GREMLIN Database
THYX - Thymidylate synthase ThyX
UniProt: Q980H6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (206)
Sequences: 1015 (587)
Seq/√Len: 40.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_E191_K4.1321.00
184_K187_E3.7761.00
70_I74_A3.3821.00
184_K188_E3.1431.00
70_I75_S2.9901.00
76_H79_V2.9771.00
75_S88_Q2.9601.00
49_A57_V2.8651.00
76_H88_Q2.8611.00
67_I155_V2.7601.00
114_K118_E2.6791.00
75_S79_V2.5061.00
79_V88_Q2.3971.00
115_E119_K2.3431.00
75_S153_I2.3121.00
116_L130_T2.3101.00
43_E198_K2.2911.00
119_K123_E2.1380.99
59_E160_R2.1110.99
165_F182_A2.0100.99
120_A124_A1.9950.99
85_S158_N1.9030.99
62_V156_T1.8870.98
6_L63_Y1.8790.98
9_Y192_V1.8780.98
77_Q175_Q1.8450.98
47_R198_K1.8190.98
161_E164_N1.8100.98
60_H156_T1.7720.98
64_T156_T1.6900.97
174_A178_I1.6570.96
75_S151_T1.6560.96
49_A58_L1.6530.96
120_A127_N1.6450.96
125_Y129_Y1.6230.96
74_A181_I1.6230.96
116_L127_N1.6150.96
14_E195_R1.6090.96
122_K126_D1.6040.96
24_S87_T1.5880.96
103_P121_Y1.5670.95
105_I118_E1.5610.95
22_K45_W1.5540.95
78_L153_I1.5540.95
59_E82_R1.5540.95
111_K114_K1.5400.95
123_E127_N1.4930.94
83_I164_N1.4860.94
123_E126_D1.4810.93
135_G138_E1.4610.93
71_S177_E1.4550.93
118_E122_K1.4320.92
6_L192_V1.4200.92
116_L119_K1.4050.92
59_E158_N1.3990.91
127_N131_L1.3930.91
53_G167_S1.3640.90
80_R169_R1.3390.89
81_H169_R1.3380.89
116_L120_A1.3380.89
90_S142_R1.3360.89
164_N168_L1.3220.89
171_C204_C1.3040.88
124_A146_P1.2970.88
163_Y196_L1.2950.88
108_S137_P1.2740.87
92_R142_R1.2710.87
20_A60_H1.2580.86
90_S93_F1.2570.86
126_D130_T1.2530.86
167_S206_I1.2520.86
65_F185_M1.2360.85
115_E126_D1.2320.85
126_D129_Y1.2200.84
73_V147_N1.2200.84
176_W180_A1.2090.84
117_V148_G1.2040.84
121_Y148_G1.1820.83
204_C210_F1.1750.82
79_V86_Y1.1720.82
6_L65_F1.1600.81
12_D15_K1.1580.81
209_N213_N1.1370.80
24_S88_Q1.1330.80
63_Y193_H1.1280.79
63_Y189_V1.1200.79
19_I34_E1.1160.79
128_Y142_R1.1140.79
188_E192_V1.0980.78
162_L189_V1.0950.77
62_V157_M1.0950.77
209_N212_R1.0610.75
60_H64_T1.0550.75
114_K123_E1.0500.74
30_W66_S1.0500.74
96_P145_L1.0420.74
190_K201_G1.0370.73
75_S78_L1.0310.73
165_F178_I1.0300.73
17_I57_V1.0080.71
126_D180_A1.0060.71
69_E150_N0.9960.70
110_K114_K0.9930.70
86_Y155_V0.9930.70
186_L197_F0.9890.70
186_L190_K0.9830.69
113_S131_L0.9820.69
14_E193_H0.9740.69
46_I161_E0.9660.68
202_P213_N0.9660.68
113_S144_V0.9550.67
72_R91_H0.9360.65
60_H85_S0.9330.65
45_W57_V0.9330.65
78_L88_Q0.9320.65
77_Q169_R0.9300.65
180_A184_K0.9260.65
119_K122_K0.9250.65
104_I150_N0.9070.63
5_K9_Y0.9040.63
107_P176_W0.8980.62
8_S16_V0.8950.62
17_I196_L0.8920.62
86_Y153_I0.8910.62
96_P125_Y0.8790.61
78_L161_E0.8790.61
112_R130_T0.8780.60
90_S177_E0.8610.59
47_R195_R0.8590.59
43_E195_R0.8490.58
45_W48_D0.8470.58
116_L131_L0.8350.57
204_C212_R0.8270.56
134_S138_E0.8270.56
166_F182_A0.8260.56
54_Y90_S0.8240.56
62_V85_S0.8240.56
79_V153_I0.8230.55
171_C201_G0.8220.55
72_R76_H0.8210.55
84_A162_L0.8200.55
92_R146_P0.8190.55
37_M42_I0.8170.55
98_D125_Y0.8150.55
88_Q153_I0.8120.54
54_Y93_F0.8080.54
121_Y144_V0.8070.54
90_S146_P0.8020.54
212_R216_E0.8000.53
3_S36_D0.8000.53
208_E212_R0.7960.53
98_D124_A0.7920.53
7_V154_V0.7900.52
157_M162_L0.7900.52
50_I58_L0.7820.52
92_R151_T0.7780.51
77_Q174_A0.7740.51
3_S31_D0.7690.50
112_R119_K0.7680.50
124_A127_N0.7590.50
119_K130_T0.7570.49
56_S86_Y0.7530.49
110_K180_A0.7470.48
81_H174_A0.7420.48
66_S152_N0.7420.48
207_H211_I0.7410.48
169_R174_A0.7410.48
113_S127_N0.7400.48
43_E196_L0.7390.48
58_L163_Y0.7350.47
130_T133_E0.7340.47
132_L138_E0.7330.47
105_I114_K0.7320.47
116_L123_E0.7290.47
142_R177_E0.7280.47
171_C210_F0.7240.46
205_I209_N0.7240.46
123_E133_E0.7220.46
22_K198_K0.7200.46
63_Y192_V0.7190.46
13_G21_A0.7160.46
130_T134_S0.7090.45
54_Y177_E0.7040.44
12_D123_E0.7000.44
111_K119_K0.7000.44
59_E85_S0.6990.44
169_R179_R0.6960.44
169_R178_I0.6930.43
68_E152_N0.6910.43
76_H147_N0.6880.43
170_L186_L0.6870.43
159_A189_V0.6850.43
48_D52_H0.6820.42
70_I73_V0.6810.42
82_R169_R0.6800.42
103_P106_P0.6760.42
13_G193_H0.6750.42
61_S196_L0.6730.42
171_C202_P0.6720.42
5_K34_E0.6710.41
82_R85_S0.6700.41
56_S151_T0.6660.41
131_L134_S0.6620.41
44_T123_E0.6570.40
67_I168_L0.6550.40
17_I157_M0.6550.40
113_S116_L0.6520.40
131_L144_V0.6510.40
175_Q178_I0.6490.40
89_M152_N0.6490.40
70_I79_V0.6490.40
166_F189_V0.6480.39
161_E168_L0.6440.39
41_E44_T0.6430.39
76_H153_I0.6430.39
54_Y57_V0.6420.39
72_R92_R0.6410.39
76_H86_Y0.6360.38
20_A64_T0.6330.38
41_E205_I0.6320.38
85_S160_R0.6320.38
51_L58_L0.6320.38
25_R128_Y0.6300.38
132_L191_K0.6280.38
90_S151_T0.6280.38
213_N216_E0.6270.38
72_R140_D0.6250.37
5_K41_E0.6250.37
115_E123_E0.6250.37
124_A133_E0.6220.37
101_Y121_Y0.6190.37
203_N211_I0.6170.37
60_H87_T0.6110.36
83_I86_Y0.6100.36
56_S75_S0.6070.36
56_S85_S0.6040.36
40_D44_T0.6030.36
127_N130_T0.6010.35
15_K34_E0.6010.35
18_A21_A0.6000.35
84_A165_F0.5980.35
157_M165_F0.5950.35
197_F200_T0.5920.35
92_R177_E0.5920.35
77_Q178_I0.5900.34
113_S130_T0.5880.34
56_S142_R0.5880.34
107_P110_K0.5870.34
190_K197_F0.5870.34
142_R151_T0.5790.34
93_F142_R0.5790.34
180_A187_E0.5760.33
118_E133_E0.5750.33
22_K49_A0.5730.33
46_I61_S0.5720.33
43_E47_R0.5710.33
143_Y176_W0.5700.33
105_I110_K0.5680.33
116_L180_A0.5680.33
151_T173_R0.5670.33
201_G204_C0.5670.33
23_M30_W0.5650.32
128_Y194_P0.5650.32
117_V121_Y0.5610.32
77_Q80_R0.5610.32
24_S56_S0.5600.32
78_L155_V0.5580.32
187_E191_K0.5560.32
9_Y191_K0.5550.32
189_V192_V0.5550.32
138_E143_Y0.5540.31
112_R133_E0.5510.31
43_E95_K0.5500.31
9_Y13_G0.5470.31
39_D42_I0.5420.31
83_I161_E0.5410.30
24_S147_N0.5380.30
20_A46_I0.5380.30
105_I133_E0.5360.30
105_I109_A0.5320.30
111_K187_E0.5300.30
82_R175_Q0.5280.29
104_I109_A0.5260.29
180_A198_K0.5250.29
84_A157_M0.5250.29
124_A145_L0.5240.29
155_V164_N0.5230.29
59_E81_H0.5230.29
90_S128_Y0.5220.29
129_Y133_E0.5210.29
20_A73_V0.5200.29
210_F216_E0.5200.29
119_K133_E0.5190.29
111_K134_S0.5190.29
84_A161_E0.5160.29
115_E191_K0.5160.29
163_Y189_V0.5150.28
54_Y139_E0.5150.28
46_I134_S0.5140.28
54_Y72_R0.5110.28
142_R194_P0.5110.28
78_L86_Y0.5100.28
3_S47_R0.5100.28
116_L133_E0.5050.28
14_E21_A0.5040.28
38_T118_E0.5040.28
113_S176_W0.5020.27
18_A23_M0.5010.27
80_R175_Q0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gwcA 3 0.7962 100 0.279 Contact Map
3fnnA 3 0.7769 100 0.292 Contact Map
4gt9A 3 0.7538 100 0.297 Contact Map
2cfaA 3 0.6654 100 0.301 Contact Map
3n3yA 4 0.7577 100 0.302 Contact Map
1q1hA 1 0.3192 17.3 0.96 Contact Map
2zxiA 2 0.8077 12.4 0.962 Contact Map
3cp8A 2 0.85 9.6 0.964 Contact Map
3dwlD 1 0.3346 7.8 0.966 Contact Map
3j21a 1 0.3154 7.3 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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