GREMLIN Database
Y352 - DNA-binding protein SSO0352
UniProt: Q980F8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (108)
Sequences: 446 (319)
Seq/√Len: 30.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_I75_L3.5101.00
41_K69_E2.9561.00
31_R35_A2.9431.00
14_E17_R2.8251.00
31_R34_K2.4480.99
21_A24_Q2.4390.99
30_E33_R2.0930.98
48_I76_I2.0520.98
50_T89_T2.0390.98
13_E17_R2.0370.98
14_E18_R1.9930.97
41_K76_I1.9220.97
77_A80_Q1.9130.96
9_D12_L1.8820.96
71_L89_T1.8030.95
37_L41_K1.7780.95
60_I93_L1.7490.94
59_N63_V1.6940.93
84_I88_I1.6920.93
22_Q25_K1.6810.93
51_P55_Q1.5930.91
44_I73_N1.5880.90
55_Q59_N1.5630.90
60_I90_D1.5530.89
16_L23_E1.5480.89
60_I68_A1.5080.88
16_L20_A1.4830.87
88_I93_L1.4810.87
89_T92_E1.4550.86
75_L92_E1.4270.85
61_K72_E1.3650.82
28_E31_R1.3610.82
45_L79_A1.3330.81
61_K78_L1.3210.80
60_I67_F1.3050.79
38_E61_K1.3010.79
63_V68_A1.2770.78
90_D94_K1.2410.76
47_V87_P1.2250.75
75_L93_L1.2250.75
20_A84_I1.2030.73
59_N68_A1.2010.73
74_Q78_L1.1920.73
20_A23_E1.1540.70
52_E90_D1.1210.68
28_E32_K1.0950.66
77_A81_S1.0700.64
58_T111_Q1.0670.64
32_K36_E1.0460.62
44_I48_I1.0390.62
60_I74_Q1.0290.61
63_V88_I1.0220.61
60_I71_L1.0160.60
33_R37_L0.9980.59
37_L80_Q0.9920.58
16_L19_K0.9900.58
21_A110_I0.9780.57
91_E108_F0.9650.56
75_L99_Q0.9640.56
50_T112_I0.9510.55
15_L23_E0.9500.55
74_Q83_R0.9490.55
21_A109_K0.9470.55
20_A24_Q0.9430.54
55_Q64_K0.9380.54
45_L97_L0.9280.53
79_A93_L0.9230.53
11_E14_E0.9220.53
10_E13_E0.9110.52
30_E34_K0.9090.52
61_K94_K0.8790.49
37_L40_Q0.8710.49
104_N108_F0.8630.48
12_L16_L0.8490.47
16_L24_Q0.8480.47
42_E47_V0.8450.46
17_R24_Q0.8440.46
22_Q26_R0.8280.45
91_E94_K0.8100.44
35_A98_E0.8080.44
29_E32_K0.8060.43
15_L115_R0.8050.43
52_E105_R0.8030.43
50_T71_L0.7990.43
81_S85_K0.7980.43
18_R22_Q0.7920.42
66_E70_S0.7900.42
46_R87_P0.7870.42
54_R80_Q0.7870.42
36_E40_Q0.7780.41
104_N107_D0.7750.41
87_P101_S0.7540.39
44_I84_I0.7530.39
29_E33_R0.7520.39
34_K75_L0.7500.39
61_K69_E0.7460.39
71_L85_K0.7340.38
39_S43_S0.7220.37
10_E14_E0.7140.36
108_F114_E0.7110.36
15_L25_K0.7060.36
45_L76_I0.7030.35
45_L53_A0.7030.35
42_E55_Q0.6960.35
45_L49_L0.6850.34
88_I107_D0.6720.33
98_E103_Q0.6710.33
108_F113_R0.6660.33
98_E101_S0.6620.33
61_K68_A0.6610.32
44_I76_I0.6610.32
46_R83_R0.6580.32
14_E112_I0.6510.32
64_K67_F0.6480.32
84_I93_L0.6340.31
19_K23_E0.6280.30
21_A64_K0.6280.30
78_L94_K0.6270.30
74_Q89_T0.6130.29
16_L22_Q0.6110.29
79_A96_I0.6110.29
73_N77_A0.6080.29
62_L81_S0.6060.29
29_E94_K0.6010.28
32_K35_A0.5980.28
47_V115_R0.5900.28
46_R50_T0.5830.27
18_R36_E0.5820.27
88_I92_E0.5740.27
26_R115_R0.5670.26
36_E69_E0.5640.26
12_L73_N0.5620.26
15_L59_N0.5610.26
65_P96_I0.5610.26
95_Q112_I0.5600.26
17_R33_R0.5590.26
90_D95_Q0.5570.26
108_F112_I0.5540.25
40_Q78_L0.5530.25
54_R65_P0.5490.25
48_I94_K0.5490.25
73_N100_I0.5480.25
75_L89_T0.5460.25
105_R109_K0.5450.25
50_T70_S0.5420.25
62_L109_K0.5410.25
71_L96_I0.5340.24
18_R64_K0.5320.24
110_I115_R0.5260.24
84_I114_E0.5250.24
42_E87_P0.5250.24
107_D111_Q0.5240.24
63_V109_K0.5130.23
23_E99_Q0.5130.23
9_D13_E0.5110.23
85_K91_E0.5080.23
63_V102_Q0.5070.23
40_Q43_S0.5040.22
43_S70_S0.5030.22
92_E103_Q0.5010.22
46_R62_L0.5010.22
8_D27_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cruA 1 0.9407 100 0.15 Contact Map
2jxnA 1 0.8983 100 0.161 Contact Map
2fh0A 1 0.6695 100 0.34 Contact Map
1eijA 1 0.6102 99.9 0.346 Contact Map
1yybA 1 0.2203 94.9 0.848 Contact Map
4y66B 1 0.8983 31.2 0.918 Contact Map
3a5tA 2 0.2881 19.3 0.926 Contact Map
4xhmA 1 0.5424 7.4 0.938 Contact Map
2m70A 1 0.839 5.4 0.942 Contact Map
1a0rP 1 0.7373 5.3 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.