Q980G7 - SULSO - GREMLIN Contacts

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Q980G7 - Uncharacterized protein

UniProt:	Q980G7	Sequences: MIRIALIGVGNVASALVQSIELIRNGKEIYGILDLPIRPNDIEIVAAFDIDKRKVNKRLREAIFTKPNVVDKYVDVKNDIIVMRGPTLDGRVGILSNIIEESEEEPVDIVDVLKKEKVDVVVNLLPTGATSASNFYAKASLEAGSAFINTTPSPTAKEFKDQFMEKRLPILGDDLLSQIGGTITHAGIIEFLKSRGVKVLKSYQIDIAGSTEALVALEDWRKDLKKSLKSSFISSFTNDVEVVAGTSDYVEFLKDRRVSYMVIEGLYGIGVPIRIDISLKTYDSFNAVAPLIDLIRIAKLLGRHGIGGAVKEVCYYYFKDPPEKAKSIMDAKRSLDSLLNKLLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (334)
Sequences:	951 (467)
Seq/√Len:	25.6

SULSO - Q980G7 Q97ZL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
20_I	44_I	6.879	1.00
130_T	134_N	4.136	1.00
4_I	44_I	3.610	1.00
111_D	115_K	3.524	1.00
200_L	266_L	3.444	1.00
161_D	164_M	3.398	1.00
146_A	298_A	3.388	1.00
184_T	277_I	3.250	1.00
82_V	85_G	2.982	1.00
19_S	268_G	2.960	1.00
82_V	86_P	2.951	1.00
21_E	24_R	2.900	1.00
121_V	145_S	2.800	1.00
161_D	165_E	2.786	1.00
167_R	307_G	2.786	1.00
79_D	82_V	2.763	0.99
138_K	162_Q	2.703	0.99
266_L	270_G	2.601	0.99
9_V	17_V	2.588	0.99
133_S	151_T	2.588	0.99
145_S	168_L	2.558	0.99
7_I	121_V	2.540	0.99
137_A	147_F	2.538	0.99
81_I	85_G	2.476	0.99
190_E	194_S	2.460	0.99
81_I	86_P	2.434	0.99
5_A	46_A	2.398	0.98
146_A	302_G	2.383	0.98
106_P	143_A	2.340	0.98
84_R	87_T	2.235	0.98
54_K	57_K	2.233	0.98
123_N	127_T	2.223	0.97
81_I	84_R	2.156	0.97
256_R	280_K	2.095	0.96
3_R	117_K	2.061	0.96
199_V	263_I	2.018	0.95
17_V	44_I	2.018	0.95
188_I	277_I	2.014	0.95
57_K	61_E	2.002	0.95
85_G	136_Y	1.987	0.95
26_G	35_L	1.942	0.94
52_K	100_E	1.907	0.94
122_V	148_I	1.899	0.94
168_L	302_G	1.896	0.94
142_E	162_Q	1.876	0.93
207_I	253_L	1.818	0.92
82_V	87_T	1.814	0.92
333_R	337_S	1.813	0.92
79_D	85_G	1.803	0.92
80_I	84_R	1.765	0.91
259_S	263_I	1.761	0.91
110_V	143_A	1.733	0.90
313_V	317_Y	1.693	0.89
156_A	170_I	1.691	0.89
105_E	140_S	1.690	0.89
148_I	298_A	1.681	0.89
150_T	291_L	1.679	0.89
18_Q	65_T	1.674	0.88
138_K	142_E	1.659	0.88
22_L	270_G	1.653	0.88
146_A	168_L	1.649	0.88
83_M	112_V	1.628	0.87
210_S	284_S	1.616	0.87
184_T	275_I	1.612	0.86
160_K	309_A	1.606	0.86
313_V	335_L	1.577	0.85
207_I	260_Y	1.567	0.85
265_G	273_I	1.547	0.84
256_R	282_Y	1.535	0.84
80_I	83_M	1.535	0.84
330_D	333_R	1.533	0.83
258_V	267_Y	1.521	0.83
255_D	284_S	1.506	0.82
188_I	192_L	1.504	0.82
292_I	296_R	1.487	0.82
150_T	175_L	1.444	0.80
6_L	9_V	1.428	0.79
74_V	78_N	1.424	0.79
212_E	257_R	1.407	0.78
231_S	320_D	1.393	0.77
127_T	216_A	1.379	0.76
267_Y	273_I	1.377	0.76
330_D	334_S	1.346	0.75
184_T	188_I	1.342	0.74
192_L	275_I	1.341	0.74
44_I	59_L	1.332	0.74
14_S	52_K	1.328	0.74
276_D	280_K	1.323	0.73
2_I	42_I	1.322	0.73
81_I	87_T	1.314	0.73
80_I	85_G	1.302	0.72
3_R	43_E	1.291	0.71
79_D	83_M	1.285	0.71
34_D	336_D	1.280	0.71
17_V	20_I	1.279	0.71
83_M	86_P	1.271	0.70
46_A	83_M	1.256	0.69
258_V	278_S	1.250	0.69
206_D	212_E	1.249	0.69
123_N	133_S	1.246	0.69
140_S	145_S	1.240	0.68
193_K	238_N	1.235	0.68
79_D	86_P	1.231	0.68
140_S	317_Y	1.220	0.67
131_S	134_N	1.218	0.67
268_G	277_I	1.218	0.67
46_A	82_V	1.216	0.67
206_D	257_R	1.216	0.67
56_N	74_V	1.215	0.67
203_Y	250_V	1.212	0.66
107_V	111_D	1.207	0.66
102_S	106_P	1.207	0.66
7_I	139_A	1.204	0.66
4_I	295_I	1.203	0.66
43_E	116_E	1.197	0.65
3_R	119_D	1.197	0.65
183_I	191_F	1.196	0.65
252_F	264_E	1.194	0.65
297_I	317_Y	1.193	0.65
187_G	191_F	1.182	0.64
195_R	316_Y	1.177	0.64
34_D	297_I	1.173	0.64
149_N	173_D	1.171	0.64
226_K	243_V	1.170	0.64
198_K	266_L	1.168	0.63
124_L	287_A	1.164	0.63
122_V	150_T	1.163	0.63
298_A	310_V	1.156	0.63
167_R	305_G	1.155	0.63
169_P	301_L	1.153	0.62
260_Y	278_S	1.153	0.62
111_D	114_K	1.147	0.62
21_E	77_K	1.145	0.62
311_K	323_E	1.142	0.62
23_I	39_P	1.141	0.62
68_N	295_I	1.141	0.62
135_F	139_A	1.140	0.62
171_L	318_F	1.139	0.61
106_P	110_V	1.121	0.60
324_K	327_S	1.118	0.60
5_A	118_V	1.112	0.60
315_Y	334_S	1.109	0.59
121_V	140_S	1.098	0.59
120_V	127_T	1.095	0.58
87_T	91_R	1.093	0.58
189_I	237_T	1.081	0.57
337_S	340_N	1.073	0.57
112_V	115_K	1.071	0.57
93_G	220_W	1.065	0.56
317_Y	335_L	1.064	0.56
80_I	86_P	1.063	0.56
232_F	236_F	1.062	0.56
306_I	312_E	1.057	0.56
114_K	166_K	1.054	0.55
301_L	307_G	1.048	0.55
97_N	214_L	1.043	0.55
102_S	107_V	1.041	0.54
216_A	247_S	1.041	0.54
21_E	25_N	1.034	0.54
210_S	255_D	1.028	0.54
4_I	16_L	1.025	0.53
301_L	313_V	1.023	0.53
104_E	107_V	1.021	0.53
224_L	227_S	1.011	0.52
187_G	332_K	0.998	0.51
25_N	76_V	0.988	0.51
38_R	114_K	0.982	0.50
107_V	165_E	0.968	0.49
228_L	320_D	0.953	0.48
58_R	79_D	0.952	0.48
24_R	76_V	0.951	0.48
336_D	340_N	0.950	0.48
106_P	139_A	0.941	0.47
192_L	265_G	0.940	0.47
247_S	261_M	0.937	0.47
140_S	159_F	0.932	0.46
125_L	151_T	0.926	0.46
139_A	267_Y	0.925	0.46
116_E	119_D	0.924	0.46
22_L	69_V	0.924	0.46
290_P	317_Y	0.920	0.46
135_F	269_I	0.919	0.46
194_S	332_K	0.919	0.46
258_V	280_K	0.914	0.45
54_K	113_L	0.914	0.45
20_I	292_I	0.906	0.45
237_T	317_Y	0.906	0.45
81_I	115_K	0.905	0.45
301_L	308_G	0.901	0.44
189_I	263_I	0.898	0.44
54_K	78_N	0.896	0.44
197_V	265_G	0.894	0.44
171_L	309_A	0.893	0.44
212_E	216_A	0.891	0.44
300_L	303_R	0.881	0.43
122_V	295_I	0.880	0.43
97_N	218_E	0.878	0.43
179_I	267_Y	0.878	0.43
199_V	237_T	0.872	0.42
252_F	276_D	0.870	0.42
205_I	250_V	0.869	0.42
19_S	301_L	0.865	0.42
103_E	110_V	0.862	0.41
120_V	126_P	0.862	0.41
181_G	277_I	0.860	0.41
14_S	64_F	0.860	0.41
253_L	260_Y	0.856	0.41
110_V	139_A	0.853	0.41
207_I	278_S	0.851	0.41
258_V	274_R	0.850	0.41
79_D	84_R	0.848	0.40
95_L	101_E	0.848	0.40
216_A	257_R	0.846	0.40
60_R	74_V	0.845	0.40
17_V	80_I	0.845	0.40
213_A	247_S	0.845	0.40
92_V	95_L	0.843	0.40
262_V	276_D	0.839	0.40
98_I	214_L	0.836	0.40
41_D	122_V	0.833	0.39
111_D	167_R	0.830	0.39
213_A	287_A	0.828	0.39
140_S	168_L	0.825	0.39
2_I	148_I	0.825	0.39
79_D	87_T	0.825	0.39
44_I	203_Y	0.817	0.38
294_L	318_F	0.815	0.38
91_R	95_L	0.813	0.38
176_L	182_T	0.810	0.38
86_P	106_P	0.807	0.38
137_A	157_K	0.807	0.38
14_S	63_I	0.800	0.37
105_E	108_D	0.799	0.37
114_K	165_E	0.796	0.37
158_E	162_Q	0.795	0.37
190_E	237_T	0.795	0.37
123_N	149_N	0.791	0.36
333_R	340_N	0.789	0.36
193_K	330_D	0.787	0.36
4_I	20_I	0.785	0.36
149_N	170_I	0.783	0.36
119_D	302_G	0.777	0.36
113_L	128_G	0.774	0.35
38_R	41_D	0.771	0.35
14_S	67_P	0.764	0.35
216_A	245_G	0.762	0.35
127_T	222_K	0.761	0.34
267_Y	282_Y	0.761	0.34
103_E	106_P	0.757	0.34
171_L	313_V	0.757	0.34
228_L	256_R	0.756	0.34
86_P	135_F	0.755	0.34
67_P	71_D	0.755	0.34
29_I	66_K	0.754	0.34
88_L	136_Y	0.751	0.34
216_A	222_K	0.749	0.34
148_I	166_K	0.748	0.34
29_I	35_L	0.748	0.34
60_R	76_V	0.744	0.33
287_A	294_L	0.742	0.33
267_Y	271_V	0.740	0.33
147_F	305_G	0.737	0.33
203_Y	264_E	0.737	0.33
306_I	310_V	0.735	0.33
84_R	136_Y	0.734	0.33
147_F	156_A	0.731	0.33
69_V	269_I	0.730	0.32
75_D	157_K	0.728	0.32
52_K	166_K	0.727	0.32
119_D	220_W	0.726	0.32
206_D	284_S	0.725	0.32
297_I	338_L	0.725	0.32
258_V	282_Y	0.725	0.32
87_T	101_E	0.722	0.32
19_S	305_G	0.721	0.32
224_L	228_L	0.721	0.32
120_V	146_A	0.720	0.32
253_L	278_S	0.719	0.32
92_V	218_E	0.718	0.32
268_G	301_L	0.715	0.31
120_V	166_K	0.713	0.31
120_V	123_N	0.711	0.31
222_K	226_K	0.707	0.31
104_E	140_S	0.706	0.31
247_S	287_A	0.705	0.31
2_I	328_I	0.704	0.31
19_S	169_P	0.704	0.31
88_L	95_L	0.703	0.31
124_L	295_I	0.702	0.31
41_D	115_K	0.700	0.31
88_L	132_A	0.700	0.31
110_V	114_K	0.700	0.31
259_S	287_A	0.698	0.30
111_D	116_E	0.697	0.30
66_K	101_E	0.696	0.30
142_E	166_K	0.694	0.30
196_G	272_P	0.692	0.30
310_V	338_L	0.691	0.30
41_D	228_L	0.691	0.30
56_N	78_N	0.690	0.30
41_D	62_A	0.689	0.30
40_N	74_V	0.683	0.30
325_A	335_L	0.681	0.29
136_Y	149_N	0.679	0.29
298_A	302_G	0.679	0.29
295_I	308_G	0.677	0.29
69_V	72_K	0.676	0.29
187_G	273_I	0.676	0.29
71_D	74_V	0.675	0.29
179_I	273_I	0.675	0.29
169_P	311_K	0.674	0.29
113_L	129_A	0.673	0.29
104_E	108_D	0.671	0.29
112_V	133_S	0.669	0.29
103_E	135_F	0.668	0.29
136_Y	140_S	0.665	0.28
138_K	159_F	0.663	0.28
190_E	250_V	0.662	0.28
93_G	199_V	0.659	0.28
274_R	280_K	0.659	0.28
207_I	259_S	0.658	0.28
282_Y	320_D	0.655	0.28
330_D	336_D	0.654	0.28
251_E	274_R	0.652	0.28
207_I	236_F	0.652	0.28
129_A	149_N	0.649	0.27
190_E	267_Y	0.648	0.27
190_E	258_V	0.644	0.27
161_D	305_G	0.643	0.27
56_N	308_G	0.642	0.27
193_K	240_V	0.638	0.27
21_E	76_V	0.638	0.27
91_R	94_I	0.637	0.27
134_N	159_F	0.637	0.27
69_V	98_I	0.636	0.27
54_K	141_L	0.635	0.27
206_D	216_A	0.633	0.27
20_I	277_I	0.631	0.26
169_P	288_V	0.631	0.26
47_A	80_I	0.630	0.26
75_D	78_N	0.629	0.26
289_A	318_F	0.626	0.26
176_L	189_I	0.624	0.26
87_T	136_Y	0.623	0.26
50_I	266_L	0.617	0.26
16_L	290_P	0.616	0.26
286_N	289_A	0.614	0.25
139_A	150_T	0.614	0.25
3_R	118_V	0.613	0.25
92_V	99_I	0.613	0.25
165_E	302_G	0.612	0.25
12_V	287_A	0.611	0.25
324_K	328_I	0.611	0.25
26_G	30_Y	0.610	0.25
3_R	113_L	0.608	0.25
160_K	164_M	0.607	0.25
233_I	241_E	0.606	0.25
118_V	121_V	0.604	0.25
68_N	266_L	0.604	0.25
71_D	164_M	0.603	0.25
148_I	197_V	0.602	0.25
304_H	307_G	0.602	0.25
264_E	276_D	0.601	0.25
101_E	106_P	0.601	0.25
25_N	35_L	0.601	0.25
122_V	298_A	0.601	0.25
26_G	270_G	0.599	0.25
120_V	148_I	0.599	0.25
324_K	338_L	0.599	0.25
86_P	90_G	0.599	0.25
43_E	46_A	0.598	0.25
185_H	204_Q	0.598	0.25
335_L	338_L	0.598	0.25
111_D	161_D	0.597	0.25
167_R	270_G	0.595	0.24
61_E	75_D	0.595	0.24
4_I	35_L	0.595	0.24
224_L	230_S	0.594	0.24
222_K	243_V	0.593	0.24
288_V	317_Y	0.593	0.24
218_E	261_M	0.591	0.24
188_I	278_S	0.590	0.24
12_V	15_A	0.589	0.24
299_K	303_R	0.588	0.24
166_K	240_V	0.588	0.24
144_G	166_K	0.588	0.24
151_T	315_Y	0.587	0.24
53_R	295_I	0.587	0.24
25_N	114_K	0.582	0.24
203_Y	276_D	0.580	0.24
2_I	35_L	0.580	0.24
156_A	304_H	0.579	0.24
213_A	261_M	0.579	0.24
127_T	154_P	0.578	0.24
14_S	53_R	0.575	0.23
243_V	255_D	0.574	0.23
176_L	186_A	0.574	0.23
221_R	318_F	0.571	0.23
227_S	309_A	0.571	0.23
170_I	187_G	0.571	0.23
44_I	169_P	0.570	0.23
176_L	212_E	0.568	0.23
325_A	334_S	0.568	0.23
312_E	335_L	0.568	0.23
9_V	79_D	0.568	0.23
107_V	112_V	0.568	0.23
115_K	166_K	0.567	0.23
138_K	309_A	0.565	0.23
193_K	199_V	0.564	0.23
260_Y	275_I	0.563	0.23
206_D	321_P	0.560	0.23
237_T	267_Y	0.559	0.23
154_P	216_A	0.558	0.22
208_A	213_A	0.558	0.22
165_E	333_R	0.557	0.22
288_V	313_V	0.557	0.22
106_P	142_E	0.556	0.22
164_M	334_S	0.553	0.22
144_G	168_L	0.552	0.22
103_E	167_R	0.552	0.22
333_R	336_D	0.552	0.22
336_D	339_L	0.552	0.22
42_I	52_K	0.552	0.22
136_Y	159_F	0.552	0.22
24_R	110_V	0.552	0.22
147_F	171_L	0.551	0.22
253_L	280_K	0.551	0.22
269_I	272_P	0.551	0.22
198_K	271_V	0.550	0.22
50_I	101_E	0.549	0.22
179_I	238_N	0.548	0.22
42_I	167_R	0.548	0.22
234_S	242_V	0.547	0.22
143_A	168_L	0.545	0.22
40_N	103_E	0.545	0.22
140_S	144_G	0.545	0.22
287_A	292_I	0.544	0.22
255_D	285_F	0.544	0.22
9_V	188_I	0.544	0.22
296_R	308_G	0.542	0.22
3_R	134_N	0.541	0.22
87_T	94_I	0.540	0.22
185_H	245_G	0.537	0.21
25_N	52_K	0.536	0.21
190_E	291_L	0.536	0.21
54_K	163_F	0.535	0.21
125_L	153_S	0.532	0.21
35_L	75_D	0.532	0.21
112_V	261_M	0.532	0.21
268_G	318_F	0.532	0.21
176_L	257_R	0.531	0.21
71_D	330_D	0.531	0.21
81_I	103_E	0.531	0.21
168_L	304_H	0.529	0.21
190_E	275_I	0.529	0.21
287_A	318_F	0.529	0.21
22_L	269_I	0.529	0.21
291_L	313_V	0.527	0.21
20_I	184_T	0.527	0.21
266_L	272_P	0.526	0.21
21_E	335_L	0.526	0.21
18_Q	54_K	0.526	0.21
173_D	196_G	0.526	0.21
95_L	99_I	0.525	0.21
66_K	114_K	0.525	0.21
201_K	264_E	0.523	0.21
37_I	297_I	0.523	0.21
141_L	166_K	0.523	0.21
86_P	249_Y	0.523	0.21
100_E	104_E	0.522	0.21
24_R	165_E	0.522	0.21
260_Y	273_I	0.522	0.21
203_Y	244_A	0.521	0.21
114_K	302_G	0.521	0.21
79_D	305_G	0.521	0.21
212_E	228_L	0.520	0.21
16_L	20_I	0.519	0.21
28_E	291_L	0.518	0.21
47_A	55_V	0.518	0.21
24_R	147_F	0.516	0.20
4_I	266_L	0.515	0.20
60_R	77_K	0.515	0.20
16_L	44_I	0.512	0.20
305_G	308_G	0.512	0.20
102_S	135_F	0.512	0.20
206_D	210_S	0.510	0.20
168_L	288_V	0.510	0.20
9_V	305_G	0.509	0.20
214_L	259_S	0.509	0.20
36_P	39_P	0.508	0.20
107_V	113_L	0.507	0.20
46_A	268_G	0.506	0.20
4_I	184_T	0.506	0.20
237_T	318_F	0.506	0.20
46_A	116_E	0.504	0.20
110_V	135_F	0.504	0.20
223_D	226_K	0.503	0.20
64_F	211_T	0.502	0.20
103_E	107_V	0.501	0.20
16_L	41_D	0.501	0.20
44_I	67_P	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cinA	3	0.9855	100	0.164	Contact Map
1gr0A	3	0.9215	100	0.183	Contact Map
1p1jA	4	0.9913	100	0.196	Contact Map
1vkoA	4	0.9913	100	0.198	Contact Map
3qvsA	2	0.9767	100	0.209	Contact Map
3do5A	2	0.7791	98	0.93	Contact Map
1f06A	2	0.7471	98	0.93	Contact Map
3wb9A	5	0.7442	98	0.931	Contact Map
3ingA	2	0.7442	98	0.931	Contact Map
3bioA	4	0.75	97.9	0.931	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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