GREMLIN Database
Q980G1 - Signal recognition particle receptor FtsY
UniProt: Q980G1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (255)
Sequences: 6590 (3277)
Seq/√Len: 205.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_S129_L5.4011.00
148_A152_R3.6921.00
17_K234_Y3.1711.00
105_S145_A2.8731.00
76_F88_I2.8621.00
103_I154_I2.8061.00
95_L156_V2.7971.00
204_K208_N2.7411.00
173_N176_K2.6741.00
119_E131_K2.5661.00
101_S154_I2.5451.00
176_K209_N2.4081.00
46_K262_Q2.3771.00
142_A159_I2.2991.00
21_D48_S2.2981.00
48_S51_E2.2941.00
104_I122_S2.2161.00
119_E123_R2.2061.00
94_M98_N2.1761.00
147_R151_S2.1691.00
186_L241_G2.1531.00
116_E119_E2.1501.00
132_G144_D2.1321.00
246_G251_D2.0811.00
93_Y97_K2.0411.00
88_I158_L1.9951.00
205_Y208_N1.9881.00
125_L249_Y1.9761.00
188_I216_I1.9691.00
207_E238_K1.9191.00
204_K235_E1.9181.00
256_N259_W1.8901.00
87_T216_I1.8621.00
107_S142_A1.8461.00
96_K126_E1.8311.00
105_S157_V1.8041.00
169_T173_N1.7391.00
166_H198_D1.7381.00
94_M242_Y1.7251.00
128_P154_I1.6591.00
188_I214_L1.6241.00
179_V211_G1.6231.00
25_N48_S1.6151.00
76_F158_L1.6131.00
203_A236_L1.6131.00
89_A121_H1.5951.00
120_V123_R1.5761.00
186_L213_D1.5681.00
92_A104_I1.5581.00
173_N177_R1.5141.00
212_F238_K1.5041.00
217_L229_I1.4921.00
17_K21_D1.4851.00
96_K127_I1.4711.00
137_D177_R1.4701.00
104_I118_L1.4671.00
148_A151_S1.4641.00
92_A127_I1.4561.00
137_D140_S1.4521.00
94_M254_P1.4491.00
10_V230_L1.4471.00
119_E129_L1.4421.00
76_F91_F1.4391.00
253_I259_W1.4371.00
130_I148_A1.4291.00
67_K72_Y1.4131.00
25_N47_K1.3971.00
188_I241_G1.3731.00
140_S144_D1.3731.00
147_R150_K1.3621.00
207_E212_F1.3621.00
67_K70_K1.3431.00
100_L155_D1.3411.00
103_I128_P1.3411.00
50_T258_E1.3221.00
89_A125_L1.3201.00
93_Y250_D1.3161.00
148_A154_I1.3071.00
93_Y249_Y1.2711.00
21_D51_E1.2651.00
193_S217_L1.2611.00
142_A182_A1.2561.00
100_L156_V1.2461.00
88_I104_I1.2441.00
15_T19_L1.2431.00
201_E205_Y1.2411.00
74_I156_V1.2371.00
220_V243_L1.2321.00
201_E204_K1.2301.00
159_I182_A1.2281.00
121_H249_Y1.2241.00
149_A157_V1.2201.00
133_R136_G1.2141.00
33_R40_I1.2111.00
145_A157_V1.2091.00
139_A181_I1.1971.00
104_I158_L1.1891.00
132_G136_G1.1831.00
46_K50_T1.1781.00
73_I146_I1.1751.00
77_F187_K1.1641.00
93_Y96_K1.1621.00
179_V187_K1.1611.00
245_I253_I1.1611.00
128_P148_A1.1581.00
43_D47_K1.1561.00
130_I144_D1.1501.00
103_I148_A1.1481.00
50_T261_I1.1321.00
214_L241_G1.1271.00
87_T244_G1.1231.00
6_L15_T1.1211.00
49_I230_L1.1211.00
176_K180_N1.1131.00
143_F147_R1.1111.00
73_I159_I1.1011.00
242_Y254_P1.0991.00
109_T141_V1.0931.00
257_A261_I1.0881.00
16_E20_E1.0851.00
195_G199_A1.0781.00
146_I182_A1.0761.00
18_I22_L1.0661.00
20_E23_K1.0561.00
102_C154_I1.0531.00
20_E24_E1.0521.00
76_F216_I1.0511.00
72_Y185_N1.0491.00
177_R181_I1.0431.00
25_N51_E1.0371.00
68_S72_Y1.0361.00
103_I149_A1.0301.00
139_A177_R1.0221.00
132_G140_S1.0221.00
103_I157_V1.0201.00
115_Q131_K1.0191.00
75_I159_I1.0131.00
116_E134_Y1.0131.00
191_L217_L1.0071.00
215_V232_L1.0011.00
144_D147_R1.0001.00
87_T252_L0.9971.00
146_I157_V0.9911.00
21_D24_E0.9861.00
179_V183_K0.9791.00
166_H201_E0.9620.99
82_V88_I0.9540.99
25_N29_K0.9530.99
107_S159_I0.9510.99
73_I157_V0.9500.99
115_Q132_G0.9490.99
69_P72_Y0.9450.99
72_Y186_L0.9400.99
4_Q7_E0.9400.99
16_E19_L0.9360.99
96_K125_L0.9320.99
93_Y125_L0.9310.99
136_G140_S0.9310.99
244_G252_L0.9260.99
105_S142_A0.9230.99
229_I240_V0.9190.99
142_A178_V0.9130.99
51_E55_K0.8990.99
110_F141_V0.8940.99
74_I158_L0.8930.99
140_S143_F0.8880.99
196_G199_A0.8870.99
3_Y7_E0.8830.99
49_I261_I0.8800.99
89_A249_Y0.8770.99
17_K20_E0.8700.99
104_I129_L0.8660.99
106_A115_Q0.8580.99
24_E28_G0.8550.99
57_N60_N0.8460.99
157_V182_A0.8450.99
75_I178_V0.8410.99
105_S159_I0.8320.99
104_I125_L0.8260.98
135_G140_S0.8240.98
44_S48_S0.8220.98
82_V195_G0.8180.98
245_I252_L0.8170.98
121_H125_L0.8160.98
119_E122_S0.8100.98
234_Y237_N0.8070.98
123_R126_E0.8040.98
13_E235_E0.8020.98
95_L158_L0.7990.98
113_A166_H0.7960.98
48_S52_I0.7930.98
139_A178_V0.7930.98
198_D202_Q0.7880.98
102_C128_P0.7880.98
220_V260_F0.7870.98
164_R174_E0.7860.98
207_E211_G0.7860.98
76_F87_T0.7840.98
122_S125_L0.7730.98
25_N30_K0.7690.98
75_I179_V0.7680.98
146_I150_K0.7680.98
170_D173_N0.7590.97
12_F16_E0.7590.97
75_I187_K0.7580.97
106_A132_G0.7530.97
94_M97_K0.7470.97
10_V18_I0.7440.97
143_F181_I0.7430.97
189_L215_V0.7420.97
28_G31_V0.7410.97
73_I185_N0.7350.97
193_S220_V0.7340.97
93_Y252_L0.7260.97
233_A237_N0.7230.96
42_K46_K0.7210.96
166_H202_Q0.7210.96
14_V234_Y0.7200.96
107_S178_V0.7150.96
22_L48_S0.7150.96
57_N256_N0.7150.96
158_L252_L0.7130.96
115_Q134_Y0.7120.96
128_P152_R0.7110.96
173_N180_N0.7110.96
191_L232_L0.7100.96
26_I34_S0.7020.96
54_T257_A0.7020.96
40_I43_D0.6950.96
200_L231_S0.6900.95
187_K210_V0.6870.95
57_N254_P0.6860.95
205_Y209_N0.6860.95
207_E210_V0.6820.95
144_D148_A0.6790.95
101_S153_G0.6790.95
177_R180_N0.6760.95
198_D201_E0.6760.95
5_L15_T0.6750.95
101_S155_D0.6750.95
74_I242_Y0.6730.95
121_H124_N0.6720.95
187_K213_D0.6720.95
76_F188_I0.6700.95
176_K210_V0.6670.94
105_S130_I0.6620.94
71_P157_V0.6580.94
3_Y6_L0.6550.94
113_A162_A0.6540.94
25_N44_S0.6540.94
216_I242_Y0.6530.94
57_N61_V0.6510.94
102_C155_D0.6510.94
122_S128_P0.6500.94
97_K250_D0.6500.94
54_T57_N0.6500.94
150_K153_G0.6500.94
13_E16_E0.6470.94
199_A223_D0.6470.94
186_L214_L0.6460.94
200_L235_E0.6460.94
132_G141_V0.6450.93
228_V231_S0.6440.93
255_F260_F0.6430.93
101_S128_P0.6420.93
136_G144_D0.6400.93
56_N59_I0.6400.93
86_T244_G0.6400.93
146_I181_I0.6390.93
15_T18_I0.6380.93
71_P149_A0.6370.93
107_S141_V0.6350.93
82_V193_S0.6350.93
106_A131_K0.6340.93
187_K211_G0.6320.93
169_T209_N0.6310.93
178_V182_A0.6300.93
139_A180_N0.6250.92
50_T53_I0.6250.92
29_K40_I0.6240.92
77_F210_V0.6230.92
258_E262_Q0.6170.92
26_I44_S0.6170.92
200_L236_L0.6160.92
194_L223_D0.6160.92
211_G238_K0.6140.92
46_K113_A0.6130.92
47_K50_T0.6120.92
166_H205_Y0.6100.91
21_D234_Y0.6090.91
171_L175_L0.6080.91
103_I152_R0.6060.91
49_I265_F0.6040.91
104_I127_I0.6000.91
142_A181_I0.5980.91
79_I167_T0.5970.91
142_A146_I0.5950.90
132_G148_A0.5930.90
79_I82_V0.5920.90
70_K150_K0.5920.90
191_L199_A0.5920.90
19_L23_K0.5920.90
124_N251_D0.5910.90
179_V210_V0.5890.90
222_A247_Q0.5880.90
120_V124_N0.5870.90
116_E133_R0.5870.90
5_L10_V0.5840.90
54_T258_E0.5830.90
9_D224_V0.5830.90
109_T138_P0.5810.89
218_T222_A0.5810.89
11_S231_S0.5810.89
95_L98_N0.5800.89
12_F15_T0.5750.89
71_P155_D0.5710.89
47_K51_E0.5710.89
29_K44_S0.5680.88
196_G225_K0.5650.88
115_Q133_R0.5650.88
59_I98_N0.5630.88
32_K35_D0.5630.88
196_G223_D0.5610.88
18_I48_S0.5560.87
13_E17_K0.5550.87
13_E234_Y0.5530.87
92_A125_L0.5520.87
25_N28_G0.5510.87
176_K208_N0.5470.86
154_I157_V0.5460.86
70_K153_G0.5460.86
45_L53_I0.5460.86
125_L128_P0.5450.86
166_H172_V0.5420.86
112_A121_H0.5390.86
61_V67_K0.5390.86
199_A228_V0.5380.85
14_V18_I0.5380.85
122_S131_K0.5380.85
143_F150_K0.5380.85
225_K264_L0.5370.85
80_N247_Q0.5350.85
55_K58_A0.5340.85
110_F138_P0.5340.85
124_N249_Y0.5320.85
108_D117_Q0.5320.85
50_T257_A0.5290.84
35_D40_I0.5290.84
23_K27_I0.5280.84
20_E69_P0.5270.84
14_V17_K0.5260.84
220_V245_I0.5260.84
67_K71_P0.5260.84
200_L228_V0.5250.84
22_L25_N0.5230.84
55_K237_N0.5230.84
165_M222_A0.5200.83
167_T173_N0.5200.83
138_P178_V0.5190.83
187_K212_F0.5190.83
87_T245_I0.5180.83
115_Q119_E0.5180.83
50_T54_T0.5170.83
96_K101_S0.5140.83
124_N248_A0.5140.83
132_G151_S0.5140.83
215_V238_K0.5130.83
119_E133_R0.5120.83
233_A241_G0.5110.82
116_E123_R0.5110.82
82_V247_Q0.5110.82
243_L255_F0.5080.82
88_I107_S0.5070.82
142_A179_V0.5070.82
131_K134_Y0.5060.82
199_A203_A0.5050.82
142_A157_V0.5040.82
80_N110_F0.5040.82
55_K257_A0.5040.82
172_V198_D0.5020.81
2_R19_L0.5020.81
115_Q141_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2og2A 1 0.9662 100 0.365 Contact Map
1vmaA 1 0.9361 100 0.37 Contact Map
2yhsA 1 0.9699 100 0.378 Contact Map
4c7oA 1 0.985 100 0.383 Contact Map
2v3cC 1 0.9774 100 0.389 Contact Map
2px0A 4 0.9398 100 0.39 Contact Map
3b9qA 1 0.9624 100 0.4 Contact Map
2j37W 1 0.9774 100 0.402 Contact Map
2xxaA 1 0.985 100 0.407 Contact Map
1ls1A 1 0.9549 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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