GREMLIN Database
Q980G2 - Uncharacterized protein
UniProt: Q980G2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (189)
Sequences: 170 (154)
Seq/√Len: 11.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_D33_A5.5021.00
133_L147_L4.4441.00
58_I180_F3.7400.99
144_T148_R3.4420.98
74_Y80_L3.1460.96
78_L81_I2.8860.93
27_V37_L2.8580.93
81_I111_I2.8530.93
42_R47_R2.5550.88
81_I105_H2.5030.87
105_H111_I2.4490.86
78_L111_I2.4330.85
13_D16_Y2.3970.85
76_L189_L2.3180.82
134_D138_S2.3060.82
78_L105_H2.2580.81
19_N52_D2.2450.80
69_V172_Y2.0730.75
103_G137_L2.0560.74
69_V154_I2.0540.74
76_L187_T2.0480.74
41_E187_T2.0390.73
13_D35_Y1.9940.72
68_E128_K1.9710.71
74_Y165_I1.9480.70
16_Y91_L1.8420.65
20_R35_Y1.7970.63
20_R33_A1.7740.62
63_N86_N1.7690.62
133_L154_I1.7490.61
32_A69_V1.7180.60
142_E185_I1.6830.58
186_S191_T1.6750.58
33_A110_I1.5870.53
131_I171_V1.5690.52
30_I34_K1.5630.52
84_I117_L1.5590.52
13_D19_N1.5560.52
144_T156_T1.5430.51
74_Y100_L1.5110.50
16_Y172_Y1.4960.49
74_Y143_I1.4700.48
68_E130_E1.4490.47
59_K178_I1.3930.44
147_L154_I1.3780.43
40_L142_E1.3780.43
59_K173_S1.3770.43
85_N139_K1.3700.43
40_L185_I1.3650.43
33_A105_H1.3590.42
69_V173_S1.3270.41
125_Y186_S1.3060.40
90_Y101_G1.2870.39
157_V163_E1.2670.38
13_D20_R1.2630.38
128_K153_E1.2560.38
27_V160_A1.2530.37
119_S150_K1.2470.37
121_Y125_Y1.2410.37
134_D174_N1.2390.37
56_E124_K1.2350.37
83_A158_N1.2250.36
16_Y128_K1.2100.35
96_F185_I1.2080.35
65_E126_R1.2030.35
32_A41_E1.1920.35
15_K23_S1.1870.34
122_C129_C1.1850.34
24_R77_A1.1780.34
35_Y159_K1.1750.34
34_K42_R1.1720.34
27_V64_N1.1720.34
128_K144_T1.1400.32
36_N87_D1.1350.32
90_Y172_Y1.1280.32
41_E139_K1.1250.32
39_S182_S1.1160.31
40_L139_K1.0990.31
50_H92_C1.0780.30
41_E108_S1.0760.30
9_E194_F1.0630.29
67_R126_R1.0400.28
41_E104_R1.0320.28
124_K195_E1.0160.27
108_S139_K1.0080.27
53_K124_K1.0070.27
70_V181_K1.0070.27
41_E142_E1.0060.27
47_R79_T0.9980.27
73_G133_L0.9840.26
115_L131_I0.9830.26
104_R139_K0.9830.26
87_D101_G0.9670.26
44_L185_I0.9630.25
154_I163_E0.9620.25
55_I92_C0.9510.25
104_R142_E0.9500.25
156_T160_A0.9450.25
182_S185_I0.9440.25
188_I193_F0.9440.25
54_E144_T0.9350.24
40_L114_T0.9320.24
66_E122_C0.9310.24
91_L127_I0.9170.24
50_H127_I0.9090.23
32_A185_I0.9050.23
11_Y37_L0.9010.23
131_I152_I0.9000.23
74_Y140_S0.8990.23
16_Y76_L0.8860.23
53_K56_E0.8730.22
66_E195_E0.8660.22
43_L122_C0.8620.22
25_K28_L0.8610.22
103_G144_T0.8520.22
133_L177_V0.8490.21
40_L85_N0.8460.21
40_L136_Q0.8380.21
139_K142_E0.8230.21
9_E86_N0.8150.20
10_A17_F0.8120.20
11_Y15_K0.8110.20
53_K135_K0.8100.20
56_E60_G0.8100.20
153_E190_N0.8100.20
57_I69_V0.8080.20
85_N127_I0.7970.20
36_N82_S0.7930.20
13_D77_A0.7920.20
54_E97_L0.7870.19
116_I178_I0.7870.19
63_N66_E0.7850.19
59_K181_K0.7850.19
43_L152_I0.7850.19
56_E66_E0.7840.19
29_D76_L0.7820.19
125_Y191_T0.7820.19
56_E59_K0.7810.19
61_K140_S0.7770.19
74_Y176_F0.7760.19
15_K93_D0.7750.19
64_N167_S0.7750.19
63_N143_I0.7740.19
49_V150_K0.7710.19
7_F122_C0.7660.19
6_V107_S0.7640.19
79_T133_L0.7610.19
14_Y127_I0.7600.19
59_K193_F0.7500.18
12_L31_I0.7350.18
31_I112_S0.7320.18
19_N157_V0.7320.18
39_S160_A0.7280.18
58_I134_D0.7250.18
74_Y161_D0.7240.18
54_E134_D0.7220.18
135_K194_F0.7220.18
18_L45_L0.7210.18
112_S146_K0.7210.18
38_S131_I0.7180.17
44_L102_L0.7170.17
12_L63_N0.7100.17
26_V160_A0.7100.17
89_L168_N0.7050.17
47_R101_G0.7050.17
172_Y183_Q0.7030.17
154_I192_I0.7000.17
14_Y27_V0.7000.17
33_A57_I0.6960.17
102_L108_S0.6940.17
40_L44_L0.6930.17
106_K162_K0.6920.17
7_F84_I0.6890.17
148_R154_I0.6870.17
33_A50_H0.6860.17
7_F188_I0.6850.17
6_V16_Y0.6850.17
93_D142_E0.6840.17
42_R143_I0.6830.17
10_A103_G0.6780.16
38_S133_L0.6740.16
30_I87_D0.6720.16
80_L100_L0.6690.16
32_A89_L0.6670.16
31_I55_I0.6660.16
10_A35_Y0.6600.16
30_I165_I0.6570.16
42_R171_V0.6530.16
73_G154_I0.6510.16
58_I103_G0.6490.16
54_E118_I0.6420.15
97_L123_E0.6410.15
20_R57_I0.6380.15
34_K186_S0.6360.15
31_I54_E0.6320.15
11_Y82_S0.6310.15
75_N98_R0.6300.15
72_D75_N0.6300.15
99_D175_D0.6300.15
75_N99_D0.6300.15
72_D175_D0.6300.15
72_D99_D0.6300.15
72_D98_R0.6300.15
75_N175_D0.6300.15
98_R175_D0.6300.15
112_S135_K0.6290.15
30_I132_I0.6260.15
85_N101_G0.6260.15
16_Y55_I0.6240.15
118_I194_F0.6230.15
173_S178_I0.6220.15
159_K162_K0.6210.15
83_A101_G0.6210.15
63_N74_Y0.6200.15
62_I104_R0.6200.15
44_L104_R0.6190.15
12_L167_S0.6180.15
28_L46_Y0.6160.15
6_V120_E0.6140.15
25_K29_D0.6120.15
69_V115_L0.6090.15
11_Y165_I0.6010.14
179_L188_I0.5980.14
42_R79_T0.5950.14
26_V29_D0.5930.14
43_L115_L0.5910.14
80_L165_I0.5860.14
21_D173_S0.5850.14
53_K71_L0.5800.14
135_K195_E0.5800.14
41_E85_N0.5790.14
39_S69_V0.5760.14
20_R67_R0.5760.14
77_A152_I0.5750.14
84_I131_I0.5750.14
30_I162_K0.5750.14
49_V145_S0.5750.14
26_V32_A0.5740.14
119_S131_I0.5690.14
34_K87_D0.5680.14
37_L120_E0.5680.14
33_A111_I0.5640.14
124_K130_E0.5630.14
6_V25_K0.5620.14
92_C173_S0.5620.14
7_F18_L0.5620.14
58_I104_R0.5610.13
27_V69_V0.5590.13
32_A179_L0.5590.13
48_C172_Y0.5560.13
120_E194_F0.5540.13
118_I131_I0.5520.13
8_R106_K0.5470.13
58_I138_S0.5470.13
57_I61_K0.5460.13
136_Q150_K0.5440.13
132_I146_K0.5430.13
127_I174_N0.5420.13
12_L83_A0.5420.13
27_V66_E0.5410.13
120_E167_S0.5410.13
186_S192_I0.5410.13
97_L149_K0.5390.13
69_V183_Q0.5380.13
28_L37_L0.5340.13
34_K173_S0.5340.13
61_K194_F0.5320.13
172_Y187_T0.5310.13
14_Y30_I0.5290.13
136_Q174_N0.5280.13
65_E116_I0.5270.13
39_S71_L0.5210.13
48_C55_I0.5210.13
9_E12_L0.5140.12
42_R133_L0.5140.12
127_I180_F0.5130.12
81_I101_G0.5110.12
12_L71_L0.5090.12
85_N110_I0.5090.12
56_E125_Y0.5050.12
65_E123_E0.5020.12
40_L104_R0.5010.12
56_E195_E0.5010.12
65_E127_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fniA 1 0.385 39.3 0.957 Contact Map
3ha2A 2 0.385 37.1 0.958 Contact Map
4q0wA 1 0.6009 29.8 0.96 Contact Map
3hlyA 1 0.3662 23.7 0.962 Contact Map
4ptzC 4 0.385 23.7 0.962 Contact Map
3zhoA 4 0.3944 22.2 0.962 Contact Map
1exnA 1 0.5822 21.4 0.963 Contact Map
1ydgA 4 0.4178 20.8 0.963 Contact Map
2arkA 4 0.3944 19.8 0.963 Contact Map
4lafA 4 0.4085 18.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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