GREMLIN Database
Q980E9 - Prolidase (Xaa-Pro dipeptidase) (PepQ)
UniProt: Q980E9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (332)
Sequences: 10964 (7962)
Seq/√Len: 437.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_R343_I5.0891.00
311_E339_K4.2761.00
257_V337_V3.2031.00
136_I336_I2.9861.00
244_E248_E2.5501.00
141_K144_E2.5111.00
238_E326_R2.4431.00
25_P294_E2.4011.00
148_V178_M2.3891.00
152_I174_T2.3751.00
264_S306_K2.3411.00
170_I173_M2.3121.00
262_M265_E2.2871.00
173_M177_S2.2711.00
267_D271_R2.2651.00
252_E273_V2.2651.00
245_V277_A2.2571.00
238_E241_K2.2551.00
251_M255_D2.2461.00
193_E205_R2.2321.00
237_S241_K2.2061.00
16_D97_M2.1821.00
139_I314_I2.1631.00
130_V310_K2.1401.00
163_N206_V2.1301.00
256_A269_T2.1281.00
109_K112_S2.1211.00
253_A270_A2.1121.00
291_V334_T2.0901.00
272_R276_K2.0271.00
10_I13_D2.0191.00
95_N116_K1.9521.00
140_R144_E1.9521.00
209_N235_K1.9291.00
138_R222_N1.8961.00
252_E255_D1.8911.00
207_L234_F1.8801.00
208_G211_D1.8701.00
242_V327_F1.8391.00
82_N85_R1.8331.00
156_K170_I1.8211.00
240_K244_E1.7581.00
273_V277_A1.7561.00
205_R211_D1.7411.00
212_I239_A1.7331.00
172_D176_R1.7291.00
268_I272_R1.7191.00
174_T177_S1.6751.00
338_T343_I1.6701.00
165_K204_D1.6561.00
174_T178_M1.6521.00
246_V329_I1.6361.00
242_V329_I1.6331.00
248_E252_E1.6331.00
154_M232_F1.6281.00
262_M308_I1.6251.00
189_V213_V1.5921.00
254_I335_L1.5651.00
184_A225_C1.5631.00
317_V335_L1.5511.00
258_R261_V1.5231.00
169_G173_M1.5201.00
248_E277_A1.5171.00
163_N166_Q1.5051.00
216_D227_D1.4961.00
247_L251_M1.4951.00
316_T334_T1.4831.00
58_A86_A1.4801.00
151_K155_E1.4751.00
310_K313_M1.4631.00
95_N118_I1.4571.00
227_D332_E1.4471.00
336_I345_L1.4461.00
129_E313_M1.4351.00
253_A266_V1.4331.00
31_L48_L1.4281.00
191_F205_R1.4221.00
67_A71_P1.4141.00
212_I233_V1.4071.00
51_P54_E1.4051.00
66_I69_Y1.4041.00
159_E209_N1.4021.00
274_I321_I1.3871.00
133_N137_E1.3781.00
167_V207_L1.3651.00
250_Q254_I1.3621.00
152_I178_M1.3561.00
220_K225_C1.3481.00
10_I14_K1.3471.00
170_I174_T1.3411.00
137_E141_K1.3411.00
152_I155_E1.3391.00
28_F223_G1.3331.00
309_L315_I1.3191.00
242_V323_L1.3131.00
17_S94_S1.3111.00
237_S240_K1.3081.00
216_D332_E1.3031.00
241_K277_A1.3031.00
270_A287_T1.3011.00
259_D310_K1.2951.00
248_E276_K1.2941.00
191_F207_L1.2861.00
249_A273_V1.2801.00
166_Q177_S1.2741.00
16_D118_I1.2731.00
30_F127_L1.2531.00
68_I71_P1.2431.00
261_V265_E1.2421.00
108_Y112_S1.2191.00
55_M59_E1.2121.00
259_D311_E1.2101.00
265_E268_I1.1991.00
146_T228_S1.1931.00
257_V266_V1.1901.00
126_R310_K1.1881.00
150_M228_S1.1861.00
144_E148_V1.1851.00
264_S268_I1.1771.00
250_Q333_D1.1771.00
141_K221_Y1.1771.00
145_I223_G1.1751.00
57_R61_V1.1751.00
145_I180_A1.1721.00
243_Y331_I1.1681.00
86_A89_K1.1561.00
170_I177_S1.1551.00
275_E280_G1.1531.00
139_I143_G1.1501.00
130_V313_M1.1481.00
248_E273_V1.1351.00
38_A41_Y1.1341.00
168_A172_D1.1331.00
38_A42_C1.1291.00
309_L337_V1.1291.00
241_K245_V1.1261.00
252_E269_T1.1221.00
254_I344_V1.1221.00
190_A200_H1.1211.00
257_V317_V1.1131.00
105_A109_K1.1071.00
192_G211_D1.0941.00
241_K244_E1.0921.00
152_I170_I1.0891.00
261_V269_T1.0891.00
143_G147_A1.0861.00
39_L42_C1.0841.00
253_A269_T1.0831.00
167_V213_V1.0821.00
152_I177_S1.0811.00
161_T170_I1.0791.00
238_E323_L1.0791.00
134_D138_R1.0771.00
205_R208_G1.0751.00
11_L16_D1.0741.00
267_D287_T1.0701.00
257_V335_L1.0671.00
312_N336_I1.0671.00
17_S95_N1.0621.00
323_L326_R1.0521.00
105_A108_Y1.0521.00
194_N200_H1.0491.00
314_I336_I1.0421.00
212_I231_T1.0411.00
137_E140_R1.0361.00
158_S161_T1.0351.00
120_F123_E1.0331.00
338_T341_K1.0321.00
266_V269_T1.0301.00
21_I30_F1.0281.00
256_A261_V1.0201.00
191_F211_D1.0171.00
134_D137_E1.0161.00
335_L344_V1.0091.00
26_N125_V1.0071.00
254_I317_V1.0061.00
85_R89_K1.0051.00
245_V274_I1.0011.00
33_Y44_S0.9961.00
140_R336_I0.9911.00
315_I337_V0.9891.00
180_A219_A0.9871.00
42_C46_F0.9861.00
150_M232_F0.9831.00
97_M120_F0.9821.00
269_T272_R0.9821.00
172_D187_S0.9781.00
272_R275_E0.9731.00
264_S304_N0.9721.00
257_V342_P0.9691.00
252_E256_A0.9681.00
165_K169_G0.9671.00
195_S214_L0.9651.00
215_F232_F0.9611.00
143_G334_T0.9571.00
245_V273_V0.9531.00
147_A347_T0.9531.00
233_V239_A0.9481.00
149_A174_T0.9461.00
172_D183_Y0.9441.00
266_V309_L0.9371.00
161_T166_Q0.9341.00
245_V248_E0.9321.00
30_F124_I0.9321.00
141_K222_N0.9311.00
126_R307_Q0.9311.00
290_G297_E0.9291.00
65_D68_I0.9281.00
190_A195_S0.9251.00
48_L58_A0.9221.00
157_L167_V0.9201.00
244_E247_L0.9201.00
106_S110_A0.9131.00
157_L232_F0.9121.00
21_I124_I0.9111.00
109_K113_E0.9071.00
100_V109_K0.9071.00
69_Y72_S0.9051.00
194_N205_R0.9021.00
249_A274_I0.8991.00
186_P201_I0.8991.00
133_N338_T0.8941.00
307_Q310_K0.8931.00
11_L18_C0.8891.00
194_N197_Y0.8891.00
67_A70_Y0.8841.00
261_V266_V0.8821.00
291_V314_I0.8811.00
238_E242_V0.8801.00
86_A90_I0.8791.00
193_E325_G0.8771.00
167_V189_V0.8751.00
171_I175_M0.8741.00
10_I126_R0.8731.00
335_L342_P0.8721.00
141_K145_I0.8701.00
84_F88_E0.8701.00
185_F218_G0.8681.00
259_D338_T0.8681.00
256_A266_V0.8671.00
263_A309_L0.8661.00
269_T273_V0.8641.00
213_V234_F0.8591.00
69_Y73_K0.8571.00
148_V151_K0.8531.00
273_V276_K0.8511.00
302_S305_S0.8511.00
254_I342_P0.8511.00
100_V119_D0.8491.00
152_I156_K0.8441.00
259_D339_K0.8401.00
247_L331_I0.8321.00
243_Y247_L0.8311.00
146_T226_F0.8301.00
49_L86_A0.8281.00
159_E234_F0.8201.00
103_V108_Y0.8191.00
28_F293_V0.8181.00
29_Y127_L0.8181.00
253_A317_V0.8171.00
270_A283_F0.8151.00
156_K174_T0.8121.00
175_M219_A0.8111.00
19_A120_F0.8101.00
155_E159_E0.8061.00
242_V279_Y0.8061.00
138_R141_K0.8061.00
18_C96_I0.8021.00
145_I221_Y0.7981.00
147_A151_K0.7951.00
230_R333_D0.7951.00
123_E126_R0.7941.00
85_R88_E0.7931.00
336_I343_I0.7901.00
66_I71_P0.7881.00
153_G215_F0.7881.00
282_Y324_K0.7871.00
195_S212_I0.7831.00
274_I279_Y0.7801.00
11_L19_A0.7771.00
249_A253_A0.7751.00
129_E310_K0.7751.00
135_E224_Y0.7741.00
210_N234_F0.7731.00
337_V342_P0.7721.00
43_D46_F0.7691.00
54_E57_R0.7681.00
216_D318_E0.7661.00
171_I215_F0.7661.00
252_E270_A0.7651.00
143_G346_E0.7641.00
318_E332_E0.7641.00
227_D289_H0.7601.00
322_Y330_R0.7601.00
60_N63_D0.7591.00
183_Y187_S0.7591.00
262_M306_K0.7551.00
289_H332_E0.7531.00
149_A175_M0.7531.00
164_E194_N0.7521.00
291_V316_T0.7521.00
93_K96_I0.7521.00
242_V245_V0.7491.00
82_N86_A0.7481.00
98_L105_A0.7461.00
144_E147_A0.7461.00
249_A269_T0.7451.00
104_E107_T0.7401.00
11_L14_K0.7391.00
138_R221_Y0.7381.00
65_D69_Y0.7351.00
169_G176_R0.7341.00
56_Y78_V0.7341.00
198_P285_H0.7331.00
143_G226_F0.7311.00
65_D70_Y0.7301.00
191_F234_F0.7291.00
171_I217_I0.7291.00
195_S328_G0.7261.00
54_E58_A0.7251.00
338_T342_P0.7241.00
225_C295_I0.7231.00
197_Y200_H0.7231.00
68_I72_S0.7211.00
136_I140_R0.7201.00
110_A113_E0.7191.00
209_N236_N0.7191.00
173_M176_R0.7171.00
166_Q169_G0.7161.00
103_V107_T0.7131.00
271_R283_F0.7121.00
66_I70_Y0.7111.00
323_L327_F0.7091.00
253_A256_A0.7071.00
290_G299_P0.7031.00
15_K95_N0.7021.00
320_G330_R0.7001.00
259_D337_V0.7001.00
258_R342_P0.6961.00
211_D239_A0.6961.00
129_E307_Q0.6951.00
238_E327_F0.6951.00
236_N240_K0.6941.00
285_H296_H0.6931.00
153_G167_V0.6901.00
239_A326_R0.6891.00
45_R65_D0.6881.00
145_I178_M0.6821.00
210_N236_N0.6821.00
195_S327_F0.6801.00
24_S27_L0.6791.00
199_H296_H0.6791.00
104_E110_A0.6781.00
50_V58_A0.6771.00
305_S308_I0.6731.00
150_M217_I0.6711.00
233_V236_N0.6701.00
146_T149_A0.6691.00
133_N312_N0.6691.00
143_G345_L0.6681.00
227_D318_E0.6651.00
143_G228_S0.6641.00
265_E269_T0.6641.00
274_I280_G0.6631.00
250_Q317_V0.6601.00
55_M58_A0.6581.00
307_Q313_M0.6571.00
98_L117_V0.6571.00
12_E43_D0.6561.00
50_V53_L0.6561.00
101_S104_E0.6540.99
252_E272_R0.6540.99
25_P293_V0.6540.99
311_E338_T0.6530.99
219_A226_F0.6450.99
245_V321_I0.6440.99
322_Y328_G0.6440.99
33_Y57_R0.6430.99
41_Y294_E0.6410.99
259_D342_P0.6410.99
168_A202_P0.6380.99
229_T332_E0.6350.99
104_E108_Y0.6350.99
249_A270_A0.6350.99
150_M153_G0.6340.99
142_A146_T0.6340.99
163_N204_D0.6330.99
189_V215_F0.6320.99
153_G170_I0.6310.99
239_A327_F0.6300.99
344_V347_T0.6300.99
253_A287_T0.6280.99
53_L58_A0.6250.99
149_A171_I0.6240.99
28_F34_S0.6230.99
308_I311_E0.6230.99
266_V287_T0.6230.99
26_N124_I0.6220.99
52_A284_I0.6190.99
301_V315_I0.6130.99
26_N29_Y0.6120.99
157_L213_V0.6100.99
216_D289_H0.6100.99
94_S116_K0.6090.99
289_H292_G0.6080.99
44_S50_V0.6060.99
187_S217_I0.6040.99
193_E196_A0.6040.99
268_I303_M0.6040.99
146_T217_I0.6020.99
27_L31_L0.6010.99
195_S233_V0.6000.99
137_E144_E0.5970.99
136_I314_I0.5950.99
263_A305_S0.5930.99
106_S109_K0.5930.99
52_A55_M0.5920.99
153_G156_K0.5910.99
64_V68_I0.5890.99
167_V215_F0.5890.99
314_I334_T0.5880.99
251_M254_I0.5880.99
260_G308_I0.5870.99
228_S334_T0.5860.99
103_V111_L0.5860.99
248_E251_M0.5850.99
274_I277_A0.5820.99
150_M154_M0.5820.99
35_G57_R0.5810.99
56_Y60_N0.5790.99
245_V249_A0.5750.99
10_I127_L0.5720.99
195_S198_P0.5720.99
257_V309_L0.5710.99
172_D180_A0.5710.99
146_T218_G0.5700.99
256_A259_D0.5700.99
107_T110_A0.5670.99
131_K135_E0.5660.99
159_E208_G0.5650.99
126_R129_E0.5630.99
245_V279_Y0.5620.98
31_L39_L0.5620.98
259_D341_K0.5620.98
334_T346_E0.5610.98
191_F213_V0.5580.98
260_G310_K0.5580.98
242_V321_I0.5540.98
258_R340_G0.5540.98
264_S305_S0.5520.98
320_G328_G0.5510.98
183_Y186_P0.5480.98
19_A123_E0.5450.98
267_D283_F0.5450.98
249_A252_E0.5440.98
99_D102_W0.5440.98
125_V298_S0.5430.98
78_V86_A0.5420.98
263_A301_V0.5410.98
157_L234_F0.5380.98
145_I219_A0.5360.98
185_F188_I0.5310.98
216_D229_T0.5310.98
271_R275_E0.5300.98
250_Q331_I0.5290.98
130_V311_E0.5280.98
267_D286_S0.5270.98
133_N311_E0.5270.98
98_L108_Y0.5260.98
169_G177_S0.5220.98
43_D47_T0.5220.98
165_K181_E0.5210.98
270_A273_V0.5190.97
179_G222_N0.5170.97
36_A41_Y0.5170.97
178_M181_E0.5160.97
143_G146_T0.5140.97
284_I324_K0.5130.97
164_E167_V0.5130.97
166_Q206_V0.5120.97
67_A72_S0.5120.97
53_L57_R0.5120.97
56_Y59_E0.5090.97
146_T219_A0.5090.97
289_H318_E0.5090.97
37_G42_C0.5090.97
148_V152_I0.5080.97
261_V337_V0.5080.97
97_M118_I0.5040.97
153_G171_I0.5030.97
149_A219_A0.5030.97
48_L62_K0.5020.97
148_V174_T0.5020.97
194_N204_D0.5020.97
10_I123_E0.5010.97
340_G343_I0.5000.97
26_N99_D0.5000.97
14_K17_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fkcA 2 0.9801 100 0.151 Contact Map
2zsgA 2 0.9801 100 0.153 Contact Map
3q6dA 1 0.9773 100 0.156 Contact Map
1wy2A 2 0.9631 100 0.161 Contact Map
4r60A 2 0.9801 100 0.168 Contact Map
1wn1A 2 0.9688 100 0.168 Contact Map
4egeA 2 0.9744 100 0.18 Contact Map
1kp0A 2 0.8835 100 0.194 Contact Map
1chmA 2 0.983 100 0.206 Contact Map
2v3zA 3 0.9943 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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