GREMLIN Database
Q980H2 - NADH dehydrogenase subunit H (NuoH)
UniProt: Q980H2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (306)
Sequences: 5302 (2495)
Seq/√Len: 142.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_T206_K4.8961.00
222_A278_F3.9111.00
43_A314_A3.7951.00
226_L308_F3.7451.00
36_I65_L3.6971.00
276_I298_T3.6401.00
46_V314_A3.5131.00
279_V298_T3.0921.00
170_A253_T2.8221.00
276_I302_A2.7991.00
283_L305_V2.5401.00
66_F69_A2.4901.00
210_S214_G2.4741.00
230_L312_L2.4651.00
225_F278_F2.4261.00
199_Y214_G2.4071.00
233_S309_A2.4051.00
99_A270_A2.3971.00
215_F283_L2.3681.00
77_I259_L2.3121.00
275_A305_V2.3081.00
206_K209_T2.3071.00
272_L306_V2.1831.00
249_I252_Y2.1071.00
162_A174_S2.0981.00
215_F222_A2.0771.00
99_A269_V2.0651.00
148_I189_I2.0481.00
95_V157_L2.0441.00
102_P273_V2.0401.00
28_T269_V2.0141.00
87_L160_F1.9881.00
73_V261_V1.9301.00
197_L344_V1.9181.00
293_V297_F1.8881.00
227_V332_F1.8671.00
226_L230_L1.8661.00
212_I216_I1.8551.00
101_L146_G1.8151.00
42_A307_F1.7801.00
304_I308_F1.7791.00
35_T306_V1.7731.00
95_V266_G1.7701.00
146_G150_L1.7581.00
218_N343_G1.7521.00
221_A282_F1.7511.00
38_F307_F1.7441.00
229_M274_Y1.7371.00
32_L269_V1.7021.00
287_L297_F1.6421.00
213_P301_K1.6411.00
34_V65_L1.6391.00
71_K75_S1.6271.00
180_L324_A1.6201.00
46_V311_F1.5991.00
194_A221_A1.5571.00
105_L146_G1.5541.00
240_I324_A1.5411.00
287_L292_F1.5301.00
260_F264_M1.4971.00
252_Y260_F1.4931.00
221_A339_S1.4811.00
240_I319_Y1.4661.00
203_D206_K1.4651.00
177_E241_V1.4571.00
57_K63_L1.4571.00
195_L207_I1.4361.00
32_L265_A1.4361.00
187_L228_A1.4221.00
42_A310_V1.4061.00
94_L98_F1.3991.00
45_I50_Y1.3991.00
190_I340_L1.3761.00
243_A247_L1.3741.00
293_V296_I1.3541.00
199_Y207_I1.3531.00
22_F26_I1.3521.00
229_M278_F1.3481.00
147_I151_E1.3411.00
243_A246_E1.3251.00
140_I146_G1.3241.00
205_A209_T1.3071.00
211_G214_G1.3031.00
311_F315_V1.2941.00
211_G284_G1.2801.00
199_Y210_S1.2781.00
197_L347_G1.2751.00
42_A46_V1.2731.00
31_F272_L1.2731.00
188_I228_A1.2711.00
167_N170_A1.2701.00
187_L336_A1.2691.00
279_V283_L1.2471.00
26_I29_L1.2471.00
173_G241_V1.2281.00
278_F305_V1.2271.00
159_I178_A1.2081.00
104_A146_G1.2081.00
89_A259_L1.2041.00
50_Y53_Y1.2011.00
38_F42_A1.1951.00
271_N306_V1.1951.00
225_F274_Y1.1921.00
30_I66_F1.1871.00
321_I325_L1.1821.00
45_I53_Y1.1741.00
327_G332_F1.1721.00
198_E218_N1.1661.00
240_I323_Q1.1641.00
39_E235_R1.1631.00
219_P223_F1.1611.00
64_Q68_D1.1580.99
57_K60_G1.1560.99
41_K45_I1.1510.99
194_A336_A1.1450.99
192_T281_L1.1450.99
31_F303_A1.1430.99
271_N309_A1.1420.99
292_F296_I1.1420.99
231_I238_F1.1400.99
19_T23_P1.1330.99
73_V258_F1.1260.99
91_S160_F1.1190.99
212_I217_A1.1150.99
53_Y60_G1.1140.99
248_V253_T1.1120.99
139_F203_D1.1110.99
289_F293_V1.1000.99
39_E313_R1.1000.99
187_L328_S1.0960.99
66_F70_I1.0920.99
103_M273_V1.0870.99
206_K210_S1.0860.99
279_V302_A1.0850.99
79_I89_A1.0830.99
161_L164_N1.0820.99
101_L150_L1.0820.99
190_I337_L1.0750.99
161_L263_T1.0690.99
307_F311_F1.0640.99
187_L333_F1.0570.99
224_V335_L1.0520.99
55_A64_Q1.0500.99
139_F205_A1.0470.99
247_L251_P1.0450.99
276_I280_D1.0340.99
91_S164_N1.0320.99
91_S161_L1.0270.99
98_F150_L1.0260.99
34_V62_I1.0200.99
240_I247_L1.0170.99
88_Y92_P1.0170.99
201_T207_I1.0130.99
208_V286_W1.0110.99
38_F310_V1.0040.99
70_I74_F1.0030.99
144_L196_G0.9990.99
239_E318_R0.9950.98
233_S274_Y0.9940.98
96_L100_F0.9920.98
80_P88_Y0.9920.98
37_W65_L0.9900.98
69_A73_V0.9830.98
69_A74_F0.9780.98
219_P222_A0.9760.98
320_R325_L0.9750.98
305_V308_F0.9740.98
283_L301_K0.9730.98
36_I268_Y0.9720.98
26_I30_I0.9690.98
80_P83_V0.9690.98
225_F282_F0.9670.98
45_I60_G0.9660.98
143_N203_D0.9630.98
285_G301_K0.9620.98
41_K75_S0.9620.98
258_F261_V0.9560.98
243_A318_R0.9560.98
44_A50_Y0.9550.98
191_S224_V0.9550.98
311_F316_Y0.9520.98
194_A340_L0.9500.98
155_P181_S0.9460.98
37_W62_I0.9450.98
213_P284_G0.9420.98
223_F227_V0.9410.98
298_T302_A0.9340.98
175_I241_V0.9320.98
339_S343_G0.9270.98
239_E242_E0.9240.98
69_A265_A0.9060.97
96_L262_L0.9040.97
97_I342_L0.9030.97
235_R239_E0.9020.97
308_F312_L0.8980.97
43_A313_R0.8950.97
207_I281_L0.8920.97
198_E347_G0.8910.97
284_G301_K0.8900.97
196_G202_L0.8880.97
226_L278_F0.8820.97
180_L234_S0.8810.97
96_L266_G0.8690.96
218_N339_S0.8560.96
226_L309_A0.8500.96
246_E318_R0.8480.96
29_L100_F0.8470.96
15_S19_T0.8450.96
161_L255_Y0.8450.96
156_I321_I0.8430.96
89_A93_V0.8420.96
241_V251_P0.8400.96
191_S228_A0.8400.96
214_G217_A0.8380.96
139_F143_N0.8360.96
194_A218_N0.8360.96
95_V263_T0.8290.95
147_I204_V0.8210.95
18_L22_F0.8200.95
34_V66_F0.8190.95
95_V154_Y0.8190.95
91_S157_L0.8160.95
37_W45_I0.8150.95
72_F261_V0.8150.95
144_L204_V0.8090.95
24_G137_P0.8080.95
110_T116_S0.8080.95
319_Y323_Q0.8070.95
63_L66_F0.8050.95
343_G347_G0.8000.94
105_L143_N0.7970.94
108_I137_P0.7970.94
236_F316_Y0.7960.94
105_L147_I0.7930.94
79_I83_V0.7920.94
72_F264_M0.7890.94
335_L339_S0.7890.94
294_G297_F0.7890.94
151_E154_Y0.7880.94
222_A282_F0.7870.94
232_G235_R0.7850.94
204_V277_L0.7820.94
148_I192_T0.7810.94
252_Y264_M0.7800.94
230_L309_A0.7740.93
183_S325_L0.7740.93
322_D325_L0.7730.93
187_L332_F0.7720.93
213_P285_G0.7620.93
180_L184_Y0.7620.93
165_T255_Y0.7580.93
25_L29_L0.7580.93
140_I263_T0.7580.93
140_I147_I0.7550.92
257_G261_V0.7550.92
163_W166_N0.7520.92
333_F336_A0.7520.92
37_W43_A0.7480.92
40_R49_R0.7460.92
106_I137_P0.7440.92
47_Q52_P0.7430.92
40_R68_D0.7420.92
144_L207_I0.7400.92
177_E243_A0.7350.91
274_Y278_F0.7340.91
39_E268_Y0.7310.91
188_I328_S0.7300.91
191_S194_A0.7260.91
245_T248_V0.7220.91
180_L183_S0.7200.91
87_L91_S0.7200.91
36_I39_E0.7150.90
302_A306_V0.7140.90
39_E43_A0.7140.90
224_V227_V0.7120.90
279_V294_G0.7120.90
231_I324_A0.7120.90
189_I192_T0.7100.90
33_L43_A0.7080.90
279_V301_K0.7080.90
68_D318_R0.7050.90
292_F295_A0.7040.90
99_A273_V0.7020.89
170_A249_I0.6980.89
225_F229_M0.6960.89
295_A299_V0.6960.89
236_F245_T0.6950.89
239_E247_L0.6940.89
208_V285_G0.6930.89
80_P92_P0.6920.89
211_G285_G0.6910.89
342_L345_V0.6900.89
106_I276_I0.6890.89
88_Y255_Y0.6890.89
16_F19_T0.6870.88
223_F340_L0.6850.88
158_V177_E0.6810.88
83_V88_Y0.6780.88
34_V37_W0.6780.88
287_L296_I0.6770.88
193_L196_G0.6740.87
40_R242_E0.6730.87
318_R322_D0.6720.87
105_L108_I0.6710.87
70_I73_V0.6710.87
94_L97_I0.6710.87
40_R51_G0.6660.87
33_L37_W0.6640.87
296_I300_F0.6640.87
286_W301_K0.6630.87
33_L69_A0.6630.87
215_F219_P0.6630.87
245_T249_I0.6620.86
110_T209_T0.6600.86
226_L305_V0.6580.86
47_Q254_E0.6580.86
287_L291_G0.6570.86
137_P265_A0.6560.86
31_F306_V0.6560.86
50_Y54_Y0.6550.86
21_I138_Y0.6530.86
188_I191_S0.6510.86
264_M313_R0.6510.86
184_Y231_I0.6480.85
278_F283_L0.6470.85
304_I307_F0.6460.85
82_G257_G0.6410.85
222_A283_L0.6400.85
170_A347_G0.6370.84
77_I88_Y0.6340.84
49_R250_G0.6340.84
194_A339_S0.6310.84
69_A261_V0.6310.84
45_I310_V0.6300.84
95_V158_V0.6300.84
167_N309_A0.6280.83
326_R330_K0.6270.83
320_R323_Q0.6270.83
261_V265_A0.6260.83
79_I85_Q0.6250.83
56_S63_L0.6230.83
153_L331_Y0.6220.83
29_L33_L0.6210.83
40_R244_E0.6190.83
194_A343_G0.6180.83
275_A279_V0.6150.82
98_F154_Y0.6150.82
336_A343_G0.6140.82
75_S330_K0.6140.82
24_G108_I0.6130.82
52_P64_Q0.6120.82
306_V310_V0.6110.82
68_D71_K0.6100.82
145_I321_I0.6090.82
92_P255_Y0.6080.81
19_T222_A0.6060.81
24_G27_F0.6050.81
157_L189_I0.6050.81
299_V302_A0.6030.81
40_R238_F0.5990.81
157_L160_F0.5980.80
242_E250_G0.5960.80
105_L227_V0.5940.80
230_L233_S0.5940.80
195_L281_L0.5930.80
16_F20_V0.5920.80
96_L253_T0.5900.80
235_R268_Y0.5900.80
174_S266_G0.5870.79
95_V102_P0.5870.79
299_V303_A0.5860.79
30_I33_L0.5850.79
56_S261_V0.5850.79
88_Y161_L0.5850.79
240_I243_A0.5850.79
160_F164_N0.5830.79
37_W60_G0.5810.79
31_F34_V0.5740.78
105_L277_L0.5730.78
42_A311_F0.5730.78
101_L206_K0.5720.77
27_F31_F0.5720.77
47_Q51_G0.5700.77
177_E247_L0.5670.77
90_I93_V0.5660.77
180_L231_I0.5650.77
191_S221_A0.5650.77
43_A48_L0.5640.76
67_A168_R0.5630.76
268_Y324_A0.5630.76
91_S152_S0.5620.76
17_F20_V0.5620.76
179_Y325_L0.5620.76
21_I25_L0.5610.76
37_W41_K0.5610.76
108_I276_I0.5600.76
249_I264_M0.5600.76
165_T170_A0.5580.76
183_S313_R0.5570.76
233_S270_A0.5560.75
184_Y329_W0.5550.75
23_P300_F0.5510.75
44_A49_R0.5500.75
234_S270_A0.5500.75
239_E246_E0.5500.75
176_R250_G0.5470.74
319_Y328_S0.5440.74
63_L67_A0.5430.74
140_I256_S0.5400.73
179_Y231_I0.5380.73
144_L192_T0.5380.73
289_F292_F0.5380.73
45_I189_I0.5380.73
156_I188_I0.5370.73
52_P71_K0.5360.73
300_F303_A0.5350.73
138_Y221_A0.5350.73
276_I336_A0.5330.72
100_F269_V0.5320.72
40_R47_Q0.5320.72
84_N166_N0.5320.72
137_P142_Y0.5310.72
99_A107_P0.5300.72
275_A309_A0.5300.72
340_L344_V0.5290.72
187_L224_V0.5290.72
158_V234_S0.5280.72
318_R321_I0.5280.72
147_I273_V0.5270.72
193_L340_L0.5270.72
16_F341_L0.5260.71
310_V313_R0.5260.71
108_I299_V0.5240.71
64_Q71_K0.5240.71
226_L311_F0.5220.71
151_E278_F0.5190.70
202_L205_A0.5190.70
28_T32_L0.5180.70
232_G267_S0.5170.70
224_V301_K0.5170.70
230_L274_Y0.5150.70
220_I224_V0.5140.70
345_V348_Y0.5140.70
324_A329_W0.5140.70
327_G331_Y0.5120.69
287_L294_G0.5110.69
244_E264_M0.5100.69
102_P270_A0.5090.69
16_F304_I0.5080.69
220_I339_S0.5080.69
224_V332_F0.5070.69
36_I69_A0.5060.68
81_N160_F0.5060.68
298_T301_K0.5050.68
65_L310_V0.5040.68
21_I24_G0.5030.68
79_I256_S0.5030.68
157_L174_S0.5030.68
242_E318_R0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8H 1 0.7727 100 0.119 Contact Map
2jpkA 1 0.0994 23.6 0.966 Contact Map
3mp7A 1 0.1534 5.8 0.975 Contact Map
1qleD 1 0.1222 4.3 0.976 Contact Map
1vryA 1 0.1733 4.1 0.976 Contact Map
3dacP 1 0.0369 3.3 0.977 Contact Map
4h25C 1 0.0625 3.2 0.977 Contact Map
2yevB 1 0.1989 3.2 0.978 Contact Map
1q90G 1 0.0852 2.5 0.979 Contact Map
1q2fA 1 0.0881 2.2 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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