GREMLIN Database
GCH1 - GTP cyclohydrolase 1
UniProt: Q980E8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (182)
Sequences: 2958 (1394)
Seq/√Len: 103.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A40_E3.3361.00
102_V118_I3.1091.00
40_E44_K2.9791.00
12_V47_L2.5481.00
15_I22_I2.5411.00
18_R21_E2.5341.00
53_L129_L2.4161.00
103_A154_M2.3211.00
37_E40_E2.2391.00
85_F159_A2.1271.00
20_R31_E2.1261.00
141_D182_R2.0761.00
107_S151_K2.0431.00
14_E21_E2.0051.00
14_E24_E1.9681.00
49_M94_L1.9321.00
46_L50_T1.9191.00
58_P146_S1.9051.00
100_I157_G1.8791.00
103_A195_V1.8281.00
56_P59_Q1.7981.00
154_M181_Y1.7861.00
28_E32_R1.7661.00
18_R25_L1.7531.00
19_I42_V1.7341.00
125_Y138_Q1.7271.00
77_I185_F1.6961.00
60_I124_Y1.6681.00
75_N186_K1.6671.00
13_E16_A1.6341.00
67_D111_K1.6081.00
190_A193_N1.5551.00
21_E24_E1.5531.00
93_M129_L1.5181.00
140_A182_R1.5081.00
128_R138_Q1.5081.00
99_K158_N1.5021.00
86_S162_M1.4991.00
77_I195_V1.4961.00
101_H158_N1.4941.00
17_R21_E1.4821.00
86_S166_V1.4761.00
84_N173_E1.4611.00
50_T129_L1.4521.00
160_I165_Y1.4061.00
151_K184_L1.4021.00
193_N197_R1.4021.00
85_F122_V1.3991.00
50_T88_L1.3991.00
184_L188_N1.3951.00
158_N175_K1.3550.99
33_E67_D1.3540.99
156_I199_L1.3410.99
189_R193_N1.3350.99
154_M195_V1.3340.99
144_M182_R1.3210.99
105_I184_L1.3200.99
51_S55_T1.3100.99
143_I148_I1.3030.99
102_V122_V1.2970.99
123_N171_D1.2770.99
11_L14_E1.2650.99
55_T124_Y1.2590.99
156_I195_V1.2470.99
45_A49_M1.2450.99
48_E170_K1.2360.99
52_G128_R1.2130.99
156_I179_V1.2060.99
15_I43_A1.2010.99
125_Y142_A1.2000.99
23_L93_M1.1960.99
107_S110_G1.1950.99
140_A180_A1.1850.99
162_M166_V1.1760.98
21_E25_L1.1520.98
77_I103_A1.1490.98
125_Y135_L1.1430.98
37_E63_F1.1410.98
107_S149_K1.1300.98
82_D99_K1.1240.98
197_R200_D1.1230.98
80_I174_A1.1170.98
23_L28_E1.1160.98
112_V131_I1.1080.98
61_K113_A1.1050.98
85_F157_G1.0920.98
122_V139_I1.0770.97
100_I139_I1.0750.97
121_I143_I1.0740.97
13_E17_R1.0690.97
136_V178_S1.0650.97
160_I173_E1.0610.97
97_I162_M1.0520.97
115_F176_L1.0470.97
22_I46_L1.0440.97
28_E34_G1.0440.97
113_A118_I1.0390.97
117_K120_R1.0300.96
179_V191_L1.0170.96
131_I134_R1.0050.96
141_D146_S1.0050.96
57_P124_Y1.0040.96
20_R30_P1.0030.96
181_Y192_Q1.0000.96
55_T60_I0.9650.95
79_L103_A0.9600.95
19_I22_I0.9500.95
100_I122_V0.9490.94
51_S127_S0.9470.94
11_L25_L0.9370.94
80_I176_L0.9240.94
88_L94_L0.9190.93
58_P147_E0.9130.93
60_I121_I0.9080.93
140_A153_V0.9070.93
77_I191_L0.9060.93
12_V16_A0.9010.93
140_A155_V0.8990.93
137_E141_D0.8940.93
20_R24_E0.8850.92
160_I175_K0.8800.92
86_S97_I0.8790.92
185_F195_V0.8780.92
135_L139_I0.8760.92
113_A154_M0.8730.92
31_E36_K0.8710.92
84_N99_K0.8700.91
32_R35_L0.8700.91
42_V46_L0.8700.91
144_M153_V0.8680.91
42_V93_M0.8660.91
12_V44_K0.8630.91
101_H156_I0.8610.91
195_V199_L0.8470.90
85_F135_L0.8420.90
94_L166_V0.8410.90
28_E35_L0.8390.90
19_I46_L0.8390.90
72_Y134_R0.8380.90
18_R22_I0.8370.90
116_S120_R0.8300.89
191_L194_H0.8270.89
81_K177_V0.8220.89
113_A148_I0.8150.89
126_S135_L0.8080.88
111_K149_K0.8030.88
14_E25_L0.8030.88
142_A146_S0.7900.87
113_A121_I0.7890.87
80_I115_F0.7870.87
165_Y172_K0.7840.87
123_N127_S0.7840.87
26_L46_L0.7830.87
141_D180_A0.7760.86
34_G90_E0.7750.86
136_V157_G0.7740.86
90_E134_R0.7650.85
30_P35_L0.7650.85
96_I162_M0.7610.85
80_I118_I0.7600.85
49_M88_L0.7560.85
184_L187_T0.7470.84
74_K134_R0.7450.84
188_N191_L0.7430.84
14_E18_R0.7400.83
12_V40_E0.7380.83
65_L111_K0.7340.83
46_L49_M0.7320.83
15_I19_I0.7290.82
116_S169_V0.7250.82
119_I164_S0.7250.82
181_Y196_F0.7170.81
121_I142_A0.7140.81
97_I160_I0.7130.81
76_Q186_K0.7120.81
162_M165_Y0.7110.81
57_P61_K0.7080.81
144_M150_P0.7050.80
118_I143_I0.7030.80
19_I93_M0.7000.80
49_M166_V0.7000.80
113_A119_I0.6980.80
164_S176_L0.6960.79
179_V194_H0.6930.79
135_L157_G0.6920.79
79_L198_L0.6890.79
141_D144_M0.6890.79
84_N160_I0.6880.79
75_N151_K0.6870.78
101_H199_L0.6860.78
61_K121_I0.6850.78
88_L166_V0.6840.78
181_Y186_K0.6820.78
76_Q180_A0.6750.77
91_H133_E0.6730.77
133_E163_C0.6700.77
119_I171_D0.6680.77
181_Y191_L0.6670.76
85_F97_I0.6650.76
154_M179_V0.6560.75
97_I165_Y0.6530.75
105_I151_K0.6520.75
98_G159_A0.6490.74
92_H133_E0.6470.74
181_Y185_F0.6440.74
53_L125_Y0.6380.73
86_S127_S0.6360.73
132_Q163_C0.6350.73
181_Y194_H0.6330.73
179_V186_K0.6300.72
88_L96_I0.6270.72
146_S149_K0.6210.71
80_I106_V0.6180.71
117_K169_V0.6150.70
144_M147_E0.6140.70
67_D73_E0.6100.70
53_L93_M0.6100.70
58_P62_V0.6090.70
144_M149_K0.6060.69
19_I23_L0.6050.69
100_I118_I0.6050.69
127_S170_K0.6040.69
137_E180_A0.5990.68
115_F120_R0.5970.68
84_N172_K0.5930.68
124_Y142_A0.5930.68
76_Q179_V0.5930.68
32_R90_E0.5910.67
142_A147_E0.5900.67
91_H163_C0.5900.67
99_K175_K0.5850.67
167_R176_L0.5840.67
47_L54_R0.5820.66
72_Y131_I0.5820.66
92_H163_C0.5810.66
15_I25_L0.5800.66
131_I176_L0.5790.66
16_A20_R0.5710.65
77_I105_I0.5710.65
115_F161_H0.5700.65
156_I198_L0.5690.65
89_C92_H0.5630.64
57_P113_A0.5590.63
175_K189_R0.5590.63
57_P65_L0.5570.63
59_Q62_V0.5550.63
15_I46_L0.5540.62
30_P34_G0.5530.62
98_G122_V0.5480.62
168_G176_L0.5470.62
121_I125_Y0.5460.61
103_A156_I0.5440.61
82_D101_H0.5440.61
156_I191_L0.5430.61
55_T59_Q0.5380.60
112_V149_K0.5350.60
11_L47_L0.5340.60
135_L138_Q0.5330.60
61_K65_L0.5310.59
184_L191_L0.5310.59
62_V124_Y0.5310.59
85_F98_G0.5300.59
78_V112_V0.5260.59
23_L42_V0.5210.58
152_G184_L0.5190.58
187_T190_A0.5140.57
12_V17_R0.5130.57
193_N196_F0.5130.57
35_L129_L0.5120.57
80_I164_S0.5120.57
76_Q191_L0.5050.56
105_I191_L0.5030.55
17_R20_R0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1is8A 5 0.9231 100 0.046 Contact Map
4uqfA 5 0.8942 100 0.057 Contact Map
1a8rA 7 0.9423 100 0.059 Contact Map
1wurA 6 0.8894 100 0.11 Contact Map
4f8bA 5 0.6827 87.4 0.935 Contact Map
3uxjA 2 0.8077 35 0.956 Contact Map
3sbtB 1 0.2067 19.5 0.961 Contact Map
1cmbA 2 0.1683 14.2 0.963 Contact Map
2nsaA 2 0.4279 14.1 0.963 Contact Map
1w79A 1 0.6394 12.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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