Q980F4 - SULSO - GREMLIN Contacts

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Q980F4 - Uncharacterized protein

UniProt:	Q980F4	Sequences: MMIRAITIFVTNYSKISDYTEKLSKLNDNNIWSKRISLPPTPIDLSLSKLIELLPTTHSEIIFSLINLQEKDKRLREIKDILKSDKRIYVHVLVKTTDNLKDLAKLIISLEPEEASRFALLFNQDFLLTPYFPTSSANTVYDSFGISLLYVDEFKQGKINEALSKADTIGRQLEKKLNIKYLGIDASLSPWMESSVGEIVESRSKKMFDISNLSAVAEINREIFEGVWRNRVNPIGFSELMLPIAEDNLLRERVKEGSLTLKDLLLMSYVCVAGIDMVGIYSDLVTYENILKSVYYIQYTKRKPYGVRMIPTNGSPVLTKMFGEIPEVKVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	331 (322)
Sequences:	628 (241)
Seq/√Len:	13.4

SULSO - Q980F4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
122_F	299_Y	7.919	1.00
6_I	20_T	5.149	1.00
36_I	63_F	4.742	1.00
80_D	84_S	4.704	1.00
198_E	248_N	4.617	1.00
280_I	287_Y	4.558	1.00
59_S	86_K	4.393	1.00
283_D	316_P	3.823	0.99
210_I	262_K	3.532	0.99
23_L	173_L	3.319	0.98
167_D	171_R	3.275	0.98
78_I	90_V	3.026	0.97
103_L	118_F	2.958	0.97
104_A	288_E	2.944	0.97
37_S	135_S	2.903	0.96
197_G	249_L	2.766	0.95
95_K	295_Y	2.651	0.94
23_L	169_I	2.622	0.93
206_K	256_E	2.604	0.93
26_L	176_K	2.590	0.93
13_Y	61_I	2.584	0.93
21_E	24_S	2.550	0.92
240_L	270_V	2.523	0.92
290_I	309_M	2.523	0.92
36_I	61_I	2.469	0.91
104_A	284_L	2.459	0.91
203_R	218_E	2.431	0.90
212_N	251_R	2.383	0.89
101_K	288_E	2.376	0.89
94_V	295_Y	2.287	0.87
155_K	198_E	2.242	0.86
101_K	105_K	2.111	0.83
167_D	173_L	2.099	0.82
5_A	147_S	2.098	0.82
252_E	256_E	2.085	0.82
15_K	18_D	2.081	0.82
167_D	228_W	2.075	0.81
67_N	102_D	2.052	0.81
254_V	258_S	2.038	0.80
167_D	202_S	2.022	0.80
51_I	81_I	1.982	0.78
108_I	112_P	1.977	0.78
72_D	76_R	1.948	0.77
167_D	170_G	1.910	0.76
22_K	176_K	1.891	0.75
312_T	320_K	1.876	0.74
95_K	122_F	1.870	0.74
279_G	312_T	1.763	0.69
170_G	173_L	1.749	0.69
172_Q	175_K	1.708	0.67
229_R	250_L	1.701	0.66
209_D	262_K	1.698	0.66
110_L	115_A	1.664	0.65
125_D	136_S	1.650	0.64
42_P	71_K	1.595	0.61
110_L	118_F	1.593	0.61
4_R	7_T	1.577	0.60
105_K	285_V	1.563	0.60
313_N	320_K	1.542	0.59
136_S	250_L	1.510	0.57
6_I	173_L	1.491	0.56
170_G	174_E	1.474	0.55
49_K	53_L	1.468	0.55
170_G	181_Y	1.457	0.54
198_E	252_E	1.454	0.54
46_S	80_D	1.448	0.54
33_S	133_P	1.437	0.53
17_S	34_K	1.434	0.53
155_K	312_T	1.407	0.52
158_K	170_G	1.382	0.50
101_K	104_A	1.377	0.50
228_W	300_T	1.354	0.49
53_L	56_T	1.351	0.49
248_N	252_E	1.348	0.48
275_I	278_V	1.342	0.48
252_E	255_K	1.330	0.47
47_L	73_K	1.324	0.47
21_E	64_S	1.308	0.46
14_S	179_I	1.305	0.46
283_D	314_G	1.291	0.45
228_W	313_N	1.286	0.45
169_I	269_Y	1.282	0.45
165_K	184_I	1.279	0.45
86_K	109_S	1.265	0.44
275_I	290_I	1.265	0.44
147_S	305_Y	1.263	0.44
111_E	114_E	1.255	0.43
213_L	265_L	1.253	0.43
133_P	305_Y	1.242	0.43
26_L	169_I	1.223	0.42
170_G	269_Y	1.215	0.41
198_E	302_R	1.210	0.41
3_I	24_S	1.194	0.40
231_R	270_V	1.173	0.39
23_L	175_K	1.170	0.39
8_I	12_N	1.165	0.39
45_L	50_L	1.162	0.39
3_I	165_K	1.158	0.38
46_S	49_K	1.158	0.38
207_M	250_L	1.154	0.38
203_R	209_D	1.150	0.38
259_L	262_K	1.148	0.38
8_I	144_F	1.132	0.37
112_P	313_N	1.129	0.37
129_T	136_S	1.123	0.37
280_I	285_V	1.118	0.37
125_D	250_L	1.117	0.36
8_I	179_I	1.109	0.36
173_L	197_G	1.109	0.36
127_L	140_V	1.108	0.36
122_F	269_Y	1.101	0.36
3_I	259_L	1.101	0.36
31_I	203_R	1.099	0.36
108_I	313_N	1.093	0.35
191_W	301_K	1.092	0.35
24_S	31_I	1.086	0.35
295_Y	302_R	1.079	0.35
21_E	25_K	1.073	0.34
144_F	232_V	1.066	0.34
130_P	246_E	1.056	0.34
126_F	251_R	1.056	0.34
187_S	271_C	1.056	0.34
176_K	280_I	1.055	0.33
39_P	129_T	1.053	0.33
280_I	316_P	1.044	0.33
101_K	167_D	1.042	0.33
167_D	206_K	1.038	0.33
35_R	246_E	1.032	0.32
20_T	64_S	1.023	0.32
206_K	258_S	1.021	0.32
80_D	158_K	1.021	0.32
150_Y	189_S	1.014	0.32
255_K	319_T	1.008	0.31
123_N	238_S	1.004	0.31
210_I	289_N	1.004	0.31
315_S	318_L	1.003	0.31
144_F	155_K	1.000	0.31
137_A	229_R	0.999	0.31
155_K	202_S	0.999	0.31
112_P	287_Y	0.991	0.31
50_L	107_I	0.990	0.30
248_N	309_M	0.989	0.30
126_F	295_Y	0.982	0.30
212_N	261_L	0.978	0.30
32_W	165_K	0.978	0.30
185_D	247_D	0.977	0.30
125_D	129_T	0.969	0.30
92_V	118_F	0.965	0.29
84_S	87_R	0.960	0.29
133_P	147_S	0.960	0.29
26_L	172_Q	0.959	0.29
213_L	297_I	0.955	0.29
104_A	289_N	0.948	0.29
179_I	289_N	0.947	0.29
67_N	70_E	0.942	0.28
12_N	261_L	0.934	0.28
301_K	305_Y	0.931	0.28
219_I	224_F	0.929	0.28
213_L	268_S	0.925	0.28
144_F	184_I	0.923	0.28
50_L	202_S	0.919	0.27
18_D	76_R	0.916	0.27
14_S	19_Y	0.916	0.27
44_D	318_L	0.913	0.27
45_L	155_K	0.910	0.27
190_P	195_S	0.907	0.27
37_S	288_E	0.902	0.27
202_S	309_M	0.898	0.26
213_L	263_D	0.896	0.26
43_I	139_T	0.896	0.26
95_K	299_Y	0.888	0.26
109_S	113_E	0.884	0.26
32_W	50_L	0.884	0.26
201_E	207_M	0.883	0.26
162_A	205_K	0.883	0.26
63_F	86_K	0.883	0.26
228_W	248_N	0.880	0.26
197_G	229_R	0.878	0.26
116_S	120_L	0.878	0.26
49_K	52_E	0.877	0.26
143_S	184_I	0.877	0.26
137_A	250_L	0.874	0.26
201_E	243_P	0.873	0.25
102_D	318_L	0.870	0.25
81_I	86_K	0.866	0.25
95_K	141_Y	0.859	0.25
156_Q	207_M	0.856	0.25
103_L	120_L	0.856	0.25
12_N	280_I	0.854	0.25
197_G	250_L	0.853	0.25
189_S	239_E	0.850	0.25
178_N	288_E	0.848	0.24
16_I	297_I	0.838	0.24
35_R	130_P	0.833	0.24
87_R	140_V	0.830	0.24
93_L	125_D	0.824	0.24
18_D	23_L	0.823	0.23
47_L	155_K	0.822	0.23
185_D	236_G	0.821	0.23
236_G	247_D	0.821	0.23
89_Y	133_P	0.814	0.23
3_I	31_I	0.814	0.23
185_D	246_E	0.813	0.23
47_L	198_E	0.812	0.23
155_K	302_R	0.807	0.23
14_S	60_E	0.807	0.23
3_I	287_Y	0.805	0.23
179_I	197_G	0.805	0.23
92_V	103_L	0.804	0.23
83_K	113_E	0.804	0.23
19_Y	86_K	0.802	0.23
97_T	100_L	0.800	0.23
50_L	101_K	0.799	0.23
144_F	156_Q	0.796	0.22
309_M	313_N	0.792	0.22
10_V	175_K	0.791	0.22
174_E	259_L	0.790	0.22
255_K	321_M	0.788	0.22
117_R	304_P	0.782	0.22
16_I	21_E	0.779	0.22
91_H	119_A	0.776	0.22
161_E	250_L	0.775	0.22
47_L	53_L	0.774	0.22
12_N	142_D	0.774	0.22
203_R	215_A	0.774	0.22
52_E	178_N	0.770	0.22
276_D	308_R	0.768	0.21
274_G	308_R	0.768	0.21
8_I	142_D	0.768	0.21
91_H	121_L	0.767	0.21
140_V	192_M	0.763	0.21
126_F	228_W	0.763	0.21
3_I	201_E	0.761	0.21
191_W	272_V	0.758	0.21
247_D	276_D	0.757	0.21
247_D	274_G	0.757	0.21
185_D	274_G	0.757	0.21
185_D	276_D	0.757	0.21
57_T	320_K	0.755	0.21
252_E	278_V	0.754	0.21
172_Q	231_R	0.752	0.21
14_S	18_D	0.750	0.21
3_I	170_G	0.744	0.21
216_V	240_L	0.740	0.20
23_L	64_S	0.740	0.20
27_N	270_V	0.739	0.20
277_M	323_G	0.739	0.20
133_P	294_V	0.739	0.20
6_I	144_F	0.738	0.20
59_S	73_K	0.738	0.20
268_S	272_V	0.737	0.20
158_K	318_L	0.736	0.20
272_V	301_K	0.734	0.20
3_I	158_K	0.733	0.20
273_A	294_V	0.733	0.20
33_S	305_Y	0.732	0.20
102_D	113_E	0.731	0.20
110_L	113_E	0.730	0.20
83_K	206_K	0.729	0.20
102_D	233_N	0.729	0.20
208_F	212_N	0.728	0.20
27_N	169_I	0.722	0.20
120_L	291_L	0.721	0.20
15_K	36_I	0.718	0.20
228_W	255_K	0.717	0.20
54_L	178_N	0.713	0.20
147_S	301_K	0.710	0.19
105_K	109_S	0.710	0.19
50_L	53_L	0.709	0.19
57_T	318_L	0.707	0.19
68_L	141_Y	0.701	0.19
6_I	289_N	0.700	0.19
270_V	300_T	0.699	0.19
64_S	86_K	0.699	0.19
198_E	201_E	0.698	0.19
37_S	87_R	0.695	0.19
50_L	83_K	0.694	0.19
73_K	155_K	0.692	0.19
4_R	35_R	0.691	0.19
60_E	280_I	0.691	0.19
19_Y	22_K	0.690	0.19
265_L	268_S	0.689	0.19
37_S	90_V	0.688	0.19
97_T	114_E	0.687	0.19
27_N	172_Q	0.687	0.19
92_V	200_V	0.685	0.19
221_R	242_L	0.683	0.19
69_Q	285_V	0.682	0.19
210_I	261_L	0.682	0.19
192_M	248_N	0.681	0.19
31_I	215_A	0.680	0.18
200_V	207_M	0.678	0.18
14_S	72_D	0.675	0.18
60_E	302_R	0.672	0.18
73_K	252_E	0.670	0.18
82_L	118_F	0.670	0.18
133_P	301_K	0.669	0.18
205_K	209_D	0.667	0.18
52_E	60_E	0.665	0.18
109_S	112_P	0.665	0.18
117_R	275_I	0.664	0.18
237_F	241_M	0.662	0.18
153_E	242_L	0.661	0.18
228_W	270_V	0.659	0.18
115_A	155_K	0.659	0.18
280_I	309_M	0.658	0.18
101_K	285_V	0.657	0.18
115_A	248_N	0.656	0.18
125_D	200_V	0.653	0.18
236_G	246_E	0.653	0.18
294_V	305_Y	0.651	0.18
220_N	239_E	0.651	0.18
283_D	321_M	0.650	0.18
115_A	313_N	0.650	0.18
211_S	293_S	0.647	0.17
102_D	105_K	0.647	0.17
98_D	199_I	0.645	0.17
231_R	290_I	0.645	0.17
80_D	113_E	0.644	0.17
115_A	220_N	0.644	0.17
93_L	192_M	0.641	0.17
288_E	302_R	0.641	0.17
273_A	301_K	0.640	0.17
3_I	156_Q	0.639	0.17
195_S	247_D	0.638	0.17
185_D	195_S	0.638	0.17
83_K	90_V	0.637	0.17
106_L	109_S	0.637	0.17
169_I	312_T	0.632	0.17
90_V	184_I	0.630	0.17
280_I	312_T	0.627	0.17
171_R	252_E	0.627	0.17
187_S	236_G	0.626	0.17
268_S	294_V	0.625	0.17
12_N	288_E	0.623	0.17
44_D	47_L	0.622	0.17
78_I	205_K	0.622	0.17
157_G	287_Y	0.622	0.17
145_G	287_Y	0.617	0.17
25_K	269_Y	0.615	0.16
187_S	246_E	0.612	0.16
39_P	212_N	0.611	0.16
152_D	241_M	0.611	0.16
14_S	21_E	0.610	0.16
130_P	247_D	0.609	0.16
130_P	185_D	0.609	0.16
115_A	310_I	0.609	0.16
5_A	10_V	0.605	0.16
145_G	179_I	0.603	0.16
49_K	176_K	0.603	0.16
26_L	167_D	0.603	0.16
236_G	274_G	0.602	0.16
236_G	276_D	0.602	0.16
95_K	126_F	0.602	0.16
181_Y	186_A	0.601	0.16
158_K	175_K	0.601	0.16
185_D	190_P	0.600	0.16
190_P	247_D	0.600	0.16
310_I	322_F	0.600	0.16
289_N	309_M	0.599	0.16
145_G	184_I	0.599	0.16
70_E	126_F	0.598	0.16
12_N	109_S	0.598	0.16
86_K	144_F	0.597	0.16
90_V	280_I	0.596	0.16
246_E	276_D	0.594	0.16
246_E	274_G	0.594	0.16
40_P	138_N	0.594	0.16
73_K	256_E	0.592	0.16
115_A	320_K	0.591	0.16
38_L	54_L	0.591	0.16
169_I	256_E	0.590	0.16
201_E	209_D	0.588	0.16
286_T	312_T	0.588	0.16
73_K	203_R	0.587	0.16
233_N	269_Y	0.586	0.16
35_R	185_D	0.582	0.16
35_R	247_D	0.582	0.16
50_L	165_K	0.582	0.16
119_A	129_T	0.582	0.16
10_V	290_I	0.582	0.16
188_L	196_V	0.579	0.15
31_I	200_V	0.578	0.15
31_I	250_L	0.578	0.15
131_Y	150_Y	0.576	0.15
129_T	200_V	0.573	0.15
236_G	271_C	0.572	0.15
237_F	306_G	0.572	0.15
171_R	302_R	0.572	0.15
5_A	222_E	0.572	0.15
173_L	176_K	0.571	0.15
172_Q	270_V	0.571	0.15
271_C	274_G	0.570	0.15
271_C	276_D	0.570	0.15
158_K	289_N	0.570	0.15
136_S	200_V	0.569	0.15
52_E	59_S	0.568	0.15
84_S	285_V	0.567	0.15
293_S	308_R	0.566	0.15
262_K	290_I	0.565	0.15
246_E	271_C	0.565	0.15
220_N	301_K	0.564	0.15
210_I	309_M	0.563	0.15
174_E	313_N	0.563	0.15
144_F	174_E	0.562	0.15
122_F	300_T	0.562	0.15
185_D	308_R	0.562	0.15
247_D	308_R	0.562	0.15
170_G	222_E	0.562	0.15
241_M	272_V	0.562	0.15
103_L	107_I	0.560	0.15
110_L	207_M	0.560	0.15
25_K	256_E	0.559	0.15
3_I	96_T	0.559	0.15
133_P	273_A	0.558	0.15
270_V	302_R	0.556	0.15
196_V	233_N	0.554	0.15
31_I	265_L	0.553	0.15
72_D	102_D	0.553	0.15
109_S	180_K	0.551	0.15
13_Y	147_S	0.550	0.15
179_I	252_E	0.549	0.15
26_L	179_I	0.548	0.15
29_N	65_L	0.548	0.15
3_I	312_T	0.546	0.15
145_G	240_L	0.546	0.15
53_L	113_E	0.546	0.15
70_E	312_T	0.545	0.15
175_K	178_N	0.544	0.15
43_I	46_S	0.544	0.15
179_I	196_V	0.543	0.14
231_R	240_L	0.543	0.14
6_I	287_Y	0.542	0.14
49_K	285_V	0.542	0.14
46_S	318_L	0.541	0.14
114_E	290_I	0.540	0.14
207_M	212_N	0.540	0.14
89_Y	294_V	0.539	0.14
239_E	301_K	0.538	0.14
140_V	157_G	0.537	0.14
52_E	206_K	0.535	0.14
115_A	172_Q	0.535	0.14
36_I	53_L	0.534	0.14
21_E	295_Y	0.533	0.14
105_K	252_E	0.533	0.14
107_I	248_N	0.532	0.14
210_I	260_T	0.530	0.14
281_Y	314_G	0.526	0.14
254_V	302_R	0.525	0.14
212_N	279_G	0.524	0.14
50_L	198_E	0.523	0.14
228_W	240_L	0.522	0.14
83_K	169_I	0.522	0.14
101_K	113_E	0.521	0.14
201_E	250_L	0.520	0.14
140_V	228_W	0.519	0.14
201_E	229_R	0.519	0.14
129_T	250_L	0.519	0.14
15_K	21_E	0.518	0.14
131_Y	239_E	0.517	0.14
216_V	245_A	0.517	0.14
171_R	233_N	0.515	0.14
197_G	207_M	0.515	0.14
69_Q	72_D	0.514	0.14
206_K	309_M	0.512	0.14
94_V	115_A	0.511	0.14
72_D	283_D	0.509	0.14
67_N	72_D	0.509	0.14
12_N	49_K	0.508	0.14
32_W	248_N	0.508	0.14
174_E	206_K	0.508	0.14
3_I	210_I	0.506	0.14
141_Y	207_M	0.506	0.14
115_A	299_Y	0.505	0.14
101_K	180_K	0.505	0.14
115_A	302_R	0.504	0.13
110_L	280_I	0.504	0.13
50_L	158_K	0.504	0.13
150_Y	245_A	0.503	0.13
3_I	203_R	0.502	0.13
50_L	145_G	0.501	0.13
151_V	323_G	0.501	0.13
26_L	197_G	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ha9A	3	0.9426	100	0.156	Contact Map
2cxiA	3	0.1843	28.6	0.971	Contact Map
2yr1A	2	0.6465	22.1	0.973	Contact Map
2mu0A	1	0.2931	17.4	0.974	Contact Map
1y80A	1	0.145	14.6	0.975	Contact Map
1rw1A	1	0.284	13.9	0.975	Contact Map
3ke3A	2	0.1843	12.5	0.976	Contact Map
3rdwA	1	0.3233	12.5	0.976	Contact Map
2bwnA	2	0.1813	12.1	0.976	Contact Map
4e9jA	2	0.3384	11.9	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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