IF6 - SULSO - GREMLIN Contacts

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IF6 - Translation initiation factor 6

UniProt:	Q980G0	Sequences: MNLQRLSVFGTDNIGVYIYTNNKYTIIPRGLDSETKENIAQVLGTELLEAEISRSFLLGIFISGNDNGILLPKSTIDDEFRFLKENLRDCRVEILNSKVTALGNTILANNKAALIYPEFNDIEEKIIKETLGVEDIKRGKIAQMITVGSVGVITNKGGLVHVDTSEKELKELEKLFGVKIDIGTVNFGSVFIKSGLVANDKGTLVGASTTGPEILRIQKALGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	223 (215)
Sequences:	394 (248)
Seq/√Len:	16.9

SULSO - IF6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_A	133_V	5.150	1.00
110_N	155_N	3.874	1.00
159_L	183_G	3.718	1.00
154_T	198_A	3.657	1.00
158_G	180_I	3.420	0.99
22_N	200_D	3.410	0.99
71_L	83_L	3.366	0.99
67_N	132_G	3.150	0.99
107_L	151_G	3.053	0.99
25_T	45_T	2.971	0.98
185_V	195_G	2.615	0.97
75_T	80_F	2.498	0.95
105_T	116_Y	2.466	0.95
22_N	66_D	2.375	0.94
114_L	176_F	2.344	0.94
28_P	58_L	2.246	0.92
158_G	172_L	2.121	0.90
198_A	221_L	2.077	0.89
72_P	102_L	2.071	0.88
172_L	176_F	2.042	0.88
64_G	69_I	2.035	0.88
149_S	191_F	2.034	0.87
153_I	176_F	1.971	0.86
108_A	133_V	1.913	0.84
153_I	158_G	1.904	0.84
154_T	200_D	1.896	0.83
26_I	62_I	1.863	0.82
112_A	176_F	1.823	0.81
20_T	25_T	1.804	0.80
22_N	201_K	1.760	0.78
155_N	200_D	1.715	0.77
139_G	168_E	1.709	0.76
6_L	18_I	1.703	0.76
193_K	218_Q	1.685	0.75
121_D	138_R	1.635	0.73
114_L	175_L	1.606	0.72
185_V	217_I	1.564	0.70
93_E	130_T	1.556	0.69
116_Y	138_R	1.554	0.69
94_I	130_T	1.544	0.68
14_I	154_T	1.517	0.67
89_D	197_V	1.505	0.66
37_E	40_A	1.489	0.66
66_D	110_N	1.488	0.66
117_P	136_I	1.452	0.64
139_G	152_V	1.441	0.63
36_K	49_E	1.428	0.62
16_V	142_A	1.424	0.62
181_D	212_P	1.403	0.61
141_I	160_V	1.393	0.60
63_S	98_K	1.376	0.59
12_D	192_I	1.370	0.59
33_S	172_L	1.369	0.59
159_L	220_A	1.355	0.58
57_L	169_L	1.350	0.58
108_A	113_A	1.347	0.58
161_H	190_V	1.309	0.55
106_I	115_I	1.289	0.54
18_I	197_V	1.282	0.54
80_F	84_K	1.279	0.54
127_I	214_I	1.252	0.52
21_N	64_G	1.251	0.52
106_I	113_A	1.234	0.51
45_T	199_N	1.230	0.51
5_R	138_R	1.215	0.50
21_N	46_E	1.191	0.48
115_I	136_I	1.188	0.48
183_G	217_I	1.182	0.48
159_L	169_L	1.182	0.48
194_S	198_A	1.175	0.47
205_V	214_I	1.164	0.47
18_I	27_I	1.162	0.47
27_I	170_K	1.147	0.46
47_L	95_L	1.135	0.45
172_L	175_L	1.131	0.45
11_T	17_Y	1.126	0.44
71_L	80_F	1.126	0.44
78_D	81_R	1.126	0.44
55_S	92_V	1.122	0.44
12_D	208_S	1.121	0.44
141_I	164_T	1.120	0.44
95_L	140_K	1.117	0.44
116_Y	150_V	1.117	0.44
14_I	76_I	1.117	0.44
22_N	154_T	1.114	0.44
132_G	143_Q	1.111	0.44
160_V	180_I	1.106	0.43
160_V	172_L	1.099	0.43
57_L	115_I	1.095	0.43
141_I	174_K	1.094	0.43
139_G	220_A	1.093	0.43
75_T	81_R	1.083	0.42
45_T	154_T	1.078	0.42
33_S	49_E	1.068	0.41
18_I	39_I	1.061	0.41
55_S	219_K	1.053	0.40
57_L	149_S	1.048	0.40
99_V	116_Y	1.042	0.40
127_I	196_L	1.041	0.40
192_I	196_L	1.033	0.39
75_T	174_K	1.013	0.38
158_G	178_V	1.009	0.38
115_I	124_E	1.005	0.38
71_L	84_K	1.003	0.37
170_K	179_K	1.002	0.37
61_F	117_P	1.001	0.37
12_D	207_A	0.987	0.37
159_L	221_L	0.978	0.36
21_N	62_I	0.975	0.36
66_D	219_K	0.968	0.35
98_K	165_S	0.967	0.35
206_G	213_E	0.964	0.35
183_G	218_Q	0.964	0.35
166_E	170_K	0.958	0.35
114_L	204_L	0.946	0.34
182_I	221_L	0.943	0.34
95_L	197_V	0.941	0.34
194_S	210_T	0.940	0.34
142_A	161_H	0.937	0.34
70_L	217_I	0.934	0.34
146_T	150_V	0.930	0.33
89_D	204_L	0.926	0.33
214_I	220_A	0.925	0.33
7_S	207_A	0.923	0.33
57_L	61_F	0.918	0.33
16_V	133_V	0.916	0.33
61_F	214_I	0.912	0.32
124_E	138_R	0.909	0.32
119_F	170_K	0.904	0.32
13_N	195_G	0.904	0.32
169_L	181_D	0.899	0.32
13_N	221_L	0.894	0.32
114_L	139_G	0.891	0.31
53_S	100_T	0.879	0.31
25_T	212_P	0.876	0.31
182_I	220_A	0.876	0.31
46_E	69_I	0.870	0.30
68_G	133_V	0.860	0.30
113_A	117_P	0.860	0.30
127_I	172_L	0.859	0.30
10_G	30_G	0.858	0.30
96_N	106_I	0.851	0.29
7_S	39_I	0.850	0.29
11_T	14_I	0.850	0.29
152_V	198_A	0.849	0.29
152_V	196_L	0.848	0.29
112_A	178_V	0.845	0.29
13_N	28_P	0.845	0.29
16_V	161_H	0.845	0.29
41_Q	93_E	0.836	0.29
113_A	116_Y	0.832	0.28
153_I	180_I	0.830	0.28
40_A	47_L	0.825	0.28
43_L	154_T	0.824	0.28
153_I	172_L	0.815	0.28
24_Y	69_I	0.812	0.27
39_I	205_V	0.810	0.27
161_H	212_P	0.810	0.27
146_T	187_F	0.805	0.27
22_N	125_K	0.800	0.27
142_A	163_D	0.799	0.27
146_T	203_T	0.796	0.27
134_E	177_G	0.794	0.27
28_P	83_L	0.793	0.27
141_I	175_L	0.783	0.26
128_K	179_K	0.783	0.26
14_I	195_G	0.777	0.26
190_V	194_S	0.771	0.26
190_V	204_L	0.765	0.25
49_E	71_L	0.758	0.25
19_Y	193_K	0.751	0.25
144_M	150_V	0.751	0.25
58_L	83_L	0.749	0.25
24_Y	75_T	0.749	0.25
52_I	67_N	0.737	0.24
69_I	120_N	0.736	0.24
126_I	130_T	0.735	0.24
91_R	125_K	0.734	0.24
184_T	188_G	0.734	0.24
125_K	185_V	0.730	0.24
77_D	204_L	0.728	0.24
20_T	176_F	0.726	0.24
126_I	177_G	0.724	0.23
71_L	105_T	0.722	0.23
97_S	147_V	0.719	0.23
83_L	92_V	0.717	0.23
72_P	162_V	0.717	0.23
70_L	93_E	0.715	0.23
91_R	134_E	0.714	0.23
125_K	128_K	0.712	0.23
110_N	157_G	0.707	0.23
75_T	94_I	0.706	0.23
173_E	182_I	0.703	0.23
152_V	192_I	0.703	0.23
28_P	114_L	0.692	0.22
14_I	199_N	0.691	0.22
154_T	191_F	0.690	0.22
206_G	209_T	0.689	0.22
53_S	90_C	0.688	0.22
122_I	129_E	0.688	0.22
122_I	136_I	0.686	0.22
9_F	155_N	0.685	0.22
37_E	81_R	0.684	0.22
107_L	194_S	0.684	0.22
52_I	128_K	0.682	0.22
41_Q	53_S	0.681	0.22
18_I	58_L	0.681	0.22
5_R	16_V	0.680	0.22
192_I	220_A	0.677	0.22
194_S	215_L	0.677	0.22
24_Y	52_I	0.675	0.21
113_A	127_I	0.675	0.21
96_N	120_N	0.673	0.21
53_S	72_P	0.673	0.21
7_S	196_L	0.672	0.21
67_N	149_S	0.671	0.21
50_A	209_T	0.664	0.21
7_S	26_I	0.661	0.21
41_Q	45_T	0.661	0.21
30_G	42_V	0.659	0.21
65_N	68_G	0.657	0.21
114_L	172_L	0.656	0.21
39_I	197_V	0.655	0.21
32_D	83_L	0.654	0.21
117_P	168_E	0.652	0.21
7_S	203_T	0.652	0.21
69_I	89_D	0.648	0.20
195_G	206_G	0.644	0.20
39_I	94_I	0.643	0.20
51_E	144_M	0.643	0.20
70_L	195_G	0.641	0.20
57_L	211_G	0.641	0.20
61_F	218_Q	0.640	0.20
33_S	47_L	0.640	0.20
167_K	174_K	0.640	0.20
212_P	216_R	0.636	0.20
100_T	158_G	0.630	0.20
96_N	123_E	0.629	0.20
134_E	137_K	0.627	0.20
70_L	102_L	0.626	0.20
127_I	136_I	0.626	0.20
43_L	108_A	0.625	0.20
61_F	162_V	0.625	0.20
97_S	193_K	0.623	0.19
105_T	212_P	0.620	0.19
124_E	132_G	0.614	0.19
13_N	185_V	0.609	0.19
181_D	211_G	0.607	0.19
10_G	79_E	0.606	0.19
48_L	120_N	0.602	0.19
37_E	129_E	0.600	0.19
146_T	202_G	0.599	0.19
29_R	51_E	0.599	0.19
17_Y	21_N	0.597	0.18
52_I	167_K	0.595	0.18
25_T	193_K	0.594	0.18
194_S	214_I	0.591	0.18
183_G	220_A	0.589	0.18
28_P	57_L	0.588	0.18
80_F	134_E	0.588	0.18
7_S	14_I	0.586	0.18
57_L	163_D	0.583	0.18
118_E	151_G	0.581	0.18
25_T	39_I	0.581	0.18
136_I	204_L	0.579	0.18
121_D	185_V	0.578	0.18
62_I	83_L	0.578	0.18
62_I	130_T	0.576	0.18
19_Y	116_Y	0.576	0.18
66_D	200_D	0.573	0.18
63_S	73_K	0.573	0.18
111_K	182_I	0.567	0.17
48_L	177_G	0.566	0.17
186_N	199_N	0.565	0.17
80_F	94_I	0.564	0.17
26_I	119_F	0.563	0.17
59_G	188_G	0.559	0.17
166_E	172_L	0.558	0.17
128_K	132_G	0.553	0.17
28_P	194_S	0.552	0.17
6_L	27_I	0.542	0.17
5_R	54_R	0.542	0.17
5_R	11_T	0.539	0.16
22_N	27_I	0.538	0.16
12_D	145_I	0.538	0.16
105_T	202_G	0.538	0.16
181_D	215_L	0.537	0.16
54_R	214_I	0.536	0.16
57_L	166_E	0.535	0.16
18_I	26_I	0.533	0.16
26_I	93_E	0.533	0.16
124_E	177_G	0.532	0.16
39_I	52_I	0.531	0.16
5_R	8_V	0.527	0.16
35_T	182_I	0.527	0.16
12_D	211_G	0.522	0.16
9_F	56_F	0.522	0.16
14_I	159_L	0.522	0.16
117_P	128_K	0.521	0.16
23_K	205_V	0.521	0.16
207_A	221_L	0.521	0.16
8_V	13_N	0.520	0.16
65_N	188_G	0.519	0.16
14_I	209_T	0.519	0.16
47_L	93_E	0.518	0.16
65_N	109_N	0.517	0.16
22_N	120_N	0.517	0.16
119_F	169_L	0.512	0.16
119_F	185_V	0.511	0.16
78_D	86_N	0.510	0.16
31_L	168_E	0.509	0.16
203_T	214_I	0.508	0.15
69_I	141_I	0.507	0.15
8_V	81_R	0.506	0.15
142_A	192_I	0.505	0.15
31_L	36_K	0.502	0.15
50_A	197_V	0.501	0.15
105_T	211_G	0.501	0.15
30_G	158_G	0.501	0.15
47_L	79_E	0.500	0.15
41_Q	106_I	0.500	0.15
40_A	160_V	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4a18J	2	0.991	100	0.15	Contact Map
1g62A	1	0.991	100	0.155	Contact Map
1g61A	1	0.9865	100	0.186	Contact Map
4adxI	1	0.9821	100	0.191	Contact Map
2yfqA	5	0.5022	16.4	0.965	Contact Map
1v9lA	4	0.5157	16.2	0.965	Contact Map
2czdA	2	0.5919	11.3	0.968	Contact Map
1gtmA	5	0.5157	8.8	0.969	Contact Map
4xgiA	6	0.5605	8.7	0.969	Contact Map
2tmgA	5	0.5112	7.6	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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