GREMLIN Database
Q980H9 - Sugar phosphate nucleotydyl transferase
UniProt: Q980H9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (313)
Sequences: 8807 (5911)
Seq/√Len: 334.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_I288_S4.0131.00
135_E165_N3.2991.00
302_I305_S3.2511.00
122_Y130_V3.1361.00
286_S303_S3.0111.00
276_D293_K2.8071.00
287_E304_G2.7781.00
158_K162_P2.7581.00
32_K40_E2.6311.00
148_E151_V2.5501.00
281_K298_E2.5331.00
135_E206_K2.4341.00
93_S183_E2.4251.00
146_Y164_S2.3691.00
184_T199_T2.2461.00
256_G275_N2.2061.00
290_L296_V2.2001.00
120_D124_K2.1861.00
101_D123_Y2.1811.00
280_G298_E2.1811.00
274_G292_N2.1741.00
278_E295_Q2.1601.00
275_N292_N2.1471.00
269_S286_S2.1301.00
154_E161_K2.1051.00
127_C203_S2.0751.00
4_A47_V2.0491.00
257_S275_N2.0471.00
118_L132_V1.9841.00
254_Y272_I1.9491.00
128_D175_K1.9431.00
36_G64_Y1.9421.00
282_G299_Y1.9381.00
102_V176_K1.9241.00
121_F125_K1.9151.00
148_E153_V1.8701.00
22_K28_P1.8701.00
146_Y154_E1.8461.00
21_T276_D1.8181.00
297_K315_R1.8091.00
4_A42_L1.8021.00
133_G204_V1.7791.00
288_S302_I1.7581.00
101_D175_K1.7491.00
152_L204_V1.7441.00
272_I289_I1.7411.00
259_N277_V1.7271.00
293_K310_K1.7191.00
290_L294_V1.7181.00
140_R158_K1.7101.00
39_L50_I1.6951.00
151_V201_S1.6931.00
294_V311_T1.6861.00
118_L173_I1.6691.00
273_L279_I1.6661.00
252_P270_N1.6621.00
264_D282_G1.6571.00
267_I271_T1.6461.00
236_Y239_S1.6281.00
83_L87_G1.6181.00
298_E315_R1.6141.00
214_I223_L1.6041.00
49_D75_K1.5971.00
51_Y77_E1.5901.00
307_I311_T1.5771.00
180_K184_T1.5751.00
260_V278_E1.5731.00
116_K120_D1.5721.00
283_T300_T1.5651.00
121_F205_Y1.5581.00
273_L277_V1.5411.00
270_N287_E1.5131.00
35_L65_L1.4981.00
284_Y301_Y1.4551.00
58_A62_I1.4511.00
125_K203_S1.4501.00
307_I313_I1.4461.00
285_I290_L1.4131.00
36_G40_E1.4121.00
42_L105_I1.3971.00
104_V174_F1.3921.00
295_Q312_K1.3821.00
238_N241_A1.3611.00
87_G90_K1.3491.00
181_L199_T1.3461.00
118_L130_V1.3451.00
181_L195_K1.3451.00
119_L173_I1.3321.00
271_T285_I1.3231.00
87_G91_L1.3151.00
301_Y318_H1.2981.00
262_G281_K1.2971.00
58_A78_V1.2901.00
141_R158_K1.2851.00
151_V203_S1.2791.00
194_P198_R1.2781.00
129_A196_L1.2761.00
277_V294_V1.2751.00
236_Y255_I1.2701.00
128_D201_S1.2691.00
253_Y267_I1.2651.00
216_V238_N1.2591.00
262_G278_E1.2551.00
291_M309_D1.2461.00
228_L231_K1.2391.00
180_K199_T1.2321.00
195_K199_T1.2211.00
280_G295_Q1.2191.00
235_G238_N1.2181.00
54_L58_A1.2171.00
133_G145_L1.2101.00
146_Y156_I1.2101.00
101_D173_I1.2021.00
249_L253_Y1.2011.00
147_T166_L1.1991.00
49_D73_K1.1931.00
34_I214_I1.1891.00
297_K312_K1.1791.00
51_Y95_K1.1761.00
74_V78_V1.1741.00
187_S190_K1.1711.00
36_G68_T1.1701.00
299_Y316_W1.1681.00
218_D238_N1.1611.00
59_D63_D1.1531.00
280_G297_K1.1521.00
26_L64_Y1.1511.00
294_V307_I1.1501.00
303_S320_L1.1461.00
117_S120_D1.1401.00
292_N309_D1.1371.00
274_G277_V1.1271.00
29_I224_N1.1201.00
106_Y109_I1.1161.00
147_T204_V1.1121.00
184_T195_K1.1101.00
236_Y241_A1.1081.00
235_G239_S1.1071.00
103_L173_I1.1031.00
74_V77_E1.0981.00
105_I115_I1.0941.00
23_P60_K1.0861.00
256_G259_N1.0851.00
262_G265_A1.0841.00
66_K76_I1.0841.00
60_K63_D1.0791.00
237_I241_A1.0731.00
168_N172_Y1.0681.00
177_D180_K1.0611.00
268_T286_S1.0591.00
156_I163_I1.0541.00
300_T315_R1.0491.00
259_N292_N1.0481.00
133_G166_L1.0461.00
159_P187_S1.0451.00
228_L232_Y1.0381.00
100_D176_K1.0351.00
99_D177_D1.0291.00
89_L104_V1.0291.00
259_N275_N1.0281.00
112_E210_I1.0271.00
114_N117_S1.0271.00
33_P36_G1.0261.00
55_R82_P1.0241.00
255_I259_N1.0201.00
90_K93_S1.0171.00
290_L307_I1.0161.00
300_T317_N1.0131.00
62_I78_V1.0101.00
25_A107_G1.0051.00
22_K60_K1.0011.00
28_P33_P0.9991.00
210_I226_E0.9961.00
138_D141_R0.9941.00
276_D292_N0.9921.00
300_T313_I0.9801.00
216_V219_D0.9771.00
240_S244_S0.9711.00
227_V231_K0.9651.00
137_E165_N0.9651.00
250_I253_Y0.9591.00
138_D158_K0.9571.00
121_F203_S0.9551.00
245_E248_T0.9471.00
218_D222_R0.9461.00
277_V290_L0.9391.00
21_T257_S0.9371.00
103_L119_L0.9261.00
244_S260_V0.9171.00
90_K183_E0.9171.00
82_P87_G0.9131.00
57_M60_K0.9101.00
129_A174_F0.9081.00
212_A222_R0.9051.00
131_V145_L0.9051.00
255_I261_I0.9041.00
33_P64_Y0.9031.00
280_G283_T0.8981.00
235_G241_A0.8961.00
136_V167_I0.8951.00
65_L74_V0.8951.00
6_V42_L0.8931.00
174_F192_F0.8891.00
250_I268_T0.8851.00
237_I240_S0.8841.00
143_G157_E0.8781.00
12_A24_K0.8781.00
192_F195_K0.8771.00
268_T284_Y0.8711.00
229_V232_Y0.8701.00
239_S242_K0.8621.00
43_I68_T0.8581.00
282_G298_E0.8571.00
35_L52_L0.8571.00
26_L60_K0.8561.00
121_F124_K0.8501.00
131_V152_L0.8481.00
100_D175_K0.8481.00
119_L123_Y0.8461.00
145_L152_L0.8461.00
117_S121_F0.8431.00
55_R87_G0.8431.00
191_D195_K0.8431.00
287_E303_S0.8411.00
241_A244_S0.8411.00
229_V233_P0.8411.00
144_V167_I0.8401.00
23_P57_M0.8391.00
302_I307_I0.8391.00
284_Y298_E0.8391.00
35_L61_I0.8331.00
197_L202_I0.8291.00
195_K198_R0.8231.00
134_T167_I0.8221.00
103_L115_I0.8211.00
289_I306_I0.8201.00
212_A226_E0.8191.00
54_L62_I0.8181.00
265_A281_K0.8131.00
52_L65_L0.8121.00
246_K250_I0.8111.00
5_I102_V0.8111.00
235_G240_S0.8091.00
294_V313_I0.8081.00
42_L47_V0.7981.00
24_K108_D0.7971.00
43_I69_S0.7961.00
156_I161_K0.7921.00
294_V308_A0.7921.00
261_I265_A0.7911.00
277_V291_M0.7911.00
299_Y315_R0.7911.00
226_E229_V0.7881.00
54_L76_I0.7871.00
59_D62_I0.7861.00
180_K183_E0.7861.00
136_V165_N0.7841.00
191_D194_P0.7841.00
225_F245_E0.7831.00
244_S263_E0.7801.00
236_Y240_S0.7721.00
222_R225_F0.7711.00
5_I51_Y0.7701.00
166_L206_K0.7691.00
41_S113_I0.7691.00
237_I242_K0.7671.00
256_G292_N0.7661.00
268_T271_T0.7631.00
30_L227_V0.7621.00
267_I273_L0.7611.00
297_K314_G0.7581.00
5_I89_L0.7561.00
146_Y153_V0.7561.00
291_M294_V0.7541.00
300_T314_G0.7541.00
256_G274_G0.7490.99
234_K238_N0.7480.99
38_I105_I0.7470.99
152_L202_I0.7470.99
185_P191_D0.7470.99
239_S244_S0.7450.99
161_K164_S0.7440.99
283_T315_R0.7440.99
93_S179_F0.7420.99
283_T298_E0.7380.99
14_R24_K0.7370.99
37_Y227_V0.7360.99
137_E208_H0.7360.99
262_G268_T0.7340.99
181_L184_T0.7330.99
43_I50_I0.7300.99
62_I76_I0.7280.99
75_K78_V0.7270.99
6_V39_L0.7210.99
291_M306_I0.7210.99
314_G317_N0.7190.99
33_P37_Y0.7170.99
151_V197_L0.7150.99
181_L196_L0.7150.99
302_I319_I0.7120.99
30_L224_N0.7110.99
45_S115_I0.7100.99
186_S190_K0.7100.99
186_S189_S0.7090.99
263_E281_K0.7070.99
51_Y92_I0.7020.99
79_E82_P0.7000.99
136_V208_H0.6990.99
258_K275_N0.6950.99
21_T275_N0.6940.99
127_C201_S0.6920.99
36_G65_L0.6910.99
266_Y284_Y0.6890.99
259_N265_A0.6880.99
133_G152_L0.6850.99
10_G24_K0.6800.99
111_S171_V0.6770.99
262_G283_T0.6750.99
283_T296_V0.6700.99
126_S175_K0.6670.99
277_V292_N0.6630.99
31_N254_Y0.6620.99
134_T211_W0.6620.99
194_P197_L0.6560.99
53_S88_P0.6560.99
7_L106_Y0.6550.99
37_Y40_E0.6520.99
129_A202_I0.6510.99
40_E44_N0.6500.99
186_S191_D0.6500.99
181_L192_F0.6490.99
225_F228_L0.6440.98
248_T266_Y0.6440.98
34_I38_I0.6430.98
244_S247_S0.6420.98
96_Y100_D0.6420.98
106_Y170_G0.6410.98
29_I34_I0.6410.98
236_Y242_K0.6400.98
79_E87_G0.6390.98
261_I267_I0.6370.98
153_V197_L0.6370.98
49_D97_N0.6350.98
256_G272_I0.6340.98
208_H211_W0.6330.98
220_Y291_M0.6310.98
77_E92_I0.6310.98
122_Y175_K0.6270.98
262_G280_G0.6260.98
212_A223_L0.6250.98
238_N242_K0.6250.98
255_I273_L0.6230.98
301_Y316_W0.6230.98
291_M308_A0.6200.98
81_E87_G0.6200.98
25_A61_I0.6190.98
127_C130_V0.6190.98
283_T299_Y0.6180.98
32_K37_Y0.6160.98
47_V119_L0.6130.98
236_Y244_S0.6120.98
185_P188_I0.6120.98
6_V38_I0.6120.98
274_G289_I0.6120.98
237_I244_S0.6120.98
265_A283_T0.6090.98
41_S44_N0.6090.98
226_E230_Q0.6060.98
63_D66_K0.6060.98
229_V270_N0.6020.98
90_K182_V0.6020.98
10_G14_R0.6000.98
54_L61_I0.6000.98
100_D177_D0.5990.98
41_S115_I0.5980.98
66_K69_S0.5980.98
132_V171_V0.5970.98
296_V302_I0.5960.97
75_K95_K0.5950.97
117_S205_Y0.5940.97
39_L65_L0.5940.97
44_N113_I0.5920.97
193_L196_L0.5920.97
16_R20_L0.5910.97
40_E43_I0.5890.97
169_G211_W0.5880.97
65_L76_I0.5860.97
294_V309_D0.5850.97
41_S45_S0.5830.97
98_L101_D0.5830.97
145_L166_L0.5800.97
108_D213_D0.5780.97
296_V300_T0.5770.97
185_P190_K0.5730.97
129_A193_L0.5720.97
120_D123_Y0.5710.97
7_L53_S0.5690.97
259_N262_G0.5690.97
105_I171_V0.5680.97
230_Q233_P0.5680.97
285_I302_I0.5670.97
242_K260_V0.5660.97
9_G53_S0.5650.97
241_A261_I0.5650.97
130_V205_Y0.5650.97
166_L204_V0.5630.96
30_L37_Y0.5550.96
264_D267_I0.5540.96
207_Y211_W0.5540.96
245_E250_I0.5530.96
259_N274_G0.5510.96
68_T72_D0.5500.96
266_Y271_T0.5490.96
312_K315_R0.5480.96
154_E194_P0.5480.96
308_A311_T0.5480.96
258_K276_D0.5470.96
246_K263_E0.5470.96
243_V247_S0.5460.96
115_I118_L0.5450.96
252_P269_S0.5450.96
174_F178_L0.5430.96
128_D178_L0.5430.96
26_L35_L0.5420.96
141_R219_D0.5400.96
70_M74_V0.5390.95
236_Y243_V0.5370.95
106_Y172_Y0.5350.95
134_T169_G0.5340.95
259_N273_L0.5330.95
136_V139_P0.5300.95
140_R160_K0.5300.95
139_P142_Y0.5280.95
246_K264_D0.5270.95
54_L78_V0.5270.95
8_A52_L0.5250.95
65_L68_T0.5250.95
228_L233_P0.5240.95
157_E168_N0.5230.95
4_A45_S0.5230.95
301_Y304_G0.5220.95
153_V156_I0.5190.94
250_I269_S0.5180.94
185_P189_S0.5180.94
222_R226_E0.5180.94
286_S301_Y0.5170.94
219_D222_R0.5170.94
139_P144_V0.5150.94
14_R25_A0.5150.94
305_S319_I0.5150.94
85_D108_D0.5150.94
152_L155_L0.5140.94
212_A219_D0.5140.94
284_Y297_K0.5130.94
249_L261_I0.5120.94
243_V261_I0.5120.94
98_L177_D0.5120.94
29_I223_L0.5090.94
98_L176_K0.5090.94
209_G212_A0.5080.94
305_S308_A0.5060.94
62_I66_K0.5060.94
149_N153_V0.5060.94
40_E68_T0.5050.94
53_S79_E0.5040.94
235_G244_S0.5040.94
253_Y271_T0.5040.94
4_A46_D0.5010.93
295_Q298_E0.5010.93
7_L88_P0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.9584 100 0.367 Contact Map
3brkX 2 0.9363 100 0.375 Contact Map
1yp2A 4 0.9529 100 0.38 Contact Map
4g3qA 3 0.9889 100 0.42 Contact Map
1hm9A 3 0.9751 100 0.423 Contact Map
2v0hA 3 0.9723 100 0.434 Contact Map
4fceA 3 0.9584 100 0.442 Contact Map
2icyA 1 0.8338 100 0.531 Contact Map
2i5kA 5 0.8393 100 0.56 Contact Map
3jukA 3 0.6343 100 0.57 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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