GREMLIN Database
Q980H4 - NADH dehydrogenase subunit C (NuoC)
UniProt: Q980H4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (142)
Sequences: 2719 (1693)
Seq/√Len: 142.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A107_L4.5871.00
44_R109_S3.6781.00
103_S130_E3.0511.00
47_A93_L2.8541.00
105_P130_E2.6521.00
43_I76_Y2.6121.00
47_A78_I2.1801.00
48_S52_D2.1291.00
42_I45_D2.0801.00
44_R110_I2.0571.00
74_V129_F2.0291.00
63_G125_L1.9861.00
115_W132_H1.9811.00
72_L127_I1.9381.00
58_V114_A1.9281.00
47_A111_F1.9241.00
38_P41_K1.8931.00
62_T75_V1.8441.00
107_L114_A1.7561.00
144_F154_Y1.7031.00
124_M139_F1.6951.00
56_D82_S1.6391.00
80_S83_N1.6351.00
83_N89_I1.6111.00
43_I47_A1.5871.00
15_N19_T1.5831.00
56_D81_Y1.5811.00
73_E96_T1.5761.00
141_D144_F1.5421.00
21_F49_F1.5281.00
98_S101_D1.4861.00
79_S90_I1.4801.00
106_S109_S1.4801.00
58_V61_V1.4761.00
112_E115_W1.4531.00
24_Q42_I1.4501.00
21_F46_V1.4461.00
58_V113_S1.4431.00
54_G82_S1.4411.00
105_P131_G1.4211.00
121_T129_F1.4201.00
34_T77_H1.4101.00
78_I107_L1.4041.00
44_R48_S1.4031.00
74_V104_L1.3851.00
76_Y107_L1.3851.00
95_T104_L1.3741.00
49_F53_F1.3641.00
37_V46_V1.3451.00
123_E137_R1.3291.00
14_V18_Q1.3171.00
132_H135_L1.3111.00
77_H92_A1.2701.00
38_P42_I1.2571.00
40_K101_D1.2331.00
15_N18_Q1.2211.00
63_G127_I1.1791.00
74_V127_I1.1560.99
57_H81_Y1.1550.99
103_S128_R1.1390.99
36_I96_T1.1170.99
63_G121_T1.1130.99
32_R92_A1.1060.99
62_T77_H1.0820.99
34_T92_A1.0770.99
124_M148_Y1.0740.99
16_D53_F1.0550.99
50_L91_L1.0440.99
20_K49_F1.0340.99
140_L144_F1.0310.99
61_V76_Y1.0140.99
69_H73_E1.0140.99
44_R105_P1.0070.99
65_D71_K0.9980.98
36_I94_R0.9870.98
123_E138_F0.9860.98
48_S110_I0.9840.98
113_S117_G0.9830.98
54_G83_N0.9790.98
155_K158_L0.9750.98
43_I93_L0.9600.98
64_I75_V0.9570.98
66_Y73_E0.9530.98
124_M140_L0.9410.98
99_Y102_P0.9400.98
45_D48_S0.9370.98
78_I111_F0.9260.98
43_I105_P0.9200.97
43_I95_T0.8990.97
79_S88_K0.8980.97
72_L99_Y0.8860.97
154_Y160_G0.8820.97
61_V74_V0.8690.96
16_D19_T0.8650.96
61_V121_T0.8590.96
14_V19_T0.8490.96
57_H113_S0.8490.96
122_Y135_L0.8480.96
24_Q45_D0.8410.96
44_R106_S0.8340.95
97_V104_L0.8220.95
108_Y133_P0.8200.95
63_G74_V0.8190.95
62_T121_T0.8140.95
40_K105_P0.8130.95
54_G80_S0.8000.94
44_R107_L0.7820.94
18_Q22_K0.7730.93
143_D154_Y0.7610.93
99_Y155_K0.7570.92
25_A38_P0.7550.92
107_L111_F0.7520.92
115_W133_P0.7510.92
62_T92_A0.7450.92
60_A77_H0.7420.92
35_V46_V0.7420.92
40_K95_T0.7370.91
73_E94_R0.7320.91
46_V49_F0.7290.91
47_A76_Y0.7230.91
17_L27_I0.7230.91
26_K38_P0.7220.91
60_A117_G0.7210.91
122_Y132_H0.7190.90
18_Q23_C0.7180.90
37_V42_I0.7160.90
59_K79_S0.7090.90
76_Y133_P0.7020.89
26_K36_I0.7020.89
75_V92_A0.6920.89
53_F89_I0.6920.89
108_Y114_A0.6910.89
48_S109_S0.6850.88
125_L150_L0.6850.88
22_K25_A0.6830.88
13_L17_L0.6820.88
35_V93_L0.6820.88
34_T94_R0.6820.88
14_V17_L0.6810.88
30_D34_T0.6720.87
16_D20_K0.6710.87
80_S88_K0.6620.86
24_Q27_I0.6570.86
122_Y148_Y0.6560.86
116_T132_H0.6560.86
141_D160_G0.6560.86
80_S89_I0.6520.86
14_V27_I0.6500.85
137_R144_F0.6390.84
122_Y128_R0.6380.84
20_K45_D0.6370.84
14_V20_K0.6350.84
19_T23_C0.6300.84
124_M150_L0.6300.84
16_D49_F0.6160.82
117_G139_F0.6140.82
144_F159_E0.6140.82
19_T22_K0.6110.82
67_P127_I0.6070.81
108_Y132_H0.6070.81
76_Y95_T0.6050.81
123_E148_Y0.6020.81
126_G149_P0.5980.80
99_Y153_S0.5910.80
69_H96_T0.5880.79
60_A90_I0.5850.79
17_L22_K0.5820.78
116_T138_F0.5800.78
61_V113_S0.5790.78
15_N26_K0.5780.78
78_I110_I0.5780.78
36_I73_E0.5740.78
140_L154_Y0.5710.77
79_S142_E0.5680.77
141_D158_L0.5670.77
121_T127_I0.5630.76
24_Q38_P0.5600.76
117_G121_T0.5600.76
107_L110_I0.5590.76
60_A121_T0.5590.76
108_Y115_W0.5580.76
62_T117_G0.5570.75
71_K153_S0.5550.75
46_V93_L0.5510.75
94_R150_L0.5490.74
17_L25_A0.5420.73
68_E98_S0.5400.73
137_R140_L0.5380.73
19_T70_E0.5370.73
128_R131_G0.5360.73
115_W138_F0.5350.72
135_L138_F0.5340.72
18_Q25_A0.5330.72
40_K96_T0.5320.72
18_Q27_I0.5320.72
60_A155_K0.5310.72
97_V102_P0.5280.72
13_L16_D0.5280.72
101_D128_R0.5150.70
56_D80_S0.5150.70
61_V129_F0.5150.70
50_L55_F0.5130.69
44_R131_G0.5120.69
141_D154_Y0.5120.69
28_E36_I0.5090.69
40_K98_S0.5090.69
140_L149_P0.5080.69
146_G160_G0.5070.68
116_T121_T0.5050.68
104_L129_F0.5050.68
54_G89_I0.5050.68
58_V123_E0.5000.67
48_S51_K0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v5 1 0.9349 100 0.266 Contact Map
3mcrA 2 0.7751 100 0.401 Contact Map
3onhA 1 0.6036 14.3 0.95 Contact Map
1wthA 3 0.8462 14 0.95 Contact Map
1d1rA 1 0.355 12.9 0.951 Contact Map
4f3qA 1 0.6272 8.4 0.955 Contact Map
2if1A 1 0.3787 7.2 0.957 Contact Map
2wa0A 1 0.9172 6.7 0.957 Contact Map
2yvqA 2 0.7396 6.6 0.957 Contact Map
2bcqA 1 0.7515 6.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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