GREMLIN Database
THII - Probable tRNA sulfurtransferase
UniProt: Q980G6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (361)
Sequences: 1458 (988)
Seq/√Len: 52.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_V185_T5.6791.00
295_Y349_L5.0761.00
360_E364_E4.0021.00
236_D361_K3.8671.00
217_M321_G3.6191.00
212_L229_I3.0351.00
77_S150_T3.0011.00
104_A118_E2.8601.00
121_A143_I2.8591.00
77_S108_G2.7751.00
263_K360_E2.7711.00
101_A134_L2.7471.00
171_T274_T2.6691.00
117_V145_I2.6321.00
76_K82_D2.6021.00
62_E220_R2.5361.00
104_A117_V2.5041.00
361_K365_N2.4961.00
102_V125_L2.4841.00
317_A322_T2.3811.00
84_V124_A2.3681.00
217_M325_H2.3621.00
290_L306_I2.3271.00
83_I150_T2.2341.00
7_P70_S2.2261.00
39_I48_L2.1981.00
172_V270_A2.1861.00
174_L273_I2.1751.00
187_M316_I2.1661.00
82_D85_N2.1591.00
209_E213_K2.1441.00
91_F141_I2.1411.00
325_H328_K2.1091.00
262_E297_I2.1071.00
7_P68_S2.0771.00
289_N343_E2.0551.00
263_K266_E2.0531.00
103_R140_E2.0401.00
87_A121_A2.0301.00
171_T272_S2.0271.00
171_T193_S1.9811.00
208_K212_L1.9561.00
316_I319_K1.9481.00
315_D319_K1.9471.00
99_I131_G1.9471.00
272_S302_F1.9140.99
244_V252_M1.9140.99
288_A342_S1.9040.99
240_K243_Q1.8970.99
259_K352_E1.8960.99
79_N82_D1.8820.99
36_G59_A1.8670.99
112_F120_R1.8600.99
350_K353_E1.8580.99
186_W221_W1.8380.99
124_A128_Y1.8320.99
271_K288_A1.8070.99
213_K328_K1.7980.99
315_D318_R1.7950.99
255_R352_E1.7730.99
88_K128_Y1.7650.99
80_L117_V1.7410.99
351_N354_R1.7370.99
307_G312_E1.7260.99
74_A149_M1.7050.99
248_S351_N1.6970.99
267_K364_E1.6930.99
83_I121_A1.6620.98
104_A145_I1.6570.98
363_L366_S1.6430.98
61_S69_F1.6380.98
88_K124_A1.6360.98
25_T167_V1.6270.98
262_E298_K1.6210.98
245_E351_N1.6020.98
172_V198_L1.5870.98
170_K196_I1.5830.98
82_D86_K1.5460.97
45_V144_E1.5440.97
117_V121_A1.5340.97
75_I86_K1.5250.97
6_R66_I1.4860.97
262_E299_Y1.4740.97
198_L264_L1.4640.96
232_V366_S1.4590.96
260_T359_Y1.4550.96
60_L66_I1.4530.96
141_I152_F1.4260.96
103_R118_E1.3950.95
311_E315_D1.3940.95
256_V357_V1.3910.95
26_L29_N1.3880.95
179_I323_Y1.3840.95
198_L261_A1.3660.95
23_E44_G1.3660.95
145_I150_T1.3630.95
15_S18_S1.3620.95
256_V355_L1.3570.95
196_I230_F1.3530.95
172_V264_L1.3510.94
9_G67_S1.3500.94
345_L348_I1.3480.94
279_L306_I1.3450.94
6_R48_L1.3430.94
175_F215_L1.3410.94
197_I227_L1.3380.94
265_C299_Y1.3370.94
217_M220_R1.3330.94
37_G48_L1.3330.94
133_D136_N1.3260.94
292_V345_L1.3250.94
208_K367_E1.3250.94
251_V289_N1.3230.94
292_V348_I1.3210.94
248_S348_I1.3210.94
120_R123_E1.3190.94
38_K49_E1.3150.94
323_Y327_I1.3130.94
241_L252_M1.2950.93
188_M274_T1.2930.93
295_Y345_L1.2900.93
213_K216_N1.2850.93
202_L239_I1.2790.93
163_L168_A1.2490.92
71_P155_K1.2470.92
256_V259_K1.2320.91
94_I155_K1.2300.91
85_N89_E1.2270.91
4_I69_F1.2030.90
105_K144_E1.2020.90
86_K89_E1.2020.90
84_V120_R1.1880.90
185_T197_I1.1850.89
250_V253_L1.1800.89
61_S157_I1.1750.89
91_F125_L1.1640.89
185_T195_P1.1620.89
5_I72_V1.1560.88
81_E85_N1.1430.88
102_V121_A1.1400.88
24_Y28_N1.1310.87
18_S334_A1.1260.87
266_E299_Y1.1260.87
25_T28_N1.1230.87
174_L275_T1.1210.87
30_I63_V1.1210.87
272_S287_M1.1200.87
345_L349_L1.1150.86
308_F316_I1.1100.86
27_I41_R1.1030.86
259_K296_G1.0980.86
30_I39_I1.0980.86
359_Y362_I1.0970.85
233_K365_N1.0970.85
163_L191_R1.0970.85
361_K364_E1.0910.85
215_L227_L1.0890.85
261_A273_I1.0870.85
302_F306_I1.0730.84
119_R123_E1.0710.84
236_D239_I1.0670.84
208_K231_I1.0650.84
57_I69_F1.0630.84
102_V141_I1.0590.83
326_S329_L1.0530.83
172_V196_I1.0500.83
196_I228_K1.0490.83
113_T116_D1.0490.83
68_S156_V1.0460.83
212_L231_I1.0390.82
233_K236_D1.0360.82
267_K366_S1.0290.82
77_S110_H1.0240.81
311_E318_R1.0210.81
232_V362_I1.0140.81
158_K315_D1.0040.80
81_E84_V1.0040.80
24_Y41_R1.0040.80
79_N84_V0.9940.79
83_I145_I0.9930.79
174_L261_A0.9920.79
90_I152_F0.9910.79
87_A125_L0.9870.79
234_G253_L0.9820.78
23_E41_R0.9810.78
346_N349_L0.9800.78
258_Y277_E0.9770.78
98_K139_V0.9680.77
203_G207_H0.9580.77
196_I270_A0.9570.77
248_S340_R0.9560.77
207_H330_P0.9520.76
76_K79_N0.9480.76
316_I321_G0.9450.76
293_T302_F0.9400.75
262_E265_C0.9400.75
91_F139_V0.9370.75
258_Y297_I0.9320.75
84_V88_K0.9270.74
7_P45_V0.9270.74
60_L69_F0.9230.74
160_P186_W0.9190.74
210_L329_L0.9170.74
98_K138_E0.9110.73
101_A135_E0.9100.73
70_S153_Y0.9090.73
71_P157_I0.9040.72
344_D347_E0.9010.72
59_A63_V0.9000.72
188_M307_G0.8990.72
101_A137_P0.8980.72
256_V358_D0.8970.72
87_A102_V0.8970.72
64_F160_P0.8930.72
40_W49_E0.8860.71
253_L260_T0.8860.71
349_L353_E0.8840.71
264_L366_S0.8830.71
125_L141_I0.8820.71
340_R343_E0.8810.70
195_P227_L0.8770.70
263_K359_Y0.8730.70
193_S287_M0.8660.69
246_R337_T0.8660.69
173_V197_I0.8630.69
30_I46_I0.8560.68
294_E301_I0.8550.68
190_K312_E0.8540.68
228_K268_T0.8510.68
186_W316_I0.8500.68
264_L268_T0.8480.68
292_V343_E0.8460.67
74_A151_Y0.8460.67
97_G139_V0.8440.67
263_K267_K0.8420.67
256_V359_Y0.8370.67
235_T330_P0.8360.66
57_I157_I0.8340.66
41_R44_G0.8320.66
279_L302_F0.8310.66
204_G207_H0.8270.66
251_V293_T0.8270.66
287_M302_F0.8260.66
80_L112_F0.8240.65
210_L214_E0.8230.65
92_A128_Y0.8220.65
146_R277_E0.8220.65
15_S168_A0.8140.64
3_V72_V0.8140.64
291_Y295_Y0.8110.64
187_M307_G0.8110.64
275_T305_L0.8100.64
58_E220_R0.8070.64
238_F332_Y0.8060.64
12_A44_G0.8020.63
360_E363_L0.8010.63
213_K325_H0.7970.63
193_S279_L0.7950.63
84_V128_Y0.7950.63
170_K194_V0.7950.63
92_A96_K0.7920.62
199_N207_H0.7900.62
34_I48_L0.7860.62
10_E19_R0.7840.61
209_E212_L0.7820.61
308_F312_E0.7800.61
236_D362_I0.7790.61
212_L216_N0.7780.61
58_E61_S0.7770.61
172_V261_A0.7760.61
122_G138_E0.7740.60
249_R253_L0.7730.60
275_T306_I0.7720.60
211_V335_I0.7710.60
179_I327_I0.7680.60
265_C270_A0.7680.60
80_L120_R0.7670.60
8_S12_A0.7660.60
88_K92_A0.7660.60
253_L289_N0.7620.59
88_K125_L0.7600.59
196_I268_T0.7580.59
34_I56_N0.7530.58
5_I144_E0.7520.58
266_E298_K0.7500.58
199_N333_C0.7500.58
37_G56_N0.7490.58
252_M259_K0.7490.58
329_L332_Y0.7460.58
240_K358_D0.7450.58
7_P153_Y0.7450.58
18_S110_H0.7420.57
292_V295_Y0.7420.57
261_A363_L0.7420.57
87_A152_F0.7410.57
298_K301_I0.7410.57
18_S332_Y0.7410.57
29_N165_V0.7400.57
81_E124_A0.7400.57
25_T341_T0.7400.57
277_E303_R0.7390.57
39_I46_I0.7370.57
6_R46_I0.7320.56
125_L130_K0.7280.56
171_T287_M0.7280.56
294_E303_R0.7280.56
27_I31_R0.7240.55
8_S45_V0.7220.55
33_T223_G0.7220.55
198_L273_I0.7210.55
30_I60_L0.7170.55
188_M193_S0.7160.55
204_G330_P0.7150.54
240_K357_V0.7120.54
237_V362_I0.7080.54
12_A23_E0.7070.54
275_T290_L0.7060.53
47_L151_Y0.7060.53
11_I46_I0.7030.53
100_F132_V0.7010.53
10_E26_L0.6960.52
204_G339_A0.6920.52
108_G147_N0.6910.52
117_V279_L0.6910.52
262_E273_I0.6900.52
290_L302_F0.6880.52
189_M222_S0.6880.52
335_I339_A0.6850.51
91_F121_A0.6820.51
122_G132_V0.6820.51
90_I94_I0.6820.51
260_T363_L0.6790.51
254_K293_T0.6740.50
249_R335_I0.6720.50
362_I367_E0.6660.49
258_Y301_I0.6660.49
115_L119_R0.6640.49
214_E325_H0.6620.49
263_K358_D0.6610.49
153_Y156_V0.6590.49
18_S254_K0.6580.48
22_F210_L0.6570.48
108_G112_F0.6560.48
218_L222_S0.6530.48
199_N335_I0.6520.48
127_P314_V0.6520.48
204_G283_S0.6510.48
120_R124_A0.6500.48
250_V254_K0.6500.48
170_K268_T0.6490.48
289_N340_R0.6460.47
107_I146_R0.6430.47
171_T188_M0.6420.47
234_G252_M0.6420.47
83_I151_Y0.6420.47
255_R259_K0.6410.47
64_F221_W0.6410.47
201_N208_K0.6400.47
210_L332_Y0.6390.46
171_T195_P0.6370.46
166_G191_R0.6350.46
18_S238_F0.6340.46
64_F320_I0.6330.46
4_I60_L0.6330.46
46_I189_M0.6320.46
214_E334_A0.6310.46
210_L334_A0.6310.46
142_F156_V0.6290.45
10_E14_K0.6270.45
329_L334_A0.6270.45
116_D119_R0.6250.45
274_T287_M0.6240.45
4_I57_I0.6240.45
198_L232_V0.6230.45
254_K334_A0.6220.45
277_E296_G0.6200.45
55_A58_E0.6200.45
359_Y363_L0.6170.44
50_V56_N0.6160.44
76_K110_H0.6160.44
233_K362_I0.6160.44
230_F268_T0.6150.44
18_S210_L0.6150.44
99_I126_Y0.6130.44
9_G336_S0.6130.44
116_D217_M0.6120.44
199_N272_S0.6120.44
13_L270_A0.6120.44
76_K226_K0.6110.44
17_R289_N0.6110.44
202_L235_T0.6100.43
238_F334_A0.6100.43
103_R134_L0.6090.43
115_L118_E0.6090.43
290_L297_I0.6080.43
165_V168_A0.6070.43
296_G352_E0.6060.43
277_E294_E0.6060.43
205_D208_K0.5990.42
290_L300_P0.5990.42
44_G335_I0.5990.42
241_L244_V0.5990.42
17_R341_T0.5980.42
99_I137_P0.5980.42
302_F305_L0.5970.42
277_E293_T0.5960.42
106_R114_S0.5950.42
54_N58_E0.5940.42
114_S118_E0.5940.42
179_I183_V0.5930.42
44_G153_Y0.5930.42
255_R296_G0.5920.42
274_T307_G0.5920.42
168_A280_S0.5920.42
153_Y335_I0.5910.42
259_K359_Y0.5900.41
210_L327_I0.5900.41
95_V138_E0.5890.41
7_P146_R0.5890.41
55_A59_A0.5880.41
97_G138_E0.5870.41
189_M256_V0.5850.41
172_V185_T0.5830.41
121_A124_A0.5810.41
207_H211_V0.5810.41
251_V348_I0.5800.40
182_P326_S0.5800.40
194_V228_K0.5790.40
230_F264_L0.5780.40
254_K336_S0.5760.40
26_L191_R0.5760.40
202_L238_F0.5750.40
22_F109_S0.5740.40
79_N155_K0.5740.40
11_I275_T0.5720.40
250_V334_A0.5710.40
15_S334_A0.5710.40
27_I46_I0.5710.40
347_E351_N0.5660.39
120_R143_I0.5660.39
182_P322_T0.5640.39
123_E127_P0.5630.39
96_K125_L0.5630.39
184_A188_M0.5620.39
267_K363_L0.5610.39
63_V321_G0.5610.39
123_E126_Y0.5590.38
250_V293_T0.5590.38
60_L72_V0.5580.38
185_T218_L0.5560.38
235_T253_L0.5560.38
142_F153_Y0.5550.38
64_F146_R0.5540.38
186_W320_I0.5530.38
202_L207_H0.5520.38
59_A269_N0.5510.38
187_M190_K0.5510.38
238_F331_E0.5510.38
38_K141_I0.5510.38
62_E221_W0.5500.37
250_V258_Y0.5500.37
87_A151_Y0.5490.37
80_L83_I0.5490.37
84_V121_A0.5480.37
273_I299_Y0.5480.37
314_V330_P0.5470.37
5_I211_V0.5460.37
256_V356_N0.5460.37
193_S271_K0.5440.37
203_G332_Y0.5440.37
350_K354_R0.5440.37
221_W320_I0.5430.37
15_S341_T0.5420.37
214_E326_S0.5410.37
9_G12_A0.5410.37
190_K193_S0.5400.36
92_A364_E0.5400.36
189_M293_T0.5390.36
263_K363_L0.5390.36
66_I160_P0.5380.36
88_K363_L0.5380.36
244_V277_E0.5380.36
33_T63_V0.5360.36
67_S311_E0.5360.36
237_V359_Y0.5360.36
15_S332_Y0.5340.36
262_E266_E0.5330.36
241_L254_K0.5330.36
105_K118_E0.5330.36
8_S39_I0.5320.36
42_S47_L0.5320.36
129_S141_I0.5320.36
271_K287_M0.5320.36
258_Y275_T0.5310.36
168_A290_L0.5310.36
12_A19_R0.5290.35
324_K328_K0.5280.35
5_I151_Y0.5280.35
133_D137_P0.5270.35
97_G130_K0.5270.35
312_E315_D0.5260.35
75_I152_F0.5260.35
27_I44_G0.5250.35
72_V312_E0.5250.35
290_L303_R0.5240.35
107_I144_E0.5230.35
193_S274_T0.5230.35
117_V314_V0.5230.35
91_F102_V0.5230.35
79_N127_P0.5210.35
45_V68_S0.5200.35
42_S151_Y0.5200.35
136_N242_S0.5200.35
200_F254_K0.5190.34
172_V268_T0.5160.34
291_Y349_L0.5160.34
18_S168_A0.5160.34
170_K228_K0.5140.34
262_E341_T0.5140.34
103_R115_L0.5130.34
87_A141_I0.5110.34
109_S210_L0.5100.34
188_M306_I0.5100.34
170_K359_Y0.5100.34
83_I87_A0.5100.34
188_M302_F0.5080.33
20_R24_Y0.5080.33
206_L264_L0.5080.33
126_Y134_L0.5070.33
232_V359_Y0.5070.33
96_K364_E0.5060.33
148_E151_Y0.5050.33
10_E191_R0.5050.33
167_V337_T0.5050.33
207_H332_Y0.5050.33
55_A129_S0.5040.33
266_E295_Y0.5040.33
31_R188_M0.5030.33
208_K229_I0.5030.33
30_I311_E0.5010.33
75_I150_T0.5000.33
81_E273_I0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kr6A 2 0.9919 100 0.381 Contact Map
2c5sA 2 0.9515 100 0.384 Contact Map
1vbkA 2 0.7951 100 0.469 Contact Map
3uowA 2 0.8652 99.9 0.833 Contact Map
2dplA 2 0.5445 99.9 0.845 Contact Map
1gpmA 3 0.8086 99.9 0.846 Contact Map
3tqiA 3 0.8086 99.9 0.849 Contact Map
2ywbA 4 0.8194 99.9 0.849 Contact Map
2derA 1 0.4825 99.8 0.859 Contact Map
2hmaA 2 0.5094 99.8 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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