GREMLIN Database
Q980E5 - Thioredoxin (TrxA-1)
UniProt: Q980E5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (104)
Sequences: 9923 (6433)
Seq/√Len: 630.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_V92_A2.6771.00
69_K121_E2.4771.00
33_L81_G2.2881.00
39_D94_K2.2591.00
73_K125_E2.0831.00
73_K121_E1.9911.00
35_E90_K1.9541.00
125_E129_N1.9521.00
104_L114_S1.8991.00
35_E91_I1.8891.00
120_D123_T1.8831.00
84_N87_E1.8481.00
95_Y106_F1.7511.00
48_V79_V1.7131.00
111_L114_S1.6931.00
66_I121_E1.6921.00
74_Y129_N1.6561.00
57_C60_C1.6261.00
51_D82_R1.6261.00
85_V100_I1.5941.00
74_Y125_E1.5881.00
104_L111_L1.5811.00
35_E88_N1.5571.00
66_I69_K1.5331.00
37_N41_V1.4671.00
39_D43_R1.4601.00
34_T37_N1.4531.00
33_L41_V1.4431.00
46_K79_V1.4411.00
67_Y80_F1.4401.00
123_T126_S1.4011.00
47_L105_I1.3831.00
41_V79_V1.3811.00
49_L67_Y1.3791.00
113_D127_T1.3771.00
29_V72_E1.3721.00
118_A123_T1.3601.00
105_I131_Y1.3341.00
48_V81_G1.3251.00
77_K129_N1.3091.00
49_L103_T1.2931.00
55_E84_N1.2821.00
29_V75_K1.2521.00
83_L91_I1.2261.00
70_V125_E1.2141.00
70_V80_F1.1971.00
34_T88_N1.1911.00
121_E125_E1.1651.00
63_Y103_T1.1641.00
105_I127_T1.1571.00
115_L119_V1.1571.00
89_Q93_D1.1521.00
115_L127_T1.1511.00
31_L41_V1.1491.00
50_V106_F1.0601.00
31_L79_V1.0591.00
64_E68_K1.0551.00
41_V48_V1.0521.00
51_D64_E1.0471.00
119_V123_T1.0331.00
103_T124_L1.0241.00
53_W82_R1.0201.00
70_V121_E0.9991.00
127_T131_Y0.9821.00
52_C97_V0.9721.00
63_Y66_I0.9431.00
64_E82_R0.9411.00
68_K82_R0.9241.00
90_K94_K0.9151.00
32_V82_R0.9111.00
83_L92_A0.9061.00
107_V112_V0.9011.00
63_Y124_L0.8821.00
45_N108_N0.8501.00
52_C95_Y0.8371.00
105_I128_V0.8331.00
122_D126_S0.8321.00
70_V124_L0.7991.00
42_I48_V0.7981.00
53_W84_N0.7881.00
67_Y103_T0.7831.00
74_Y77_K0.7821.00
38_F42_I0.7741.00
66_I120_D0.7691.00
90_K93_D0.7681.00
49_L80_F0.7671.00
78_A128_V0.7651.00
32_V87_E0.7581.00
119_V127_T0.7561.00
70_V74_Y0.7521.00
127_T130_K0.7511.00
52_C85_V0.7491.00
37_N81_G0.7481.00
58_A61_H0.7301.00
52_C104_L0.7271.00
126_S129_N0.7261.00
51_D59_P0.7091.00
38_F91_I0.7071.00
47_L107_V0.7041.00
55_E86_D0.7041.00
110_Q113_D0.6881.00
49_L128_V0.6861.00
88_N91_I0.6851.00
98_L114_S0.6821.00
33_L83_L0.6551.00
63_Y67_Y0.6531.00
46_K76_G0.6481.00
33_L37_N0.6451.00
66_I118_A0.6441.00
106_F111_L0.6411.00
40_E43_R0.6381.00
54_A86_D0.6361.00
58_A62_L0.6351.00
63_Y119_V0.6341.00
38_F52_C0.6321.00
113_D130_K0.6311.00
89_Q92_A0.6271.00
30_T71_A0.6261.00
51_D63_Y0.6261.00
28_D68_K0.6241.00
38_F95_Y0.6161.00
56_W61_H0.6151.00
71_A80_F0.6151.00
91_I94_K0.6121.00
55_E87_E0.6021.00
56_W86_D0.5971.00
67_Y128_V0.5941.00
59_P99_N0.5781.00
31_L81_G0.5731.00
37_N40_E0.5731.00
62_L118_A0.5701.00
72_E75_K0.5701.00
52_C83_L0.5681.00
62_L66_I0.5671.00
55_E100_I0.5651.00
97_V102_T0.5581.00
109_G113_D0.5541.00
49_L105_I0.5531.00
74_Y78_A0.5521.00
59_P62_L0.5511.00
96_S114_S0.5451.00
54_A60_C0.5400.99
83_L88_N0.5350.99
30_T67_Y0.5310.99
53_W100_I0.5280.99
113_D131_Y0.5230.99
126_S130_K0.5210.99
56_W100_I0.5190.99
33_L50_V0.5190.99
85_V97_V0.5110.99
28_D32_V0.5090.99
31_L48_V0.5080.99
60_C65_P0.5070.99
103_T115_L0.5050.99
55_E61_H0.5030.99
46_K108_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f8uA 2 0.797 99.9 0.242 Contact Map
2r2jA 2 0.7744 99.9 0.245 Contact Map
2b5eA 1 0.8722 99.8 0.264 Contact Map
3apoA 1 0.8271 99.8 0.267 Contact Map
3us3A 2 0.8797 99.8 0.283 Contact Map
1sjiA 2 0.8647 99.8 0.285 Contact Map
4ekzA 1 0.9549 99.8 0.298 Contact Map
3ed3A 1 0.8496 99.8 0.3 Contact Map
3idvA 1 0.8496 99.8 0.318 Contact Map
3bj5A 1 0.7895 99.8 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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