GREMLIN Database
Q980G8 - NADH dehydrogenase subunit N (NuoN)
UniProt: Q980G8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (440)
Sequences: 20091 (12461)
Seq/√Len: 594.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_D270_R4.8541.00
352_G389_L4.5551.00
140_Y153_T4.3221.00
206_L209_T4.0181.00
100_S143_F3.6941.00
166_M177_G3.6231.00
345_A400_F3.1891.00
179_K243_D3.1401.00
107_G135_L3.1241.00
305_D367_S3.0881.00
293_M425_N2.9181.00
204_S209_T2.8451.00
342_Q404_G2.8351.00
304_R370_S2.7881.00
289_S326_A2.6651.00
387_V437_V2.6451.00
366_T371_G2.5911.00
310_L357_V2.5821.00
103_V142_S2.5801.00
36_L136_L2.5741.00
194_G223_F2.4801.00
137_G156_I2.4781.00
100_S139_F2.4631.00
234_A322_L2.4331.00
114_S127_M2.4111.00
38_S60_L2.3831.00
368_D371_G2.3641.00
91_L145_N2.2651.00
390_I433_Y2.2581.00
301_F431_G2.1861.00
309_I369_I2.1651.00
450_K453_E2.1441.00
323_I422_A2.1411.00
104_F139_F2.1411.00
62_V108_I2.0391.00
245_Y253_V1.9941.00
245_Y261_K1.9581.00
283_V287_V1.9311.00
324_G408_L1.8661.00
209_T212_I1.8621.00
313_S432_Y1.8621.00
93_D96_G1.8321.00
229_L234_A1.8301.00
379_D382_L1.8171.00
294_L425_N1.8171.00
304_R368_D1.7771.00
297_N316_T1.7751.00
62_V66_G1.7681.00
147_I210_S1.7631.00
306_V436_I1.7501.00
75_S78_A1.7421.00
150_V267_P1.7271.00
338_G411_S1.7231.00
286_I326_A1.7201.00
470_V473_I1.7101.00
65_L105_S1.6951.00
341_V404_G1.6931.00
197_S220_S1.6871.00
233_G241_L1.6731.00
147_I271_V1.6611.00
435_P439_E1.6521.00
303_R308_A1.6401.00
459_V463_L1.6401.00
327_M335_A1.6221.00
145_N208_T1.6211.00
409_F422_A1.6181.00
456_I459_V1.6101.00
261_K314_S1.6061.00
64_L68_S1.6041.00
102_T347_G1.5861.00
376_S383_A1.5801.00
462_I466_I1.5791.00
416_P420_I1.5771.00
290_V421_I1.5681.00
269_F325_F1.5671.00
225_S229_L1.5621.00
96_G266_I1.5621.00
348_I463_L1.5591.00
410_E414_T1.5511.00
201_S220_S1.5391.00
75_S79_S1.5381.00
144_A149_I1.5301.00
235_F291_A1.5211.00
170_D173_S1.5191.00
46_D125_S1.4921.00
412_S419_T1.4911.00
146_N205_L1.4891.00
146_N206_L1.4851.00
141_M263_I1.4591.00
91_L94_V1.4561.00
285_F326_A1.4531.00
61_S65_L1.4431.00
98_F344_L1.4271.00
111_I128_L1.4091.00
321_I339_I1.4051.00
199_L205_L1.3981.00
130_L163_A1.3961.00
451_S455_N1.3951.00
286_I418_L1.3941.00
325_F339_I1.3931.00
215_N219_F1.3781.00
194_G227_A1.3631.00
297_N425_N1.3601.00
386_I390_I1.3551.00
164_I252_S1.3541.00
234_A288_I1.3501.00
324_G335_A1.3481.00
282_L286_I1.3481.00
383_A442_R1.3461.00
32_S35_I1.3361.00
123_T126_S1.3311.00
111_I131_M1.3271.00
388_V461_A1.3261.00
327_M412_S1.3241.00
228_F267_P1.3221.00
32_S136_L1.3201.00
176_A247_D1.3161.00
61_S64_L1.3151.00
458_V462_I1.3111.00
194_G224_I1.3011.00
39_S133_L1.3001.00
386_I436_I1.2981.00
449_I453_E1.2931.00
196_A200_I1.2921.00
116_D119_I1.2881.00
68_S104_F1.2811.00
383_A437_V1.2751.00
225_S285_F1.2751.00
51_E55_R1.2701.00
349_A392_S1.2621.00
113_L355_G1.2611.00
92_I143_F1.2531.00
79_S82_N1.2511.00
98_F340_L1.2491.00
353_L389_L1.2411.00
269_F339_I1.2391.00
89_S145_N1.2331.00
183_M239_A1.2331.00
150_V207_F1.2331.00
268_L322_L1.2291.00
191_M227_A1.2271.00
43_L46_D1.2261.00
60_L64_L1.2181.00
31_P35_I1.2121.00
243_D308_A1.2111.00
390_I437_V1.2111.00
106_I347_G1.2071.00
280_V283_V1.2021.00
323_I412_S1.1921.00
51_E54_F1.1921.00
194_G220_S1.1911.00
381_P384_F1.1861.00
151_L192_I1.1831.00
69_L73_I1.1811.00
324_G339_I1.1791.00
172_K246_T1.1731.00
99_F343_S1.1691.00
287_V291_A1.1641.00
369_I440_V1.1601.00
387_V441_F1.1551.00
106_I351_V1.1521.00
278_N281_E1.1461.00
316_T429_S1.1441.00
429_S432_Y1.1331.00
413_F419_T1.1311.00
463_L467_L1.1301.00
289_S319_G1.1281.00
147_I195_F1.1201.00
195_F224_I1.1191.00
393_L433_Y1.1181.00
104_F108_I1.1171.00
356_I386_I1.1171.00
145_N206_L1.1161.00
295_V299_T1.1161.00
134_S138_L1.1151.00
66_G70_A1.1121.00
148_I205_L1.1111.00
31_P67_V1.1111.00
338_G407_F1.1081.00
461_A464_S1.1081.00
407_F410_E1.0951.00
230_F237_F1.0931.00
345_A404_G1.0931.00
235_F295_V1.0921.00
197_S216_L1.0771.00
329_T335_A1.0771.00
391_L396_I1.0761.00
296_G319_G1.0711.00
356_I457_A1.0701.00
382_L448_V1.0671.00
229_L288_I1.0661.00
420_I424_L1.0641.00
187_S230_F1.0631.00
106_I258_S1.0611.00
461_A465_I1.0601.00
451_S454_R1.0581.00
133_L160_A1.0571.00
361_E367_S1.0551.00
191_M195_F1.0541.00
232_I265_I1.0541.00
389_L461_A1.0531.00
175_D179_K1.0531.00
105_S109_L1.0361.00
460_S464_S1.0341.00
67_V71_F1.0291.00
373_R446_F1.0271.00
95_P269_F1.0241.00
108_I112_L1.0171.00
76_W79_S1.0151.00
202_T210_S1.0141.00
213_Y217_F1.0121.00
359_H382_L1.0051.00
54_F57_S1.0051.00
39_S43_L1.0021.00
335_A411_S1.0021.00
225_S268_L1.0001.00
385_A461_A0.9991.00
207_F211_V0.9991.00
92_I97_Y0.9961.00
109_L459_V0.9931.00
201_S216_L0.9901.00
220_S224_I0.9891.00
59_I63_V0.9891.00
65_L104_F0.9841.00
250_R307_A0.9831.00
39_S129_S0.9831.00
68_S72_L0.9771.00
385_A457_A0.9761.00
417_W420_I0.9751.00
448_V453_E0.9751.00
113_L358_S0.9741.00
90_L143_F0.9731.00
96_G270_R0.9721.00
297_N428_I0.9711.00
363_V379_D0.9711.00
82_N85_L0.9681.00
199_L202_T0.9671.00
425_N428_I0.9671.00
245_Y257_S0.9671.00
381_P458_V0.9651.00
29_L32_S0.9641.00
383_A441_F0.9631.00
190_I223_F0.9621.00
214_P218_F0.9601.00
103_V135_L0.9571.00
266_I270_R0.9561.00
89_S206_L0.9561.00
254_A355_G0.9551.00
381_P385_A0.9501.00
47_N50_D0.9501.00
174_V177_G0.9481.00
208_T212_I0.9421.00
400_F467_L0.9421.00
68_S71_F0.9421.00
95_P340_L0.9391.00
131_M255_F0.9381.00
190_I226_I0.9371.00
386_I441_F0.9371.00
258_S262_L0.9361.00
265_I343_S0.9341.00
75_S80_V0.9331.00
346_Y350_Q0.9331.00
170_D246_T0.9321.00
58_V61_S0.9301.00
306_V357_V0.9301.00
54_F58_V0.9301.00
57_S60_L0.9291.00
171_Y175_D0.9271.00
321_I343_S0.9261.00
242_P312_F0.9191.00
132_L136_L0.9171.00
55_R59_I0.9171.00
77_T80_V0.9121.00
137_G160_A0.9121.00
80_V84_T0.9121.00
61_S111_I0.9091.00
297_N432_Y0.9091.00
198_Y210_S0.9061.00
215_N218_F0.9061.00
99_F266_I0.9051.00
265_I321_I0.9051.00
373_R439_E0.9041.00
198_Y220_S0.9021.00
317_Q342_Q0.8991.00
359_H457_A0.8931.00
454_R458_V0.8931.00
57_S128_L0.8921.00
214_P217_F0.8921.00
57_S61_S0.8921.00
448_V451_S0.8901.00
466_I470_V0.8861.00
289_S323_I0.8841.00
241_L245_Y0.8841.00
324_G338_G0.8821.00
151_L155_A0.8811.00
96_G100_S0.8781.00
70_A73_I0.8781.00
245_Y314_S0.8771.00
341_V345_A0.8761.00
305_D368_D0.8761.00
52_N55_R0.8751.00
330_V334_I0.8711.00
385_A458_V0.8691.00
204_S210_S0.8691.00
286_I289_S0.8671.00
71_F75_S0.8661.00
317_Q432_Y0.8631.00
86_F148_I0.8621.00
257_S350_Q0.8611.00
298_I428_I0.8601.00
139_F143_F0.8601.00
151_L195_F0.8601.00
137_G153_T0.8571.00
30_I34_F0.8571.00
433_Y436_I0.8571.00
138_L157_S0.8541.00
43_L129_S0.8531.00
197_S201_S0.8521.00
314_S346_Y0.8501.00
283_V286_I0.8491.00
62_V65_L0.8491.00
293_M319_G0.8481.00
293_M323_I0.8451.00
81_I85_L0.8451.00
76_W80_V0.8431.00
317_Q429_S0.8431.00
360_V375_I0.8391.00
165_A244_V0.8381.00
80_V85_L0.8371.00
213_Y216_L0.8351.00
290_V323_I0.8341.00
138_L259_V0.8321.00
65_L68_S0.8311.00
291_A295_V0.8291.00
378_Q445_E0.8281.00
77_T82_N0.8281.00
50_D54_F0.8271.00
259_V262_L0.8261.00
268_L325_F0.8251.00
219_F223_F0.8251.00
265_I322_L0.8231.00
221_I281_E0.8231.00
286_I290_V0.8201.00
373_R443_E0.8191.00
142_S266_I0.8181.00
222_S226_I0.8151.00
300_A432_Y0.8141.00
78_A81_I0.8111.00
265_I318_M0.8111.00
39_S136_L0.8101.00
162_Y177_G0.8101.00
218_F222_S0.8101.00
384_F441_F0.8081.00
109_L456_I0.8071.00
406_L410_E0.8071.00
257_S314_S0.8061.00
38_S42_V0.8001.00
125_S129_S0.8001.00
320_Y408_L0.7981.00
64_L67_V0.7961.00
107_G131_M0.7961.00
102_T344_L0.7931.00
309_I436_I0.7921.00
466_I473_I0.7911.00
306_V372_L0.7911.00
172_K247_D0.7911.00
290_V418_L0.7911.00
38_S64_L0.7911.00
289_S322_L0.7891.00
50_D53_R0.7871.00
464_S468_G0.7871.00
437_V442_R0.7851.00
64_L71_F0.7851.00
352_G460_S0.7851.00
296_G299_T0.7831.00
400_F464_S0.7831.00
449_I452_S0.7821.00
383_A387_V0.7821.00
110_A355_G0.7811.00
78_A82_N0.7811.00
269_F336_V0.7801.00
296_G316_T0.7781.00
455_N459_V0.7771.00
349_A401_G0.7771.00
409_F419_T0.7761.00
377_S380_K0.7741.00
127_M251_I0.7731.00
48_G51_E0.7701.00
103_V138_L0.7691.00
33_I37_F0.7681.00
434_V438_R0.7671.00
58_V64_L0.7661.00
262_L318_M0.7611.00
157_S263_I0.7611.00
392_S399_I0.7591.00
390_I436_I0.7581.00
421_I425_N0.7571.00
178_I182_I0.7571.00
55_R58_V0.7561.00
134_S161_S0.7541.00
310_L353_L0.7541.00
63_V67_V0.7501.00
89_S146_N0.7491.00
384_F387_V0.7481.00
65_L69_L0.7471.00
369_I439_E0.7471.00
384_F388_V0.7461.00
40_I43_L0.7451.00
32_S143_F0.7411.00
53_R56_L0.7401.00
366_T372_L0.7381.00
116_D450_K0.7371.00
154_W191_M0.7361.00
394_L430_A0.7351.00
165_A256_I0.7311.00
330_V337_V0.7311.00
294_L298_I0.7291.00
187_S227_A0.7261.00
101_I105_S0.7251.00
427_A431_G0.7241.00
39_S42_V0.7231.00
47_N51_E0.7211.00
216_L220_S0.7181.00
124_R128_L0.7121.00
138_L260_G0.7121.00
192_I196_A0.7111.00
467_L474_V0.7101.00
72_L101_I0.7091.00
198_Y224_I0.7071.00
106_I255_F0.7071.00
355_G456_I0.7061.00
313_S346_Y0.7041.00
117_H251_I0.7031.00
460_S463_L0.7031.00
162_Y184_G0.7031.00
398_P469_I0.7031.00
57_S64_L0.7031.00
46_D50_D0.7031.00
399_I403_W0.7021.00
430_A434_V0.7021.00
297_N313_S0.7021.00
204_S207_F0.7021.00
57_S72_L0.7011.00
395_G405_K0.6991.00
76_W82_N0.6981.00
342_Q349_A0.6971.00
250_R358_S0.6971.00
62_V72_L0.6961.00
75_S81_I0.6941.00
34_F38_S0.6911.00
146_N149_I0.6911.00
185_L188_S0.6901.00
423_V426_S0.6881.00
303_R312_F0.6851.00
385_A389_L0.6851.00
81_I84_T0.6841.00
217_F220_S0.6821.00
77_T84_T0.6801.00
271_V275_S0.6791.00
253_V261_K0.6791.00
69_L101_I0.6781.00
38_S132_L0.6761.00
42_V46_D0.6751.00
246_T308_A0.6741.00
61_S67_V0.6711.00
246_T305_D0.6711.00
356_I389_L0.6701.00
61_S68_S0.6681.00
392_S401_G0.6681.00
95_P266_I0.6671.00
114_S251_I0.6671.00
145_N149_I0.6661.00
58_V62_V0.6661.00
55_R60_L0.6641.00
290_V294_L0.6631.00
197_S219_F0.6631.00
335_A339_I0.6631.00
320_Y425_N0.6621.00
104_F135_L0.6611.00
116_D452_S0.6611.00
205_L209_T0.6581.00
369_I436_I0.6581.00
56_L60_L0.6571.00
32_S90_L0.6561.00
78_A84_T0.6561.00
101_I104_F0.6551.00
110_A254_A0.6541.00
297_N429_S0.6541.00
284_I287_V0.6541.00
172_K175_D0.6541.00
232_I264_G0.6531.00
35_I38_S0.6531.00
134_S255_F0.6521.00
364_S372_L0.6511.00
456_I460_S0.6491.00
109_L351_V0.6461.00
57_S111_I0.6461.00
80_V83_Y0.6441.00
289_S293_M0.6431.00
457_A460_S0.6421.00
455_N458_V0.6421.00
68_S100_S0.6411.00
299_T312_F0.6411.00
107_G255_F0.6401.00
97_Y101_I0.6401.00
294_L421_I0.6401.00
53_R57_S0.6391.00
239_A242_P0.6371.00
356_I385_A0.6341.00
381_P454_R0.6341.00
218_F280_V0.6341.00
286_I323_I0.6321.00
219_F222_S0.6311.00
157_S261_K0.6301.00
95_P99_F0.6301.00
349_A393_L0.6291.00
257_S261_K0.6281.00
92_I96_G0.6271.00
395_G399_I0.6251.00
35_I136_L0.6251.00
61_S71_F0.6241.00
91_L208_T0.6241.00
154_W263_I0.6241.00
253_V307_A0.6211.00
48_G52_N0.6201.00
75_S83_Y0.6181.00
303_R309_I0.6181.00
76_W84_T0.6171.00
437_V441_F0.6151.00
348_I400_F0.6141.00
409_F426_S0.6121.00
242_P315_I0.6101.00
258_S351_V0.6091.00
112_L455_N0.6051.00
56_L59_I0.6051.00
245_Y311_S0.6041.00
64_L104_F0.6021.00
313_S350_Q0.6011.00
293_M320_Y0.6001.00
216_L219_F0.5991.00
317_Q350_Q0.5991.00
253_V256_I0.5981.00
62_V68_S0.5971.00
257_S262_L0.5961.00
448_V452_S0.5941.00
349_A464_S0.5941.00
79_S84_T0.5931.00
287_V290_V0.5931.00
451_S456_I0.5911.00
465_I468_G0.5911.00
465_I469_I0.5901.00
211_V273_Y0.5891.00
344_L474_V0.5861.00
329_T411_S0.5861.00
387_V442_R0.5861.00
279_M282_L0.5861.00
161_S260_G0.5841.00
257_S346_Y0.5841.00
397_P402_F0.5821.00
29_L88_K0.5811.00
363_V453_E0.5811.00
170_D247_D0.5801.00
155_A231_K0.5801.00
126_S130_L0.5791.00
35_I39_S0.5781.00
79_S83_Y0.5771.00
376_S387_V0.5741.00
359_H449_I0.5721.00
382_L449_I0.5701.00
298_I302_S0.5691.00
245_Y258_S0.5681.00
32_S39_S0.5671.00
376_S441_F0.5671.00
454_R457_A0.5651.00
127_M252_S0.5641.00
113_L254_A0.5631.00
65_L72_L0.5631.00
150_V191_M0.5631.00
72_L97_Y0.5631.00
73_I77_T0.5631.00
145_N270_R0.5621.00
385_A454_R0.5611.00
144_A153_T0.5611.00
110_A131_M0.5601.00
221_I225_S0.5601.00
299_T303_R0.5570.99
110_A251_I0.5570.99
388_V465_I0.5570.99
103_V139_F0.5540.99
346_Y354_F0.5540.99
314_S318_M0.5540.99
115_K452_S0.5530.99
299_T302_S0.5530.99
417_W421_I0.5520.99
193_I197_S0.5520.99
102_T343_S0.5510.99
452_S456_I0.5500.99
306_V440_V0.5490.99
383_A440_V0.5480.99
313_S317_Q0.5470.99
29_L33_I0.5470.99
105_S463_L0.5460.99
388_V392_S0.5450.99
62_V71_F0.5450.99
133_L137_G0.5440.99
463_L466_I0.5430.99
334_I414_T0.5400.99
395_G401_G0.5370.99
64_L73_I0.5360.99
109_L460_S0.5360.99
151_L188_S0.5360.99
149_I152_T0.5330.99
59_I66_G0.5320.99
127_M167_L0.5320.99
467_L471_I0.5290.99
60_L132_L0.5280.99
380_K383_A0.5280.99
375_I379_D0.5280.99
37_F41_S0.5270.99
48_G53_R0.5260.99
235_F296_G0.5260.99
138_L263_I0.5260.99
135_L139_F0.5260.99
386_I433_Y0.5240.99
341_V407_F0.5240.99
431_G435_P0.5240.99
355_G460_S0.5240.99
249_D307_A0.5240.99
399_I465_I0.5220.99
103_V107_G0.5220.99
62_V70_A0.5210.99
342_Q345_A0.5170.99
403_W407_F0.5170.99
130_L160_A0.5170.99
250_R253_V0.5170.99
44_F48_G0.5170.99
304_R313_S0.5150.99
359_H363_V0.5120.99
96_G142_S0.5120.99
34_F63_V0.5100.99
261_K318_M0.5100.99
161_S256_I0.5100.99
449_I454_R0.5090.99
273_Y276_D0.5090.99
34_F60_L0.5090.99
257_S354_F0.5080.99
47_N52_N0.5080.99
58_V65_L0.5070.99
369_I372_L0.5070.99
469_I473_I0.5070.99
38_S43_L0.5070.99
409_F423_V0.5070.99
438_R443_E0.5060.99
457_A461_A0.5050.99
195_F205_L0.5040.99
72_L76_W0.5030.99
317_Q393_L0.5030.99
50_D55_R0.5020.99
241_L244_V0.5020.99
161_S165_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9379 100 0.223 Contact Map
3rkoN 1 0.9379 100 0.236 Contact Map
4he8L 1 0.9296 100 0.241 Contact Map
3rkoL 1 0.9358 100 0.243 Contact Map
4he8M 1 0.9027 100 0.254 Contact Map
4he8N 1 0.8716 100 0.296 Contact Map
4he8K 1 0.1905 52.5 0.961 Contact Map
3rkoK 1 0.1988 45.1 0.963 Contact Map
3imoA 2 0.0932 12.2 0.972 Contact Map
2yevB 1 0.1718 4.8 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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