GREMLIN Database
Q980F2 - Cysteine synthase B (CysM)
UniProt: Q980F2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (270)
Sequences: 21088 (11183)
Seq/√Len: 680.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_S89_F3.9121.00
31_D274_T3.4061.00
125_L128_K3.2731.00
25_K31_D3.0671.00
99_K103_V2.6261.00
171_R200_I2.6211.00
238_E267_K2.6091.00
158_I276_V2.5811.00
245_S249_T2.5471.00
65_H90_T2.5121.00
92_F129_F2.4901.00
95_V116_G2.4391.00
20_P160_E2.4121.00
205_S235_S2.3901.00
88_R111_N2.3361.00
90_T111_N2.3221.00
57_Q145_I2.2951.00
198_E230_R2.2781.00
193_Y196_D2.1551.00
90_T113_I2.1191.00
20_P161_Q2.1031.00
148_I152_E2.0771.00
33_W274_T2.0651.00
186_A227_K2.0531.00
56_R85_F2.0331.00
235_S238_E2.0301.00
206_E236_L2.0181.00
261_T277_L2.0081.00
156_R188_Y1.9841.00
186_A199_I1.9551.00
139_D142_N1.9341.00
193_Y197_V1.9011.00
151_Y191_E1.8651.00
142_N221_S1.8541.00
23_L276_V1.8541.00
176_M201_G1.8271.00
202_V264_A1.8101.00
200_I230_R1.7901.00
172_I189_F1.7691.00
246_V254_I1.7371.00
170_S274_T1.7291.00
42_F80_S1.7181.00
151_Y187_K1.7121.00
65_H88_R1.7051.00
245_S266_K1.6681.00
33_W162_L1.6681.00
169_P276_V1.6661.00
25_K33_W1.6441.00
242_G263_A1.6341.00
102_K114_E1.6191.00
172_I185_I1.6101.00
128_K132_M1.6021.00
170_S273_S1.5801.00
171_R273_S1.5801.00
52_W56_R1.5741.00
246_V262_V1.5611.00
230_R271_V1.5361.00
34_A279_F1.5241.00
190_K229_D1.5191.00
155_A185_I1.5111.00
159_D192_K1.5061.00
70_T75_G1.4951.00
103_V106_K1.4931.00
55_F66_I1.4411.00
123_I127_K1.4391.00
102_K106_K1.4261.00
242_G266_K1.4181.00
117_N121_D1.4131.00
113_I125_L1.3971.00
127_K130_A1.3921.00
99_K102_K1.3901.00
171_R198_E1.3811.00
173_I268_I1.3801.00
54_L143_N1.3601.00
173_I202_V1.3571.00
155_A189_F1.3481.00
182_I228_I1.3331.00
205_S233_D1.3141.00
263_A267_K1.3051.00
219_S260_A1.2961.00
268_I271_V1.2911.00
238_E263_A1.2891.00
132_M135_A1.2861.00
162_L169_P1.2741.00
105_V110_G1.2691.00
118_S121_D1.2571.00
53_F152_E1.2561.00
155_A188_Y1.2561.00
93_L105_V1.2551.00
208_S233_D1.2511.00
254_I279_F1.2431.00
241_D245_S1.2251.00
188_Y192_K1.2171.00
214_K217_N1.2171.00
26_L34_A1.2151.00
159_D188_Y1.2101.00
242_G262_V1.2001.00
22_P39_Y1.1981.00
182_I199_I1.1961.00
120_N124_P1.1961.00
258_A279_F1.1951.00
102_K112_V1.1871.00
125_L129_F1.1831.00
23_L162_L1.1821.00
267_K270_D1.1741.00
168_K274_T1.1681.00
24_L36_L1.1651.00
187_K224_R1.1651.00
232_V264_A1.1631.00
189_F197_V1.1561.00
156_R160_E1.1401.00
13_E16_E1.1281.00
75_G105_V1.1241.00
201_G231_V1.1221.00
92_F125_L1.1211.00
171_R275_T1.1211.00
53_F149_A1.1131.00
59_L62_N1.1101.00
238_E241_D1.1071.00
13_E53_F1.1051.00
247_A253_L1.0951.00
30_N273_S1.0951.00
182_I201_G1.0901.00
200_I232_V1.0901.00
23_L158_I1.0871.00
121_D124_P1.0801.00
162_L276_V1.0711.00
234_V263_A1.0711.00
216_Q240_I1.0611.00
129_F132_M1.0591.00
215_R220_N1.0521.00
65_H135_A1.0501.00
124_P128_K1.0491.00
124_P127_K1.0421.00
53_F57_Q1.0361.00
237_E241_D1.0331.00
93_L114_E1.0331.00
32_T265_Y1.0291.00
53_F56_R1.0281.00
159_D193_Y1.0261.00
163_S168_K1.0191.00
55_F85_F1.0141.00
95_V117_N1.0111.00
62_N87_M1.0091.00
243_T259_G1.0051.00
60_L64_T1.0031.00
150_H154_T1.0011.00
244_I248_R0.9991.00
185_I278_I0.9971.00
67_V135_A0.9961.00
80_S108_L0.9961.00
106_K111_N0.9961.00
54_L138_L0.9941.00
30_N272_S0.9911.00
158_I169_P0.9911.00
128_K131_E0.9881.00
66_I82_S0.9861.00
51_A77_A0.9851.00
78_L89_F0.9741.00
55_F81_L0.9701.00
139_D143_N0.9691.00
265_Y277_L0.9661.00
198_E229_D0.9661.00
119_T122_V0.9631.00
83_S89_F0.9481.00
77_A81_L0.9411.00
152_E156_R0.9351.00
79_A110_G0.9331.00
232_V267_K0.9311.00
68_E91_M0.9251.00
176_M182_I0.9121.00
173_I265_Y0.9121.00
60_L63_A0.9091.00
67_V129_F0.9091.00
188_Y191_E0.9071.00
64_T134_N0.9011.00
129_F133_T0.8981.00
254_I258_A0.8941.00
156_R192_K0.8941.00
151_Y188_Y0.8851.00
58_A136_L0.8851.00
61_K64_T0.8841.00
258_A280_P0.8811.00
174_A185_I0.8771.00
242_G245_S0.8621.00
17_G52_W0.8491.00
253_L283_A0.8461.00
90_T129_F0.8441.00
26_L250_S0.8431.00
36_L279_F0.8431.00
59_L63_A0.8311.00
67_V126_V0.8291.00
162_L274_T0.8281.00
171_R268_I0.8281.00
103_V107_L0.8271.00
57_Q148_I0.8261.00
262_V279_F0.8251.00
106_K114_E0.8201.00
261_T280_P0.8171.00
173_I200_I0.8151.00
126_V137_N0.8141.00
182_I224_R0.8121.00
198_E273_S0.8121.00
26_L262_V0.8111.00
21_T40_N0.7981.00
76_I105_V0.7981.00
232_V271_V0.7971.00
154_T185_I0.7971.00
53_F145_I0.7961.00
117_N124_P0.7891.00
69_A119_T0.7871.00
36_L39_Y0.7871.00
224_R227_K0.7831.00
83_S108_L0.7811.00
159_D189_F0.7801.00
211_P214_K0.7801.00
80_S84_I0.7801.00
154_T181_H0.7731.00
187_K191_E0.7661.00
127_K131_E0.7641.00
91_M105_V0.7621.00
115_A125_L0.7571.00
183_A222_L0.7571.00
64_T88_R0.7541.00
173_I264_A0.7541.00
90_T135_A0.7541.00
266_K270_D0.7501.00
159_D163_S0.7481.00
31_D272_S0.7481.00
148_I187_K0.7451.00
149_A152_E0.7451.00
225_D228_I0.7421.00
62_N65_H0.7421.00
66_I87_M0.7401.00
154_T278_I0.7361.00
30_N275_T0.7351.00
216_Q219_S0.7321.00
262_V277_L0.7291.00
76_I104_F0.7231.00
239_A260_A0.7211.00
176_M231_V0.7181.00
210_I224_R0.7141.00
240_I256_I0.7131.00
89_F110_G0.7121.00
34_A277_L0.7121.00
88_R135_A0.7111.00
267_K271_V0.7091.00
185_I189_F0.7071.00
92_F113_I0.7061.00
254_I259_G0.7051.00
169_P197_V0.7031.00
168_K193_Y0.7011.00
46_V181_H0.7001.00
213_I217_N0.6991.00
215_R236_L0.6981.00
69_A137_N0.6981.00
18_M48_D0.6951.00
130_A133_T0.6951.00
51_A81_L0.6941.00
44_R282_D0.6931.00
95_V114_E0.6921.00
65_H129_F0.6911.00
210_I231_V0.6901.00
30_N269_S0.6901.00
34_A262_V0.6821.00
230_R268_I0.6821.00
148_I151_Y0.6821.00
100_V288_D0.6791.00
92_F115_A0.6751.00
264_A268_I0.6751.00
68_E78_L0.6701.00
158_I185_I0.6681.00
54_L145_I0.6681.00
175_T280_P0.6681.00
14_L17_G0.6671.00
99_K106_K0.6621.00
212_G217_N0.6601.00
224_R228_I0.6591.00
160_E192_K0.6591.00
222_L226_V0.6581.00
154_T158_I0.6571.00
42_F45_S0.6571.00
173_I275_T0.6561.00
246_V279_F0.6511.00
50_T54_L0.6461.00
172_I278_I0.6451.00
127_K137_N0.6451.00
159_D162_L0.6441.00
172_I197_V0.6401.00
19_W41_P0.6401.00
75_G91_M0.6361.00
222_L225_D0.6351.00
23_L33_W0.6341.00
174_A182_I0.6311.00
121_D125_L0.6301.00
246_V250_S0.6301.00
175_T261_T0.6291.00
119_T123_I0.6211.00
42_F108_L0.6201.00
93_L97_A0.6201.00
54_L136_L0.6191.00
35_K157_E0.6181.00
97_A102_K0.6161.00
200_I268_I0.6161.00
169_P274_T0.6151.00
202_V232_V0.6141.00
118_S122_V0.6111.00
190_K227_K0.6101.00
202_V260_A0.6091.00
176_M210_I0.6071.00
149_A187_K0.6061.00
243_T285_K0.6041.00
38_F282_D0.6041.00
93_L102_K0.6031.00
129_F135_A0.6031.00
36_L252_I0.6011.00
72_G75_G0.6001.00
243_T256_I0.6001.00
217_N239_A0.6001.00
236_L240_I0.5971.00
79_A105_V0.5971.00
212_G215_R0.5951.00
48_D80_S0.5921.00
66_I89_F0.5901.00
246_V252_I0.5871.00
13_E56_R0.5871.00
262_V266_K0.5871.00
65_H111_N0.5851.00
78_L138_L0.5851.00
203_Q209_R0.5821.00
213_I219_S0.5811.00
90_T133_T0.5791.00
61_K136_L0.5791.00
60_L66_I0.5781.00
201_G228_I0.5771.00
97_A100_V0.5761.00
221_S225_D0.5751.00
213_I216_Q0.5741.00
111_N133_T0.5741.00
172_I199_I0.5731.00
113_I129_F0.5721.00
104_F107_L0.5721.00
38_F252_I0.5721.00
54_L147_V0.5691.00
19_W40_N0.5691.00
216_Q220_N0.5681.00
69_A126_V0.5661.00
68_E74_T0.5651.00
79_A89_F0.5621.00
147_V151_Y0.5611.00
18_M52_W0.5601.00
183_A187_K0.5581.00
50_T74_T0.5571.00
67_V137_N0.5551.00
145_I149_A0.5541.00
162_L168_K0.5541.00
41_P48_D0.5521.00
50_T147_V0.5521.00
61_K134_N0.5481.00
63_A134_N0.5471.00
147_V222_L0.5461.00
78_L91_M0.5461.00
67_V92_F0.5401.00
17_G39_Y0.5401.00
70_T91_M0.5391.00
258_A261_T0.5391.00
241_D244_I0.5391.00
200_I229_D0.5391.00
190_K226_V0.5381.00
123_I126_V0.5351.00
34_A246_V0.5351.00
265_Y269_S0.5331.00
168_K196_D0.5321.00
212_G216_Q0.5291.00
205_S208_S0.5281.00
236_L239_A0.5261.00
217_N220_N0.5261.00
29_G272_S0.5261.00
119_T140_Q0.5251.00
74_T138_L0.5231.00
92_F126_V0.5231.00
223_L228_I0.5210.99
23_L161_Q0.5210.99
26_L246_V0.5200.99
234_V260_A0.5190.99
185_I188_Y0.5190.99
53_F148_I0.5160.99
169_P193_Y0.5160.99
66_I138_L0.5160.99
69_A138_L0.5160.99
235_S267_K0.5140.99
59_L136_L0.5130.99
122_V126_V0.5130.99
136_L141_F0.5130.99
91_M110_G0.5110.99
158_I172_I0.5110.99
88_R133_T0.5080.99
214_K218_G0.5060.99
200_I264_A0.5060.99
24_L250_S0.5050.99
241_D248_R0.5040.99
185_I199_I0.5040.99
159_D197_V0.5010.99
17_G56_R0.5000.99
54_L57_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gn0A 2 0.9663 100 0.172 Contact Map
1v71A 2 0.9697 100 0.181 Contact Map
1ve5A 3 0.9428 100 0.188 Contact Map
3l6bA 2 0.9663 100 0.189 Contact Map
3tbhA 2 0.9798 100 0.196 Contact Map
1tdjA 2 0.9663 100 0.197 Contact Map
2q3bA 2 0.9259 100 0.197 Contact Map
4r2vA 2 0.9461 100 0.199 Contact Map
4lmbA 2 0.9461 100 0.199 Contact Map
4ql4A 2 0.8687 100 0.2 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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