GREMLIN Database
Q980E3 - Uncharacterized protein
UniProt: Q980E3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (272)
Sequences: 350 (280)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_L210_A3.9811.00
81_A97_L3.6781.00
6_G79_S3.3690.99
223_E247_L3.2670.99
41_S83_L3.2120.99
31_A113_A3.0480.99
112_Y146_L2.8660.98
158_V253_A2.8410.98
247_L250_F2.8200.98
30_V156_I2.7470.97
16_D22_G2.7100.97
223_E250_F2.6870.97
113_A120_I2.6800.97
220_K247_L2.6790.97
186_T213_L2.6340.97
220_K223_E2.6320.97
185_D189_R2.4350.95
16_D19_G2.4180.95
152_F199_V2.3860.94
114_F283_A2.2840.93
224_V247_L2.2370.92
123_G147_I2.2250.92
85_A91_R2.1950.91
89_F213_L2.0080.87
38_V62_E1.9890.86
14_L106_T1.9700.86
94_S115_E1.9540.85
47_P55_V1.9390.85
106_T220_K1.9190.84
152_F156_I1.8870.83
218_G223_E1.8640.82
25_D106_T1.8180.81
13_T247_L1.8010.80
108_G122_D1.7970.80
5_V284_K1.7970.80
123_G145_P1.7900.80
106_T247_L1.7870.80
95_Y115_E1.7820.79
3_K286_F1.7650.79
73_T106_T1.7640.79
25_D250_F1.7560.78
5_V38_V1.7540.78
225_F247_L1.7400.78
19_G22_G1.7250.77
204_L208_L1.7060.76
25_D223_E1.6870.75
3_K38_V1.6720.75
106_T223_E1.6640.74
107_S122_D1.6360.73
220_K250_F1.6360.73
261_K265_D1.6320.73
39_V60_I1.6200.72
13_T223_E1.6140.72
25_D247_L1.5770.70
106_T250_F1.5600.69
13_T224_V1.5450.69
224_V250_F1.5370.68
5_V36_R1.5340.68
22_G193_M1.5330.68
16_D193_M1.5290.68
13_T250_F1.5260.68
226_L250_F1.5110.67
158_V274_F1.5100.67
11_H29_G1.4880.66
75_Q114_F1.4830.65
121_V196_I1.4830.65
220_K224_V1.4650.64
42_G57_K1.4620.64
152_F280_N1.4420.63
58_I83_L1.4050.61
75_Q219_F1.3930.60
281_E284_K1.3880.60
119_F199_V1.3820.60
34_Y62_E1.3740.59
225_F250_F1.3720.59
73_T77_L1.3600.58
9_R27_G1.3460.58
108_G214_I1.3180.56
31_A279_N1.3150.56
188_A253_A1.2920.54
16_D21_Y1.2820.54
195_L209_N1.2800.54
203_D206_G1.2790.54
107_S114_F1.2730.53
93_N96_E1.2720.53
121_V191_V1.2720.53
161_V254_V1.2600.53
16_D192_L1.2530.52
75_Q107_S1.2500.52
43_N87_Y1.2270.51
50_S57_K1.2200.50
49_V58_I1.2160.50
58_I65_E1.2150.50
161_V255_Y1.2100.50
29_G110_G1.2050.49
258_V267_L1.1990.49
15_F278_P1.1930.49
181_L189_R1.1880.48
18_E193_M1.1870.48
157_Y267_L1.1810.48
19_G189_R1.1770.48
32_L70_L1.1510.46
238_M243_F1.1500.46
16_D25_D1.1460.46
11_H110_G1.1390.45
93_N151_N1.1390.45
159_N256_T1.1340.45
25_D226_L1.1300.45
106_T224_V1.1290.45
84_A189_R1.1230.44
119_F278_P1.1170.44
9_R14_L1.1110.44
198_S208_L1.1060.43
25_D218_G1.1040.43
23_R201_E1.1040.43
56_P88_N1.1030.43
223_E226_L1.1000.43
66_Q230_E1.0960.43
16_D145_P1.0950.43
4_I120_I1.0950.43
85_A97_L1.0940.43
37_I64_F1.0920.43
190_V210_A1.0820.42
176_F219_F1.0790.42
28_A121_V1.0710.41
14_L27_G1.0530.40
28_A257_F1.0490.40
179_A254_V1.0480.40
5_V285_V1.0360.39
74_T107_S1.0320.39
110_G249_S1.0300.39
25_D220_K1.0130.38
31_A280_N1.0100.38
40_R61_E0.9940.37
143_P218_G0.9910.37
193_M228_T0.9900.37
166_R215_Q0.9890.37
109_V248_S0.9790.36
33_K276_S0.9780.36
19_G193_M0.9740.36
9_R246_G0.9710.36
90_K266_E0.9690.36
31_A120_I0.9650.35
105_G223_E0.9590.35
82_K94_S0.9510.35
14_L25_D0.9490.35
22_G81_A0.9460.34
246_G255_Y0.9420.34
13_T220_K0.9320.34
73_T169_G0.9280.33
39_V269_S0.9240.33
29_G249_S0.9220.33
218_G226_L0.9200.33
48_E79_S0.9190.33
119_F256_T0.9160.33
113_A143_P0.9150.33
12_I244_P0.9120.33
207_A256_T0.9060.32
13_T225_F0.9000.32
145_P192_L0.8930.32
43_N96_E0.8890.31
7_L113_A0.8860.31
21_Y188_A0.8840.31
198_S210_A0.8840.31
12_I199_V0.8820.31
228_T255_Y0.8800.31
55_V88_N0.8790.31
175_A250_F0.8780.31
62_E275_V0.8750.31
105_G125_H0.8730.31
125_H141_A0.8640.30
109_V278_P0.8600.30
30_V285_V0.8580.30
108_G215_Q0.8550.30
114_F219_F0.8550.30
16_D123_G0.8530.30
17_L23_R0.8510.29
78_L114_F0.8500.29
114_F166_R0.8480.29
218_G247_L0.8460.29
17_L31_A0.8430.29
65_E247_L0.8400.29
179_A184_L0.8390.29
9_R67_H0.8390.29
106_T227_Q0.8390.29
189_R193_M0.8370.29
12_I30_V0.8360.29
40_R59_C0.8340.29
218_G250_F0.8330.29
19_G123_G0.8290.28
13_T25_D0.8160.28
151_N178_Q0.8160.28
8_S35_P0.8140.28
122_D215_Q0.8100.27
78_L282_G0.8070.27
198_S279_N0.8070.27
157_Y238_M0.8010.27
214_I241_A0.8010.27
123_G184_L0.7910.27
142_P285_V0.7910.27
91_R97_L0.7900.26
74_T122_D0.7900.26
240_K277_E0.7890.26
32_L260_S0.7870.26
5_V286_F0.7830.26
85_A88_N0.7820.26
154_W207_A0.7800.26
121_V157_Y0.7760.26
281_E285_V0.7750.26
27_G109_V0.7720.26
107_S219_F0.7720.26
121_V257_F0.7710.26
67_H72_H0.7700.26
27_G111_V0.7690.26
95_Y109_V0.7690.26
27_G161_V0.7680.25
78_L107_S0.7640.25
98_A115_E0.7630.25
75_Q109_V0.7620.25
212_S244_P0.7600.25
75_Q154_W0.7580.25
81_A101_V0.7560.25
223_E232_K0.7560.25
196_I208_L0.7540.25
60_I70_L0.7500.25
62_E68_I0.7470.25
80_V85_A0.7460.24
82_K90_K0.7430.24
154_W219_F0.7410.24
208_L243_F0.7410.24
60_I202_R0.7410.24
14_L247_L0.7380.24
84_A242_G0.7360.24
220_K225_F0.7350.24
160_V253_A0.7320.24
34_Y279_N0.7290.24
74_T154_W0.7290.24
241_A270_R0.7280.24
82_K114_F0.7280.24
9_R72_H0.7280.24
10_I153_P0.7270.24
17_L34_Y0.7250.24
4_I9_R0.7240.24
7_L189_R0.7230.23
38_V61_E0.7200.23
38_V240_K0.7190.23
84_A245_A0.7170.23
100_L270_R0.7160.23
14_L220_K0.7160.23
144_P179_A0.7140.23
75_Q215_Q0.7110.23
106_T169_G0.7090.23
12_I70_L0.7070.23
46_K202_R0.7040.23
148_A200_A0.7040.23
227_Q250_F0.6980.22
156_I257_F0.6970.22
11_H249_S0.6940.22
14_L112_Y0.6930.22
92_L100_L0.6890.22
61_E91_R0.6880.22
35_P276_S0.6860.22
13_T64_F0.6840.22
6_G258_V0.6840.22
199_V266_E0.6810.22
40_R168_F0.6810.22
74_T103_R0.6800.22
158_V198_S0.6800.22
96_E266_E0.6790.22
14_L250_F0.6790.22
105_G220_K0.6650.21
18_E156_I0.6630.21
97_L111_V0.6630.21
107_S176_F0.6610.21
8_S64_F0.6600.21
124_G144_P0.6590.21
25_D221_K0.6580.21
14_L254_V0.6540.21
169_G222_V0.6540.21
8_S14_L0.6540.21
3_K277_E0.6490.20
86_E170_K0.6490.20
12_I222_V0.6460.20
231_V254_V0.6430.20
86_E283_A0.6430.20
213_L217_L0.6410.20
46_K50_S0.6410.20
7_L31_A0.6410.20
23_R184_L0.6400.20
105_G218_G0.6380.20
158_V179_A0.6380.20
80_V148_A0.6370.20
169_G188_A0.6370.20
114_F122_D0.6280.20
27_G213_L0.6270.20
196_I246_G0.6270.20
113_A156_I0.6260.20
82_K283_A0.6250.20
3_K60_I0.6250.20
74_T124_G0.6250.20
208_L244_P0.6240.20
152_F278_P0.6230.19
14_L223_E0.6220.19
75_Q166_R0.6200.19
109_V173_I0.6200.19
49_V99_K0.6190.19
65_E223_E0.6180.19
41_S56_P0.6180.19
20_K27_G0.6170.19
44_C285_V0.6160.19
27_G223_E0.6160.19
70_L176_F0.6150.19
14_L219_F0.6130.19
47_P58_I0.6120.19
172_E251_G0.6120.19
69_G251_G0.6120.19
69_G172_E0.6120.19
24_L51_L0.6110.19
174_N257_F0.6100.19
179_A224_V0.6050.19
162_R202_R0.6040.19
15_F188_A0.6030.19
27_G121_V0.6030.19
107_S124_G0.5990.19
3_K8_S0.5960.18
88_N112_Y0.5960.18
119_F198_S0.5930.18
176_F242_G0.5930.18
216_D224_V0.5930.18
43_N178_Q0.5930.18
4_I11_H0.5920.18
5_V269_S0.5910.18
10_I247_L0.5880.18
186_T284_K0.5870.18
60_I77_L0.5870.18
238_M246_G0.5860.18
42_G240_K0.5830.18
14_L107_S0.5820.18
4_I100_L0.5820.18
98_A219_F0.5800.18
93_N163_G0.5790.18
4_I76_Y0.5760.18
56_P269_S0.5750.18
208_L256_T0.5710.18
12_I152_F0.5690.18
220_K227_Q0.5680.17
16_D189_R0.5670.17
213_L216_D0.5670.17
34_Y37_I0.5660.17
122_D144_P0.5660.17
85_A92_L0.5650.17
75_Q122_D0.5620.17
7_L279_N0.5610.17
156_I167_V0.5600.17
45_F253_A0.5590.17
190_V213_L0.5590.17
146_L192_L0.5580.17
61_E286_F0.5560.17
212_S239_V0.5550.17
125_H246_G0.5530.17
187_L222_V0.5510.17
68_I188_A0.5490.17
93_N268_I0.5450.17
57_K178_Q0.5450.17
16_D188_A0.5450.17
144_P148_A0.5440.17
49_V211_I0.5400.17
16_D231_V0.5380.16
191_V245_A0.5380.16
191_V214_I0.5370.16
108_G246_G0.5370.16
120_I275_V0.5370.16
79_S203_D0.5340.16
14_L176_F0.5340.16
208_L259_S0.5330.16
81_A253_A0.5310.16
38_V79_S0.5290.16
222_V258_V0.5290.16
106_T175_A0.5290.16
4_I14_L0.5280.16
25_D224_V0.5280.16
184_L231_V0.5280.16
10_I255_Y0.5270.16
74_T78_L0.5270.16
88_N211_I0.5250.16
175_A228_T0.5240.16
168_F176_F0.5230.16
17_L167_V0.5220.16
194_E285_V0.5210.16
3_K236_N0.5210.16
11_H27_G0.5210.16
98_A250_F0.5180.16
98_A114_F0.5170.16
115_E146_L0.5170.16
229_D233_K0.5160.16
221_K227_Q0.5160.16
126_S221_K0.5150.16
268_I272_G0.5130.16
61_E170_K0.5090.16
200_A204_L0.5060.15
75_Q250_F0.5050.15
6_G76_Y0.5050.15
46_K267_L0.5040.15
82_K115_E0.5040.15
14_L218_G0.5030.15
23_R122_D0.5010.15
154_W215_Q0.5010.15
238_M254_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hulA 4 0.8219 100 0.716 Contact Map
3qt5A 2 0.9247 100 0.723 Contact Map
2cz9A 1 0.863 100 0.725 Contact Map
4rpfA 2 0.8801 100 0.725 Contact Map
1h72C 2 0.8562 100 0.728 Contact Map
4p52A 2 0.863 100 0.729 Contact Map
3pyfA 1 0.863 100 0.729 Contact Map
2gs8A 1 0.8973 100 0.73 Contact Map
4rksA 1 0.9041 100 0.735 Contact Map
2v8pA 1 0.8219 100 0.735 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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