Q980H2 - SULSO - GREMLIN Contacts

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Q980H2 - NADH dehydrogenase subunit H (NuoH)

UniProt:	Q980H2	Sequences: MSVLSALQYYFFYPSFFLTVIFPGLIFTLIFLLVTIWFERKAAAIVQLRYGPYYASKRLGGILQLFADAIKFVFSEIIIPNGVNQTLYAISPVLVLIFAFLPMALIPISTIPTQGSILSVYHGIFYDTQIHQGILVPYFIEYNLIGIIALESLYPILVIFLAWNTNNRFAIVGSIREAYLSVSYDVLIIISTLALGLEYHTLDVAKIVTSGIPGFIANPIAAFVFLVAMLIGSSRFPFEIVEAETELVIGPYTEYSGFLFVLTMAGSYVANLVYAILFVDLFLGGWLPFTGFVGAIFTVFKAAIVVFFAVFLRAVYGRYRIDQALRGSWKYFFPLALASLLLGVVVGYLWIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (306)
Sequences:	5302 (2495)
Seq/√Len:	142.6

ECOLI - NUOH HYFC HYCD
HALSA - Q9HRL8
SULSO - Q980H2 Q97ZA4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
201_T	206_K	4.896	1.00
222_A	278_F	3.911	1.00
43_A	314_A	3.795	1.00
226_L	308_F	3.745	1.00
36_I	65_L	3.697	1.00
276_I	298_T	3.640	1.00
46_V	314_A	3.513	1.00
279_V	298_T	3.092	1.00
170_A	253_T	2.822	1.00
276_I	302_A	2.799	1.00
283_L	305_V	2.540	1.00
66_F	69_A	2.490	1.00
210_S	214_G	2.474	1.00
230_L	312_L	2.465	1.00
225_F	278_F	2.426	1.00
199_Y	214_G	2.407	1.00
233_S	309_A	2.405	1.00
99_A	270_A	2.397	1.00
215_F	283_L	2.368	1.00
77_I	259_L	2.312	1.00
275_A	305_V	2.308	1.00
206_K	209_T	2.307	1.00
272_L	306_V	2.183	1.00
249_I	252_Y	2.107	1.00
162_A	174_S	2.098	1.00
215_F	222_A	2.077	1.00
99_A	269_V	2.065	1.00
148_I	189_I	2.048	1.00
95_V	157_L	2.044	1.00
102_P	273_V	2.040	1.00
28_T	269_V	2.014	1.00
87_L	160_F	1.988	1.00
73_V	261_V	1.930	1.00
197_L	344_V	1.918	1.00
293_V	297_F	1.888	1.00
227_V	332_F	1.867	1.00
226_L	230_L	1.866	1.00
212_I	216_I	1.855	1.00
101_L	146_G	1.815	1.00
42_A	307_F	1.780	1.00
304_I	308_F	1.779	1.00
35_T	306_V	1.773	1.00
95_V	266_G	1.770	1.00
146_G	150_L	1.758	1.00
218_N	343_G	1.752	1.00
221_A	282_F	1.751	1.00
38_F	307_F	1.744	1.00
229_M	274_Y	1.737	1.00
32_L	269_V	1.702	1.00
287_L	297_F	1.642	1.00
213_P	301_K	1.641	1.00
34_V	65_L	1.639	1.00
71_K	75_S	1.627	1.00
180_L	324_A	1.620	1.00
46_V	311_F	1.599	1.00
194_A	221_A	1.557	1.00
105_L	146_G	1.554	1.00
240_I	324_A	1.541	1.00
287_L	292_F	1.530	1.00
260_F	264_M	1.497	1.00
252_Y	260_F	1.493	1.00
221_A	339_S	1.481	1.00
240_I	319_Y	1.466	1.00
203_D	206_K	1.465	1.00
177_E	241_V	1.457	1.00
57_K	63_L	1.457	1.00
195_L	207_I	1.436	1.00
32_L	265_A	1.436	1.00
187_L	228_A	1.422	1.00
42_A	310_V	1.406	1.00
94_L	98_F	1.399	1.00
45_I	50_Y	1.399	1.00
190_I	340_L	1.376	1.00
243_A	247_L	1.374	1.00
293_V	296_I	1.354	1.00
199_Y	207_I	1.353	1.00
22_F	26_I	1.352	1.00
229_M	278_F	1.348	1.00
147_I	151_E	1.341	1.00
243_A	246_E	1.325	1.00
140_I	146_G	1.324	1.00
205_A	209_T	1.307	1.00
211_G	214_G	1.303	1.00
311_F	315_V	1.294	1.00
211_G	284_G	1.280	1.00
199_Y	210_S	1.278	1.00
197_L	347_G	1.275	1.00
42_A	46_V	1.273	1.00
31_F	272_L	1.273	1.00
188_I	228_A	1.271	1.00
167_N	170_A	1.270	1.00
187_L	336_A	1.269	1.00
279_V	283_L	1.247	1.00
26_I	29_L	1.247	1.00
173_G	241_V	1.228	1.00
278_F	305_V	1.227	1.00
159_I	178_A	1.208	1.00
104_A	146_G	1.208	1.00
89_A	259_L	1.204	1.00
50_Y	53_Y	1.201	1.00
38_F	42_A	1.195	1.00
271_N	306_V	1.195	1.00
225_F	274_Y	1.192	1.00
30_I	66_F	1.187	1.00
321_I	325_L	1.182	1.00
45_I	53_Y	1.174	1.00
327_G	332_F	1.172	1.00
198_E	218_N	1.166	1.00
240_I	323_Q	1.164	1.00
39_E	235_R	1.163	1.00
219_P	223_F	1.161	1.00
64_Q	68_D	1.158	0.99
57_K	60_G	1.156	0.99
41_K	45_I	1.151	0.99
194_A	336_A	1.145	0.99
192_T	281_L	1.145	0.99
31_F	303_A	1.143	0.99
271_N	309_A	1.142	0.99
292_F	296_I	1.142	0.99
231_I	238_F	1.140	0.99
19_T	23_P	1.133	0.99
73_V	258_F	1.126	0.99
91_S	160_F	1.119	0.99
212_I	217_A	1.115	0.99
53_Y	60_G	1.114	0.99
248_V	253_T	1.112	0.99
139_F	203_D	1.111	0.99
289_F	293_V	1.100	0.99
39_E	313_R	1.100	0.99
187_L	328_S	1.096	0.99
66_F	70_I	1.092	0.99
103_M	273_V	1.087	0.99
206_K	210_S	1.086	0.99
279_V	302_A	1.085	0.99
79_I	89_A	1.083	0.99
161_L	164_N	1.082	0.99
101_L	150_L	1.082	0.99
190_I	337_L	1.075	0.99
161_L	263_T	1.069	0.99
307_F	311_F	1.064	0.99
187_L	333_F	1.057	0.99
224_V	335_L	1.052	0.99
55_A	64_Q	1.050	0.99
139_F	205_A	1.047	0.99
247_L	251_P	1.045	0.99
276_I	280_D	1.034	0.99
91_S	164_N	1.032	0.99
91_S	161_L	1.027	0.99
98_F	150_L	1.026	0.99
34_V	62_I	1.020	0.99
240_I	247_L	1.017	0.99
88_Y	92_P	1.017	0.99
201_T	207_I	1.013	0.99
208_V	286_W	1.011	0.99
38_F	310_V	1.004	0.99
70_I	74_F	1.003	0.99
144_L	196_G	0.999	0.99
239_E	318_R	0.995	0.98
233_S	274_Y	0.994	0.98
96_L	100_F	0.992	0.98
80_P	88_Y	0.992	0.98
37_W	65_L	0.990	0.98
69_A	73_V	0.983	0.98
69_A	74_F	0.978	0.98
219_P	222_A	0.976	0.98
320_R	325_L	0.975	0.98
305_V	308_F	0.974	0.98
283_L	301_K	0.973	0.98
36_I	268_Y	0.972	0.98
26_I	30_I	0.969	0.98
80_P	83_V	0.969	0.98
225_F	282_F	0.967	0.98
45_I	60_G	0.966	0.98
143_N	203_D	0.963	0.98
285_G	301_K	0.962	0.98
41_K	75_S	0.962	0.98
258_F	261_V	0.956	0.98
243_A	318_R	0.956	0.98
44_A	50_Y	0.955	0.98
191_S	224_V	0.955	0.98
311_F	316_Y	0.952	0.98
194_A	340_L	0.950	0.98
155_P	181_S	0.946	0.98
37_W	62_I	0.945	0.98
213_P	284_G	0.942	0.98
223_F	227_V	0.941	0.98
298_T	302_A	0.934	0.98
175_I	241_V	0.932	0.98
339_S	343_G	0.927	0.98
239_E	242_E	0.924	0.98
69_A	265_A	0.906	0.97
96_L	262_L	0.904	0.97
97_I	342_L	0.903	0.97
235_R	239_E	0.902	0.97
308_F	312_L	0.898	0.97
43_A	313_R	0.895	0.97
207_I	281_L	0.892	0.97
198_E	347_G	0.891	0.97
284_G	301_K	0.890	0.97
196_G	202_L	0.888	0.97
226_L	278_F	0.882	0.97
180_L	234_S	0.881	0.97
96_L	266_G	0.869	0.96
218_N	339_S	0.856	0.96
226_L	309_A	0.850	0.96
246_E	318_R	0.848	0.96
29_L	100_F	0.847	0.96
15_S	19_T	0.845	0.96
161_L	255_Y	0.845	0.96
156_I	321_I	0.843	0.96
89_A	93_V	0.842	0.96
241_V	251_P	0.840	0.96
191_S	228_A	0.840	0.96
214_G	217_A	0.838	0.96
139_F	143_N	0.836	0.96
194_A	218_N	0.836	0.96
95_V	263_T	0.829	0.95
147_I	204_V	0.821	0.95
18_L	22_F	0.820	0.95
34_V	66_F	0.819	0.95
95_V	154_Y	0.819	0.95
91_S	157_L	0.816	0.95
37_W	45_I	0.815	0.95
72_F	261_V	0.815	0.95
144_L	204_V	0.809	0.95
24_G	137_P	0.808	0.95
110_T	116_S	0.808	0.95
319_Y	323_Q	0.807	0.95
63_L	66_F	0.805	0.95
343_G	347_G	0.800	0.94
105_L	143_N	0.797	0.94
108_I	137_P	0.797	0.94
236_F	316_Y	0.796	0.94
105_L	147_I	0.793	0.94
79_I	83_V	0.792	0.94
72_F	264_M	0.789	0.94
335_L	339_S	0.789	0.94
294_G	297_F	0.789	0.94
151_E	154_Y	0.788	0.94
222_A	282_F	0.787	0.94
232_G	235_R	0.785	0.94
204_V	277_L	0.782	0.94
148_I	192_T	0.781	0.94
252_Y	264_M	0.780	0.94
230_L	309_A	0.774	0.93
183_S	325_L	0.774	0.93
322_D	325_L	0.773	0.93
187_L	332_F	0.772	0.93
213_P	285_G	0.762	0.93
180_L	184_Y	0.762	0.93
165_T	255_Y	0.758	0.93
25_L	29_L	0.758	0.93
140_I	263_T	0.758	0.93
140_I	147_I	0.755	0.92
257_G	261_V	0.755	0.92
163_W	166_N	0.752	0.92
333_F	336_A	0.752	0.92
37_W	43_A	0.748	0.92
40_R	49_R	0.746	0.92
106_I	137_P	0.744	0.92
47_Q	52_P	0.743	0.92
40_R	68_D	0.742	0.92
144_L	207_I	0.740	0.92
177_E	243_A	0.735	0.91
274_Y	278_F	0.734	0.91
39_E	268_Y	0.731	0.91
188_I	328_S	0.730	0.91
191_S	194_A	0.726	0.91
245_T	248_V	0.722	0.91
180_L	183_S	0.720	0.91
87_L	91_S	0.720	0.91
36_I	39_E	0.715	0.90
302_A	306_V	0.714	0.90
39_E	43_A	0.714	0.90
224_V	227_V	0.712	0.90
279_V	294_G	0.712	0.90
231_I	324_A	0.712	0.90
189_I	192_T	0.710	0.90
33_L	43_A	0.708	0.90
279_V	301_K	0.708	0.90
68_D	318_R	0.705	0.90
292_F	295_A	0.704	0.90
99_A	273_V	0.702	0.89
170_A	249_I	0.698	0.89
225_F	229_M	0.696	0.89
295_A	299_V	0.696	0.89
236_F	245_T	0.695	0.89
239_E	247_L	0.694	0.89
208_V	285_G	0.693	0.89
80_P	92_P	0.692	0.89
211_G	285_G	0.691	0.89
342_L	345_V	0.690	0.89
106_I	276_I	0.689	0.89
88_Y	255_Y	0.689	0.89
16_F	19_T	0.687	0.88
223_F	340_L	0.685	0.88
158_V	177_E	0.681	0.88
83_V	88_Y	0.678	0.88
34_V	37_W	0.678	0.88
287_L	296_I	0.677	0.88
193_L	196_G	0.674	0.87
40_R	242_E	0.673	0.87
318_R	322_D	0.672	0.87
105_L	108_I	0.671	0.87
70_I	73_V	0.671	0.87
94_L	97_I	0.671	0.87
40_R	51_G	0.666	0.87
33_L	37_W	0.664	0.87
296_I	300_F	0.664	0.87
286_W	301_K	0.663	0.87
33_L	69_A	0.663	0.87
215_F	219_P	0.663	0.87
245_T	249_I	0.662	0.86
110_T	209_T	0.660	0.86
226_L	305_V	0.658	0.86
47_Q	254_E	0.658	0.86
287_L	291_G	0.657	0.86
137_P	265_A	0.656	0.86
31_F	306_V	0.656	0.86
50_Y	54_Y	0.655	0.86
21_I	138_Y	0.653	0.86
188_I	191_S	0.651	0.86
264_M	313_R	0.651	0.86
184_Y	231_I	0.648	0.85
278_F	283_L	0.647	0.85
304_I	307_F	0.646	0.85
82_G	257_G	0.641	0.85
222_A	283_L	0.640	0.85
170_A	347_G	0.637	0.84
77_I	88_Y	0.634	0.84
49_R	250_G	0.634	0.84
194_A	339_S	0.631	0.84
69_A	261_V	0.631	0.84
45_I	310_V	0.630	0.84
95_V	158_V	0.630	0.84
167_N	309_A	0.628	0.83
326_R	330_K	0.627	0.83
320_R	323_Q	0.627	0.83
261_V	265_A	0.626	0.83
79_I	85_Q	0.625	0.83
56_S	63_L	0.623	0.83
153_L	331_Y	0.622	0.83
29_L	33_L	0.621	0.83
40_R	244_E	0.619	0.83
194_A	343_G	0.618	0.83
275_A	279_V	0.615	0.82
98_F	154_Y	0.615	0.82
336_A	343_G	0.614	0.82
75_S	330_K	0.614	0.82
24_G	108_I	0.613	0.82
52_P	64_Q	0.612	0.82
306_V	310_V	0.611	0.82
68_D	71_K	0.610	0.82
145_I	321_I	0.609	0.82
92_P	255_Y	0.608	0.81
19_T	222_A	0.606	0.81
24_G	27_F	0.605	0.81
157_L	189_I	0.605	0.81
299_V	302_A	0.603	0.81
40_R	238_F	0.599	0.81
157_L	160_F	0.598	0.80
242_E	250_G	0.596	0.80
105_L	227_V	0.594	0.80
230_L	233_S	0.594	0.80
195_L	281_L	0.593	0.80
16_F	20_V	0.592	0.80
96_L	253_T	0.590	0.80
235_R	268_Y	0.590	0.80
174_S	266_G	0.587	0.79
95_V	102_P	0.587	0.79
299_V	303_A	0.586	0.79
30_I	33_L	0.585	0.79
56_S	261_V	0.585	0.79
88_Y	161_L	0.585	0.79
240_I	243_A	0.585	0.79
160_F	164_N	0.583	0.79
37_W	60_G	0.581	0.79
31_F	34_V	0.574	0.78
105_L	277_L	0.573	0.78
42_A	311_F	0.573	0.78
101_L	206_K	0.572	0.77
27_F	31_F	0.572	0.77
47_Q	51_G	0.570	0.77
177_E	247_L	0.567	0.77
90_I	93_V	0.566	0.77
180_L	231_I	0.565	0.77
191_S	221_A	0.565	0.77
43_A	48_L	0.564	0.76
67_A	168_R	0.563	0.76
268_Y	324_A	0.563	0.76
91_S	152_S	0.562	0.76
17_F	20_V	0.562	0.76
179_Y	325_L	0.562	0.76
21_I	25_L	0.561	0.76
37_W	41_K	0.561	0.76
108_I	276_I	0.560	0.76
249_I	264_M	0.560	0.76
165_T	170_A	0.558	0.76
183_S	313_R	0.557	0.76
233_S	270_A	0.556	0.75
184_Y	329_W	0.555	0.75
23_P	300_F	0.551	0.75
44_A	49_R	0.550	0.75
234_S	270_A	0.550	0.75
239_E	246_E	0.550	0.75
176_R	250_G	0.547	0.74
319_Y	328_S	0.544	0.74
63_L	67_A	0.543	0.74
140_I	256_S	0.540	0.73
179_Y	231_I	0.538	0.73
144_L	192_T	0.538	0.73
289_F	292_F	0.538	0.73
45_I	189_I	0.538	0.73
156_I	188_I	0.537	0.73
52_P	71_K	0.536	0.73
300_F	303_A	0.535	0.73
138_Y	221_A	0.535	0.73
276_I	336_A	0.533	0.72
100_F	269_V	0.532	0.72
40_R	47_Q	0.532	0.72
84_N	166_N	0.532	0.72
137_P	142_Y	0.531	0.72
99_A	107_P	0.530	0.72
275_A	309_A	0.530	0.72
340_L	344_V	0.529	0.72
187_L	224_V	0.529	0.72
158_V	234_S	0.528	0.72
318_R	321_I	0.528	0.72
147_I	273_V	0.527	0.72
193_L	340_L	0.527	0.72
16_F	341_L	0.526	0.71
310_V	313_R	0.526	0.71
108_I	299_V	0.524	0.71
64_Q	71_K	0.524	0.71
226_L	311_F	0.522	0.71
151_E	278_F	0.519	0.70
202_L	205_A	0.519	0.70
28_T	32_L	0.518	0.70
232_G	267_S	0.517	0.70
224_V	301_K	0.517	0.70
230_L	274_Y	0.515	0.70
220_I	224_V	0.514	0.70
345_V	348_Y	0.514	0.70
324_A	329_W	0.514	0.70
327_G	331_Y	0.512	0.69
287_L	294_G	0.511	0.69
244_E	264_M	0.510	0.69
102_P	270_A	0.509	0.69
16_F	304_I	0.508	0.69
220_I	339_S	0.508	0.69
224_V	332_F	0.507	0.69
36_I	69_A	0.506	0.68
81_N	160_F	0.506	0.68
298_T	301_K	0.505	0.68
65_L	310_V	0.504	0.68
21_I	24_G	0.503	0.68
79_I	256_S	0.503	0.68
157_L	174_S	0.503	0.68
242_E	318_R	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4he8H	1	0.7727	100	0.119	Contact Map
2jpkA	1	0.0994	23.6	0.966	Contact Map
3mp7A	1	0.1534	5.8	0.975	Contact Map
1qleD	1	0.1222	4.3	0.976	Contact Map
1vryA	1	0.1733	4.1	0.976	Contact Map
3dacP	1	0.0369	3.3	0.977	Contact Map
4h25C	1	0.0625	3.2	0.977	Contact Map
2yevB	1	0.1989	3.2	0.978	Contact Map
1q90G	1	0.0852	2.5	0.979	Contact Map
1q2fA	1	0.0881	2.2	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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