Q980F2 - SULSO - GREMLIN Contacts

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Q980F2 - Cysteine synthase B (CysM)

UniProt:	Q980F2	Sequences: MSNPLHVFSNEQELLEGMWPTPLLKLRIGNDTWAKLEFYNPFSRSVKDRTAWFLFRQALLKNATHIVEATSGNTGIALASLSSIFGMRFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTNDVIPLVKKFAEMTNALNLDQFNNPINVIAHYETTAREIDEQLSSIGKKPSRIIATMGTGGHIAGIAKYFKEKYGNDVEIIGVQPSENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAIDGTISVARTSGILIGISAGATVAAYKKISDVSSTTVLIFPDDAFKYVDILEQTLKEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (270)
Sequences:	21088 (11183)
Seq/√Len:	680.6

ECOLI - ILVA CYSM CYSK TDCB DPAL SDHD TRPB DCYD THRC
BACSU - ILVA CYSM CYSK MCCA TRPB THRC SDHD
HALSA - Q9HNH6 Q9HQ70 Q9HRU4 Q9HMQ7 TRPB Q9HNH0 Q9HRP3
SULSO - Q980F2 Q980P1 TRPB2 TRPB1 Q97ZL6 Q97ZT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
82_S	89_F	3.912	1.00
31_D	274_T	3.406	1.00
125_L	128_K	3.273	1.00
25_K	31_D	3.067	1.00
99_K	103_V	2.626	1.00
171_R	200_I	2.621	1.00
238_E	267_K	2.609	1.00
158_I	276_V	2.581	1.00
245_S	249_T	2.547	1.00
65_H	90_T	2.512	1.00
92_F	129_F	2.490	1.00
95_V	116_G	2.439	1.00
20_P	160_E	2.412	1.00
205_S	235_S	2.390	1.00
88_R	111_N	2.336	1.00
90_T	111_N	2.322	1.00
57_Q	145_I	2.295	1.00
198_E	230_R	2.278	1.00
193_Y	196_D	2.155	1.00
90_T	113_I	2.119	1.00
20_P	161_Q	2.103	1.00
148_I	152_E	2.077	1.00
33_W	274_T	2.065	1.00
186_A	227_K	2.053	1.00
56_R	85_F	2.033	1.00
235_S	238_E	2.030	1.00
206_E	236_L	2.018	1.00
261_T	277_L	2.008	1.00
156_R	188_Y	1.984	1.00
186_A	199_I	1.955	1.00
139_D	142_N	1.934	1.00
193_Y	197_V	1.901	1.00
151_Y	191_E	1.865	1.00
142_N	221_S	1.854	1.00
23_L	276_V	1.854	1.00
176_M	201_G	1.827	1.00
202_V	264_A	1.810	1.00
200_I	230_R	1.790	1.00
172_I	189_F	1.769	1.00
246_V	254_I	1.737	1.00
170_S	274_T	1.729	1.00
42_F	80_S	1.718	1.00
151_Y	187_K	1.712	1.00
65_H	88_R	1.705	1.00
245_S	266_K	1.668	1.00
33_W	162_L	1.668	1.00
169_P	276_V	1.666	1.00
25_K	33_W	1.644	1.00
242_G	263_A	1.634	1.00
102_K	114_E	1.619	1.00
172_I	185_I	1.610	1.00
128_K	132_M	1.602	1.00
170_S	273_S	1.580	1.00
171_R	273_S	1.580	1.00
52_W	56_R	1.574	1.00
246_V	262_V	1.561	1.00
230_R	271_V	1.536	1.00
34_A	279_F	1.524	1.00
190_K	229_D	1.519	1.00
155_A	185_I	1.511	1.00
159_D	192_K	1.506	1.00
70_T	75_G	1.495	1.00
103_V	106_K	1.493	1.00
55_F	66_I	1.441	1.00
123_I	127_K	1.439	1.00
102_K	106_K	1.426	1.00
242_G	266_K	1.418	1.00
117_N	121_D	1.413	1.00
113_I	125_L	1.397	1.00
127_K	130_A	1.392	1.00
99_K	102_K	1.390	1.00
171_R	198_E	1.381	1.00
173_I	268_I	1.380	1.00
54_L	143_N	1.360	1.00
173_I	202_V	1.357	1.00
155_A	189_F	1.348	1.00
182_I	228_I	1.333	1.00
205_S	233_D	1.314	1.00
263_A	267_K	1.305	1.00
219_S	260_A	1.296	1.00
268_I	271_V	1.291	1.00
238_E	263_A	1.289	1.00
132_M	135_A	1.286	1.00
162_L	169_P	1.274	1.00
105_V	110_G	1.269	1.00
118_S	121_D	1.257	1.00
53_F	152_E	1.256	1.00
155_A	188_Y	1.256	1.00
93_L	105_V	1.255	1.00
208_S	233_D	1.251	1.00
254_I	279_F	1.243	1.00
241_D	245_S	1.225	1.00
188_Y	192_K	1.217	1.00
214_K	217_N	1.217	1.00
26_L	34_A	1.215	1.00
159_D	188_Y	1.210	1.00
242_G	262_V	1.200	1.00
22_P	39_Y	1.198	1.00
182_I	199_I	1.196	1.00
120_N	124_P	1.196	1.00
258_A	279_F	1.195	1.00
102_K	112_V	1.187	1.00
125_L	129_F	1.183	1.00
23_L	162_L	1.182	1.00
267_K	270_D	1.174	1.00
168_K	274_T	1.168	1.00
24_L	36_L	1.165	1.00
187_K	224_R	1.165	1.00
232_V	264_A	1.163	1.00
189_F	197_V	1.156	1.00
156_R	160_E	1.140	1.00
13_E	16_E	1.128	1.00
75_G	105_V	1.124	1.00
201_G	231_V	1.122	1.00
92_F	125_L	1.121	1.00
171_R	275_T	1.121	1.00
53_F	149_A	1.113	1.00
59_L	62_N	1.110	1.00
238_E	241_D	1.107	1.00
13_E	53_F	1.105	1.00
247_A	253_L	1.095	1.00
30_N	273_S	1.095	1.00
182_I	201_G	1.090	1.00
200_I	232_V	1.090	1.00
23_L	158_I	1.087	1.00
121_D	124_P	1.080	1.00
162_L	276_V	1.071	1.00
234_V	263_A	1.071	1.00
216_Q	240_I	1.061	1.00
129_F	132_M	1.059	1.00
215_R	220_N	1.052	1.00
65_H	135_A	1.050	1.00
124_P	128_K	1.049	1.00
124_P	127_K	1.042	1.00
53_F	57_Q	1.036	1.00
237_E	241_D	1.033	1.00
93_L	114_E	1.033	1.00
32_T	265_Y	1.029	1.00
53_F	56_R	1.028	1.00
159_D	193_Y	1.026	1.00
163_S	168_K	1.019	1.00
55_F	85_F	1.014	1.00
95_V	117_N	1.011	1.00
62_N	87_M	1.009	1.00
243_T	259_G	1.005	1.00
60_L	64_T	1.003	1.00
150_H	154_T	1.001	1.00
244_I	248_R	0.999	1.00
185_I	278_I	0.997	1.00
67_V	135_A	0.996	1.00
80_S	108_L	0.996	1.00
106_K	111_N	0.996	1.00
54_L	138_L	0.994	1.00
30_N	272_S	0.991	1.00
158_I	169_P	0.991	1.00
128_K	131_E	0.988	1.00
66_I	82_S	0.986	1.00
51_A	77_A	0.985	1.00
78_L	89_F	0.974	1.00
55_F	81_L	0.970	1.00
139_D	143_N	0.969	1.00
265_Y	277_L	0.966	1.00
198_E	229_D	0.966	1.00
119_T	122_V	0.963	1.00
83_S	89_F	0.948	1.00
77_A	81_L	0.941	1.00
152_E	156_R	0.935	1.00
79_A	110_G	0.933	1.00
232_V	267_K	0.931	1.00
68_E	91_M	0.925	1.00
176_M	182_I	0.912	1.00
173_I	265_Y	0.912	1.00
60_L	63_A	0.909	1.00
67_V	129_F	0.909	1.00
188_Y	191_E	0.907	1.00
64_T	134_N	0.901	1.00
129_F	133_T	0.898	1.00
254_I	258_A	0.894	1.00
156_R	192_K	0.894	1.00
151_Y	188_Y	0.885	1.00
58_A	136_L	0.885	1.00
61_K	64_T	0.884	1.00
258_A	280_P	0.881	1.00
174_A	185_I	0.877	1.00
242_G	245_S	0.862	1.00
17_G	52_W	0.849	1.00
253_L	283_A	0.846	1.00
90_T	129_F	0.844	1.00
26_L	250_S	0.843	1.00
36_L	279_F	0.843	1.00
59_L	63_A	0.831	1.00
67_V	126_V	0.829	1.00
162_L	274_T	0.828	1.00
171_R	268_I	0.828	1.00
103_V	107_L	0.827	1.00
57_Q	148_I	0.826	1.00
262_V	279_F	0.825	1.00
106_K	114_E	0.820	1.00
261_T	280_P	0.817	1.00
173_I	200_I	0.815	1.00
126_V	137_N	0.814	1.00
182_I	224_R	0.812	1.00
198_E	273_S	0.812	1.00
26_L	262_V	0.811	1.00
21_T	40_N	0.798	1.00
76_I	105_V	0.798	1.00
232_V	271_V	0.797	1.00
154_T	185_I	0.797	1.00
53_F	145_I	0.796	1.00
117_N	124_P	0.789	1.00
69_A	119_T	0.787	1.00
36_L	39_Y	0.787	1.00
224_R	227_K	0.783	1.00
83_S	108_L	0.781	1.00
159_D	189_F	0.780	1.00
211_P	214_K	0.780	1.00
80_S	84_I	0.780	1.00
154_T	181_H	0.773	1.00
187_K	191_E	0.766	1.00
127_K	131_E	0.764	1.00
91_M	105_V	0.762	1.00
115_A	125_L	0.757	1.00
183_A	222_L	0.757	1.00
64_T	88_R	0.754	1.00
173_I	264_A	0.754	1.00
90_T	135_A	0.754	1.00
266_K	270_D	0.750	1.00
159_D	163_S	0.748	1.00
31_D	272_S	0.748	1.00
148_I	187_K	0.745	1.00
149_A	152_E	0.745	1.00
225_D	228_I	0.742	1.00
62_N	65_H	0.742	1.00
66_I	87_M	0.740	1.00
154_T	278_I	0.736	1.00
30_N	275_T	0.735	1.00
216_Q	219_S	0.732	1.00
262_V	277_L	0.729	1.00
76_I	104_F	0.723	1.00
239_A	260_A	0.721	1.00
176_M	231_V	0.718	1.00
210_I	224_R	0.714	1.00
240_I	256_I	0.713	1.00
89_F	110_G	0.712	1.00
34_A	277_L	0.712	1.00
88_R	135_A	0.711	1.00
267_K	271_V	0.709	1.00
185_I	189_F	0.707	1.00
92_F	113_I	0.706	1.00
254_I	259_G	0.705	1.00
169_P	197_V	0.703	1.00
168_K	193_Y	0.701	1.00
46_V	181_H	0.700	1.00
213_I	217_N	0.699	1.00
215_R	236_L	0.698	1.00
69_A	137_N	0.698	1.00
18_M	48_D	0.695	1.00
130_A	133_T	0.695	1.00
51_A	81_L	0.694	1.00
44_R	282_D	0.693	1.00
95_V	114_E	0.692	1.00
65_H	129_F	0.691	1.00
210_I	231_V	0.690	1.00
30_N	269_S	0.690	1.00
34_A	262_V	0.682	1.00
230_R	268_I	0.682	1.00
148_I	151_Y	0.682	1.00
100_V	288_D	0.679	1.00
92_F	115_A	0.675	1.00
264_A	268_I	0.675	1.00
68_E	78_L	0.670	1.00
158_I	185_I	0.668	1.00
54_L	145_I	0.668	1.00
175_T	280_P	0.668	1.00
14_L	17_G	0.667	1.00
99_K	106_K	0.662	1.00
212_G	217_N	0.660	1.00
224_R	228_I	0.659	1.00
160_E	192_K	0.659	1.00
222_L	226_V	0.658	1.00
154_T	158_I	0.657	1.00
42_F	45_S	0.657	1.00
173_I	275_T	0.656	1.00
246_V	279_F	0.651	1.00
50_T	54_L	0.646	1.00
172_I	278_I	0.645	1.00
127_K	137_N	0.645	1.00
159_D	162_L	0.644	1.00
172_I	197_V	0.640	1.00
19_W	41_P	0.640	1.00
75_G	91_M	0.636	1.00
222_L	225_D	0.635	1.00
23_L	33_W	0.634	1.00
174_A	182_I	0.631	1.00
121_D	125_L	0.630	1.00
246_V	250_S	0.630	1.00
175_T	261_T	0.629	1.00
119_T	123_I	0.621	1.00
42_F	108_L	0.620	1.00
93_L	97_A	0.620	1.00
54_L	136_L	0.619	1.00
35_K	157_E	0.618	1.00
97_A	102_K	0.616	1.00
200_I	268_I	0.616	1.00
169_P	274_T	0.615	1.00
202_V	232_V	0.614	1.00
118_S	122_V	0.611	1.00
190_K	227_K	0.610	1.00
202_V	260_A	0.609	1.00
176_M	210_I	0.607	1.00
149_A	187_K	0.606	1.00
243_T	285_K	0.604	1.00
38_F	282_D	0.604	1.00
93_L	102_K	0.603	1.00
129_F	135_A	0.603	1.00
36_L	252_I	0.601	1.00
72_G	75_G	0.600	1.00
243_T	256_I	0.600	1.00
217_N	239_A	0.600	1.00
236_L	240_I	0.597	1.00
79_A	105_V	0.597	1.00
212_G	215_R	0.595	1.00
48_D	80_S	0.592	1.00
66_I	89_F	0.590	1.00
246_V	252_I	0.587	1.00
13_E	56_R	0.587	1.00
262_V	266_K	0.587	1.00
65_H	111_N	0.585	1.00
78_L	138_L	0.585	1.00
203_Q	209_R	0.582	1.00
213_I	219_S	0.581	1.00
90_T	133_T	0.579	1.00
61_K	136_L	0.579	1.00
60_L	66_I	0.578	1.00
201_G	228_I	0.577	1.00
97_A	100_V	0.576	1.00
221_S	225_D	0.575	1.00
213_I	216_Q	0.574	1.00
111_N	133_T	0.574	1.00
172_I	199_I	0.573	1.00
113_I	129_F	0.572	1.00
104_F	107_L	0.572	1.00
38_F	252_I	0.572	1.00
54_L	147_V	0.569	1.00
19_W	40_N	0.569	1.00
216_Q	220_N	0.568	1.00
69_A	126_V	0.566	1.00
68_E	74_T	0.565	1.00
79_A	89_F	0.562	1.00
147_V	151_Y	0.561	1.00
18_M	52_W	0.560	1.00
183_A	187_K	0.558	1.00
50_T	74_T	0.557	1.00
67_V	137_N	0.555	1.00
145_I	149_A	0.554	1.00
162_L	168_K	0.554	1.00
41_P	48_D	0.552	1.00
50_T	147_V	0.552	1.00
61_K	134_N	0.548	1.00
63_A	134_N	0.547	1.00
147_V	222_L	0.546	1.00
78_L	91_M	0.546	1.00
67_V	92_F	0.540	1.00
17_G	39_Y	0.540	1.00
70_T	91_M	0.539	1.00
258_A	261_T	0.539	1.00
241_D	244_I	0.539	1.00
200_I	229_D	0.539	1.00
190_K	226_V	0.538	1.00
123_I	126_V	0.535	1.00
34_A	246_V	0.535	1.00
265_Y	269_S	0.533	1.00
168_K	196_D	0.532	1.00
212_G	216_Q	0.529	1.00
205_S	208_S	0.528	1.00
236_L	239_A	0.526	1.00
217_N	220_N	0.526	1.00
29_G	272_S	0.526	1.00
119_T	140_Q	0.525	1.00
74_T	138_L	0.523	1.00
92_F	126_V	0.523	1.00
223_L	228_I	0.521	0.99
23_L	161_Q	0.521	0.99
26_L	246_V	0.520	0.99
234_V	260_A	0.519	0.99
185_I	188_Y	0.519	0.99
53_F	148_I	0.516	0.99
169_P	193_Y	0.516	0.99
66_I	138_L	0.516	0.99
69_A	138_L	0.516	0.99
235_S	267_K	0.514	0.99
59_L	136_L	0.513	0.99
122_V	126_V	0.513	0.99
136_L	141_F	0.513	0.99
91_M	110_G	0.511	0.99
158_I	172_I	0.511	0.99
88_R	133_T	0.508	0.99
214_K	218_G	0.506	0.99
200_I	264_A	0.506	0.99
24_L	250_S	0.505	0.99
241_D	248_R	0.504	0.99
185_I	199_I	0.504	0.99
159_D	197_V	0.501	0.99
17_G	56_R	0.500	0.99
54_L	57_Q	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gn0A	2	0.9663	100	0.172	Contact Map
1v71A	2	0.9697	100	0.181	Contact Map
1ve5A	3	0.9428	100	0.188	Contact Map
3l6bA	2	0.9663	100	0.189	Contact Map
3tbhA	2	0.9798	100	0.196	Contact Map
1tdjA	2	0.9663	100	0.197	Contact Map
2q3bA	2	0.9259	100	0.197	Contact Map
4r2vA	2	0.9461	100	0.199	Contact Map
4lmbA	2	0.9461	100	0.199	Contact Map
4ql4A	2	0.8687	100	0.2	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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