GREMLIN Database
Q980E1 - Ferripyochelin binding protein
UniProt: Q980E1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (146)
Sequences: 6603 (4155)
Seq/√Len: 343.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_E77_K3.1181.00
64_I72_V3.0261.00
54_K76_D2.7711.00
127_I133_A2.7551.00
94_H112_Y2.6951.00
92_S111_E2.6271.00
33_D54_K2.5091.00
34_L55_E2.4471.00
116_G134_V2.3851.00
77_K94_H2.3451.00
32_G54_K2.3201.00
112_Y130_Y2.3091.00
14_S33_D2.3011.00
93_S111_E2.1331.00
111_E129_P2.1161.00
30_E51_R2.0631.00
76_D93_S2.0381.00
75_G93_S2.0001.00
92_S108_Q1.9691.00
70_Y106_G1.9321.00
90_K108_Q1.9251.00
86_I89_A1.7681.00
28_D49_S1.7621.00
73_E90_K1.7431.00
53_G76_D1.6771.00
110_K129_P1.6211.00
12_K30_E1.6181.00
16_K34_L1.5881.00
113_S131_S1.5831.00
119_S138_A1.4961.00
58_V62_T1.4961.00
51_R73_E1.4681.00
145_R148_E1.4171.00
131_S143_K1.4061.00
35_T76_D1.4011.00
61_N83_N1.3901.00
128_P140_V1.3781.00
134_V141_I1.3711.00
133_A140_V1.3571.00
83_N100_G1.3421.00
40_Y61_N1.3381.00
110_K128_P1.3201.00
128_P131_S1.3101.00
131_S140_V1.3091.00
140_V143_K1.3001.00
55_E160_L1.2911.00
20_H39_H1.2591.00
95_V113_S1.2271.00
115_I121_V1.2271.00
63_T83_N1.2221.00
56_S93_S1.2121.00
32_G51_R1.2031.00
41_V62_T1.2011.00
103_L107_S1.2001.00
97_V103_L1.1681.00
113_S129_P1.1611.00
22_T40_Y1.1581.00
130_Y149_I1.1371.00
29_V43_I1.1241.00
95_V129_P1.1001.00
133_A138_A1.0961.00
56_S78_V1.0921.00
31_I35_T1.0661.00
43_I50_I1.0551.00
121_V138_A1.0531.00
78_V93_S1.0351.00
118_G136_V1.0341.00
91_V95_V1.0321.00
150_L153_D1.0211.00
53_G73_E1.0151.00
154_E157_E1.0141.00
16_K33_D1.0111.00
105_N123_Q1.0111.00
62_T84_A1.0071.00
157_E161_K1.0031.00
102_I118_G1.0021.00
113_S127_I0.9711.00
35_T54_K0.9471.00
15_Q33_D0.9461.00
154_E158_E0.9421.00
32_G76_D0.9321.00
115_I127_I0.9311.00
155_N159_Y0.9291.00
75_G92_S0.9151.00
84_A101_A0.9131.00
119_S136_V0.9131.00
30_E49_S0.8811.00
35_T56_S0.8781.00
31_I37_I0.8721.00
104_L117_A0.8671.00
120_V136_V0.8621.00
13_V17_A0.8581.00
56_S76_D0.8551.00
142_K148_E0.8551.00
58_V80_I0.8511.00
107_S121_V0.8491.00
25_I29_V0.8441.00
95_V111_E0.8401.00
86_I91_V0.8381.00
115_I133_A0.8321.00
91_V97_V0.8301.00
96_I114_I0.8301.00
85_V99_M0.8261.00
48_D71_P0.8261.00
102_I120_V0.8161.00
72_V86_I0.8141.00
49_S71_P0.8131.00
97_V101_A0.8111.00
97_V115_I0.8101.00
107_S124_G0.8051.00
57_N79_T0.8011.00
75_G90_K0.7971.00
109_V113_S0.7961.00
52_I56_S0.7941.00
34_L54_K0.7861.00
92_S129_P0.7841.00
47_N66_T0.7781.00
24_Y40_Y0.7781.00
152_I155_N0.7761.00
110_K127_I0.7721.00
132_V144_L0.7711.00
128_P133_A0.7691.00
17_A35_T0.7661.00
82_H99_M0.7651.00
32_G53_G0.7611.00
79_T155_N0.7561.00
22_T39_H0.7551.00
108_Q124_G0.7431.00
155_N158_E0.7360.99
158_E161_K0.7360.99
112_Y149_I0.7330.99
53_G56_S0.7330.99
106_G124_G0.7310.99
104_L120_V0.7280.99
92_S110_K0.7250.99
74_I78_V0.7210.99
78_V111_E0.7150.99
88_G105_N0.7140.99
78_V91_V0.7130.99
78_V95_V0.7120.99
42_V61_N0.7110.99
80_I86_I0.6980.99
113_S133_A0.6960.99
100_G118_G0.6900.99
48_D70_Y0.6900.99
101_A115_I0.6880.99
110_K113_S0.6870.99
92_S95_V0.6830.99
112_Y153_D0.6830.99
14_S17_A0.6820.99
144_L148_E0.6800.99
80_I84_A0.6790.99
130_Y143_K0.6790.99
94_H111_E0.6740.99
94_H153_D0.6740.99
58_V64_I0.6660.99
151_I155_N0.6640.99
43_I52_I0.6540.99
130_Y146_E0.6540.99
85_V100_G0.6500.99
55_E76_D0.6490.99
127_I140_V0.6440.99
19_I23_S0.6440.99
146_E149_I0.6440.99
104_L107_S0.6400.99
153_D157_E0.6350.98
37_I43_I0.6340.98
151_I154_E0.6340.98
77_K153_D0.6280.98
59_Q82_H0.6200.98
101_A119_S0.6170.98
127_I131_S0.6160.98
150_L154_E0.6140.98
25_I31_I0.6110.98
89_A107_S0.6100.98
56_S74_I0.6100.98
157_E160_L0.6030.98
66_T70_Y0.5950.98
47_N158_E0.5920.98
74_I80_I0.5880.98
44_R65_H0.5850.97
40_Y83_N0.5820.97
53_G93_S0.5800.97
37_I41_V0.5800.97
114_I132_V0.5760.97
116_G141_I0.5750.97
48_D66_T0.5740.97
24_Y39_H0.5730.97
122_T134_V0.5650.97
81_G99_M0.5620.97
80_I97_V0.5580.97
14_S32_G0.5580.97
34_L160_L0.5560.97
70_Y88_G0.5560.97
85_V102_I0.5550.96
24_Y42_V0.5540.96
149_I153_D0.5530.96
135_G138_A0.5500.96
41_V58_V0.5490.96
77_K160_L0.5440.96
35_T52_I0.5440.96
146_E150_L0.5400.96
38_W57_N0.5370.96
29_V45_G0.5340.96
46_D49_S0.5310.95
49_S73_E0.5240.95
119_S134_V0.5230.95
42_V60_E0.5230.95
154_E161_K0.5210.95
116_G132_V0.5200.95
132_V142_K0.5190.95
86_I103_L0.5180.95
52_I58_V0.5180.95
111_E130_Y0.5120.95
107_S123_Q0.5070.94
87_H105_N0.5060.94
44_R60_E0.5050.94
18_Y39_H0.5010.94
32_G35_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xhdA 3 1 100 0.293 Contact Map
1v3wA 3 1 100 0.298 Contact Map
3r3rA 3 0.9941 100 0.31 Contact Map
3ixcA 3 0.9704 100 0.315 Contact Map
4mfgA 3 0.9822 100 0.32 Contact Map
4n27A 3 0.9941 100 0.322 Contact Map
3r1wA 3 1 100 0.323 Contact Map
3tv0A 3 0.8047 100 0.377 Contact Map
3hsqA 3 0.9882 100 0.377 Contact Map
3c8vA 3 0.9112 100 0.379 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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