THII - SULSO - GREMLIN Contacts

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THII - Probable tRNA sulfurtransferase

UniProt:	Q980G6	Sequences: MLVIIRPSGEIALKSPRSRRNFEYTLINNIRNTIGGGKIWRSQGVILLEVNDNNANIEALSEVFGISSFSPVIAIKSNNLEDIVNKAKEIFAEIVKGKIFAVRAKRIGSHSFTSLDVERRAGEALYPYSKGVDLENPEVEIFIEIRNEMTYFYHKVIKGPKGLPVGVAGKTVVLFSGGIDSPVATWMMMKRGSVPIILNFNLGGDLHKELVLKELNMLKRWSGGHKLKIFIVKGTDVFIKLSQVERRSRVVMLKRVMYKTAEKLCEKTNAKSITTGESLSQVSSQTMANLYVTEYGIKYPIFRPLIGFDKEEIVDIARKIGTYKHSIKLPEYCAISTKARTSEDLNEILKNEERLNVDYEKILENSEVIEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (361)
Sequences:	1458 (988)
Seq/√Len:	52.0

ECOLI - THII
BACSU - THII
HALSA - THII
SULSO - THII

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
173_V	185_T	5.679	1.00
295_Y	349_L	5.076	1.00
360_E	364_E	4.002	1.00
236_D	361_K	3.867	1.00
217_M	321_G	3.619	1.00
212_L	229_I	3.035	1.00
77_S	150_T	3.001	1.00
104_A	118_E	2.860	1.00
121_A	143_I	2.859	1.00
77_S	108_G	2.775	1.00
263_K	360_E	2.771	1.00
101_A	134_L	2.747	1.00
171_T	274_T	2.669	1.00
117_V	145_I	2.632	1.00
76_K	82_D	2.602	1.00
62_E	220_R	2.536	1.00
104_A	117_V	2.504	1.00
361_K	365_N	2.496	1.00
102_V	125_L	2.484	1.00
317_A	322_T	2.381	1.00
84_V	124_A	2.368	1.00
217_M	325_H	2.362	1.00
290_L	306_I	2.327	1.00
83_I	150_T	2.234	1.00
7_P	70_S	2.226	1.00
39_I	48_L	2.198	1.00
172_V	270_A	2.186	1.00
174_L	273_I	2.175	1.00
187_M	316_I	2.166	1.00
82_D	85_N	2.159	1.00
209_E	213_K	2.144	1.00
91_F	141_I	2.141	1.00
325_H	328_K	2.109	1.00
262_E	297_I	2.107	1.00
7_P	68_S	2.077	1.00
289_N	343_E	2.055	1.00
263_K	266_E	2.053	1.00
103_R	140_E	2.040	1.00
87_A	121_A	2.030	1.00
171_T	272_S	2.027	1.00
171_T	193_S	1.981	1.00
208_K	212_L	1.956	1.00
316_I	319_K	1.948	1.00
315_D	319_K	1.947	1.00
99_I	131_G	1.947	1.00
272_S	302_F	1.914	0.99
244_V	252_M	1.914	0.99
288_A	342_S	1.904	0.99
240_K	243_Q	1.897	0.99
259_K	352_E	1.896	0.99
79_N	82_D	1.882	0.99
36_G	59_A	1.867	0.99
112_F	120_R	1.860	0.99
350_K	353_E	1.858	0.99
186_W	221_W	1.838	0.99
124_A	128_Y	1.832	0.99
271_K	288_A	1.807	0.99
213_K	328_K	1.798	0.99
315_D	318_R	1.795	0.99
255_R	352_E	1.773	0.99
88_K	128_Y	1.765	0.99
80_L	117_V	1.741	0.99
351_N	354_R	1.737	0.99
307_G	312_E	1.726	0.99
74_A	149_M	1.705	0.99
248_S	351_N	1.697	0.99
267_K	364_E	1.693	0.99
83_I	121_A	1.662	0.98
104_A	145_I	1.657	0.98
363_L	366_S	1.643	0.98
61_S	69_F	1.638	0.98
88_K	124_A	1.636	0.98
25_T	167_V	1.627	0.98
262_E	298_K	1.621	0.98
245_E	351_N	1.602	0.98
172_V	198_L	1.587	0.98
170_K	196_I	1.583	0.98
82_D	86_K	1.546	0.97
45_V	144_E	1.544	0.97
117_V	121_A	1.534	0.97
75_I	86_K	1.525	0.97
6_R	66_I	1.486	0.97
262_E	299_Y	1.474	0.97
198_L	264_L	1.464	0.96
232_V	366_S	1.459	0.96
260_T	359_Y	1.455	0.96
60_L	66_I	1.453	0.96
141_I	152_F	1.426	0.96
103_R	118_E	1.395	0.95
311_E	315_D	1.394	0.95
256_V	357_V	1.391	0.95
26_L	29_N	1.388	0.95
179_I	323_Y	1.384	0.95
198_L	261_A	1.366	0.95
23_E	44_G	1.366	0.95
145_I	150_T	1.363	0.95
15_S	18_S	1.362	0.95
256_V	355_L	1.357	0.95
196_I	230_F	1.353	0.95
172_V	264_L	1.351	0.94
9_G	67_S	1.350	0.94
345_L	348_I	1.348	0.94
279_L	306_I	1.345	0.94
6_R	48_L	1.343	0.94
175_F	215_L	1.341	0.94
197_I	227_L	1.338	0.94
265_C	299_Y	1.337	0.94
217_M	220_R	1.333	0.94
37_G	48_L	1.333	0.94
133_D	136_N	1.326	0.94
292_V	345_L	1.325	0.94
208_K	367_E	1.325	0.94
251_V	289_N	1.323	0.94
292_V	348_I	1.321	0.94
248_S	348_I	1.321	0.94
120_R	123_E	1.319	0.94
38_K	49_E	1.315	0.94
323_Y	327_I	1.313	0.94
241_L	252_M	1.295	0.93
188_M	274_T	1.293	0.93
295_Y	345_L	1.290	0.93
213_K	216_N	1.285	0.93
202_L	239_I	1.279	0.93
163_L	168_A	1.249	0.92
71_P	155_K	1.247	0.92
256_V	259_K	1.232	0.91
94_I	155_K	1.230	0.91
85_N	89_E	1.227	0.91
4_I	69_F	1.203	0.90
105_K	144_E	1.202	0.90
86_K	89_E	1.202	0.90
84_V	120_R	1.188	0.90
185_T	197_I	1.185	0.89
250_V	253_L	1.180	0.89
61_S	157_I	1.175	0.89
91_F	125_L	1.164	0.89
185_T	195_P	1.162	0.89
5_I	72_V	1.156	0.88
81_E	85_N	1.143	0.88
102_V	121_A	1.140	0.88
24_Y	28_N	1.131	0.87
18_S	334_A	1.126	0.87
266_E	299_Y	1.126	0.87
25_T	28_N	1.123	0.87
174_L	275_T	1.121	0.87
30_I	63_V	1.121	0.87
272_S	287_M	1.120	0.87
345_L	349_L	1.115	0.86
308_F	316_I	1.110	0.86
27_I	41_R	1.103	0.86
259_K	296_G	1.098	0.86
30_I	39_I	1.098	0.86
359_Y	362_I	1.097	0.85
233_K	365_N	1.097	0.85
163_L	191_R	1.097	0.85
361_K	364_E	1.091	0.85
215_L	227_L	1.089	0.85
261_A	273_I	1.087	0.85
302_F	306_I	1.073	0.84
119_R	123_E	1.071	0.84
236_D	239_I	1.067	0.84
208_K	231_I	1.065	0.84
57_I	69_F	1.063	0.84
102_V	141_I	1.059	0.83
326_S	329_L	1.053	0.83
172_V	196_I	1.050	0.83
196_I	228_K	1.049	0.83
113_T	116_D	1.049	0.83
68_S	156_V	1.046	0.83
212_L	231_I	1.039	0.82
233_K	236_D	1.036	0.82
267_K	366_S	1.029	0.82
77_S	110_H	1.024	0.81
311_E	318_R	1.021	0.81
232_V	362_I	1.014	0.81
158_K	315_D	1.004	0.80
81_E	84_V	1.004	0.80
24_Y	41_R	1.004	0.80
79_N	84_V	0.994	0.79
83_I	145_I	0.993	0.79
174_L	261_A	0.992	0.79
90_I	152_F	0.991	0.79
87_A	125_L	0.987	0.79
234_G	253_L	0.982	0.78
23_E	41_R	0.981	0.78
346_N	349_L	0.980	0.78
258_Y	277_E	0.977	0.78
98_K	139_V	0.968	0.77
203_G	207_H	0.958	0.77
196_I	270_A	0.957	0.77
248_S	340_R	0.956	0.77
207_H	330_P	0.952	0.76
76_K	79_N	0.948	0.76
316_I	321_G	0.945	0.76
293_T	302_F	0.940	0.75
262_E	265_C	0.940	0.75
91_F	139_V	0.937	0.75
258_Y	297_I	0.932	0.75
84_V	88_K	0.927	0.74
7_P	45_V	0.927	0.74
60_L	69_F	0.923	0.74
160_P	186_W	0.919	0.74
210_L	329_L	0.917	0.74
98_K	138_E	0.911	0.73
101_A	135_E	0.910	0.73
70_S	153_Y	0.909	0.73
71_P	157_I	0.904	0.72
344_D	347_E	0.901	0.72
59_A	63_V	0.900	0.72
188_M	307_G	0.899	0.72
101_A	137_P	0.898	0.72
256_V	358_D	0.897	0.72
87_A	102_V	0.897	0.72
64_F	160_P	0.893	0.72
40_W	49_E	0.886	0.71
253_L	260_T	0.886	0.71
349_L	353_E	0.884	0.71
264_L	366_S	0.883	0.71
125_L	141_I	0.882	0.71
340_R	343_E	0.881	0.70
195_P	227_L	0.877	0.70
263_K	359_Y	0.873	0.70
193_S	287_M	0.866	0.69
246_R	337_T	0.866	0.69
173_V	197_I	0.863	0.69
30_I	46_I	0.856	0.68
294_E	301_I	0.855	0.68
190_K	312_E	0.854	0.68
228_K	268_T	0.851	0.68
186_W	316_I	0.850	0.68
264_L	268_T	0.848	0.68
292_V	343_E	0.846	0.67
74_A	151_Y	0.846	0.67
97_G	139_V	0.844	0.67
263_K	267_K	0.842	0.67
256_V	359_Y	0.837	0.67
235_T	330_P	0.836	0.66
57_I	157_I	0.834	0.66
41_R	44_G	0.832	0.66
279_L	302_F	0.831	0.66
204_G	207_H	0.827	0.66
251_V	293_T	0.827	0.66
287_M	302_F	0.826	0.66
80_L	112_F	0.824	0.65
210_L	214_E	0.823	0.65
92_A	128_Y	0.822	0.65
146_R	277_E	0.822	0.65
15_S	168_A	0.814	0.64
3_V	72_V	0.814	0.64
291_Y	295_Y	0.811	0.64
187_M	307_G	0.811	0.64
275_T	305_L	0.810	0.64
58_E	220_R	0.807	0.64
238_F	332_Y	0.806	0.64
12_A	44_G	0.802	0.63
360_E	363_L	0.801	0.63
213_K	325_H	0.797	0.63
193_S	279_L	0.795	0.63
84_V	128_Y	0.795	0.63
170_K	194_V	0.795	0.63
92_A	96_K	0.792	0.62
199_N	207_H	0.790	0.62
34_I	48_L	0.786	0.62
10_E	19_R	0.784	0.61
209_E	212_L	0.782	0.61
308_F	312_E	0.780	0.61
236_D	362_I	0.779	0.61
212_L	216_N	0.778	0.61
58_E	61_S	0.777	0.61
172_V	261_A	0.776	0.61
122_G	138_E	0.774	0.60
249_R	253_L	0.773	0.60
275_T	306_I	0.772	0.60
211_V	335_I	0.771	0.60
179_I	327_I	0.768	0.60
265_C	270_A	0.768	0.60
80_L	120_R	0.767	0.60
8_S	12_A	0.766	0.60
88_K	92_A	0.766	0.60
253_L	289_N	0.762	0.59
88_K	125_L	0.760	0.59
196_I	268_T	0.758	0.59
34_I	56_N	0.753	0.58
5_I	144_E	0.752	0.58
266_E	298_K	0.750	0.58
199_N	333_C	0.750	0.58
37_G	56_N	0.749	0.58
252_M	259_K	0.749	0.58
329_L	332_Y	0.746	0.58
240_K	358_D	0.745	0.58
7_P	153_Y	0.745	0.58
18_S	110_H	0.742	0.57
292_V	295_Y	0.742	0.57
261_A	363_L	0.742	0.57
87_A	152_F	0.741	0.57
298_K	301_I	0.741	0.57
18_S	332_Y	0.741	0.57
29_N	165_V	0.740	0.57
81_E	124_A	0.740	0.57
25_T	341_T	0.740	0.57
277_E	303_R	0.739	0.57
39_I	46_I	0.737	0.57
6_R	46_I	0.732	0.56
125_L	130_K	0.728	0.56
171_T	287_M	0.728	0.56
294_E	303_R	0.728	0.56
27_I	31_R	0.724	0.55
8_S	45_V	0.722	0.55
33_T	223_G	0.722	0.55
198_L	273_I	0.721	0.55
30_I	60_L	0.717	0.55
188_M	193_S	0.716	0.55
204_G	330_P	0.715	0.54
240_K	357_V	0.712	0.54
237_V	362_I	0.708	0.54
12_A	23_E	0.707	0.54
275_T	290_L	0.706	0.53
47_L	151_Y	0.706	0.53
11_I	46_I	0.703	0.53
100_F	132_V	0.701	0.53
10_E	26_L	0.696	0.52
204_G	339_A	0.692	0.52
108_G	147_N	0.691	0.52
117_V	279_L	0.691	0.52
262_E	273_I	0.690	0.52
290_L	302_F	0.688	0.52
189_M	222_S	0.688	0.52
335_I	339_A	0.685	0.51
91_F	121_A	0.682	0.51
122_G	132_V	0.682	0.51
90_I	94_I	0.682	0.51
260_T	363_L	0.679	0.51
254_K	293_T	0.674	0.50
249_R	335_I	0.672	0.50
362_I	367_E	0.666	0.49
258_Y	301_I	0.666	0.49
115_L	119_R	0.664	0.49
214_E	325_H	0.662	0.49
263_K	358_D	0.661	0.49
153_Y	156_V	0.659	0.49
18_S	254_K	0.658	0.48
22_F	210_L	0.657	0.48
108_G	112_F	0.656	0.48
218_L	222_S	0.653	0.48
199_N	335_I	0.652	0.48
127_P	314_V	0.652	0.48
204_G	283_S	0.651	0.48
120_R	124_A	0.650	0.48
250_V	254_K	0.650	0.48
170_K	268_T	0.649	0.48
289_N	340_R	0.646	0.47
107_I	146_R	0.643	0.47
171_T	188_M	0.642	0.47
234_G	252_M	0.642	0.47
83_I	151_Y	0.642	0.47
255_R	259_K	0.641	0.47
64_F	221_W	0.641	0.47
201_N	208_K	0.640	0.47
210_L	332_Y	0.639	0.46
171_T	195_P	0.637	0.46
166_G	191_R	0.635	0.46
18_S	238_F	0.634	0.46
64_F	320_I	0.633	0.46
4_I	60_L	0.633	0.46
46_I	189_M	0.632	0.46
214_E	334_A	0.631	0.46
210_L	334_A	0.631	0.46
142_F	156_V	0.629	0.45
10_E	14_K	0.627	0.45
329_L	334_A	0.627	0.45
116_D	119_R	0.625	0.45
274_T	287_M	0.624	0.45
4_I	57_I	0.624	0.45
198_L	232_V	0.623	0.45
254_K	334_A	0.622	0.45
277_E	296_G	0.620	0.45
55_A	58_E	0.620	0.45
359_Y	363_L	0.617	0.44
50_V	56_N	0.616	0.44
76_K	110_H	0.616	0.44
233_K	362_I	0.616	0.44
230_F	268_T	0.615	0.44
18_S	210_L	0.615	0.44
99_I	126_Y	0.613	0.44
9_G	336_S	0.613	0.44
116_D	217_M	0.612	0.44
199_N	272_S	0.612	0.44
13_L	270_A	0.612	0.44
76_K	226_K	0.611	0.44
17_R	289_N	0.611	0.44
202_L	235_T	0.610	0.43
238_F	334_A	0.610	0.43
103_R	134_L	0.609	0.43
115_L	118_E	0.609	0.43
290_L	297_I	0.608	0.43
165_V	168_A	0.607	0.43
296_G	352_E	0.606	0.43
277_E	294_E	0.606	0.43
205_D	208_K	0.599	0.42
290_L	300_P	0.599	0.42
44_G	335_I	0.599	0.42
241_L	244_V	0.599	0.42
17_R	341_T	0.598	0.42
99_I	137_P	0.598	0.42
302_F	305_L	0.597	0.42
277_E	293_T	0.596	0.42
106_R	114_S	0.595	0.42
54_N	58_E	0.594	0.42
114_S	118_E	0.594	0.42
179_I	183_V	0.593	0.42
44_G	153_Y	0.593	0.42
255_R	296_G	0.592	0.42
274_T	307_G	0.592	0.42
168_A	280_S	0.592	0.42
153_Y	335_I	0.591	0.42
259_K	359_Y	0.590	0.41
210_L	327_I	0.590	0.41
95_V	138_E	0.589	0.41
7_P	146_R	0.589	0.41
55_A	59_A	0.588	0.41
97_G	138_E	0.587	0.41
189_M	256_V	0.585	0.41
172_V	185_T	0.583	0.41
121_A	124_A	0.581	0.41
207_H	211_V	0.581	0.41
251_V	348_I	0.580	0.40
182_P	326_S	0.580	0.40
194_V	228_K	0.579	0.40
230_F	264_L	0.578	0.40
254_K	336_S	0.576	0.40
26_L	191_R	0.576	0.40
202_L	238_F	0.575	0.40
22_F	109_S	0.574	0.40
79_N	155_K	0.574	0.40
11_I	275_T	0.572	0.40
250_V	334_A	0.571	0.40
15_S	334_A	0.571	0.40
27_I	46_I	0.571	0.40
347_E	351_N	0.566	0.39
120_R	143_I	0.566	0.39
182_P	322_T	0.564	0.39
123_E	127_P	0.563	0.39
96_K	125_L	0.563	0.39
184_A	188_M	0.562	0.39
267_K	363_L	0.561	0.39
63_V	321_G	0.561	0.39
123_E	126_Y	0.559	0.38
250_V	293_T	0.559	0.38
60_L	72_V	0.558	0.38
185_T	218_L	0.556	0.38
235_T	253_L	0.556	0.38
142_F	153_Y	0.555	0.38
64_F	146_R	0.554	0.38
186_W	320_I	0.553	0.38
202_L	207_H	0.552	0.38
59_A	269_N	0.551	0.38
187_M	190_K	0.551	0.38
238_F	331_E	0.551	0.38
38_K	141_I	0.551	0.38
62_E	221_W	0.550	0.37
250_V	258_Y	0.550	0.37
87_A	151_Y	0.549	0.37
80_L	83_I	0.549	0.37
84_V	121_A	0.548	0.37
273_I	299_Y	0.548	0.37
314_V	330_P	0.547	0.37
5_I	211_V	0.546	0.37
256_V	356_N	0.546	0.37
193_S	271_K	0.544	0.37
203_G	332_Y	0.544	0.37
350_K	354_R	0.544	0.37
221_W	320_I	0.543	0.37
15_S	341_T	0.542	0.37
214_E	326_S	0.541	0.37
9_G	12_A	0.541	0.37
190_K	193_S	0.540	0.36
92_A	364_E	0.540	0.36
189_M	293_T	0.539	0.36
263_K	363_L	0.539	0.36
66_I	160_P	0.538	0.36
88_K	363_L	0.538	0.36
244_V	277_E	0.538	0.36
33_T	63_V	0.536	0.36
67_S	311_E	0.536	0.36
237_V	359_Y	0.536	0.36
15_S	332_Y	0.534	0.36
262_E	266_E	0.533	0.36
241_L	254_K	0.533	0.36
105_K	118_E	0.533	0.36
8_S	39_I	0.532	0.36
42_S	47_L	0.532	0.36
129_S	141_I	0.532	0.36
271_K	287_M	0.532	0.36
258_Y	275_T	0.531	0.36
168_A	290_L	0.531	0.36
12_A	19_R	0.529	0.35
324_K	328_K	0.528	0.35
5_I	151_Y	0.528	0.35
133_D	137_P	0.527	0.35
97_G	130_K	0.527	0.35
312_E	315_D	0.526	0.35
75_I	152_F	0.526	0.35
27_I	44_G	0.525	0.35
72_V	312_E	0.525	0.35
290_L	303_R	0.524	0.35
107_I	144_E	0.523	0.35
193_S	274_T	0.523	0.35
117_V	314_V	0.523	0.35
91_F	102_V	0.523	0.35
79_N	127_P	0.521	0.35
45_V	68_S	0.520	0.35
42_S	151_Y	0.520	0.35
136_N	242_S	0.520	0.35
200_F	254_K	0.519	0.34
172_V	268_T	0.516	0.34
291_Y	349_L	0.516	0.34
18_S	168_A	0.516	0.34
170_K	228_K	0.514	0.34
262_E	341_T	0.514	0.34
103_R	115_L	0.513	0.34
87_A	141_I	0.511	0.34
109_S	210_L	0.510	0.34
188_M	306_I	0.510	0.34
170_K	359_Y	0.510	0.34
83_I	87_A	0.510	0.34
188_M	302_F	0.508	0.33
20_R	24_Y	0.508	0.33
206_L	264_L	0.508	0.33
126_Y	134_L	0.507	0.33
232_V	359_Y	0.507	0.33
96_K	364_E	0.506	0.33
148_E	151_Y	0.505	0.33
10_E	191_R	0.505	0.33
167_V	337_T	0.505	0.33
207_H	332_Y	0.505	0.33
55_A	129_S	0.504	0.33
266_E	295_Y	0.504	0.33
31_R	188_M	0.503	0.33
208_K	229_I	0.503	0.33
30_I	311_E	0.501	0.33
75_I	150_T	0.500	0.33
81_E	273_I	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kr6A	2	0.9919	100	0.381	Contact Map
2c5sA	2	0.9515	100	0.384	Contact Map
1vbkA	2	0.7951	100	0.469	Contact Map
3uowA	2	0.8652	99.9	0.833	Contact Map
2dplA	2	0.5445	99.9	0.845	Contact Map
1gpmA	3	0.8086	99.9	0.846	Contact Map
3tqiA	3	0.8086	99.9	0.849	Contact Map
2ywbA	4	0.8194	99.9	0.849	Contact Map
2derA	1	0.4825	99.8	0.859	Contact Map
2hmaA	2	0.5094	99.8	0.861	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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