GREMLIN Database
Q980F6 - Nicotinic acid phosphoribosyltransferase, putative
UniProt: Q980F6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (350)
Sequences: 3533 (1905)
Seq/√Len: 101.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_K172_P4.4951.00
186_D189_K4.2681.00
232_I251_V4.2001.00
356_K359_E4.0241.00
369_S372_E3.7341.00
327_Q352_P3.4641.00
192_K224_L3.0511.00
67_E363_I3.0301.00
223_T260_Y2.9551.00
62_V105_F2.8191.00
368_P376_Y2.7591.00
93_G98_F2.7441.00
27_T180_L2.6841.00
158_G173_S2.5501.00
208_V251_V2.5351.00
188_V192_K2.5201.00
74_Y356_K2.4961.00
66_L73_V2.4571.00
280_R286_F2.4411.00
205_I231_G2.4071.00
136_L145_P2.3331.00
37_K92_E2.3211.00
266_F285_G2.3181.00
90_I354_L2.2261.00
42_V105_F2.2061.00
76_M82_F2.1811.00
163_M166_E2.1561.00
208_V232_I2.1211.00
131_L156_M2.0851.00
123_K157_D2.0771.00
250_E253_W2.0671.00
192_K196_E2.0511.00
152_Y374_R2.0251.00
77_P355_Q1.9941.00
214_E250_E1.9771.00
219_L222_A1.9571.00
252_K256_K1.9431.00
264_K284_D1.9331.00
184_V193_A1.9271.00
208_V254_T1.9181.00
253_W257_I1.8871.00
132_F173_S1.8861.00
92_E325_A1.8761.00
42_V62_V1.8681.00
39_R92_E1.8271.00
275_D278_N1.8221.00
74_Y359_E1.8201.00
355_Q365_K1.8141.00
53_W124_F1.7911.00
74_Y92_E1.7411.00
136_L161_G1.7371.00
218_A221_A1.7281.00
53_W120_A1.7271.00
152_Y170_V1.6991.00
31_L196_E1.6791.00
31_L193_A1.6771.00
94_N97_D1.6591.00
63_L357_Y1.6491.00
217_E221_A1.6481.00
368_P372_E1.6341.00
129_K280_R1.6211.00
220_K224_L1.6161.00
56_F59_L1.6121.00
228_K262_H1.6111.00
248_I267_A1.6091.00
42_V109_L1.6051.00
62_V89_M1.6011.00
147_A293_A1.6001.00
132_F158_G1.5801.00
66_L101_Y1.5721.00
26_K198_M1.5581.00
31_L197_A1.5241.00
76_M328_V1.5151.00
59_L357_Y1.5141.00
44_S47_L1.5121.00
63_L358_M1.5061.00
30_Y197_A1.4981.00
123_K128_D1.4971.00
219_L254_T1.4901.00
226_G229_L1.4701.00
358_M363_I1.4661.00
148_D164_S1.4541.00
276_I288_I1.4511.00
189_K192_K1.4511.00
371_K375_E1.4501.00
130_T157_D1.4301.00
277_I281_D1.4261.00
222_A229_L1.4051.00
163_M167_Y1.3901.00
117_T121_R1.3851.00
118_K121_R1.3841.00
129_K286_F1.3841.00
231_G263_V1.3700.99
222_A225_L1.3700.99
332_G351_K1.3620.99
176_M181_M1.3530.99
89_M109_L1.3450.99
152_Y370_P1.3400.99
329_Y352_P1.3360.99
26_K30_Y1.3350.99
111_H115_I1.3310.99
24_T177_P1.3290.99
123_K131_L1.3280.99
65_L104_A1.3250.99
28_L99_G1.3210.99
119_A156_M1.3140.99
19_I172_P1.3110.99
55_L81_L1.3030.99
334_L349_D1.2990.99
329_Y339_T1.2880.99
357_Y365_K1.2820.99
60_E64_H1.2740.99
221_A225_L1.2720.99
254_T258_H1.2630.99
73_V358_M1.2590.99
189_K193_A1.2530.99
91_I105_F1.2510.99
340_L343_Q1.2440.99
357_Y363_I1.2420.99
368_P373_I1.2360.99
331_C350_C1.2360.99
217_E220_K1.2350.99
103_T136_L1.2280.99
54_A113_S1.2190.99
77_P376_Y1.2100.99
57_T116_S1.2080.99
188_V220_K1.2060.99
339_T343_Q1.2040.99
91_I306_E1.1990.99
121_R273_E1.1970.99
310_D313_W1.1950.99
371_K374_R1.1920.99
195_D204_R1.1910.99
152_Y171_D1.1890.99
218_A223_T1.1880.99
67_E362_K1.1850.98
63_L363_I1.1730.98
132_F285_G1.1690.98
122_L131_L1.1690.98
352_P356_K1.1580.98
218_A222_A1.1550.98
251_V254_T1.1530.98
25_L69_V1.1480.98
19_I162_A1.1440.98
140_H144_A1.1400.98
270_G303_D1.1240.98
327_Q354_L1.1200.98
231_G264_K1.1090.98
37_K94_N1.1040.98
153_I373_I1.1040.98
39_R313_W1.1030.98
219_L251_V1.0930.97
82_F88_V1.0900.97
74_Y90_I1.0830.97
351_K355_Q1.0790.97
188_V224_L1.0770.97
173_S285_G1.0700.97
193_A196_E1.0670.97
62_V104_A1.0660.97
267_A283_V1.0610.97
41_E90_I1.0600.97
77_P80_T1.0410.97
120_A124_F1.0400.97
221_A224_L1.0400.97
41_E326_K1.0390.97
244_F283_V1.0270.96
363_I366_P1.0210.96
39_R90_I1.0190.96
75_A79_G1.0170.96
38_V95_Y1.0160.96
295_P300_F1.0140.96
321_K326_K1.0120.96
272_D291_S1.0100.96
205_I266_F1.0080.96
30_Y196_E1.0060.96
369_S373_I1.0050.96
58_G116_S0.9970.96
214_E247_I0.9970.96
291_S296_P0.9860.95
25_L96_L0.9860.95
152_Y371_K0.9820.95
217_E222_A0.9790.95
111_H139_L0.9740.95
62_V109_L0.9740.95
26_K197_A0.9640.95
40_M99_G0.9630.95
47_L54_A0.9610.95
372_E375_E0.9580.95
17_T22_E0.9580.95
297_S300_F0.9560.94
59_L368_P0.9560.94
78_E149_R0.9560.94
218_A225_L0.9540.94
356_K364_I0.9440.94
319_R326_K0.9380.94
365_K368_P0.9380.94
358_M364_I0.9320.94
182_L210_T0.9280.94
42_V89_M0.9250.93
159_V174_G0.9230.93
76_M80_T0.9190.93
359_E362_K0.9160.93
341_M344_E0.9130.93
142_A163_M0.9130.93
321_K325_A0.9110.93
260_Y263_V0.9090.93
80_T353_L0.9080.93
73_V79_G0.9080.93
351_K376_Y0.9060.93
118_K122_L0.9040.93
245_R249_Q0.9000.92
358_M365_K0.8980.92
36_A312_K0.8970.92
254_T257_I0.8950.92
28_L95_Y0.8950.92
180_L184_V0.8940.92
366_P372_E0.8900.92
121_R125_L0.8890.92
90_I325_A0.8870.92
95_Y183_I0.8870.92
355_Q371_K0.8840.92
76_M86_E0.8840.92
112_Y150_A0.8830.92
122_L288_I0.8820.92
195_D225_L0.8770.92
126_A131_L0.8720.91
234_L247_I0.8720.91
132_F266_F0.8670.91
329_Y350_C0.8570.91
219_L223_T0.8560.90
66_L104_A0.8550.90
327_Q342_D0.8500.90
213_D234_L0.8380.90
356_K360_N0.8360.89
349_D352_P0.8340.89
357_Y364_I0.8340.89
243_N278_N0.8280.89
35_D94_N0.8270.89
296_P301_S0.8230.89
192_K225_L0.8210.89
86_E328_V0.8200.89
56_F76_M0.8170.88
65_L69_V0.8170.88
135_G139_L0.8150.88
157_D374_R0.8130.88
56_F88_V0.8080.88
373_I376_Y0.8060.88
59_L75_A0.8060.88
267_A279_L0.8040.88
75_A80_T0.8000.87
62_V73_V0.7990.87
369_S375_E0.7990.87
27_T198_M0.7990.87
336_D340_L0.7980.87
205_I263_V0.7960.87
125_L277_I0.7950.87
336_D339_T0.7950.87
319_R324_G0.7940.87
200_S227_K0.7910.87
63_L364_I0.7900.87
325_A341_M0.7890.87
290_T301_S0.7880.86
245_R278_N0.7860.86
57_T153_I0.7860.86
108_I142_A0.7860.86
64_H366_P0.7840.86
110_R304_I0.7840.86
227_K230_Y0.7810.86
134_F158_G0.7800.86
113_S304_I0.7800.86
229_L263_V0.7790.86
189_K196_E0.7790.86
101_Y105_F0.7780.86
47_L51_Y0.7780.86
131_L276_I0.7770.86
41_E309_V0.7770.86
122_L125_L0.7750.86
129_K284_D0.7730.85
135_G293_A0.7700.85
252_K284_D0.7690.85
195_D221_A0.7660.85
44_S304_I0.7650.85
331_C334_L0.7650.85
44_S54_A0.7640.85
144_A147_A0.7620.85
16_V136_L0.7610.85
122_L276_I0.7600.84
61_E64_H0.7580.84
321_K324_G0.7570.84
151_A292_I0.7530.84
76_M79_G0.7530.84
217_E225_L0.7510.84
31_L184_V0.7460.83
49_K295_P0.7430.83
217_E223_T0.7420.83
14_G65_L0.7420.83
234_L267_A0.7410.83
300_F307_K0.7400.83
153_I370_P0.7390.83
351_K372_E0.7370.83
188_V225_L0.7360.83
73_V80_T0.7350.82
55_L58_G0.7350.82
64_H68_G0.7350.82
213_D247_I0.7330.82
187_N217_E0.7320.82
164_S170_V0.7290.82
169_G371_K0.7290.82
16_V142_A0.7290.82
27_T197_A0.7270.82
220_K223_T0.7240.81
111_H147_A0.7190.81
34_K96_L0.7180.81
117_T120_A0.7180.81
269_G275_D0.7170.81
218_A224_L0.7150.81
264_K285_G0.7140.81
356_K365_K0.7130.80
319_R322_W0.7120.80
173_S266_F0.7090.80
191_W206_T0.7090.80
230_Y263_V0.7060.80
355_Q372_E0.7050.80
42_V106_L0.7050.80
270_G291_S0.7030.80
232_I265_I0.7010.79
200_S228_K0.7000.79
352_P355_Q0.6990.79
337_V350_C0.6990.79
17_T162_A0.6990.79
332_G349_D0.6970.79
246_K250_E0.6940.79
359_E364_I0.6920.78
181_M190_A0.6920.78
25_L100_I0.6880.78
334_L350_C0.6860.78
143_L146_M0.6860.78
360_N371_K0.6850.78
139_L293_A0.6820.77
36_A308_F0.6800.77
119_A123_K0.6800.77
332_G350_C0.6790.77
145_P161_G0.6780.77
162_A172_P0.6770.77
55_L116_S0.6770.77
245_R279_L0.6760.77
29_E34_K0.6760.77
274_D278_N0.6750.77
188_V221_A0.6620.75
370_P373_I0.6610.75
200_S230_Y0.6590.75
131_L288_I0.6560.75
344_E371_K0.6490.74
64_H67_E0.6490.74
16_V107_G0.6480.74
328_V338_I0.6480.74
171_D374_R0.6460.74
326_K329_Y0.6450.73
139_L147_A0.6440.73
19_I23_R0.6420.73
119_A122_L0.6410.73
104_A108_I0.6400.73
195_D199_G0.6390.73
95_Y99_G0.6390.73
123_K126_A0.6390.73
252_K265_I0.6380.73
151_A156_M0.6370.73
62_V66_L0.6370.73
325_A354_L0.6370.73
208_V234_L0.6360.72
278_N281_D0.6340.72
15_K166_E0.6310.72
246_K278_N0.6310.72
192_K221_A0.6310.72
32_G193_A0.6300.72
328_V354_L0.6300.72
270_G290_T0.6280.71
256_K259_G0.6270.71
110_R114_S0.6270.71
360_N375_E0.6270.71
150_A154_G0.6260.71
192_K227_K0.6220.71
245_R248_I0.6220.71
114_S294_F0.6200.71
60_E373_I0.6190.70
219_L224_L0.6180.70
301_S304_I0.6170.70
56_F82_F0.6160.70
37_K312_K0.6150.70
357_Y368_P0.6100.69
170_V370_P0.6100.69
106_L110_R0.6080.69
266_F269_G0.6080.69
73_V76_M0.6070.69
123_K127_M0.6070.69
244_F279_L0.6060.69
323_P326_K0.6060.69
355_Q366_P0.6050.69
319_R325_A0.6040.69
351_K369_S0.6020.68
232_I254_T0.6020.68
339_T348_S0.6000.68
160_S175_T0.6000.68
75_A357_Y0.5970.68
295_P299_D0.5960.68
138_S290_T0.5960.68
146_M167_Y0.5930.67
327_Q341_M0.5900.67
365_K372_E0.5900.67
103_T145_P0.5880.66
125_L128_D0.5850.66
61_E112_Y0.5840.66
115_I292_I0.5830.66
246_K249_Q0.5830.66
123_K156_M0.5830.66
136_L142_A0.5820.66
362_K366_P0.5790.65
333_K355_Q0.5790.65
56_F75_A0.5790.65
146_M163_M0.5780.65
199_G228_K0.5750.65
111_H140_H0.5740.65
65_L101_Y0.5730.65
330_R336_D0.5720.64
187_N191_W0.5710.64
331_C339_T0.5680.64
320_G323_P0.5670.64
187_N244_F0.5670.64
219_L225_L0.5660.64
336_D341_M0.5660.64
348_S366_P0.5650.63
181_M191_W0.5630.63
205_I229_L0.5630.63
270_G301_S0.5630.63
126_A288_I0.5630.63
141_P144_A0.5620.63
148_D151_A0.5620.63
175_T207_L0.5610.63
349_D375_E0.5610.63
366_P371_K0.5590.63
28_L183_I0.5580.62
273_E291_S0.5580.62
90_I341_M0.5550.62
66_L358_M0.5550.62
213_D251_V0.5550.62
355_Q360_N0.5540.62
182_L270_G0.5530.62
314_V371_K0.5510.62
234_L283_V0.5490.61
301_S305_V0.5480.61
364_I373_I0.5470.61
159_V236_T0.5470.61
223_T258_H0.5470.61
372_E376_Y0.5470.61
296_P300_F0.5460.61
119_A154_G0.5450.61
320_G325_A0.5420.60
43_H85_I0.5420.60
176_M194_F0.5400.60
56_F60_E0.5390.60
156_M292_I0.5380.60
335_N375_E0.5380.60
329_Y348_S0.5380.60
21_F136_L0.5370.60
342_D352_P0.5340.59
365_K376_Y0.5330.59
40_M98_F0.5330.59
256_K282_I0.5330.59
26_K29_E0.5310.59
111_H156_M0.5310.59
349_D371_K0.5300.59
185_G189_K0.5300.59
355_Q368_P0.5300.59
28_L38_V0.5300.59
91_I98_F0.5300.59
342_D371_K0.5290.58
80_T351_K0.5290.58
229_L260_Y0.5290.58
335_N355_Q0.5290.58
338_I342_D0.5280.58
67_E358_M0.5270.58
28_L40_M0.5270.58
185_G316_F0.5260.58
344_E348_S0.5260.58
73_V101_Y0.5260.58
362_K375_E0.5260.58
44_S269_G0.5250.58
31_L310_D0.5250.58
231_G285_G0.5240.58
39_R74_Y0.5230.58
348_S365_K0.5220.57
54_A302_A0.5210.57
339_T344_E0.5190.57
205_I285_G0.5180.57
58_G79_G0.5180.57
57_T150_A0.5180.57
76_M353_L0.5170.57
249_Q360_N0.5160.57
198_M201_E0.5160.57
184_V211_F0.5150.56
302_A307_K0.5150.56
304_I307_K0.5150.56
21_F29_E0.5140.56
217_E224_L0.5140.56
188_V217_E0.5130.56
334_L348_S0.5110.56
337_V371_K0.5110.56
135_G151_A0.5100.56
300_F309_V0.5090.56
106_L271_I0.5080.55
341_M369_S0.5080.55
159_V170_V0.5070.55
204_R229_L0.5070.55
118_K125_L0.5060.55
360_N373_I0.5060.55
131_L157_D0.5060.55
60_E149_R0.5060.55
243_N246_K0.5050.55
21_F177_P0.5040.55
319_R323_P0.5040.55
62_V101_Y0.5030.55
219_L258_H0.5020.55
201_E205_I0.5020.55
349_D369_S0.5020.55
92_E359_E0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yubA 2 0.9121 100 0.17 Contact Map
2i14A 5 0.9871 100 0.224 Contact Map
4lvfA 2 0.9225 100 0.242 Contact Map
2i1oA 5 0.9716 100 0.251 Contact Map
4mzyA 2 0.9638 100 0.253 Contact Map
1ybeA 2 0.8295 100 0.285 Contact Map
3os4A 1 0.8191 100 0.3 Contact Map
1vlpA 1 0.8475 100 0.31 Contact Map
1yirA 1 0.8191 100 0.322 Contact Map
4hl7A 4 0.845 100 0.324 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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