L58_L0.7620.74
68_G95_E0.7610.74
85_L88_R0.7600.74
142_A145_S0.7560.73
61_T174_R0.7560.73
114_H140_K0.7560.73
32_R95_E0.7540.73
51_L110_I0.7480.73
79_I83_N0.7470.72
37_R201_K0.7430.72
96_V131_K0.7430.72
149_Y155_P0.7380.72
10_P98_F0.7380.72
41_V84_E0.7370.71
124_K127_E0.7360.71
62_L81_I0.7360.71
156_L180_L0.7350.71
9_L21_E0.7340.71
119_L166_P0.7320.71
164_V180_L0.7310.71
15_E19_L0.7310.71
133_S139_V0.7300.71
82_L86_Y0.7280.70
6_V163_T0.7220.70
174_R197_Q0.7170.69
17_L31_L0.7030.68
141_I187_S0.6980.67
123_E134_E0.6960.67
116_F194_A0.6950.67
115_Y119_L0.6870.66
142_A177_V0.6870.66
61_T194_A0.6860.66
130_S134_E0.6800.65
150_K179_L0.6790.65
39_R62_L0.6770.65
6_V60_V0.6760.65
152_V165_I0.6750.65
25_D201_K0.6730.64
116_F197_Q0.6710.64
170_N185_V0.6700.64
114_H196_G0.6700.64
41_V51_L0.6690.64
148_G170_N0.6670.64
115_Y128_I0.6630.63
65_K202_K0.6620.63
22_N50_F0.6620.63
128_I132_F0.6560.62
31_L193_L0.6550.62
80_K84_E0.6550.62
59_I132_F0.6540.62
19_L87_E0.6530.62
83_N100_Q0.6450.61
132_F136_A0.6420.61
162_V177_V0.6410.61
147_K204_I0.6320.60
116_F119_L0.6320.60
112_S139_V0.6300.59
141_I151_E0.6290.59
93_D167_M0.6280.59
136_A161_N0.6280.59
122_L126_K0.6230.58
178_G188_Y0.6170.58
12_K35_Y0.6160.58
4_L138_S0.6160.58
139_V163_T0.6080.57
129_V155_P0.6070.57
154_L157_L0.6050.56
133_S159_Y0.6020.56
119_L146_L0.5980.55
201_K206_I0.5980.55
45_S88_R0.5980.55
45_S48_Y0.5910.55
138_S182_S0.5860.54
70_I173_E0.5840.54
5_I200_Y0.5840.54
200_Y204_I0.5840.54
127_E130_S0.5740.52
69_G93_D0.5720.52
110_I163_T0.5710.52
4_L178_G0.5710.52
167_M197_Q0.5700.52
27_D67_E0.5680.52
48_Y52_D0.5640.51
75_D79_I0.5640.51
62_L78_K0.5630.51
75_D101_K0.5620.51
42_S84_E0.5610.51
171_S203_V0.5600.51
12_K19_L0.5560.50
178_G207_F0.5550.50
176_A179_L0.5540.50
27_D204_I0.5540.50
109_R175_I0.5520.50
67_E96_V0.5520.50
187_S199_Y0.5470.49
143_V166_P0.5470.49
130_S147_K0.5460.49
59_I176_A0.5460.49
163_T183_K0.5440.49
205_Q208_N0.5440.49
175_I209_Y0.5420.48
29_I58_L0.5420.48
83_N175_I0.5400.48
114_H165_I0.5390.48
144_P185_V0.5390.48
118_Y124_K0.5370.48
112_S140_K0.5360.48
52_D161_N0.5360.48
32_R93_D0.5360.48
23_F46_D0.5350.48
115_Y167_M0.5330.47
171_S210_I0.5320.47
10_P186_Y0.5310.47
48_Y85_L0.5280.47
155_P183_K0.5280.47
118_Y134_E0.5270.47
87_E106_Y0.5270.47
171_S202_K0.5270.47
92_Y117_N0.5240.46
64_D145_S0.5230.46
25_D200_Y0.5230.46
78_K132_F0.5230.46
42_S45_S0.5180.45
79_I98_F0.5170.45
31_L47_Y0.5170.45
32_R63_R0.5160.45
170_N173_E0.5160.45
14_I38_E0.5150.45
75_D99_L0.5150.45
12_K70_I0.5140.45
175_I198_L0.5130.45
54_Y101_K0.5090.44
18_K22_N0.5070.44
156_L177_V0.5060.44
42_S104_I0.5040.44
12_K191_E0.5030.44
6_V28_L0.5020.43
23_F134_E0.5010.43
94_I134_E0.5000.43
46_D55_K0.5000.43
28_L177_V0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cnnA 2 0.95 100 0.217 Contact Map
4h3dA 2 0.9773 100 0.221 Contact Map
4ph6A 2 0.9227 100 0.23 Contact Map
3l9cA 1 0.9318 100 0.247 Contact Map
2o7sA 2 0.9909 100 0.249 Contact Map
1sflA 2 0.9455 100 0.252 Contact Map
2oczA 2 0.9045 100 0.256 Contact Map
2ox1A 2 0.8682 100 0.259 Contact Map
2egzA 1 0.9273 100 0.264 Contact Map
2yr1A 2 0.9773 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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