GREMLIN Database
MOAA - Probable cyclic pyranopterin monophosphate synthase
UniProt: Q980F0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (274)
Sequences: 11641 (8826)
Seq/√Len: 533.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_F94_F4.2201.00
45_L78_G3.5791.00
140_K174_L3.5661.00
245_C262_C2.9071.00
101_H145_V2.7781.00
119_S133_D2.7611.00
73_V102_K2.7311.00
49_K78_G2.7271.00
40_S43_D2.5811.00
21_N92_N2.5741.00
43_D276_L2.4791.00
97_K141_S2.4521.00
49_K82_L2.3841.00
141_S144_D2.3251.00
122_T163_E2.2141.00
101_H105_L2.2111.00
80_K109_D2.1931.00
116_H127_T2.1851.00
258_K274_D2.1471.00
73_V99_L2.0811.00
46_L50_V2.0751.00
99_L102_K2.0651.00
258_K271_D2.0491.00
12_L51_A1.9741.00
154_F167_F1.9721.00
124_K130_D1.9601.00
48_A79_L1.9351.00
163_E166_K1.9051.00
152_L171_S1.9031.00
78_G81_Q1.8081.00
19_A38_L1.7861.00
132_F136_I1.7771.00
41_K74_E1.7701.00
44_I75_I1.7671.00
74_E77_R1.7461.00
118_V163_E1.7411.00
132_F170_L1.7341.00
71_D74_E1.7281.00
102_K105_L1.7231.00
21_N95_L1.7101.00
141_S145_V1.6901.00
118_V122_T1.6731.00
61_L79_L1.6711.00
93_G113_I1.6501.00
137_E140_K1.6391.00
77_R102_K1.6171.00
119_S163_E1.6151.00
26_F116_H1.6141.00
41_K45_L1.5931.00
117_A122_T1.5891.00
140_K143_I1.5791.00
102_K106_A1.5721.00
254_S260_K1.5681.00
254_S258_K1.5621.00
133_D137_E1.5611.00
279_E282_E1.5591.00
43_D46_L1.5561.00
170_L174_L1.5311.00
169_E173_N1.5271.00
166_K169_E1.5241.00
67_T89_M1.5101.00
165_F209_K1.5091.00
140_K144_D1.5051.00
113_I138_G1.4981.00
271_D274_D1.4971.00
41_K71_D1.4901.00
78_G82_L1.4861.00
134_R137_E1.4681.00
158_R202_E1.4671.00
278_G282_E1.4601.00
52_R82_L1.4601.00
77_R81_Q1.4481.00
143_I175_G1.4361.00
125_K159_R1.4161.00
25_F125_K1.4051.00
45_L49_K1.3751.00
104_K145_V1.3701.00
169_E210_I1.3701.00
80_K87_V1.3641.00
113_I139_I1.3581.00
135_V138_G1.3571.00
10_E57_N1.3541.00
97_K144_D1.3471.00
274_D277_K1.3441.00
97_K137_E1.3411.00
100_A104_K1.3311.00
100_A141_S1.3221.00
123_F135_V1.3171.00
59_V79_L1.3001.00
205_E209_K1.2961.00
143_I174_L1.2941.00
67_T95_L1.2651.00
122_T162_E1.2641.00
38_L69_R1.2611.00
90_T112_N1.2551.00
16_L61_L1.2531.00
275_I288_L1.2381.00
136_I140_K1.2371.00
52_R84_Y1.2361.00
45_L74_E1.2321.00
79_L87_V1.2321.00
123_F131_A1.2251.00
50_V279_E1.2101.00
61_L76_V1.2081.00
199_D202_E1.2011.00
154_F179_I1.1991.00
259_L283_D1.1971.00
61_L87_V1.1881.00
111_I142_A1.1841.00
69_R75_I1.1761.00
76_V108_L1.1721.00
136_I170_L1.1551.00
137_E141_S1.1541.00
100_A138_G1.1461.00
204_E208_E1.1431.00
122_T125_K1.1251.00
14_I44_I1.1101.00
124_K131_A1.1081.00
281_S284_V1.0971.00
39_L43_D1.0821.00
143_I176_V1.0811.00
202_E205_E1.0791.00
126_I157_N1.0571.00
206_Y209_K1.0561.00
152_L176_V1.0531.00
280_Y284_V1.0531.00
73_V77_R1.0451.00
169_E213_K1.0431.00
201_R205_E1.0421.00
169_E172_Q1.0421.00
16_L72_L1.0411.00
278_G283_D1.0351.00
165_F169_E1.0261.00
41_K78_G1.0221.00
100_A145_V1.0221.00
205_E208_E1.0161.00
202_E206_Y1.0151.00
51_A59_V1.0141.00
118_V170_L1.0131.00
74_E78_G1.0101.00
119_S124_K1.0051.00
121_D125_K1.0031.00
117_A132_F0.9901.00
50_V54_F0.9881.00
104_K147_L0.9871.00
171_S176_V0.9851.00
119_S166_K0.9821.00
112_N153_N0.9801.00
97_K145_V0.9721.00
67_T72_L0.9701.00
143_I150_V0.9691.00
45_L81_Q0.9651.00
39_L44_I0.9631.00
281_S285_K0.9601.00
48_A82_L0.9541.00
139_I176_V0.9531.00
138_G141_S0.9531.00
26_F126_I0.9511.00
131_A134_R0.9501.00
119_S122_T0.9491.00
53_K286_E0.9461.00
76_V106_A0.9461.00
18_H255_V0.9461.00
113_I142_A0.9321.00
72_L76_V0.9241.00
80_K106_A0.9231.00
58_S88_S0.9211.00
136_I174_L0.9151.00
221_F225_Y0.9121.00
48_A59_V0.9091.00
77_R106_A0.9051.00
111_I147_L0.8971.00
37_Y256_D0.8941.00
14_I253_L0.8931.00
41_K75_I0.8911.00
282_E286_E0.8901.00
28_H62_T0.8881.00
16_L75_I0.8831.00
123_F127_T0.8791.00
21_N65_E0.8791.00
178_E232_I0.8781.00
114_S155_V0.8721.00
58_S86_D0.8661.00
47_V253_L0.8651.00
72_L89_M0.8581.00
12_L251_I0.8581.00
51_A56_I0.8551.00
96_L138_G0.8521.00
171_S179_I0.8521.00
46_L276_L0.8521.00
98_D101_H0.8461.00
17_T38_L0.8431.00
89_M108_L0.8421.00
86_D110_R0.8411.00
156_V164_A0.8401.00
209_K213_K0.8391.00
278_G286_E0.8381.00
59_V84_Y0.8311.00
25_F126_I0.8311.00
115_L152_L0.8291.00
139_I152_L0.8281.00
45_L82_L0.8281.00
46_L49_K0.8271.00
71_D75_I0.8261.00
39_L47_V0.8231.00
65_E92_N0.8211.00
15_T62_T0.8191.00
134_R138_G0.8171.00
142_A147_L0.8161.00
139_I150_V0.8091.00
50_V53_K0.8061.00
21_N94_F0.8021.00
101_H104_K0.8011.00
92_N95_L0.8001.00
124_K132_F0.7981.00
101_H141_S0.7981.00
223_P228_P0.7971.00
142_A150_V0.7961.00
96_L113_I0.7951.00
118_V166_K0.7941.00
223_P227_L0.7901.00
75_I79_L0.7861.00
12_L253_L0.7861.00
213_K217_R0.7851.00
133_D136_I0.7851.00
67_T99_L0.7851.00
208_E212_I0.7831.00
170_L173_N0.7771.00
213_K216_I0.7711.00
89_M111_I0.7691.00
207_I210_I0.7681.00
86_D109_D0.7681.00
65_E68_L0.7631.00
236_V239_Y0.7601.00
167_F179_I0.7581.00
67_T138_G0.7571.00
98_D102_K0.7571.00
16_L69_R0.7541.00
48_A84_Y0.7541.00
273_L283_D0.7501.00
10_E249_N0.7461.00
117_A163_E0.7421.00
260_K271_D0.7421.00
97_K100_A0.7411.00
76_V87_V0.7361.00
123_F132_F0.7291.00
199_D203_I0.7281.00
70_R73_V0.7271.00
104_K109_D0.7261.00
96_L142_A0.7241.00
276_L279_E0.7231.00
42_E45_L0.7201.00
152_L179_I0.7171.00
99_L103_L0.7131.00
17_T69_R0.7121.00
49_K53_K0.7111.00
167_F171_S0.7101.00
41_K69_R0.7091.00
200_L203_I0.7081.00
60_K88_S0.7021.00
91_T113_I0.6971.00
73_V106_A0.6961.00
211_S214_K0.6941.00
46_L282_E0.6941.00
22_F131_A0.6861.00
193_A196_E0.6841.00
20_C24_C0.6831.00
200_L204_E0.6761.00
73_V76_V0.6751.00
15_T255_V0.6741.00
234_E240_A0.6711.00
60_K90_T0.6701.00
89_M103_L0.6701.00
251_I280_Y0.6701.00
258_K268_N0.6701.00
14_I48_A0.6701.00
222_R225_Y0.6691.00
221_F224_R0.6681.00
216_I219_K0.6661.00
77_R105_L0.6661.00
138_G142_A0.6651.00
15_T252_R0.6621.00
62_T90_T0.6541.00
44_I69_R0.6541.00
261_T265_R0.6531.00
87_V108_L0.6521.00
203_I207_I0.6491.00
117_A127_T0.6491.00
96_L100_A0.6451.00
39_L273_L0.6401.00
13_R250_R0.6381.00
24_C27_C0.6371.00
90_T153_N0.6361.00
165_F206_Y0.6341.00
104_K146_G0.6341.00
62_T263_L0.6341.00
200_L237_K0.6321.00
26_F127_T0.6301.00
90_T263_L0.6291.00
20_C27_C0.6281.00
124_K129_V0.6281.00
275_I280_Y0.6271.00
13_R62_T0.6261.00
165_F210_I0.6261.00
252_R263_L0.6241.00
154_F171_S0.6231.00
260_K268_N0.6211.00
117_A123_F0.6191.00
124_K127_T0.6191.00
13_R263_L0.6171.00
110_R149_P0.6171.00
201_R204_E0.6151.00
61_L75_I0.6141.00
44_I47_V0.6121.00
112_N151_K0.6121.00
14_I47_V0.6111.00
253_L259_L0.6111.00
104_K107_G0.6111.00
150_V176_V0.6101.00
165_F213_K0.6091.00
214_K217_R0.6081.00
59_V87_V0.6081.00
273_L278_G0.6081.00
236_V240_A0.6061.00
79_L82_L0.6041.00
225_Y229_S0.6041.00
165_F168_I0.6031.00
246_A262_C0.6011.00
160_N163_E0.6011.00
220_H224_R0.6001.00
94_F134_R0.6001.00
96_L103_L0.5971.00
97_K101_H0.5961.00
222_R226_V0.5921.00
84_Y87_V0.5900.99
69_R72_L0.5900.99
168_I172_Q0.5900.99
234_E237_K0.5900.99
203_I206_Y0.5880.99
11_D58_S0.5870.99
50_V281_S0.5840.99
279_E284_V0.5840.99
25_F128_G0.5820.99
115_L135_V0.5820.99
198_D202_E0.5820.99
119_S162_E0.5810.99
115_L136_I0.5810.99
211_S215_L0.5810.99
284_V287_E0.5800.99
240_A245_C0.5790.99
204_E235_V0.5780.99
235_V238_P0.5780.99
9_L284_V0.5780.99
29_M62_T0.5750.99
161_R202_E0.5730.99
42_E46_L0.5710.99
282_E285_K0.5690.99
113_I135_V0.5690.99
30_E128_G0.5680.99
184_L190_G0.5670.99
168_I179_I0.5650.99
218_K221_F0.5640.99
115_L132_F0.5630.99
99_L104_K0.5610.99
226_V229_S0.5610.99
198_D203_I0.5570.99
31_G189_L0.5550.99
233_V237_K0.5540.99
283_D286_E0.5530.99
147_L150_V0.5530.99
65_E91_T0.5530.99
47_V51_A0.5520.99
22_F123_F0.5510.99
48_A61_L0.5510.99
12_L56_I0.5490.99
137_E144_D0.5480.99
153_N182_I0.5480.99
95_L98_D0.5420.99
65_E93_G0.5400.99
16_L44_I0.5390.99
127_T130_D0.5380.99
251_I284_V0.5380.99
69_R74_E0.5380.99
42_E78_G0.5380.99
212_I215_L0.5380.99
80_K107_G0.5350.99
279_E283_D0.5280.99
46_L279_E0.5280.99
15_T29_M0.5280.99
83_G87_V0.5270.99
88_S110_R0.5260.99
225_Y228_P0.5260.99
110_R151_K0.5230.99
94_F138_G0.5230.99
221_F227_L0.5220.99
62_T153_N0.5180.99
70_R99_L0.5170.99
234_E238_P0.5160.99
204_E207_I0.5150.99
35_D38_L0.5130.99
121_D124_K0.5120.99
56_I84_Y0.5090.99
44_I48_A0.5090.99
220_H227_L0.5090.99
50_V280_Y0.5060.98
158_R199_D0.5040.98
154_F164_A0.5010.98
221_F226_V0.5010.98
275_I278_G0.5000.98
90_T264_Y0.5000.98
26_F155_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.961 100 0.332 Contact Map
1tv8A 2 0.961 100 0.347 Contact Map
4m7tA 1 0.7175 100 0.441 Contact Map
3c8fA 1 0.6981 100 0.541 Contact Map
4rtbA 2 0.9286 100 0.556 Contact Map
2yx0A 1 0.7825 100 0.568 Contact Map
2z2uA 1 0.6851 99.9 0.581 Contact Map
2a5hA 4 0.8994 99.9 0.596 Contact Map
4wcxA 1 0.9383 99.9 0.597 Contact Map
2qgqA 1 0.8084 99.9 0.598 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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