GREMLIN Database
Q980G7 - Uncharacterized protein
UniProt: Q980G7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (334)
Sequences: 951 (467)
Seq/√Len: 25.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_I44_I6.8791.00
130_T134_N4.1361.00
4_I44_I3.6101.00
111_D115_K3.5241.00
200_L266_L3.4441.00
161_D164_M3.3981.00
146_A298_A3.3881.00
184_T277_I3.2501.00
82_V85_G2.9821.00
19_S268_G2.9601.00
82_V86_P2.9511.00
21_E24_R2.9001.00
121_V145_S2.8001.00
161_D165_E2.7861.00
167_R307_G2.7861.00
79_D82_V2.7630.99
138_K162_Q2.7030.99
266_L270_G2.6010.99
9_V17_V2.5880.99
133_S151_T2.5880.99
145_S168_L2.5580.99
7_I121_V2.5400.99
137_A147_F2.5380.99
81_I85_G2.4760.99
190_E194_S2.4600.99
81_I86_P2.4340.99
5_A46_A2.3980.98
146_A302_G2.3830.98
106_P143_A2.3400.98
84_R87_T2.2350.98
54_K57_K2.2330.98
123_N127_T2.2230.97
81_I84_R2.1560.97
256_R280_K2.0950.96
3_R117_K2.0610.96
199_V263_I2.0180.95
17_V44_I2.0180.95
188_I277_I2.0140.95
57_K61_E2.0020.95
85_G136_Y1.9870.95
26_G35_L1.9420.94
52_K100_E1.9070.94
122_V148_I1.8990.94
168_L302_G1.8960.94
142_E162_Q1.8760.93
207_I253_L1.8180.92
82_V87_T1.8140.92
333_R337_S1.8130.92
79_D85_G1.8030.92
80_I84_R1.7650.91
259_S263_I1.7610.91
110_V143_A1.7330.90
313_V317_Y1.6930.89
156_A170_I1.6910.89
105_E140_S1.6900.89
148_I298_A1.6810.89
150_T291_L1.6790.89
18_Q65_T1.6740.88
138_K142_E1.6590.88
22_L270_G1.6530.88
146_A168_L1.6490.88
83_M112_V1.6280.87
210_S284_S1.6160.87
184_T275_I1.6120.86
160_K309_A1.6060.86
313_V335_L1.5770.85
207_I260_Y1.5670.85
265_G273_I1.5470.84
256_R282_Y1.5350.84
80_I83_M1.5350.84
330_D333_R1.5330.83
258_V267_Y1.5210.83
255_D284_S1.5060.82
188_I192_L1.5040.82
292_I296_R1.4870.82
150_T175_L1.4440.80
6_L9_V1.4280.79
74_V78_N1.4240.79
212_E257_R1.4070.78
231_S320_D1.3930.77
127_T216_A1.3790.76
267_Y273_I1.3770.76
330_D334_S1.3460.75
184_T188_I1.3420.74
192_L275_I1.3410.74
44_I59_L1.3320.74
14_S52_K1.3280.74
276_D280_K1.3230.73
2_I42_I1.3220.73
81_I87_T1.3140.73
80_I85_G1.3020.72
3_R43_E1.2910.71
79_D83_M1.2850.71
34_D336_D1.2800.71
17_V20_I1.2790.71
83_M86_P1.2710.70
46_A83_M1.2560.69
258_V278_S1.2500.69
206_D212_E1.2490.69
123_N133_S1.2460.69
140_S145_S1.2400.68
193_K238_N1.2350.68
79_D86_P1.2310.68
140_S317_Y1.2200.67
131_S134_N1.2180.67
268_G277_I1.2180.67
46_A82_V1.2160.67
206_D257_R1.2160.67
56_N74_V1.2150.67
203_Y250_V1.2120.66
107_V111_D1.2070.66
102_S106_P1.2070.66
7_I139_A1.2040.66
4_I295_I1.2030.66
43_E116_E1.1970.65
3_R119_D1.1970.65
183_I191_F1.1960.65
252_F264_E1.1940.65
297_I317_Y1.1930.65
187_G191_F1.1820.64
195_R316_Y1.1770.64
34_D297_I1.1730.64
149_N173_D1.1710.64
226_K243_V1.1700.64
198_K266_L1.1680.63
124_L287_A1.1640.63
122_V150_T1.1630.63
298_A310_V1.1560.63
167_R305_G1.1550.63
169_P301_L1.1530.62
260_Y278_S1.1530.62
111_D114_K1.1470.62
21_E77_K1.1450.62
311_K323_E1.1420.62
23_I39_P1.1410.62
68_N295_I1.1410.62
135_F139_A1.1400.62
171_L318_F1.1390.61
106_P110_V1.1210.60
324_K327_S1.1180.60
5_A118_V1.1120.60
315_Y334_S1.1090.59
121_V140_S1.0980.59
120_V127_T1.0950.58
87_T91_R1.0930.58
189_I237_T1.0810.57
337_S340_N1.0730.57
112_V115_K1.0710.57
93_G220_W1.0650.56
317_Y335_L1.0640.56
80_I86_P1.0630.56
232_F236_F1.0620.56
306_I312_E1.0570.56
114_K166_K1.0540.55
301_L307_G1.0480.55
97_N214_L1.0430.55
102_S107_V1.0410.54
216_A247_S1.0410.54
21_E25_N1.0340.54
210_S255_D1.0280.54
4_I16_L1.0250.53
301_L313_V1.0230.53
104_E107_V1.0210.53
224_L227_S1.0110.52
187_G332_K0.9980.51
25_N76_V0.9880.51
38_R114_K0.9820.50
107_V165_E0.9680.49
228_L320_D0.9530.48
58_R79_D0.9520.48
24_R76_V0.9510.48
336_D340_N0.9500.48
106_P139_A0.9410.47
192_L265_G0.9400.47
247_S261_M0.9370.47
140_S159_F0.9320.46
125_L151_T0.9260.46
139_A267_Y0.9250.46
116_E119_D0.9240.46
22_L69_V0.9240.46
290_P317_Y0.9200.46
135_F269_I0.9190.46
194_S332_K0.9190.46
258_V280_K0.9140.45
54_K113_L0.9140.45
20_I292_I0.9060.45
237_T317_Y0.9060.45
81_I115_K0.9050.45
301_L308_G0.9010.44
189_I263_I0.8980.44
54_K78_N0.8960.44
197_V265_G0.8940.44
171_L309_A0.8930.44
212_E216_A0.8910.44
300_L303_R0.8810.43
122_V295_I0.8800.43
97_N218_E0.8780.43
179_I267_Y0.8780.43
199_V237_T0.8720.42
252_F276_D0.8700.42
205_I250_V0.8690.42
19_S301_L0.8650.42
103_E110_V0.8620.41
120_V126_P0.8620.41
181_G277_I0.8600.41
14_S64_F0.8600.41
253_L260_Y0.8560.41
110_V139_A0.8530.41
207_I278_S0.8510.41
258_V274_R0.8500.41
79_D84_R0.8480.40
95_L101_E0.8480.40
216_A257_R0.8460.40
60_R74_V0.8450.40
17_V80_I0.8450.40
213_A247_S0.8450.40
92_V95_L0.8430.40
262_V276_D0.8390.40
98_I214_L0.8360.40
41_D122_V0.8330.39
111_D167_R0.8300.39
213_A287_A0.8280.39
140_S168_L0.8250.39
2_I148_I0.8250.39
79_D87_T0.8250.39
44_I203_Y0.8170.38
294_L318_F0.8150.38
91_R95_L0.8130.38
176_L182_T0.8100.38
86_P106_P0.8070.38
137_A157_K0.8070.38
14_S63_I0.8000.37
105_E108_D0.7990.37
114_K165_E0.7960.37
158_E162_Q0.7950.37
190_E237_T0.7950.37
123_N149_N0.7910.36
333_R340_N0.7890.36
193_K330_D0.7870.36
4_I20_I0.7850.36
149_N170_I0.7830.36
119_D302_G0.7770.36
113_L128_G0.7740.35
38_R41_D0.7710.35
14_S67_P0.7640.35
216_A245_G0.7620.35
127_T222_K0.7610.34
267_Y282_Y0.7610.34
103_E106_P0.7570.34
171_L313_V0.7570.34
228_L256_R0.7560.34
86_P135_F0.7550.34
67_P71_D0.7550.34
29_I66_K0.7540.34
88_L136_Y0.7510.34
216_A222_K0.7490.34
148_I166_K0.7480.34
29_I35_L0.7480.34
60_R76_V0.7440.33
287_A294_L0.7420.33
267_Y271_V0.7400.33
147_F305_G0.7370.33
203_Y264_E0.7370.33
306_I310_V0.7350.33
84_R136_Y0.7340.33
147_F156_A0.7310.33
69_V269_I0.7300.32
75_D157_K0.7280.32
52_K166_K0.7270.32
119_D220_W0.7260.32
206_D284_S0.7250.32
297_I338_L0.7250.32
258_V282_Y0.7250.32
87_T101_E0.7220.32
19_S305_G0.7210.32
224_L228_L0.7210.32
120_V146_A0.7200.32
253_L278_S0.7190.32
92_V218_E0.7180.32
268_G301_L0.7150.31
120_V166_K0.7130.31
120_V123_N0.7110.31
222_K226_K0.7070.31
104_E140_S0.7060.31
247_S287_A0.7050.31
2_I328_I0.7040.31
19_S169_P0.7040.31
88_L95_L0.7030.31
124_L295_I0.7020.31
41_D115_K0.7000.31
88_L132_A0.7000.31
110_V114_K0.7000.31
259_S287_A0.6980.30
111_D116_E0.6970.30
66_K101_E0.6960.30
142_E166_K0.6940.30
196_G272_P0.6920.30
310_V338_L0.6910.30
41_D228_L0.6910.30
56_N78_N0.6900.30
41_D62_A0.6890.30
40_N74_V0.6830.30
325_A335_L0.6810.29
136_Y149_N0.6790.29
298_A302_G0.6790.29
295_I308_G0.6770.29
69_V72_K0.6760.29
187_G273_I0.6760.29
71_D74_V0.6750.29
179_I273_I0.6750.29
169_P311_K0.6740.29
113_L129_A0.6730.29
104_E108_D0.6710.29
112_V133_S0.6690.29
103_E135_F0.6680.29
136_Y140_S0.6650.28
138_K159_F0.6630.28
190_E250_V0.6620.28
93_G199_V0.6590.28
274_R280_K0.6590.28
207_I259_S0.6580.28
282_Y320_D0.6550.28
330_D336_D0.6540.28
251_E274_R0.6520.28
207_I236_F0.6520.28
129_A149_N0.6490.27
190_E267_Y0.6480.27
190_E258_V0.6440.27
161_D305_G0.6430.27
56_N308_G0.6420.27
193_K240_V0.6380.27
21_E76_V0.6380.27
91_R94_I0.6370.27
134_N159_F0.6370.27
69_V98_I0.6360.27
54_K141_L0.6350.27
206_D216_A0.6330.27
20_I277_I0.6310.26
169_P288_V0.6310.26
47_A80_I0.6300.26
75_D78_N0.6290.26
289_A318_F0.6260.26
176_L189_I0.6240.26
87_T136_Y0.6230.26
50_I266_L0.6170.26
16_L290_P0.6160.26
286_N289_A0.6140.25
139_A150_T0.6140.25
3_R118_V0.6130.25
92_V99_I0.6130.25
165_E302_G0.6120.25
12_V287_A0.6110.25
324_K328_I0.6110.25
26_G30_Y0.6100.25
3_R113_L0.6080.25
160_K164_M0.6070.25
233_I241_E0.6060.25
118_V121_V0.6040.25
68_N266_L0.6040.25
71_D164_M0.6030.25
148_I197_V0.6020.25
304_H307_G0.6020.25
264_E276_D0.6010.25
101_E106_P0.6010.25
25_N35_L0.6010.25
122_V298_A0.6010.25
26_G270_G0.5990.25
120_V148_I0.5990.25
324_K338_L0.5990.25
86_P90_G0.5990.25
43_E46_A0.5980.25
185_H204_Q0.5980.25
335_L338_L0.5980.25
111_D161_D0.5970.25
167_R270_G0.5950.24
61_E75_D0.5950.24
4_I35_L0.5950.24
224_L230_S0.5940.24
222_K243_V0.5930.24
288_V317_Y0.5930.24
218_E261_M0.5910.24
188_I278_S0.5900.24
12_V15_A0.5890.24
299_K303_R0.5880.24
166_K240_V0.5880.24
144_G166_K0.5880.24
151_T315_Y0.5870.24
53_R295_I0.5870.24
25_N114_K0.5820.24
203_Y276_D0.5800.24
2_I35_L0.5800.24
156_A304_H0.5790.24
213_A261_M0.5790.24
127_T154_P0.5780.24
14_S53_R0.5750.23
243_V255_D0.5740.23
176_L186_A0.5740.23
221_R318_F0.5710.23
227_S309_A0.5710.23
170_I187_G0.5710.23
44_I169_P0.5700.23
176_L212_E0.5680.23
325_A334_S0.5680.23
312_E335_L0.5680.23
9_V79_D0.5680.23
107_V112_V0.5680.23
115_K166_K0.5670.23
138_K309_A0.5650.23
193_K199_V0.5640.23
260_Y275_I0.5630.23
206_D321_P0.5600.23
237_T267_Y0.5590.23
154_P216_A0.5580.22
208_A213_A0.5580.22
165_E333_R0.5570.22
288_V313_V0.5570.22
106_P142_E0.5560.22
164_M334_S0.5530.22
144_G168_L0.5520.22
103_E167_R0.5520.22
333_R336_D0.5520.22
336_D339_L0.5520.22
42_I52_K0.5520.22
136_Y159_F0.5520.22
24_R110_V0.5520.22
147_F171_L0.5510.22
253_L280_K0.5510.22
269_I272_P0.5510.22
198_K271_V0.5500.22
50_I101_E0.5490.22
179_I238_N0.5480.22
42_I167_R0.5480.22
234_S242_V0.5470.22
143_A168_L0.5450.22
40_N103_E0.5450.22
140_S144_G0.5450.22
287_A292_I0.5440.22
255_D285_F0.5440.22
9_V188_I0.5440.22
296_R308_G0.5420.22
3_R134_N0.5410.22
87_T94_I0.5400.22
185_H245_G0.5370.21
25_N52_K0.5360.21
190_E291_L0.5360.21
54_K163_F0.5350.21
125_L153_S0.5320.21
35_L75_D0.5320.21
112_V261_M0.5320.21
268_G318_F0.5320.21
176_L257_R0.5310.21
71_D330_D0.5310.21
81_I103_E0.5310.21
168_L304_H0.5290.21
190_E275_I0.5290.21
287_A318_F0.5290.21
22_L269_I0.5290.21
291_L313_V0.5270.21
20_I184_T0.5270.21
266_L272_P0.5260.21
21_E335_L0.5260.21
18_Q54_K0.5260.21
173_D196_G0.5260.21
95_L99_I0.5250.21
66_K114_K0.5250.21
201_K264_E0.5230.21
37_I297_I0.5230.21
141_L166_K0.5230.21
86_P249_Y0.5230.21
100_E104_E0.5220.21
24_R165_E0.5220.21
260_Y273_I0.5220.21
203_Y244_A0.5210.21
114_K302_G0.5210.21
79_D305_G0.5210.21
212_E228_L0.5200.21
16_L20_I0.5190.21
28_E291_L0.5180.21
47_A55_V0.5180.21
24_R147_F0.5160.20
4_I266_L0.5150.20
60_R77_K0.5150.20
16_L44_I0.5120.20
305_G308_G0.5120.20
102_S135_F0.5120.20
206_D210_S0.5100.20
168_L288_V0.5100.20
9_V305_G0.5090.20
214_L259_S0.5090.20
36_P39_P0.5080.20
107_V113_L0.5070.20
46_A268_G0.5060.20
4_I184_T0.5060.20
237_T318_F0.5060.20
46_A116_E0.5040.20
110_V135_F0.5040.20
223_D226_K0.5030.20
64_F211_T0.5020.20
103_E107_V0.5010.20
16_L41_D0.5010.20
44_I67_P0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cinA 3 0.9855 100 0.164 Contact Map
1gr0A 3 0.9215 100 0.183 Contact Map
1p1jA 4 0.9913 100 0.196 Contact Map
1vkoA 4 0.9913 100 0.198 Contact Map
3qvsA 2 0.9767 100 0.209 Contact Map
3do5A 2 0.7791 98 0.93 Contact Map
1f06A 2 0.7471 98 0.93 Contact Map
3wb9A 5 0.7442 98 0.931 Contact Map
3ingA 2 0.7442 98 0.931 Contact Map
3bioA 4 0.75 97.9 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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