GREMLIN Database
Q980D9 - XerC/D integrase-recombinase protein (XerC/D)
UniProt: Q980D9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (261)
Sequences: 37355 (30052)
Seq/√Len: 1860.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_A255_L5.0271.00
54_T57_D3.2631.00
159_V196_I3.2561.00
180_R256_G3.1481.00
229_R232_I2.8271.00
148_G237_F2.7821.00
144_L230_P2.7421.00
151_A231_H2.7121.00
237_F254_L2.5731.00
65_L80_K2.5001.00
158_L207_D2.2411.00
170_R181_I2.1751.00
235_H268_H2.1421.00
158_L204_K2.1291.00
144_L154_L2.1251.00
257_H263_T2.1201.00
167_N189_K2.1091.00
38_A79_K2.0241.00
139_L195_Y2.0131.00
121_D124_Q1.9781.00
168_M181_I1.9631.00
247_N250_T1.9271.00
146_D185_T1.9071.00
158_L203_D1.8821.00
242_L251_L1.8811.00
62_I81_R1.8411.00
163_D166_N1.8321.00
189_K193_R1.8281.00
41_D80_K1.7851.00
249_I252_Q1.7831.00
38_A83_K1.7601.00
255_L263_T1.7271.00
36_S40_R1.7181.00
153_E180_R1.6791.00
15_Y39_V1.6651.00
58_L104_S1.6571.00
178_E258_K1.6481.00
183_F254_L1.6411.00
19_I36_S1.6071.00
241_S246_I1.5971.00
261_K264_Q1.5781.00
137_D216_K1.5741.00
149_L154_L1.5471.00
237_F241_S1.5431.00
122_E240_L1.5351.00
243_K273_D1.5251.00
138_K142_R1.5011.00
163_D168_M1.5011.00
15_Y87_I1.4801.00
49_D52_K1.4791.00
184_F189_K1.4781.00
90_Y96_R1.4691.00
145_L240_L1.4691.00
31_T35_Y1.4361.00
164_L193_R1.4361.00
158_L161_D1.4341.00
75_D79_K1.4311.00
242_L267_T1.4281.00
87_I91_I1.4241.00
53_V88_R1.4201.00
142_R191_L1.3951.00
151_A155_L1.3941.00
45_F64_S1.3881.00
262_T265_I1.3821.00
120_L236_T1.3811.00
48_K57_D1.3811.00
239_T268_H1.3791.00
241_S251_L1.3791.00
161_D172_R1.3631.00
252_Q260_I1.3411.00
139_L194_K1.3331.00
14_L91_I1.3331.00
140_I213_L1.3231.00
249_I253_K1.3201.00
159_V205_L1.3171.00
133_K138_K1.3131.00
125_I145_L1.3121.00
151_A210_Y1.3101.00
210_Y214_Y1.3071.00
146_D188_T1.2961.00
29_N33_K1.2951.00
30_G33_K1.2921.00
149_L171_V1.2891.00
124_Q127_K1.2881.00
132_C220_L1.2781.00
152_N156_S1.2611.00
61_W65_L1.2471.00
172_R179_E1.2451.00
120_L228_L1.2391.00
139_L191_L1.2351.00
23_I32_I1.2321.00
129_L142_R1.2291.00
140_I154_L1.2161.00
66_L77_V1.2151.00
61_W80_K1.2131.00
252_Q263_T1.2071.00
209_K212_T1.2051.00
236_T240_L1.2051.00
125_I240_L1.2021.00
42_F45_F1.1911.00
89_Y105_V1.1901.00
19_I32_I1.1811.00
62_I66_L1.1781.00
126_Q130_N1.1551.00
167_N186_D1.1541.00
17_A21_A1.1481.00
211_D214_Y1.1481.00
145_L233_L1.1471.00
18_F86_T1.1441.00
81_R85_V1.1411.00
243_K270_V1.1391.00
160_K203_D1.1291.00
33_K37_T1.1231.00
76_E80_K1.1191.00
73_K76_E1.1171.00
157_V169_I1.1161.00
150_R231_H1.1101.00
119_A236_T1.1071.00
14_L90_Y1.1061.00
122_E244_R1.1041.00
238_A251_L1.1021.00
151_A214_Y1.1021.00
259_D264_Q1.0981.00
160_K202_E1.0961.00
78_E110_P1.0921.00
204_K207_D1.0781.00
217_L221_G1.0761.00
216_K219_R1.0741.00
32_I36_S1.0701.00
170_R179_E1.0671.00
212_T215_R1.0661.00
59_N63_S1.0621.00
145_L236_T1.0591.00
221_G228_L1.0551.00
127_K131_A1.0471.00
237_F255_L1.0461.00
185_T188_T1.0441.00
38_A80_K1.0421.00
120_L128_V1.0381.00
159_V199_K1.0291.00
34_L37_T1.0271.00
72_V80_K1.0261.00
238_A267_T1.0261.00
131_A224_V1.0251.00
140_I206_F1.0201.00
35_Y83_K1.0121.00
34_L38_A1.0121.00
14_L50_P1.0061.00
186_D190_L0.9991.00
131_A223_K0.9981.00
146_D187_E0.9981.00
195_Y199_K0.9961.00
239_T267_T0.9891.00
97_F101_I0.9841.00
275_R279_L0.9841.00
214_Y218_K0.9811.00
143_L169_I0.9791.00
259_D262_T0.9751.00
142_R187_E0.9721.00
122_E126_Q0.9711.00
120_L124_Q0.9631.00
273_D276_N0.9591.00
138_K191_L0.9481.00
88_R99_K0.9461.00
240_L243_K0.9431.00
27_A32_I0.9371.00
45_F60_R0.9371.00
45_F61_W0.9301.00
66_L74_G0.9281.00
30_G34_L0.9251.00
28_G31_T0.9161.00
55_S59_N0.9091.00
250_T277_E0.9011.00
219_R223_K0.8941.00
132_C141_I0.8911.00
187_E190_L0.8841.00
16_N20_N0.8801.00
164_L189_K0.8691.00
95_R108_P0.8661.00
94_V99_K0.8611.00
119_A268_H0.8591.00
220_L223_K0.8581.00
122_E243_K0.8571.00
22_L27_A0.8571.00
37_T41_D0.8521.00
65_L72_V0.8501.00
246_I250_T0.8501.00
72_V77_V0.8481.00
253_K274_L0.8461.00
85_V89_Y0.8431.00
79_K82_A0.8421.00
143_L188_T0.8391.00
27_A35_Y0.8371.00
238_A242_L0.8371.00
29_N32_I0.8291.00
88_R103_V0.8281.00
72_V76_E0.8281.00
89_Y102_N0.8281.00
235_H265_I0.8251.00
252_Q264_Q0.8211.00
248_V264_Q0.8191.00
34_L79_K0.8151.00
57_D60_R0.8111.00
218_K222_K0.8101.00
55_S95_R0.8081.00
151_A213_L0.8051.00
184_F188_T0.8031.00
88_R104_S0.8021.00
42_F88_R0.7991.00
148_G255_L0.7981.00
118_K232_I0.7971.00
155_L210_Y0.7941.00
163_D167_N0.7931.00
17_A98_L0.7931.00
172_R177_G0.7931.00
65_L77_V0.7911.00
214_Y230_P0.7911.00
147_T182_V0.7811.00
157_V162_I0.7781.00
238_A263_T0.7781.00
16_N36_S0.7781.00
23_I36_S0.7771.00
188_T191_L0.7721.00
272_D276_N0.7671.00
155_L213_L0.7631.00
151_A230_P0.7601.00
91_I98_L0.7591.00
60_R64_S0.7571.00
143_L206_F0.7561.00
159_V200_K0.7551.00
59_N96_R0.7541.00
212_T216_K0.7531.00
248_V260_I0.7501.00
194_K198_G0.7491.00
91_I99_K0.7471.00
163_D170_R0.7451.00
97_F106_R0.7361.00
75_D78_E0.7311.00
243_K272_D0.7311.00
143_L154_L0.7301.00
139_L206_F0.7291.00
18_F22_L0.7251.00
217_L230_P0.7201.00
157_V205_L0.7191.00
137_D220_L0.7161.00
150_R173_N0.7141.00
215_R219_R0.7111.00
196_I200_K0.7101.00
81_R104_S0.7091.00
193_R196_I0.7081.00
131_A220_L0.7021.00
216_K220_L0.7021.00
228_L232_I0.7001.00
15_Y19_I0.6971.00
144_L151_A0.6961.00
128_V141_I0.6941.00
22_L25_A0.6931.00
193_R197_K0.6921.00
87_I90_Y0.6911.00
14_L87_I0.6911.00
120_L232_I0.6911.00
63_S66_L0.6901.00
20_N23_I0.6901.00
254_L274_L0.6891.00
95_R106_R0.6891.00
136_K195_Y0.6881.00
242_L270_V0.6871.00
128_V221_G0.6841.00
218_K221_G0.6811.00
22_L86_T0.6781.00
196_I199_K0.6771.00
149_L169_I0.6771.00
102_N105_V0.6761.00
132_C138_K0.6751.00
53_V58_L0.6741.00
56_E96_R0.6741.00
238_A257_H0.6741.00
17_A96_R0.6681.00
14_L96_R0.6661.00
37_T40_R0.6651.00
56_E60_R0.6641.00
58_L84_S0.6631.00
59_N62_I0.6621.00
260_I264_Q0.6621.00
231_H235_H0.6611.00
42_F61_W0.6611.00
143_L149_L0.6581.00
40_R44_D0.6581.00
142_R188_T0.6571.00
61_W64_S0.6571.00
276_N279_L0.6561.00
250_T254_L0.6531.00
127_K130_N0.6521.00
19_I23_I0.6521.00
246_I277_E0.6481.00
141_I233_L0.6471.00
211_D218_K0.6441.00
190_L194_K0.6441.00
139_L143_L0.6441.00
78_E82_A0.6431.00
42_F84_S0.6421.00
63_S67_N0.6391.00
129_L138_K0.6351.00
123_I127_K0.6311.00
41_D61_W0.6301.00
133_K142_R0.6291.00
191_L194_K0.6291.00
242_L249_I0.6291.00
271_L274_L0.6271.00
17_A20_N0.6241.00
85_V104_S0.6241.00
62_I77_V0.6231.00
260_I263_T0.6211.00
186_D279_L0.6181.00
246_I251_L0.6141.00
119_A239_T0.6091.00
232_I235_H0.6081.00
78_E112_V0.6081.00
213_L230_P0.6081.00
39_V83_K0.6081.00
190_L193_R0.6071.00
249_I264_Q0.6051.00
55_S97_F0.6051.00
242_L247_N0.6041.00
147_T185_T0.6031.00
139_L188_T0.6021.00
104_S107_P0.6011.00
134_R138_K0.5981.00
125_I129_L0.5981.00
84_S104_S0.5971.00
131_A134_R0.5961.00
94_V106_R0.5921.00
13_D17_A0.5901.00
74_G78_E0.5891.00
208_L212_T0.5831.00
42_F46_I0.5831.00
149_L153_E0.5811.00
22_L35_Y0.5801.00
136_K139_L0.5801.00
272_D275_R0.5761.00
94_V102_N0.5741.00
88_R102_N0.5741.00
251_L267_T0.5681.00
125_I236_T0.5681.00
270_V273_D0.5661.00
156_S207_D0.5661.00
17_A90_Y0.5651.00
122_E236_T0.5641.00
153_E171_V0.5641.00
22_L26_G0.5641.00
242_L248_V0.5631.00
258_K262_T0.5631.00
259_D263_T0.5611.00
45_F48_K0.5591.00
142_R146_D0.5561.00
217_L233_L0.5541.00
149_L157_V0.5531.00
61_W84_S0.5521.00
139_L192_L0.5521.00
120_L125_I0.5511.00
117_V229_R0.5511.00
195_Y198_G0.5481.00
123_I126_Q0.5471.00
252_Q262_T0.5431.00
164_L184_F0.5401.00
39_V44_D0.5391.00
159_V192_L0.5391.00
248_V263_T0.5381.00
135_T138_K0.5361.00
39_V87_I0.5361.00
136_K216_K0.5331.00
39_V43_L0.5291.00
55_S106_R0.5291.00
162_I192_L0.5271.00
85_V109_I0.5231.00
242_L269_L0.5231.00
86_T89_Y0.5211.00
81_R107_P0.5201.00
144_L233_L0.5201.00
252_Q255_L0.5201.00
171_V174_T0.5161.00
143_L192_L0.5151.00
153_E256_G0.5121.00
23_I29_N0.5111.00
183_F275_R0.5111.00
161_D173_N0.5101.00
85_V105_V0.5101.00
220_L224_V0.5101.00
21_A90_Y0.5091.00
164_L167_N0.5081.00
75_D112_V0.5081.00
158_L202_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.8454 100 0.216 Contact Map
2a3vA 3 0.921 100 0.231 Contact Map
1z1bA 3 0.9313 100 0.24 Contact Map
1z19A 3 0.9038 100 0.248 Contact Map
4a8eA 2 0.8797 100 0.251 Contact Map
1xo0A 3 0.921 100 0.269 Contact Map
3nkhA 2 0.5979 100 0.426 Contact Map
1ae9A 4 0.5223 100 0.495 Contact Map
1aihA 2 0.5601 100 0.507 Contact Map
4e0gA 2 0.8763 99.9 0.578 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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