GREMLIN Database
Q980E2 - Sun (Fmu) protein (Sun-1)
UniProt: Q980E2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (269)
Sequences: 4494 (3416)
Seq/√Len: 208.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_I323_L4.0381.00
278_V324_I3.8721.00
231_V273_L3.8001.00
278_V322_K3.6121.00
160_E230_K3.5741.00
163_V228_V3.4681.00
217_R264_Q3.0761.00
184_K210_E2.8731.00
263_K294_V2.7901.00
305_E319_F2.7731.00
173_L187_G2.6811.00
229_D274_K2.6801.00
273_L279_V2.6281.00
165_M269_A2.6111.00
233_I265_F2.5801.00
109_Y119_V2.5681.00
104_A107_K2.4901.00
56_E80_L2.4691.00
202_A209_I2.4181.00
103_V108_Y2.3571.00
67_E288_T2.3411.00
186_I228_V2.2861.00
280_I322_K2.2141.00
189_D195_V2.2081.00
195_V211_I2.1691.00
122_S145_K2.1421.00
108_Y140_I2.0781.00
63_K289_W2.0161.00
156_P160_E2.0021.00
173_L185_L1.9931.00
167_A198_L1.9401.00
151_A175_H1.9331.00
161_K184_K1.9251.00
111_M139_L1.9201.00
240_L287_T1.9121.00
133_P137_N1.8891.00
259_H294_V1.8131.00
176_I232_V1.7691.00
283_T291_N1.7611.00
102_P206_G1.7601.00
292_E307_R1.7481.00
69_A73_A1.7261.00
58_K62_D1.6731.00
240_L285_T1.6641.00
154_L230_K1.6251.00
73_A77_K1.6091.00
154_L176_I1.6011.00
177_Y207_M1.5901.00
157_H160_E1.5771.00
273_L325_K1.5601.00
293_K296_N1.5591.00
174_T205_M1.5561.00
146_A315_I1.5511.00
98_D108_Y1.5481.00
103_V139_L1.5451.00
105_E121_N1.5421.00
96_Y140_I1.5101.00
308_F315_I1.5081.00
162_I183_V1.5041.00
196_E199_R1.4911.00
266_L279_V1.4551.00
161_K186_I1.4551.00
152_H179_L1.4451.00
155_D230_K1.4451.00
195_V213_K1.4411.00
153_L320_I1.4381.00
151_A176_I1.4231.00
141_Y174_T1.4041.00
84_V93_V1.3951.00
63_K287_T1.3501.00
72_G311_H1.3491.00
150_V320_I1.3421.00
115_L134_E1.3301.00
56_E79_G1.3251.00
98_D105_E1.3191.00
161_K228_V1.3161.00
270_Y279_V1.3151.00
263_K267_N1.3131.00
158_P180_E1.2981.00
186_I212_Y1.2961.00
238_S258_F1.2841.00
167_A173_L1.2731.00
195_V198_L1.2711.00
155_D278_V1.2701.00
175_H179_L1.2521.00
289_W293_K1.2501.00
68_S309_H1.2471.00
288_T293_K1.2441.00
230_K278_V1.2311.00
150_V175_H1.2221.00
65_T73_A1.2211.00
95_V145_K1.2201.00
141_Y178_Q1.2161.00
256_L289_W1.2121.00
216_S265_F1.2071.00
255_I259_H1.1961.00
158_P182_R1.1921.00
100_G178_Q1.1881.00
69_A72_G1.1801.00
165_M188_F1.1751.00
176_I230_K1.1741.00
260_K264_Q1.1731.00
156_P162_I1.1621.00
220_Y268_S1.1551.00
161_K227_D1.1521.00
156_P176_I1.1461.00
134_E139_L1.1361.00
192_E213_K1.1301.00
120_T124_Y1.1171.00
146_A308_F1.1131.00
61_V76_Y1.0941.00
250_K254_D1.0791.00
174_T201_L1.0791.00
199_R211_I1.0771.00
154_L280_I1.0561.00
134_E140_I1.0531.00
167_A187_G1.0471.00
119_V122_S1.0441.00
150_V280_I1.0441.00
174_T202_A1.0411.00
64_K287_T1.0391.00
188_F212_Y1.0381.00
102_P139_L1.0331.00
300_F303_E1.0321.00
118_E124_Y1.0231.00
238_S255_I1.0151.00
165_M216_S1.0111.00
176_I185_L1.0091.00
173_L202_A1.0071.00
300_F305_E1.0071.00
235_P265_F1.0061.00
141_Y201_L1.0021.00
299_R302_V0.9961.00
101_I207_M0.9921.00
259_H263_K0.9871.00
63_K67_E0.9831.00
300_F304_Y0.9791.00
288_T292_E0.9781.00
268_S271_K0.9761.00
109_Y121_N0.9731.00
301_S304_Y0.9721.00
63_K252_K0.9651.00
51_E58_K0.9631.00
217_R265_F0.9621.00
156_P179_L0.9480.99
145_K315_I0.9460.99
62_D66_A0.9410.99
173_L209_I0.9350.99
297_D300_F0.9190.99
101_I181_P0.9170.99
147_S318_F0.9140.99
99_N102_P0.9140.99
231_V269_A0.9120.99
268_S272_I0.9070.99
280_I320_I0.9060.99
103_V111_M0.9000.99
105_E109_Y0.8950.99
245_K249_H0.8930.99
311_H315_I0.8900.99
232_V282_S0.8880.99
302_V305_E0.8790.99
51_E61_V0.8790.99
251_T254_D0.8790.99
163_V188_F0.8730.99
116_V119_V0.8720.99
219_L272_I0.8700.99
233_I269_A0.8680.99
107_K111_M0.8670.99
225_I271_K0.8660.99
218_Y221_E0.8550.99
188_F219_L0.8520.99
214_A219_L0.8510.99
308_F313_H0.8480.99
257_N260_K0.8360.99
292_E296_N0.8350.99
178_Q207_M0.8350.99
145_K149_Y0.8350.99
176_I183_V0.8330.99
113_T119_V0.8300.99
110_G113_T0.8280.99
193_K197_K0.8270.99
74_N78_P0.8250.99
231_V279_V0.8250.99
181_P208_R0.8220.98
163_V231_V0.8220.98
165_M233_I0.8190.98
49_P53_N0.8180.98
188_F214_A0.8160.98
202_A211_I0.8150.98
193_K196_E0.8060.98
270_Y273_L0.8060.98
257_N261_Y0.8050.98
144_G316_T0.8040.98
252_K256_L0.8020.98
301_S305_E0.8010.98
52_I55_H0.8000.98
133_P136_K0.7990.98
57_N60_I0.7990.98
310_P317_G0.7980.98
233_I266_L0.7970.98
189_D198_L0.7970.98
154_L232_V0.7960.98
75_V79_G0.7960.98
221_E268_S0.7950.98
61_V77_K0.7890.98
254_D257_N0.7850.98
199_R203_N0.7850.98
110_G114_N0.7820.98
115_L132_L0.7780.98
72_G75_V0.7770.98
56_E61_V0.7740.98
112_N116_V0.7740.98
270_Y325_K0.7720.98
95_V122_S0.7710.98
54_I61_V0.7710.98
186_I210_E0.7690.98
219_L268_S0.7630.98
103_V107_K0.7600.98
161_K274_K0.7580.97
64_K68_S0.7550.97
81_K85_I0.7550.97
149_Y306_I0.7530.97
64_K77_K0.7480.97
177_Y185_L0.7430.97
200_D203_N0.7360.97
56_E60_I0.7360.97
71_L74_N0.7350.97
262_Q281_Y0.7350.97
275_K325_K0.7340.97
261_Y264_Q0.7330.97
153_L306_I0.7300.97
295_I321_A0.7300.97
77_K81_K0.7280.97
273_L277_G0.7270.97
160_E278_V0.7260.97
185_L207_M0.7210.97
72_G312_I0.7200.97
165_M231_V0.7170.96
64_K69_A0.7150.96
109_Y113_T0.7150.96
56_E77_K0.7120.96
306_I320_I0.7110.96
93_V97_S0.7110.96
113_T116_V0.7100.96
201_L204_K0.7100.96
111_M114_N0.7070.96
267_N294_V0.7010.96
299_R305_E0.6990.96
197_K200_D0.6980.96
298_P304_Y0.6910.96
78_P82_S0.6910.96
291_N307_R0.6910.96
156_P278_V0.6900.96
214_A218_Y0.6840.95
60_I64_K0.6820.95
240_L255_I0.6810.95
308_F312_I0.6790.95
106_G110_G0.6780.95
141_Y205_M0.6740.95
150_V282_S0.6730.95
188_F216_S0.6720.95
259_H289_W0.6680.95
108_Y134_E0.6670.95
65_T70_M0.6640.95
99_N103_V0.6640.95
169_A282_S0.6620.94
297_D302_V0.6580.94
100_G105_E0.6580.94
138_G204_K0.6570.94
217_R261_Y0.6550.94
200_D204_K0.6540.94
292_E319_F0.6530.94
299_R304_Y0.6530.94
220_Y272_I0.6520.94
255_I287_T0.6510.94
196_E200_D0.6490.94
77_K80_L0.6480.94
166_T233_I0.6480.94
97_S104_A0.6470.94
75_V78_P0.6470.94
105_E108_Y0.6450.94
192_E196_E0.6450.94
245_K248_D0.6430.94
81_K84_V0.6420.94
194_K240_L0.6410.94
157_H230_K0.6360.93
72_G76_Y0.6350.93
85_I94_T0.6350.93
305_E321_A0.6340.93
108_Y117_V0.6340.93
60_I287_T0.6300.93
273_L323_L0.6280.93
253_Q257_N0.6260.93
169_A194_K0.6230.93
156_P230_K0.6220.92
51_E55_H0.6220.92
168_Y282_S0.6220.92
149_Y315_I0.6210.92
162_I230_K0.6190.92
267_N271_K0.6180.92
299_R306_I0.6170.92
65_T69_A0.6120.92
111_M115_L0.6110.92
298_P302_V0.6100.92
117_V120_T0.6100.92
99_N206_G0.6100.92
60_I240_L0.6100.92
177_Y209_I0.6080.92
155_D179_L0.6040.91
81_K247_Y0.6040.91
235_P266_L0.6040.91
298_P305_E0.6030.91
292_E305_E0.6000.91
135_L140_I0.6000.91
172_K234_D0.5990.91
221_E272_I0.5970.91
115_L133_P0.5910.90
231_V271_K0.5910.90
256_L259_H0.5870.90
59_V64_K0.5830.90
70_M74_N0.5830.90
158_P181_P0.5820.90
101_I182_R0.5800.90
191_T197_K0.5790.90
260_K263_K0.5780.89
65_T72_G0.5770.89
62_D65_T0.5760.89
306_I319_F0.5740.89
135_L204_K0.5730.89
124_Y129_L0.5690.89
224_K227_D0.5680.89
181_P207_M0.5670.89
127_P132_L0.5670.89
54_I77_K0.5660.88
80_L84_V0.5650.88
270_Y323_L0.5640.88
112_N119_V0.5640.88
94_T97_S0.5630.88
178_Q205_M0.5600.88
57_N64_K0.5590.88
116_V120_T0.5590.88
232_V280_I0.5590.88
115_L119_V0.5570.88
59_V69_A0.5570.88
211_I214_A0.5540.87
152_H175_H0.5530.87
254_D258_F0.5510.87
189_D202_A0.5490.87
171_G236_P0.5460.87
61_V65_T0.5450.87
49_P52_I0.5450.87
61_V73_A0.5430.86
151_A179_L0.5430.86
71_L75_V0.5420.86
155_D322_K0.5420.86
73_A76_Y0.5410.86
234_D284_C0.5390.86
108_Y112_N0.5390.86
128_K131_D0.5370.86
165_M265_F0.5370.86
108_Y111_M0.5330.85
155_D160_E0.5320.85
188_F213_K0.5320.85
63_K66_A0.5310.85
243_R246_L0.5280.85
198_L211_I0.5280.85
234_D237_C0.5280.85
133_P194_K0.5270.85
225_I272_I0.5260.85
180_E183_V0.5250.85
216_S219_L0.5240.84
188_F272_I0.5240.84
70_M73_A0.5240.84
229_D277_G0.5220.84
131_D136_K0.5210.84
100_G104_A0.5210.84
239_A242_I0.5210.84
64_K286_V0.5210.84
303_E319_F0.5190.84
163_V272_I0.5180.84
135_L138_G0.5160.83
168_Y201_L0.5160.83
148_M151_A0.5160.83
96_Y142_V0.5160.83
68_S72_G0.5150.83
148_M175_H0.5150.83
73_A78_P0.5140.83
299_R303_E0.5130.83
56_E76_Y0.5130.83
220_Y225_I0.5120.83
141_Y168_Y0.5100.83
55_H61_V0.5090.83
269_A272_I0.5090.83
111_M134_E0.5080.83
99_N104_A0.5070.82
169_A198_L0.5060.82
238_S285_T0.5050.82
198_L201_L0.5040.82
154_L322_K0.5040.82
71_L77_K0.5030.82
100_G103_V0.5010.82
239_A247_Y0.5010.82
243_R249_H0.5000.82
117_V132_L0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yxlA 1 0.9572 100 0.374 Contact Map
1sqgA 1 0.9572 100 0.378 Contact Map
2frxA 1 0.7859 100 0.389 Contact Map
1ixkA 1 0.8135 100 0.399 Contact Map
3m4xA 1 0.789 100 0.412 Contact Map
3m6wA 2 0.8073 100 0.414 Contact Map
2b9eA 1 0.6789 100 0.442 Contact Map
3ajdA 1 0.6697 100 0.485 Contact Map
4fzvA 1 0.8165 100 0.53 Contact Map
4dmgA 2 0.9327 99.9 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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