Q980E9 - SULSO - GREMLIN Contacts

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Q980E9 - Prolidase (Xaa-Pro dipeptidase) (PepQ)

UniProt:	Q980E9	Sequences: MNRLRKLKAILEDKKDSCAIIFGSPNLFYFLEYSGAGALIYCDSRFTLLVPALEMYRAENVKDVDIAIYYPSKILENVIEGNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDFSNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEGTSNEKQVAGIIDMTMRSMGAEDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSEAKKVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHESPAVSMNSKQILKENMIITVEPGIYLKGRFGIRIEDTLIVTKGKPIVLETAYKLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (332)
Sequences:	10964 (7962)
Seq/√Len:	437.0

ECOLI - YPDF AMPP PEPQ MAP1
BACSU - YKVY YQHT MAP11 MAP12
HALSA - Q9HRF6 Q9HQC0 Q9HMB3 Q9HP03
SULSO - Q980E9 Q981D7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_R	343_I	5.089	1.00
311_E	339_K	4.276	1.00
257_V	337_V	3.203	1.00
136_I	336_I	2.986	1.00
244_E	248_E	2.550	1.00
141_K	144_E	2.511	1.00
238_E	326_R	2.443	1.00
25_P	294_E	2.401	1.00
148_V	178_M	2.389	1.00
152_I	174_T	2.375	1.00
264_S	306_K	2.341	1.00
170_I	173_M	2.312	1.00
262_M	265_E	2.287	1.00
173_M	177_S	2.271	1.00
267_D	271_R	2.265	1.00
252_E	273_V	2.265	1.00
245_V	277_A	2.257	1.00
238_E	241_K	2.255	1.00
251_M	255_D	2.246	1.00
193_E	205_R	2.232	1.00
237_S	241_K	2.206	1.00
16_D	97_M	2.182	1.00
139_I	314_I	2.163	1.00
130_V	310_K	2.140	1.00
163_N	206_V	2.130	1.00
256_A	269_T	2.128	1.00
109_K	112_S	2.121	1.00
253_A	270_A	2.112	1.00
291_V	334_T	2.090	1.00
272_R	276_K	2.027	1.00
10_I	13_D	2.019	1.00
95_N	116_K	1.952	1.00
140_R	144_E	1.952	1.00
209_N	235_K	1.929	1.00
138_R	222_N	1.896	1.00
252_E	255_D	1.891	1.00
207_L	234_F	1.880	1.00
208_G	211_D	1.870	1.00
242_V	327_F	1.839	1.00
82_N	85_R	1.833	1.00
156_K	170_I	1.821	1.00
240_K	244_E	1.758	1.00
273_V	277_A	1.756	1.00
205_R	211_D	1.741	1.00
212_I	239_A	1.733	1.00
172_D	176_R	1.729	1.00
268_I	272_R	1.719	1.00
174_T	177_S	1.675	1.00
338_T	343_I	1.670	1.00
165_K	204_D	1.656	1.00
174_T	178_M	1.652	1.00
246_V	329_I	1.636	1.00
242_V	329_I	1.633	1.00
248_E	252_E	1.633	1.00
154_M	232_F	1.628	1.00
262_M	308_I	1.625	1.00
189_V	213_V	1.592	1.00
254_I	335_L	1.565	1.00
184_A	225_C	1.563	1.00
317_V	335_L	1.551	1.00
258_R	261_V	1.523	1.00
169_G	173_M	1.520	1.00
248_E	277_A	1.517	1.00
163_N	166_Q	1.505	1.00
216_D	227_D	1.496	1.00
247_L	251_M	1.495	1.00
316_T	334_T	1.483	1.00
58_A	86_A	1.480	1.00
151_K	155_E	1.475	1.00
310_K	313_M	1.463	1.00
95_N	118_I	1.457	1.00
227_D	332_E	1.447	1.00
336_I	345_L	1.446	1.00
129_E	313_M	1.435	1.00
253_A	266_V	1.433	1.00
31_L	48_L	1.428	1.00
191_F	205_R	1.422	1.00
67_A	71_P	1.414	1.00
212_I	233_V	1.407	1.00
51_P	54_E	1.405	1.00
66_I	69_Y	1.404	1.00
159_E	209_N	1.402	1.00
274_I	321_I	1.387	1.00
133_N	137_E	1.378	1.00
167_V	207_L	1.365	1.00
250_Q	254_I	1.362	1.00
152_I	178_M	1.356	1.00
220_K	225_C	1.348	1.00
10_I	14_K	1.347	1.00
170_I	174_T	1.341	1.00
137_E	141_K	1.341	1.00
152_I	155_E	1.339	1.00
28_F	223_G	1.333	1.00
309_L	315_I	1.319	1.00
242_V	323_L	1.313	1.00
17_S	94_S	1.311	1.00
237_S	240_K	1.308	1.00
216_D	332_E	1.303	1.00
241_K	277_A	1.303	1.00
270_A	287_T	1.301	1.00
259_D	310_K	1.295	1.00
248_E	276_K	1.294	1.00
191_F	207_L	1.286	1.00
249_A	273_V	1.280	1.00
166_Q	177_S	1.274	1.00
16_D	118_I	1.273	1.00
30_F	127_L	1.253	1.00
68_I	71_P	1.243	1.00
261_V	265_E	1.242	1.00
108_Y	112_S	1.219	1.00
55_M	59_E	1.212	1.00
259_D	311_E	1.210	1.00
265_E	268_I	1.199	1.00
146_T	228_S	1.193	1.00
257_V	266_V	1.190	1.00
126_R	310_K	1.188	1.00
150_M	228_S	1.186	1.00
144_E	148_V	1.185	1.00
264_S	268_I	1.177	1.00
250_Q	333_D	1.177	1.00
141_K	221_Y	1.177	1.00
145_I	223_G	1.175	1.00
57_R	61_V	1.175	1.00
145_I	180_A	1.172	1.00
243_Y	331_I	1.168	1.00
86_A	89_K	1.156	1.00
170_I	177_S	1.155	1.00
275_E	280_G	1.153	1.00
139_I	143_G	1.150	1.00
130_V	313_M	1.148	1.00
248_E	273_V	1.135	1.00
38_A	41_Y	1.134	1.00
168_A	172_D	1.133	1.00
38_A	42_C	1.129	1.00
309_L	337_V	1.129	1.00
241_K	245_V	1.126	1.00
252_E	269_T	1.122	1.00
254_I	344_V	1.122	1.00
190_A	200_H	1.121	1.00
257_V	317_V	1.113	1.00
105_A	109_K	1.107	1.00
192_G	211_D	1.094	1.00
241_K	244_E	1.092	1.00
152_I	170_I	1.089	1.00
261_V	269_T	1.089	1.00
143_G	147_A	1.086	1.00
39_L	42_C	1.084	1.00
253_A	269_T	1.083	1.00
167_V	213_V	1.082	1.00
152_I	177_S	1.081	1.00
161_T	170_I	1.079	1.00
238_E	323_L	1.079	1.00
134_D	138_R	1.077	1.00
205_R	208_G	1.075	1.00
11_L	16_D	1.074	1.00
267_D	287_T	1.070	1.00
257_V	335_L	1.067	1.00
312_N	336_I	1.067	1.00
17_S	95_N	1.062	1.00
323_L	326_R	1.052	1.00
105_A	108_Y	1.052	1.00
194_N	200_H	1.049	1.00
314_I	336_I	1.042	1.00
212_I	231_T	1.041	1.00
137_E	140_R	1.036	1.00
158_S	161_T	1.035	1.00
120_F	123_E	1.033	1.00
338_T	341_K	1.032	1.00
266_V	269_T	1.030	1.00
21_I	30_F	1.028	1.00
256_A	261_V	1.020	1.00
191_F	211_D	1.017	1.00
134_D	137_E	1.016	1.00
335_L	344_V	1.009	1.00
26_N	125_V	1.007	1.00
254_I	317_V	1.006	1.00
85_R	89_K	1.005	1.00
245_V	274_I	1.001	1.00
33_Y	44_S	0.996	1.00
140_R	336_I	0.991	1.00
315_I	337_V	0.989	1.00
180_A	219_A	0.987	1.00
42_C	46_F	0.986	1.00
150_M	232_F	0.983	1.00
97_M	120_F	0.982	1.00
269_T	272_R	0.982	1.00
172_D	187_S	0.978	1.00
272_R	275_E	0.973	1.00
264_S	304_N	0.972	1.00
257_V	342_P	0.969	1.00
252_E	256_A	0.968	1.00
165_K	169_G	0.967	1.00
195_S	214_L	0.965	1.00
215_F	232_F	0.961	1.00
143_G	334_T	0.957	1.00
245_V	273_V	0.953	1.00
147_A	347_T	0.953	1.00
233_V	239_A	0.948	1.00
149_A	174_T	0.946	1.00
172_D	183_Y	0.944	1.00
266_V	309_L	0.937	1.00
161_T	166_Q	0.934	1.00
245_V	248_E	0.932	1.00
30_F	124_I	0.932	1.00
141_K	222_N	0.931	1.00
126_R	307_Q	0.931	1.00
290_G	297_E	0.929	1.00
65_D	68_I	0.928	1.00
190_A	195_S	0.925	1.00
48_L	58_A	0.922	1.00
157_L	167_V	0.920	1.00
244_E	247_L	0.920	1.00
106_S	110_A	0.913	1.00
157_L	232_F	0.912	1.00
21_I	124_I	0.911	1.00
109_K	113_E	0.907	1.00
100_V	109_K	0.907	1.00
69_Y	72_S	0.905	1.00
194_N	205_R	0.902	1.00
249_A	274_I	0.899	1.00
186_P	201_I	0.899	1.00
133_N	338_T	0.894	1.00
307_Q	310_K	0.893	1.00
11_L	18_C	0.889	1.00
194_N	197_Y	0.889	1.00
67_A	70_Y	0.884	1.00
261_V	266_V	0.882	1.00
291_V	314_I	0.881	1.00
238_E	242_V	0.880	1.00
86_A	90_I	0.879	1.00
193_E	325_G	0.877	1.00
167_V	189_V	0.875	1.00
171_I	175_M	0.874	1.00
10_I	126_R	0.873	1.00
335_L	342_P	0.872	1.00
141_K	145_I	0.870	1.00
84_F	88_E	0.870	1.00
185_F	218_G	0.868	1.00
259_D	338_T	0.868	1.00
256_A	266_V	0.867	1.00
263_A	309_L	0.866	1.00
269_T	273_V	0.864	1.00
213_V	234_F	0.859	1.00
69_Y	73_K	0.857	1.00
148_V	151_K	0.853	1.00
273_V	276_K	0.851	1.00
302_S	305_S	0.851	1.00
254_I	342_P	0.851	1.00
100_V	119_D	0.849	1.00
152_I	156_K	0.844	1.00
259_D	339_K	0.840	1.00
247_L	331_I	0.832	1.00
243_Y	247_L	0.831	1.00
146_T	226_F	0.830	1.00
49_L	86_A	0.828	1.00
159_E	234_F	0.820	1.00
103_V	108_Y	0.819	1.00
28_F	293_V	0.818	1.00
29_Y	127_L	0.818	1.00
253_A	317_V	0.817	1.00
270_A	283_F	0.815	1.00
156_K	174_T	0.812	1.00
175_M	219_A	0.811	1.00
19_A	120_F	0.810	1.00
155_E	159_E	0.806	1.00
242_V	279_Y	0.806	1.00
138_R	141_K	0.806	1.00
18_C	96_I	0.802	1.00
145_I	221_Y	0.798	1.00
147_A	151_K	0.795	1.00
230_R	333_D	0.795	1.00
123_E	126_R	0.794	1.00
85_R	88_E	0.793	1.00
336_I	343_I	0.790	1.00
66_I	71_P	0.788	1.00
153_G	215_F	0.788	1.00
282_Y	324_K	0.787	1.00
195_S	212_I	0.783	1.00
274_I	279_Y	0.780	1.00
11_L	19_A	0.777	1.00
249_A	253_A	0.775	1.00
129_E	310_K	0.775	1.00
135_E	224_Y	0.774	1.00
210_N	234_F	0.773	1.00
337_V	342_P	0.772	1.00
43_D	46_F	0.769	1.00
54_E	57_R	0.768	1.00
216_D	318_E	0.766	1.00
171_I	215_F	0.766	1.00
252_E	270_A	0.765	1.00
143_G	346_E	0.764	1.00
318_E	332_E	0.764	1.00
227_D	289_H	0.760	1.00
322_Y	330_R	0.760	1.00
60_N	63_D	0.759	1.00
183_Y	187_S	0.759	1.00
262_M	306_K	0.755	1.00
289_H	332_E	0.753	1.00
149_A	175_M	0.753	1.00
164_E	194_N	0.752	1.00
291_V	316_T	0.752	1.00
93_K	96_I	0.752	1.00
242_V	245_V	0.749	1.00
82_N	86_A	0.748	1.00
98_L	105_A	0.746	1.00
144_E	147_A	0.746	1.00
249_A	269_T	0.745	1.00
104_E	107_T	0.740	1.00
11_L	14_K	0.739	1.00
138_R	221_Y	0.738	1.00
65_D	69_Y	0.735	1.00
169_G	176_R	0.734	1.00
56_Y	78_V	0.734	1.00
198_P	285_H	0.733	1.00
143_G	226_F	0.731	1.00
65_D	70_Y	0.730	1.00
191_F	234_F	0.729	1.00
171_I	217_I	0.729	1.00
195_S	328_G	0.726	1.00
54_E	58_A	0.725	1.00
338_T	342_P	0.724	1.00
225_C	295_I	0.723	1.00
197_Y	200_H	0.723	1.00
68_I	72_S	0.721	1.00
136_I	140_R	0.720	1.00
110_A	113_E	0.719	1.00
209_N	236_N	0.719	1.00
173_M	176_R	0.717	1.00
166_Q	169_G	0.716	1.00
103_V	107_T	0.713	1.00
271_R	283_F	0.712	1.00
66_I	70_Y	0.711	1.00
323_L	327_F	0.709	1.00
253_A	256_A	0.707	1.00
290_G	299_P	0.703	1.00
15_K	95_N	0.702	1.00
320_G	330_R	0.700	1.00
259_D	337_V	0.700	1.00
258_R	342_P	0.696	1.00
211_D	239_A	0.696	1.00
129_E	307_Q	0.695	1.00
238_E	327_F	0.695	1.00
236_N	240_K	0.694	1.00
285_H	296_H	0.693	1.00
153_G	167_V	0.690	1.00
239_A	326_R	0.689	1.00
45_R	65_D	0.688	1.00
145_I	178_M	0.682	1.00
210_N	236_N	0.682	1.00
195_S	327_F	0.680	1.00
24_S	27_L	0.679	1.00
199_H	296_H	0.679	1.00
104_E	110_A	0.678	1.00
50_V	58_A	0.677	1.00
305_S	308_I	0.673	1.00
150_M	217_I	0.671	1.00
233_V	236_N	0.670	1.00
146_T	149_A	0.669	1.00
133_N	312_N	0.669	1.00
143_G	345_L	0.668	1.00
227_D	318_E	0.665	1.00
143_G	228_S	0.664	1.00
265_E	269_T	0.664	1.00
274_I	280_G	0.663	1.00
250_Q	317_V	0.660	1.00
55_M	58_A	0.658	1.00
307_Q	313_M	0.657	1.00
98_L	117_V	0.657	1.00
12_E	43_D	0.656	1.00
50_V	53_L	0.656	1.00
101_S	104_E	0.654	0.99
252_E	272_R	0.654	0.99
25_P	293_V	0.654	0.99
311_E	338_T	0.653	0.99
219_A	226_F	0.645	0.99
245_V	321_I	0.644	0.99
322_Y	328_G	0.644	0.99
33_Y	57_R	0.643	0.99
41_Y	294_E	0.641	0.99
259_D	342_P	0.641	0.99
168_A	202_P	0.638	0.99
229_T	332_E	0.635	0.99
104_E	108_Y	0.635	0.99
249_A	270_A	0.635	0.99
150_M	153_G	0.634	0.99
142_A	146_T	0.634	0.99
163_N	204_D	0.633	0.99
189_V	215_F	0.632	0.99
153_G	170_I	0.631	0.99
239_A	327_F	0.630	0.99
344_V	347_T	0.630	0.99
253_A	287_T	0.628	0.99
53_L	58_A	0.625	0.99
149_A	171_I	0.624	0.99
28_F	34_S	0.623	0.99
308_I	311_E	0.623	0.99
266_V	287_T	0.623	0.99
26_N	124_I	0.622	0.99
52_A	284_I	0.619	0.99
301_V	315_I	0.613	0.99
26_N	29_Y	0.612	0.99
157_L	213_V	0.610	0.99
216_D	289_H	0.610	0.99
94_S	116_K	0.609	0.99
289_H	292_G	0.608	0.99
44_S	50_V	0.606	0.99
187_S	217_I	0.604	0.99
193_E	196_A	0.604	0.99
268_I	303_M	0.604	0.99
146_T	217_I	0.602	0.99
27_L	31_L	0.601	0.99
195_S	233_V	0.600	0.99
137_E	144_E	0.597	0.99
136_I	314_I	0.595	0.99
263_A	305_S	0.593	0.99
106_S	109_K	0.593	0.99
52_A	55_M	0.592	0.99
153_G	156_K	0.591	0.99
64_V	68_I	0.589	0.99
167_V	215_F	0.589	0.99
314_I	334_T	0.588	0.99
251_M	254_I	0.588	0.99
260_G	308_I	0.587	0.99
228_S	334_T	0.586	0.99
103_V	111_L	0.586	0.99
248_E	251_M	0.585	0.99
274_I	277_A	0.582	0.99
150_M	154_M	0.582	0.99
35_G	57_R	0.581	0.99
56_Y	60_N	0.579	0.99
245_V	249_A	0.575	0.99
10_I	127_L	0.572	0.99
195_S	198_P	0.572	0.99
257_V	309_L	0.571	0.99
172_D	180_A	0.571	0.99
146_T	218_G	0.570	0.99
256_A	259_D	0.570	0.99
107_T	110_A	0.567	0.99
131_K	135_E	0.566	0.99
159_E	208_G	0.565	0.99
126_R	129_E	0.563	0.99
245_V	279_Y	0.562	0.98
31_L	39_L	0.562	0.98
259_D	341_K	0.562	0.98
334_T	346_E	0.561	0.98
191_F	213_V	0.558	0.98
260_G	310_K	0.558	0.98
242_V	321_I	0.554	0.98
258_R	340_G	0.554	0.98
264_S	305_S	0.552	0.98
320_G	328_G	0.551	0.98
183_Y	186_P	0.548	0.98
19_A	123_E	0.545	0.98
267_D	283_F	0.545	0.98
249_A	252_E	0.544	0.98
99_D	102_W	0.544	0.98
125_V	298_S	0.543	0.98
78_V	86_A	0.542	0.98
263_A	301_V	0.541	0.98
157_L	234_F	0.538	0.98
145_I	219_A	0.536	0.98
185_F	188_I	0.531	0.98
216_D	229_T	0.531	0.98
271_R	275_E	0.530	0.98
250_Q	331_I	0.529	0.98
130_V	311_E	0.528	0.98
267_D	286_S	0.527	0.98
133_N	311_E	0.527	0.98
98_L	108_Y	0.526	0.98
169_G	177_S	0.522	0.98
43_D	47_T	0.522	0.98
165_K	181_E	0.521	0.98
270_A	273_V	0.519	0.97
179_G	222_N	0.517	0.97
36_A	41_Y	0.517	0.97
178_M	181_E	0.516	0.97
143_G	146_T	0.514	0.97
284_I	324_K	0.513	0.97
164_E	167_V	0.513	0.97
166_Q	206_V	0.512	0.97
67_A	72_S	0.512	0.97
53_L	57_R	0.512	0.97
56_Y	59_E	0.509	0.97
146_T	219_A	0.509	0.97
289_H	318_E	0.509	0.97
37_G	42_C	0.509	0.97
148_V	152_I	0.508	0.97
261_V	337_V	0.508	0.97
97_M	118_I	0.504	0.97
153_G	171_I	0.503	0.97
149_A	219_A	0.503	0.97
48_L	62_K	0.502	0.97
148_V	174_T	0.502	0.97
194_N	204_D	0.502	0.97
10_I	123_E	0.501	0.97
340_G	343_I	0.500	0.97
26_N	99_D	0.500	0.97
14_K	17_S	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fkcA	2	0.9801	100	0.151	Contact Map
2zsgA	2	0.9801	100	0.153	Contact Map
3q6dA	1	0.9773	100	0.156	Contact Map
1wy2A	2	0.9631	100	0.161	Contact Map
4r60A	2	0.9801	100	0.168	Contact Map
1wn1A	2	0.9688	100	0.168	Contact Map
4egeA	2	0.9744	100	0.18	Contact Map
1kp0A	2	0.8835	100	0.194	Contact Map
1chmA	2	0.983	100	0.206	Contact Map
2v3zA	3	0.9943	100	0.209	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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