GREMLIN Database
Q980E0 - Heme biosynthesis related protein (NirJ-like)
UniProt: Q980E0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (268)
Sequences: 11286 (8792)
Seq/√Len: 537.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L107_Y4.2041.00
59_K92_Y3.5851.00
143_C176_C3.2021.00
87_L117_K2.8171.00
112_E144_R2.7271.00
63_D92_Y2.7191.00
54_S57_R2.6891.00
57_R263_A2.6771.00
116_T148_Y2.6621.00
35_N105_N2.5501.00
235_V252_D2.5421.00
60_K64_N2.3991.00
247_D261_N2.3601.00
26_A65_L2.2761.00
247_D258_I2.2581.00
144_R147_K2.2551.00
94_H123_D2.1911.00
116_T120_D2.1471.00
55_T88_D2.0861.00
132_Y165_K2.0651.00
266_P269_K2.0151.00
33_R52_E1.9931.00
92_Y95_D1.9841.00
58_V89_L1.9541.00
85_D88_D1.9101.00
156_T169_K1.8391.00
87_L114_F1.8201.00
63_D96_G1.7941.00
165_K168_E1.7761.00
154_V173_V1.7531.00
62_I93_A1.7451.00
55_T59_K1.7291.00
261_N264_E1.7241.00
35_N108_R1.7161.00
106_G127_Y1.7121.00
265_E269_K1.6901.00
243_Y250_Y1.6681.00
243_Y247_D1.6651.00
130_D137_K1.6641.00
40_F130_D1.6631.00
112_E147_K1.6491.00
144_R148_Y1.6241.00
91_E117_K1.6191.00
55_T85_D1.5981.00
117_K120_D1.5801.00
59_K88_D1.5791.00
140_E143_C1.5721.00
119_A148_Y1.5681.00
75_F93_A1.5581.00
88_D91_E1.5571.00
91_E95_D1.5571.00
114_F117_K1.5551.00
143_C147_K1.5531.00
66_R96_G1.5461.00
57_R60_K1.5451.00
24_A71_V1.5281.00
143_C146_R1.5271.00
59_K63_D1.5111.00
81_T102_L1.4911.00
138_E141_N1.4811.00
110_K114_F1.4731.00
171_R175_E1.4691.00
172_K176_C1.4671.00
198_D201_E1.4651.00
112_E148_Y1.4631.00
276_V280_Q1.4591.00
110_K140_E1.4411.00
103_T126_H1.4391.00
127_Y142_L1.4311.00
115_L144_R1.4291.00
39_T135_N1.4201.00
30_V75_F1.3941.00
135_N161_Y1.3911.00
71_V99_Y1.3831.00
168_E171_R1.3831.00
64_N266_P1.3741.00
83_R89_L1.3671.00
73_L93_A1.3671.00
167_E208_D1.3661.00
140_E144_R1.3511.00
75_F100_I1.3391.00
160_R201_E1.3251.00
94_H100_I1.3061.00
146_R177_G1.2971.00
204_K208_D1.2961.00
28_F58_V1.2641.00
66_R98_F1.2601.00
115_L141_N1.2471.00
86_I90_L1.2351.00
233_K237_S1.2341.00
268_N272_Q1.2301.00
88_D92_Y1.2141.00
92_Y96_G1.2091.00
81_T108_R1.2091.00
286_N289_K1.2091.00
206_L209_L1.2071.00
207_Y211_R1.2061.00
171_R209_L1.2031.00
203_Y207_Y1.1851.00
127_Y141_N1.1851.00
139_L143_C1.1841.00
93_A100_I1.1731.00
248_L270_I1.1651.00
167_E171_R1.1581.00
53_G57_R1.1571.00
200_Y204_K1.1491.00
90_L122_I1.1431.00
110_K113_D1.1411.00
204_K207_Y1.1361.00
94_H121_K1.1251.00
209_L213_Y1.1221.00
258_I261_N1.1101.00
133_H138_E1.1011.00
125_L145_F1.0961.00
52_E83_R1.0881.00
171_R174_A1.0851.00
146_R176_C1.0841.00
156_T181_L1.0831.00
114_F118_L1.0801.00
127_Y145_F1.0781.00
205_V208_D1.0691.00
75_F90_L1.0691.00
26_A240_I1.0681.00
35_N79_E1.0671.00
184_P187_D1.0661.00
31_T52_E1.0501.00
132_Y164_Y1.0471.00
61_I242_I1.0411.00
115_L119_A1.0321.00
132_Y135_N1.0281.00
40_F136_V1.0261.00
139_L172_K1.0261.00
32_S244_P1.0231.00
146_R178_Y1.0131.00
119_A150_L1.0121.00
250_Y258_I1.0111.00
64_N68_S1.0101.00
87_L91_E1.0101.00
269_K273_S1.0081.00
201_E204_K1.0071.00
72_V101_M0.9951.00
55_T92_Y0.9901.00
171_R212_K0.9901.00
126_H155_Q0.9801.00
112_E116_T0.9791.00
131_E135_N0.9771.00
208_D212_K0.9771.00
51_G245_N0.9741.00
145_F152_V0.9641.00
284_L287_Q0.9631.00
154_V178_Y0.9631.00
28_F242_I0.9581.00
136_V159_T0.9581.00
141_N144_R0.9531.00
62_I96_G0.9511.00
60_K263_A0.9391.00
115_L148_Y0.9391.00
83_R86_I0.9361.00
172_K175_E0.9351.00
53_G58_V0.9351.00
87_L90_L0.9351.00
139_L176_C0.9311.00
271_L280_Q0.9261.00
81_T114_F0.9261.00
141_N145_F0.9201.00
24_A238_Y0.9201.00
35_N107_Y0.9101.00
128_S157_V0.9091.00
191_S194_K0.9071.00
206_L210_K0.9071.00
274_S278_E0.9051.00
275_K278_E0.9051.00
30_V86_I0.9041.00
60_K63_D0.9021.00
133_H136_V0.9011.00
173_V178_Y0.9001.00
233_K236_V0.8991.00
265_E270_I0.8871.00
125_L150_L0.8861.00
202_F205_V0.8721.00
29_K244_P0.8701.00
240_I267_L0.8681.00
199_P203_Y0.8661.00
63_D67_D0.8621.00
142_L154_V0.8621.00
265_E273_S0.8611.00
81_T86_I0.8601.00
26_A242_I0.8591.00
146_R152_V0.8531.00
79_E105_N0.8521.00
30_V83_R0.8411.00
211_R214_G0.8361.00
104_T127_Y0.8351.00
113_D116_T0.8311.00
119_A149_G0.8301.00
86_I102_L0.8221.00
208_D211_R0.8211.00
65_L73_L0.8211.00
205_V209_L0.8201.00
102_L118_L0.8191.00
202_F206_L0.8191.00
62_I98_F0.8191.00
142_L152_V0.8181.00
209_L212_K0.8181.00
28_F61_I0.8151.00
210_K214_G0.8131.00
30_V89_L0.8081.00
117_K121_K0.8031.00
109_L115_L0.8021.00
65_L70_I0.8011.00
59_K95_D0.8001.00
55_T83_R0.7991.00
64_N67_D0.7981.00
192_K195_L0.7971.00
131_E134_W0.7971.00
277_K281_Q0.7931.00
89_L93_A0.7921.00
184_P188_Y0.7901.00
102_L125_L0.7891.00
105_N108_R0.7861.00
210_K213_Y0.7861.00
64_N268_N0.7841.00
85_D89_L0.7811.00
263_A266_P0.7771.00
90_L100_I0.7731.00
258_I263_A0.7731.00
62_I73_L0.7701.00
27_T239_A0.7691.00
116_T119_A0.7691.00
87_L120_D0.7671.00
55_T89_L0.7651.00
113_D117_K0.7641.00
79_E82_Y0.7631.00
267_L271_L0.7621.00
129_I154_V0.7621.00
179_K223_F0.7611.00
219_N222_G0.7611.00
274_S277_K0.7561.00
29_K76_E0.7531.00
278_E281_Q0.7511.00
146_R179_K0.7511.00
56_E59_K0.7481.00
84_P87_L0.7461.00
185_A188_Y0.7431.00
167_E170_V0.7411.00
76_E103_T0.7411.00
145_F150_L0.7381.00
29_K241_T0.7381.00
31_T83_R0.7371.00
223_F226_A0.7331.00
74_S103_T0.7321.00
53_G61_I0.7321.00
73_L98_F0.7311.00
284_L288_A0.7311.00
158_V166_L0.7301.00
156_T173_V0.7271.00
169_K173_V0.7251.00
151_K179_K0.7221.00
222_G226_A0.7211.00
58_V83_R0.7171.00
102_L122_I0.7171.00
116_T144_R0.7171.00
74_S101_M0.7121.00
201_E205_V0.7111.00
90_L93_A0.7111.00
109_L141_N0.7091.00
197_P201_E0.7091.00
142_L178_Y0.7071.00
230_K233_K0.7041.00
42_S76_E0.7041.00
203_Y206_L0.7031.00
61_I65_L0.7011.00
109_L127_Y0.6981.00
90_L117_K0.6931.00
91_E121_K0.6891.00
240_I271_L0.6841.00
76_E253_D0.6831.00
205_V213_Y0.6801.00
33_R50_L0.6791.00
191_S195_L0.6741.00
260_G270_I0.6731.00
82_Y108_R0.6721.00
23_P271_L0.6711.00
110_K144_R0.6701.00
260_G263_A0.6701.00
35_N82_Y0.6701.00
103_T253_D0.6701.00
154_V181_L0.6681.00
222_G225_N0.6681.00
124_F153_N0.6671.00
277_K280_Q0.6671.00
231_V234_R0.6631.00
67_D268_N0.6621.00
258_I264_E0.6611.00
39_T136_V0.6611.00
57_R61_I0.6581.00
132_Y136_V0.6561.00
103_T155_Q0.6561.00
167_E212_K0.6551.00
110_K141_N0.6531.00
81_T141_N0.6531.00
109_L145_F0.6491.00
124_F151_K0.6481.00
83_R88_D0.6461.00
109_L118_L0.6431.00
197_P205_V0.6341.00
285_E288_A0.6331.00
73_L100_I0.6331.00
129_I139_L0.6321.00
43_P76_E0.6311.00
199_P228_I0.6311.00
199_P202_F0.6311.00
259_V276_V0.6291.00
51_G244_P0.6281.00
200_Y203_Y0.6271.00
58_V61_I0.6261.00
27_T253_D0.6261.00
129_I138_E0.6251.00
126_H153_N0.6191.00
25_Y72_V0.6191.00
233_K252_D0.6181.00
72_V99_Y0.6181.00
100_I123_D0.6171.00
94_H97_S0.6121.00
34_C38_C0.6101.00
38_C41_C0.6091.00
84_P114_F0.6091.00
115_L145_F0.6091.00
26_A70_I0.6081.00
133_H137_K0.6061.00
248_L267_L0.6051.00
234_R237_S0.6041.00
56_E60_K0.6031.00
40_F157_V0.5991.00
241_T253_D0.5981.00
203_Y226_A0.5971.00
247_D250_Y0.5931.00
58_V62_I0.5931.00
28_F62_I0.5911.00
170_V174_A0.5891.00
70_I98_F0.5891.00
260_G265_E0.5850.99
79_E104_T0.5810.99
164_Y201_E0.5810.99
275_K279_L0.5800.99
196_A199_P0.5780.99
40_F43_P0.5780.99
59_K96_G0.5770.99
226_A229_G0.5770.99
34_C41_C0.5750.99
207_Y210_K0.5730.99
232_P235_V0.5730.99
269_K272_Q0.5690.99
75_F89_L0.5670.99
91_E120_D0.5670.99
162_N165_K0.5650.99
273_S276_V0.5640.99
81_T109_L0.5630.99
290_F293_L0.5610.99
202_F210_K0.5580.99
101_M124_F0.5570.99
27_T241_T0.5560.99
273_S277_K0.5550.99
160_R163_L0.5540.99
90_L121_K0.5530.99
156_T166_L0.5520.99
31_T78_G0.5520.99
106_G141_N0.5500.99
62_I75_F0.5490.99
130_D157_V0.5490.99
134_W137_K0.5480.99
282_K291_E0.5470.99
107_Y141_N0.5460.99
40_F103_T0.5460.99
143_C175_E0.5440.99
271_L275_K0.5430.99
185_A190_N0.5430.99
28_F53_G0.5420.99
77_G80_P0.5400.99
61_I64_N0.5380.99
63_D66_R0.5380.99
30_V58_V0.5380.99
225_N228_I0.5350.99
215_S220_S0.5340.99
27_T76_E0.5320.99
186_V189_P0.5300.99
127_Y138_E0.5250.99
103_T254_I0.5240.99
55_T58_V0.5240.99
81_T118_L0.5230.99
164_Y167_E0.5210.99
36_L133_H0.5180.99
25_Y74_S0.5180.99
203_Y213_Y0.5100.99
170_V181_L0.5080.99
119_A123_D0.5080.99
271_L274_S0.5070.99
173_V176_C0.5050.98
58_V75_F0.5040.98
168_E172_K0.5020.98
242_I248_L0.5020.98
159_T162_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9286 100 0.357 Contact Map
4m7tA 1 0.7019 100 0.502 Contact Map
1tv8A 2 0.8416 100 0.51 Contact Map
4rtbA 2 0.9037 99.9 0.59 Contact Map
3c8fA 1 0.6553 99.9 0.61 Contact Map
4wcxA 1 0.9752 99.9 0.636 Contact Map
2a5hA 4 0.9099 99.9 0.641 Contact Map
2yx0A 1 0.7422 99.9 0.646 Contact Map
2qgqA 1 0.7081 99.9 0.655 Contact Map
2z2uA 1 0.6739 99.9 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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