GREMLIN Database
Q980F4 - Uncharacterized protein
UniProt: Q980F4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (322)
Sequences: 628 (241)
Seq/√Len: 13.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_F299_Y7.9191.00
6_I20_T5.1491.00
36_I63_F4.7421.00
80_D84_S4.7041.00
198_E248_N4.6171.00
280_I287_Y4.5581.00
59_S86_K4.3931.00
283_D316_P3.8230.99
210_I262_K3.5320.99
23_L173_L3.3190.98
167_D171_R3.2750.98
78_I90_V3.0260.97
103_L118_F2.9580.97
104_A288_E2.9440.97
37_S135_S2.9030.96
197_G249_L2.7660.95
95_K295_Y2.6510.94
23_L169_I2.6220.93
206_K256_E2.6040.93
26_L176_K2.5900.93
13_Y61_I2.5840.93
21_E24_S2.5500.92
240_L270_V2.5230.92
290_I309_M2.5230.92
36_I61_I2.4690.91
104_A284_L2.4590.91
203_R218_E2.4310.90
212_N251_R2.3830.89
101_K288_E2.3760.89
94_V295_Y2.2870.87
155_K198_E2.2420.86
101_K105_K2.1110.83
167_D173_L2.0990.82
5_A147_S2.0980.82
252_E256_E2.0850.82
15_K18_D2.0810.82
167_D228_W2.0750.81
67_N102_D2.0520.81
254_V258_S2.0380.80
167_D202_S2.0220.80
51_I81_I1.9820.78
108_I112_P1.9770.78
72_D76_R1.9480.77
167_D170_G1.9100.76
22_K176_K1.8910.75
312_T320_K1.8760.74
95_K122_F1.8700.74
279_G312_T1.7630.69
170_G173_L1.7490.69
172_Q175_K1.7080.67
229_R250_L1.7010.66
209_D262_K1.6980.66
110_L115_A1.6640.65
125_D136_S1.6500.64
42_P71_K1.5950.61
110_L118_F1.5930.61
4_R7_T1.5770.60
105_K285_V1.5630.60
313_N320_K1.5420.59
136_S250_L1.5100.57
6_I173_L1.4910.56
170_G174_E1.4740.55
49_K53_L1.4680.55
170_G181_Y1.4570.54
198_E252_E1.4540.54
46_S80_D1.4480.54
33_S133_P1.4370.53
17_S34_K1.4340.53
155_K312_T1.4070.52
158_K170_G1.3820.50
101_K104_A1.3770.50
228_W300_T1.3540.49
53_L56_T1.3510.49
248_N252_E1.3480.48
275_I278_V1.3420.48
252_E255_K1.3300.47
47_L73_K1.3240.47
21_E64_S1.3080.46
14_S179_I1.3050.46
283_D314_G1.2910.45
228_W313_N1.2860.45
169_I269_Y1.2820.45
165_K184_I1.2790.45
86_K109_S1.2650.44
275_I290_I1.2650.44
147_S305_Y1.2630.44
111_E114_E1.2550.43
213_L265_L1.2530.43
133_P305_Y1.2420.43
26_L169_I1.2230.42
170_G269_Y1.2150.41
198_E302_R1.2100.41
3_I24_S1.1940.40
231_R270_V1.1730.39
23_L175_K1.1700.39
8_I12_N1.1650.39
45_L50_L1.1620.39
3_I165_K1.1580.38
46_S49_K1.1580.38
207_M250_L1.1540.38
203_R209_D1.1500.38
259_L262_K1.1480.38
8_I144_F1.1320.37
112_P313_N1.1290.37
129_T136_S1.1230.37
280_I285_V1.1180.37
125_D250_L1.1170.36
8_I179_I1.1090.36
173_L197_G1.1090.36
127_L140_V1.1080.36
122_F269_Y1.1010.36
3_I259_L1.1010.36
31_I203_R1.0990.36
108_I313_N1.0930.35
191_W301_K1.0920.35
24_S31_I1.0860.35
295_Y302_R1.0790.35
21_E25_K1.0730.34
144_F232_V1.0660.34
130_P246_E1.0560.34
126_F251_R1.0560.34
187_S271_C1.0560.34
176_K280_I1.0550.33
39_P129_T1.0530.33
280_I316_P1.0440.33
101_K167_D1.0420.33
167_D206_K1.0380.33
35_R246_E1.0320.32
20_T64_S1.0230.32
206_K258_S1.0210.32
80_D158_K1.0210.32
150_Y189_S1.0140.32
255_K319_T1.0080.31
123_N238_S1.0040.31
210_I289_N1.0040.31
315_S318_L1.0030.31
144_F155_K1.0000.31
137_A229_R0.9990.31
155_K202_S0.9990.31
112_P287_Y0.9910.31
50_L107_I0.9900.30
248_N309_M0.9890.30
126_F295_Y0.9820.30
212_N261_L0.9780.30
32_W165_K0.9780.30
185_D247_D0.9770.30
125_D129_T0.9690.30
92_V118_F0.9650.29
84_S87_R0.9600.29
133_P147_S0.9600.29
26_L172_Q0.9590.29
213_L297_I0.9550.29
104_A289_N0.9480.29
179_I289_N0.9470.29
67_N70_E0.9420.28
12_N261_L0.9340.28
301_K305_Y0.9310.28
219_I224_F0.9290.28
213_L268_S0.9250.28
144_F184_I0.9230.28
50_L202_S0.9190.27
18_D76_R0.9160.27
14_S19_Y0.9160.27
44_D318_L0.9130.27
45_L155_K0.9100.27
190_P195_S0.9070.27
37_S288_E0.9020.27
202_S309_M0.8980.26
213_L263_D0.8960.26
43_I139_T0.8960.26
95_K299_Y0.8880.26
109_S113_E0.8840.26
32_W50_L0.8840.26
201_E207_M0.8830.26
162_A205_K0.8830.26
63_F86_K0.8830.26
228_W248_N0.8800.26
197_G229_R0.8780.26
116_S120_L0.8780.26
49_K52_E0.8770.26
143_S184_I0.8770.26
137_A250_L0.8740.26
201_E243_P0.8730.25
102_D318_L0.8700.25
81_I86_K0.8660.25
95_K141_Y0.8590.25
156_Q207_M0.8560.25
103_L120_L0.8560.25
12_N280_I0.8540.25
197_G250_L0.8530.25
189_S239_E0.8500.25
178_N288_E0.8480.24
16_I297_I0.8380.24
35_R130_P0.8330.24
87_R140_V0.8300.24
93_L125_D0.8240.24
18_D23_L0.8230.23
47_L155_K0.8220.23
185_D236_G0.8210.23
236_G247_D0.8210.23
89_Y133_P0.8140.23
3_I31_I0.8140.23
185_D246_E0.8130.23
47_L198_E0.8120.23
155_K302_R0.8070.23
14_S60_E0.8070.23
3_I287_Y0.8050.23
179_I197_G0.8050.23
92_V103_L0.8040.23
83_K113_E0.8040.23
19_Y86_K0.8020.23
97_T100_L0.8000.23
50_L101_K0.7990.23
144_F156_Q0.7960.22
309_M313_N0.7920.22
10_V175_K0.7910.22
174_E259_L0.7900.22
255_K321_M0.7880.22
117_R304_P0.7820.22
16_I21_E0.7790.22
91_H119_A0.7760.22
161_E250_L0.7750.22
47_L53_L0.7740.22
12_N142_D0.7740.22
203_R215_A0.7740.22
52_E178_N0.7700.22
276_D308_R0.7680.21
274_G308_R0.7680.21
8_I142_D0.7680.21
91_H121_L0.7670.21
140_V192_M0.7630.21
126_F228_W0.7630.21
3_I201_E0.7610.21
191_W272_V0.7580.21
247_D276_D0.7570.21
247_D274_G0.7570.21
185_D274_G0.7570.21
185_D276_D0.7570.21
57_T320_K0.7550.21
252_E278_V0.7540.21
172_Q231_R0.7520.21
14_S18_D0.7500.21
3_I170_G0.7440.21
216_V240_L0.7400.20
23_L64_S0.7400.20
27_N270_V0.7390.20
277_M323_G0.7390.20
133_P294_V0.7390.20
6_I144_F0.7380.20
59_S73_K0.7380.20
268_S272_V0.7370.20
158_K318_L0.7360.20
272_V301_K0.7340.20
3_I158_K0.7330.20
273_A294_V0.7330.20
33_S305_Y0.7320.20
102_D113_E0.7310.20
110_L113_E0.7300.20
83_K206_K0.7290.20
102_D233_N0.7290.20
208_F212_N0.7280.20
27_N169_I0.7220.20
120_L291_L0.7210.20
15_K36_I0.7180.20
228_W255_K0.7170.20
54_L178_N0.7130.20
147_S301_K0.7100.19
105_K109_S0.7100.19
50_L53_L0.7090.19
57_T318_L0.7070.19
68_L141_Y0.7010.19
6_I289_N0.7000.19
270_V300_T0.6990.19
64_S86_K0.6990.19
198_E201_E0.6980.19
37_S87_R0.6950.19
50_L83_K0.6940.19
73_K155_K0.6920.19
4_R35_R0.6910.19
60_E280_I0.6910.19
19_Y22_K0.6900.19
265_L268_S0.6890.19
37_S90_V0.6880.19
97_T114_E0.6870.19
27_N172_Q0.6870.19
92_V200_V0.6850.19
221_R242_L0.6830.19
69_Q285_V0.6820.19
210_I261_L0.6820.19
192_M248_N0.6810.19
31_I215_A0.6800.18
200_V207_M0.6780.18
14_S72_D0.6750.18
60_E302_R0.6720.18
73_K252_E0.6700.18
82_L118_F0.6700.18
133_P301_K0.6690.18
205_K209_D0.6670.18
52_E60_E0.6650.18
109_S112_P0.6650.18
117_R275_I0.6640.18
237_F241_M0.6620.18
153_E242_L0.6610.18
228_W270_V0.6590.18
115_A155_K0.6590.18
280_I309_M0.6580.18
101_K285_V0.6570.18
115_A248_N0.6560.18
125_D200_V0.6530.18
236_G246_E0.6530.18
294_V305_Y0.6510.18
220_N239_E0.6510.18
283_D321_M0.6500.18
115_A313_N0.6500.18
211_S293_S0.6470.17
102_D105_K0.6470.17
98_D199_I0.6450.17
231_R290_I0.6450.17
80_D113_E0.6440.17
115_A220_N0.6440.17
93_L192_M0.6410.17
288_E302_R0.6410.17
273_A301_K0.6400.17
3_I156_Q0.6390.17
195_S247_D0.6380.17
185_D195_S0.6380.17
83_K90_V0.6370.17
106_L109_S0.6370.17
169_I312_T0.6320.17
90_V184_I0.6300.17
280_I312_T0.6270.17
171_R252_E0.6270.17
187_S236_G0.6260.17
268_S294_V0.6250.17
12_N288_E0.6230.17
44_D47_L0.6220.17
78_I205_K0.6220.17
157_G287_Y0.6220.17
145_G287_Y0.6170.17
25_K269_Y0.6150.16
187_S246_E0.6120.16
39_P212_N0.6110.16
152_D241_M0.6110.16
14_S21_E0.6100.16
130_P247_D0.6090.16
130_P185_D0.6090.16
115_A310_I0.6090.16
5_A10_V0.6050.16
145_G179_I0.6030.16
49_K176_K0.6030.16
26_L167_D0.6030.16
236_G274_G0.6020.16
236_G276_D0.6020.16
95_K126_F0.6020.16
181_Y186_A0.6010.16
158_K175_K0.6010.16
185_D190_P0.6000.16
190_P247_D0.6000.16
310_I322_F0.6000.16
289_N309_M0.5990.16
145_G184_I0.5990.16
70_E126_F0.5980.16
12_N109_S0.5980.16
86_K144_F0.5970.16
90_V280_I0.5960.16
246_E276_D0.5940.16
246_E274_G0.5940.16
40_P138_N0.5940.16
73_K256_E0.5920.16
115_A320_K0.5910.16
38_L54_L0.5910.16
169_I256_E0.5900.16
201_E209_D0.5880.16
286_T312_T0.5880.16
73_K203_R0.5870.16
233_N269_Y0.5860.16
35_R185_D0.5820.16
35_R247_D0.5820.16
50_L165_K0.5820.16
119_A129_T0.5820.16
10_V290_I0.5820.16
188_L196_V0.5790.15
31_I200_V0.5780.15
31_I250_L0.5780.15
131_Y150_Y0.5760.15
129_T200_V0.5730.15
236_G271_C0.5720.15
237_F306_G0.5720.15
171_R302_R0.5720.15
5_A222_E0.5720.15
173_L176_K0.5710.15
172_Q270_V0.5710.15
271_C274_G0.5700.15
271_C276_D0.5700.15
158_K289_N0.5700.15
136_S200_V0.5690.15
52_E59_S0.5680.15
84_S285_V0.5670.15
293_S308_R0.5660.15
262_K290_I0.5650.15
246_E271_C0.5650.15
220_N301_K0.5640.15
210_I309_M0.5630.15
174_E313_N0.5630.15
144_F174_E0.5620.15
122_F300_T0.5620.15
185_D308_R0.5620.15
247_D308_R0.5620.15
170_G222_E0.5620.15
241_M272_V0.5620.15
103_L107_I0.5600.15
110_L207_M0.5600.15
25_K256_E0.5590.15
3_I96_T0.5590.15
133_P273_A0.5580.15
270_V302_R0.5560.15
196_V233_N0.5540.15
31_I265_L0.5530.15
72_D102_D0.5530.15
109_S180_K0.5510.15
13_Y147_S0.5500.15
179_I252_E0.5490.15
26_L179_I0.5480.15
29_N65_L0.5480.15
3_I312_T0.5460.15
145_G240_L0.5460.15
53_L113_E0.5460.15
70_E312_T0.5450.15
175_K178_N0.5440.15
43_I46_S0.5440.15
179_I196_V0.5430.14
231_R240_L0.5430.14
6_I287_Y0.5420.14
49_K285_V0.5420.14
46_S318_L0.5410.14
114_E290_I0.5400.14
207_M212_N0.5400.14
89_Y294_V0.5390.14
239_E301_K0.5380.14
140_V157_G0.5370.14
52_E206_K0.5350.14
115_A172_Q0.5350.14
36_I53_L0.5340.14
21_E295_Y0.5330.14
105_K252_E0.5330.14
107_I248_N0.5320.14
210_I260_T0.5300.14
281_Y314_G0.5260.14
254_V302_R0.5250.14
212_N279_G0.5240.14
50_L198_E0.5230.14
228_W240_L0.5220.14
83_K169_I0.5220.14
101_K113_E0.5210.14
201_E250_L0.5200.14
140_V228_W0.5190.14
201_E229_R0.5190.14
129_T250_L0.5190.14
15_K21_E0.5180.14
131_Y239_E0.5170.14
216_V245_A0.5170.14
171_R233_N0.5150.14
197_G207_M0.5150.14
69_Q72_D0.5140.14
206_K309_M0.5120.14
94_V115_A0.5110.14
72_D283_D0.5090.14
67_N72_D0.5090.14
12_N49_K0.5080.14
32_W248_N0.5080.14
174_E206_K0.5080.14
3_I210_I0.5060.14
141_Y207_M0.5060.14
115_A299_Y0.5050.14
101_K180_K0.5050.14
115_A302_R0.5040.13
110_L280_I0.5040.13
50_L158_K0.5040.13
150_Y245_A0.5030.13
3_I203_R0.5020.13
50_L145_G0.5010.13
151_V323_G0.5010.13
26_L197_G0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ha9A 3 0.9426 100 0.156 Contact Map
2cxiA 3 0.1843 28.6 0.971 Contact Map
2yr1A 2 0.6465 22.1 0.973 Contact Map
2mu0A 1 0.2931 17.4 0.974 Contact Map
1y80A 1 0.145 14.6 0.975 Contact Map
1rw1A 1 0.284 13.9 0.975 Contact Map
3ke3A 2 0.1843 12.5 0.976 Contact Map
3rdwA 1 0.3233 12.5 0.976 Contact Map
2bwnA 2 0.1813 12.1 0.976 Contact Map
4e9jA 2 0.3384 11.9 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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