GREMLIN Database
IF6 - Translation initiation factor 6
UniProt: Q980G0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (215)
Sequences: 394 (248)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_A133_V5.1501.00
110_N155_N3.8741.00
159_L183_G3.7181.00
154_T198_A3.6571.00
158_G180_I3.4200.99
22_N200_D3.4100.99
71_L83_L3.3660.99
67_N132_G3.1500.99
107_L151_G3.0530.99
25_T45_T2.9710.98
185_V195_G2.6150.97
75_T80_F2.4980.95
105_T116_Y2.4660.95
22_N66_D2.3750.94
114_L176_F2.3440.94
28_P58_L2.2460.92
158_G172_L2.1210.90
198_A221_L2.0770.89
72_P102_L2.0710.88
172_L176_F2.0420.88
64_G69_I2.0350.88
149_S191_F2.0340.87
153_I176_F1.9710.86
108_A133_V1.9130.84
153_I158_G1.9040.84
154_T200_D1.8960.83
26_I62_I1.8630.82
112_A176_F1.8230.81
20_T25_T1.8040.80
22_N201_K1.7600.78
155_N200_D1.7150.77
139_G168_E1.7090.76
6_L18_I1.7030.76
193_K218_Q1.6850.75
121_D138_R1.6350.73
114_L175_L1.6060.72
185_V217_I1.5640.70
93_E130_T1.5560.69
116_Y138_R1.5540.69
94_I130_T1.5440.68
14_I154_T1.5170.67
89_D197_V1.5050.66
37_E40_A1.4890.66
66_D110_N1.4880.66
117_P136_I1.4520.64
139_G152_V1.4410.63
36_K49_E1.4280.62
16_V142_A1.4240.62
181_D212_P1.4030.61
141_I160_V1.3930.60
63_S98_K1.3760.59
12_D192_I1.3700.59
33_S172_L1.3690.59
159_L220_A1.3550.58
57_L169_L1.3500.58
108_A113_A1.3470.58
161_H190_V1.3090.55
106_I115_I1.2890.54
18_I197_V1.2820.54
80_F84_K1.2790.54
127_I214_I1.2520.52
21_N64_G1.2510.52
106_I113_A1.2340.51
45_T199_N1.2300.51
5_R138_R1.2150.50
21_N46_E1.1910.48
115_I136_I1.1880.48
183_G217_I1.1820.48
159_L169_L1.1820.48
194_S198_A1.1750.47
205_V214_I1.1640.47
18_I27_I1.1620.47
27_I170_K1.1470.46
47_L95_L1.1350.45
172_L175_L1.1310.45
11_T17_Y1.1260.44
71_L80_F1.1260.44
78_D81_R1.1260.44
55_S92_V1.1220.44
12_D208_S1.1210.44
141_I164_T1.1200.44
95_L140_K1.1170.44
116_Y150_V1.1170.44
14_I76_I1.1170.44
22_N154_T1.1140.44
132_G143_Q1.1110.44
160_V180_I1.1060.43
160_V172_L1.0990.43
57_L115_I1.0950.43
141_I174_K1.0940.43
139_G220_A1.0930.43
75_T81_R1.0830.42
45_T154_T1.0780.42
33_S49_E1.0680.41
18_I39_I1.0610.41
55_S219_K1.0530.40
57_L149_S1.0480.40
99_V116_Y1.0420.40
127_I196_L1.0410.40
192_I196_L1.0330.39
75_T174_K1.0130.38
158_G178_V1.0090.38
115_I124_E1.0050.38
71_L84_K1.0030.37
170_K179_K1.0020.37
61_F117_P1.0010.37
12_D207_A0.9870.37
159_L221_L0.9780.36
21_N62_I0.9750.36
66_D219_K0.9680.35
98_K165_S0.9670.35
206_G213_E0.9640.35
183_G218_Q0.9640.35
166_E170_K0.9580.35
114_L204_L0.9460.34
182_I221_L0.9430.34
95_L197_V0.9410.34
194_S210_T0.9400.34
142_A161_H0.9370.34
70_L217_I0.9340.34
146_T150_V0.9300.33
89_D204_L0.9260.33
214_I220_A0.9250.33
7_S207_A0.9230.33
57_L61_F0.9180.33
16_V133_V0.9160.33
61_F214_I0.9120.32
124_E138_R0.9090.32
119_F170_K0.9040.32
13_N195_G0.9040.32
169_L181_D0.8990.32
13_N221_L0.8940.32
114_L139_G0.8910.31
53_S100_T0.8790.31
25_T212_P0.8760.31
182_I220_A0.8760.31
46_E69_I0.8700.30
68_G133_V0.8600.30
113_A117_P0.8600.30
127_I172_L0.8590.30
10_G30_G0.8580.30
96_N106_I0.8510.29
7_S39_I0.8500.29
11_T14_I0.8500.29
152_V198_A0.8490.29
152_V196_L0.8480.29
112_A178_V0.8450.29
13_N28_P0.8450.29
16_V161_H0.8450.29
41_Q93_E0.8360.29
113_A116_Y0.8320.28
153_I180_I0.8300.28
40_A47_L0.8250.28
43_L154_T0.8240.28
153_I172_L0.8150.28
24_Y69_I0.8120.27
39_I205_V0.8100.27
161_H212_P0.8100.27
146_T187_F0.8050.27
22_N125_K0.8000.27
142_A163_D0.7990.27
146_T203_T0.7960.27
134_E177_G0.7940.27
28_P83_L0.7930.27
141_I175_L0.7830.26
128_K179_K0.7830.26
14_I195_G0.7770.26
190_V194_S0.7710.26
190_V204_L0.7650.25
49_E71_L0.7580.25
19_Y193_K0.7510.25
144_M150_V0.7510.25
58_L83_L0.7490.25
24_Y75_T0.7490.25
52_I67_N0.7370.24
69_I120_N0.7360.24
126_I130_T0.7350.24
91_R125_K0.7340.24
184_T188_G0.7340.24
125_K185_V0.7300.24
77_D204_L0.7280.24
20_T176_F0.7260.24
126_I177_G0.7240.23
71_L105_T0.7220.23
97_S147_V0.7190.23
83_L92_V0.7170.23
72_P162_V0.7170.23
70_L93_E0.7150.23
91_R134_E0.7140.23
125_K128_K0.7120.23
110_N157_G0.7070.23
75_T94_I0.7060.23
173_E182_I0.7030.23
152_V192_I0.7030.23
28_P114_L0.6920.22
14_I199_N0.6910.22
154_T191_F0.6900.22
206_G209_T0.6890.22
53_S90_C0.6880.22
122_I129_E0.6880.22
122_I136_I0.6860.22
9_F155_N0.6850.22
37_E81_R0.6840.22
107_L194_S0.6840.22
52_I128_K0.6820.22
41_Q53_S0.6810.22
18_I58_L0.6810.22
5_R16_V0.6800.22
192_I220_A0.6770.22
194_S215_L0.6770.22
24_Y52_I0.6750.21
113_A127_I0.6750.21
96_N120_N0.6730.21
53_S72_P0.6730.21
7_S196_L0.6720.21
67_N149_S0.6710.21
50_A209_T0.6640.21
7_S26_I0.6610.21
41_Q45_T0.6610.21
30_G42_V0.6590.21
65_N68_G0.6570.21
114_L172_L0.6560.21
39_I197_V0.6550.21
32_D83_L0.6540.21
117_P168_E0.6520.21
7_S203_T0.6520.21
69_I89_D0.6480.20
195_G206_G0.6440.20
39_I94_I0.6430.20
51_E144_M0.6430.20
70_L195_G0.6410.20
57_L211_G0.6410.20
61_F218_Q0.6400.20
33_S47_L0.6400.20
167_K174_K0.6400.20
212_P216_R0.6360.20
100_T158_G0.6300.20
96_N123_E0.6290.20
134_E137_K0.6270.20
70_L102_L0.6260.20
127_I136_I0.6260.20
43_L108_A0.6250.20
61_F162_V0.6250.20
97_S193_K0.6230.19
105_T212_P0.6200.19
124_E132_G0.6140.19
13_N185_V0.6090.19
181_D211_G0.6070.19
10_G79_E0.6060.19
48_L120_N0.6020.19
37_E129_E0.6000.19
146_T202_G0.5990.19
29_R51_E0.5990.19
17_Y21_N0.5970.18
52_I167_K0.5950.18
25_T193_K0.5940.18
194_S214_I0.5910.18
183_G220_A0.5890.18
28_P57_L0.5880.18
80_F134_E0.5880.18
7_S14_I0.5860.18
57_L163_D0.5830.18
118_E151_G0.5810.18
25_T39_I0.5810.18
136_I204_L0.5790.18
121_D185_V0.5780.18
62_I83_L0.5780.18
62_I130_T0.5760.18
19_Y116_Y0.5760.18
66_D200_D0.5730.18
63_S73_K0.5730.18
111_K182_I0.5670.17
48_L177_G0.5660.17
186_N199_N0.5650.17
80_F94_I0.5640.17
26_I119_F0.5630.17
59_G188_G0.5590.17
166_E172_L0.5580.17
128_K132_G0.5530.17
28_P194_S0.5520.17
6_L27_I0.5420.17
5_R54_R0.5420.17
5_R11_T0.5390.16
22_N27_I0.5380.16
12_D145_I0.5380.16
105_T202_G0.5380.16
181_D215_L0.5370.16
54_R214_I0.5360.16
57_L166_E0.5350.16
18_I26_I0.5330.16
26_I93_E0.5330.16
124_E177_G0.5320.16
39_I52_I0.5310.16
5_R8_V0.5270.16
35_T182_I0.5270.16
12_D211_G0.5220.16
9_F56_F0.5220.16
14_I159_L0.5220.16
117_P128_K0.5210.16
23_K205_V0.5210.16
207_A221_L0.5210.16
8_V13_N0.5200.16
65_N188_G0.5190.16
14_I209_T0.5190.16
47_L93_E0.5180.16
65_N109_N0.5170.16
22_N120_N0.5170.16
119_F169_L0.5120.16
119_F185_V0.5110.16
78_D86_N0.5100.16
31_L168_E0.5090.16
203_T214_I0.5080.15
69_I141_I0.5070.15
8_V81_R0.5060.15
142_A192_I0.5050.15
31_L36_K0.5020.15
50_A197_V0.5010.15
105_T211_G0.5010.15
30_G158_G0.5010.15
47_L79_E0.5000.15
41_Q106_I0.5000.15
40_A160_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a18J 2 0.991 100 0.15 Contact Map
1g62A 1 0.991 100 0.155 Contact Map
1g61A 1 0.9865 100 0.186 Contact Map
4adxI 1 0.9821 100 0.191 Contact Map
2yfqA 5 0.5022 16.4 0.965 Contact Map
1v9lA 4 0.5157 16.2 0.965 Contact Map
2czdA 2 0.5919 11.3 0.968 Contact Map
1gtmA 5 0.5157 8.8 0.969 Contact Map
4xgiA 6 0.5605 8.7 0.969 Contact Map
2tmgA 5 0.5112 7.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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