GREMLIN Database
Q980H1 - NADH dehydrogenase subunit I (NuoI)
UniProt: Q980H1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (144)
Sequences: 601 (245)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_Q45_V3.6201.00
68_L137_H3.4121.00
85_G102_T2.9620.99
92_I125_V2.7700.99
114_G147_L2.7580.99
125_V130_A2.7080.99
43_S47_G2.6530.98
106_K109_P2.3890.97
40_H44_I2.3300.96
31_E34_A2.2840.96
48_I51_F2.2430.95
70_T135_K2.1690.94
118_F146_Q2.1250.94
164_Q168_V2.0990.93
38_A42_Q2.0170.92
29_K32_N2.0110.92
41_I45_V1.8370.87
76_I95_A1.7850.86
160_D164_Q1.7570.85
40_H43_S1.7430.84
123_V133_E1.7290.84
29_K33_I1.6900.82
166_K170_K1.6580.81
143_N146_Q1.6410.80
103_E106_K1.6310.80
85_G125_V1.6240.80
167_P171_V1.6150.79
30_K34_A1.5780.78
135_K168_V1.5710.77
145_K148_I1.5250.75
141_F147_L1.4890.73
123_V131_L1.4650.72
76_I131_L1.4650.72
56_R109_P1.4620.72
33_I42_Q1.4420.71
111_I117_V1.4030.69
116_C126_C1.3990.68
64_D135_K1.3660.67
167_P170_K1.3500.66
75_M141_F1.3090.63
122_C126_C1.3010.63
59_L67_T1.2800.61
88_L102_T1.2250.58
40_H46_T1.2200.58
103_E107_K1.2130.57
52_V171_V1.2110.57
144_R148_I1.2030.56
141_F146_Q1.2020.56
157_D161_V1.1810.55
104_S138_D1.1800.55
100_M129_D1.1740.55
43_S109_P1.1580.54
64_D67_T1.1550.53
37_F41_I1.1350.52
60_Q63_E1.1300.52
49_K163_M1.1280.52
145_K150_D1.1260.51
149_F157_D1.1200.51
112_N115_R1.1110.50
78_L154_F1.0950.49
97_A111_I1.0790.48
117_V131_L1.0770.48
168_V172_K1.0740.48
141_F148_I1.0670.48
33_I36_L1.0660.48
113_Y118_F1.0470.46
84_I132_K1.0300.45
75_M136_V1.0290.45
44_I47_G1.0290.45
163_M166_K1.0240.45
95_A117_V1.0170.44
75_M113_Y1.0010.43
170_K173_A0.9870.42
34_A38_A0.9750.42
163_M167_P0.9700.41
45_V49_K0.9520.40
138_D147_L0.9470.40
110_Q123_V0.9460.40
87_T90_A0.9400.39
61_Y138_D0.9370.39
101_V108_F0.9340.39
100_M112_N0.9110.38
78_L124_D0.9100.38
81_D88_L0.9070.37
102_T113_Y0.8960.37
164_Q169_R0.8920.36
97_A109_P0.8860.36
119_C122_C0.8860.36
98_M131_L0.8780.36
84_I128_V0.8680.35
64_D152_D0.8660.35
75_M146_Q0.8510.34
83_C93_C0.8510.34
83_C89_C0.8510.34
89_C93_C0.8510.34
86_C93_C0.8510.34
86_C89_C0.8510.34
83_C86_C0.8510.34
160_D171_V0.8430.34
79_Y95_A0.8420.33
30_K33_I0.8400.33
93_C119_C0.8350.33
86_C119_C0.8350.33
83_C119_C0.8350.33
89_C119_C0.8350.33
117_V124_D0.8300.33
149_F153_R0.8300.33
100_M115_R0.8290.33
136_V141_F0.8260.33
71_G80_K0.8240.32
81_D90_A0.8120.32
73_R154_F0.8040.31
58_T62_P0.8020.31
97_A117_V0.8010.31
87_T91_L0.7980.31
85_G95_A0.7920.31
156_V170_K0.7880.30
42_Q53_K0.7870.30
166_K173_A0.7790.30
41_I110_Q0.7610.29
65_S137_H0.7610.29
57_I137_H0.7580.29
65_S138_D0.7510.28
57_I102_T0.7400.28
136_V157_D0.7390.28
48_I57_I0.7380.28
45_V70_T0.7370.28
33_I38_A0.7330.27
38_A163_M0.7300.27
51_F146_Q0.7280.27
65_S131_L0.7270.27
74_G123_V0.7250.27
81_D151_P0.7170.27
50_Y53_K0.7140.26
35_S49_K0.7130.26
93_C116_C0.7130.26
83_C116_C0.7130.26
89_C116_C0.7130.26
86_C116_C0.7130.26
143_N150_D0.7100.26
53_K60_Q0.7040.26
30_K44_I0.7020.26
43_S62_P0.7010.26
88_L91_L0.6980.26
152_D155_N0.6970.26
116_C119_C0.6940.25
29_K54_P0.6910.25
100_M106_K0.6880.25
47_G56_R0.6880.25
109_P114_G0.6860.25
76_I115_R0.6850.25
84_I133_E0.6770.25
51_F59_L0.6760.25
92_I155_N0.6750.25
56_R59_L0.6720.24
89_C122_C0.6680.24
83_C122_C0.6680.24
86_C122_C0.6680.24
93_C122_C0.6680.24
158_I161_V0.6680.24
43_S46_T0.6630.24
49_K169_R0.6620.24
81_D132_K0.6570.24
37_F148_I0.6560.24
40_H71_G0.6550.24
114_G148_I0.6410.23
54_P74_G0.6410.23
141_F149_F0.6390.23
73_R127_P0.6380.23
48_I61_Y0.6380.23
78_L95_A0.6340.23
57_I134_T0.6310.22
95_A109_P0.6220.22
50_Y54_P0.6180.22
114_G141_F0.6170.22
121_F171_V0.6050.21
125_V128_V0.6040.21
84_I106_K0.6040.21
85_G124_D0.6000.21
38_A103_E0.5970.21
78_L151_P0.5960.21
78_L131_L0.5840.20
58_T64_D0.5800.20
98_M111_I0.5760.20
82_V91_L0.5740.20
100_M111_I0.5730.20
42_Q60_Q0.5680.20
155_N162_P0.5650.20
60_Q66_L0.5640.20
73_R76_I0.5620.19
63_E136_V0.5610.19
98_M154_F0.5600.19
37_F124_D0.5590.19
83_C126_C0.5470.19
89_C126_C0.5470.19
86_C126_C0.5470.19
93_C126_C0.5470.19
46_T92_I0.5460.19
95_A128_V0.5450.19
53_K142_N0.5410.19
163_M171_V0.5410.19
113_Y123_V0.5400.19
100_M109_P0.5400.19
78_L130_A0.5360.18
38_A48_I0.5340.18
80_K151_P0.5290.18
119_C126_C0.5250.18
153_R159_D0.5230.18
45_V164_Q0.5210.18
34_A170_K0.5160.18
52_V149_F0.5130.18
150_D153_R0.5090.17
151_P154_F0.5060.17
158_I165_D0.5040.17
136_V149_F0.5030.17
68_L168_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v9 1 0.6755 99.9 0.588 Contact Map
1gteA 4 0.7128 99.5 0.754 Contact Map
1xerA 2 0.4947 99.5 0.754 Contact Map
5c4iB 1 0.6489 99.5 0.756 Contact Map
1hfeL 2 0.6968 99.4 0.763 Contact Map
1rgvA 1 0.3936 99.4 0.77 Contact Map
2fgoA 1 0.3989 99.4 0.771 Contact Map
2gmhA 1 0.75 99.4 0.771 Contact Map
3eunA 1 0.3989 99.4 0.772 Contact Map
1jb0C 1 0.4043 99.3 0.772 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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