GREMLIN Database
Q980D8 - Na(+)/H(+) antiporter
UniProt: Q980D8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 505 (435)
Sequences: 8088 (5926)
Seq/√Len: 284.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
336_L339_G4.9871.00
105_V109_I4.1331.00
108_Y112_F4.0371.00
177_I181_L3.9301.00
292_F355_L3.9091.00
335_G338_L3.4161.00
191_R195_K3.4141.00
335_G339_G3.4091.00
195_K199_K3.2801.00
175_T182_V3.1891.00
104_L108_Y3.1801.00
174_I178_E2.9391.00
181_L185_F2.8561.00
423_E426_P2.7001.00
371_S374_I2.5931.00
173_L177_I2.5311.00
366_I370_I2.4561.00
289_L293_S2.4451.00
395_Y406_I2.4211.00
102_V298_S2.4101.00
334_T339_G2.3941.00
106_A294_L2.3851.00
328_D349_S2.3581.00
304_F318_G2.3301.00
320_A363_L2.3251.00
191_R194_A2.3161.00
180_F184_A2.3141.00
335_G340_Y2.3131.00
111_G114_N2.3091.00
192_T196_I2.3071.00
192_T195_K2.2981.00
194_A198_E2.2931.00
286_L290_L2.2841.00
365_Q369_K2.2821.00
107_I115_Y2.2321.00
175_T179_I2.2211.00
300_F319_F2.1881.00
104_L119_I2.1811.00
199_K202_Y2.0941.00
105_V108_Y2.0931.00
258_H261_T2.0791.00
257_L261_T2.0291.00
187_I191_R2.0281.00
49_F52_I2.0171.00
397_S402_L2.0101.00
175_T178_E2.0021.00
195_K198_E2.0011.00
104_L112_F1.9961.00
367_N371_S1.9501.00
196_I200_I1.9421.00
176_I180_F1.8681.00
285_I289_L1.8671.00
121_P332_L1.8611.00
198_E201_E1.8501.00
445_S449_C1.8411.00
334_T338_L1.8041.00
182_V185_F1.8001.00
444_E447_K1.7901.00
182_V186_T1.7891.00
342_N345_M1.7801.00
332_L349_S1.7381.00
105_V112_F1.7331.00
291_F352_A1.7161.00
430_V433_Q1.6961.00
178_E181_L1.6801.00
160_V331_L1.6671.00
110_I115_Y1.6641.00
100_F162_L1.6581.00
56_E59_S1.6491.00
428_G432_I1.6451.00
426_P430_V1.6281.00
179_I182_V1.6241.00
387_I390_Q1.6091.00
399_E402_L1.6031.00
252_E256_R1.5911.00
39_L43_L1.5901.00
104_L116_L1.5741.00
248_K251_P1.5721.00
178_E182_V1.5551.00
368_F371_S1.5551.00
377_S380_V1.5531.00
288_S351_L1.5331.00
182_V190_G1.5321.00
334_T337_T1.5291.00
22_S40_M1.5231.00
17_I216_A1.5151.00
336_L346_Y1.5071.00
148_I320_A1.5011.00
367_N370_I1.4971.00
366_I369_K1.4881.00
256_R261_T1.4811.00
172_I175_T1.4461.00
395_Y405_V1.4441.00
440_P445_S1.4431.00
179_I183_F1.4411.00
222_G232_S1.4361.00
257_L260_F1.4351.00
172_I176_I1.4331.00
395_Y402_L1.4331.00
336_L340_Y1.4291.00
184_A188_M1.4261.00
427_L430_V1.4211.00
48_V52_I1.4211.00
423_E427_L1.4141.00
409_I413_G1.4101.00
420_V423_E1.4081.00
355_L359_I1.4071.00
398_C406_I1.4021.00
444_E448_A1.3971.00
100_F120_V1.3931.00
442_L448_A1.3791.00
426_P429_Y1.3761.00
305_I309_I1.3761.00
424_N427_L1.3661.00
182_V194_A1.3661.00
444_E449_C1.3551.00
287_F348_F1.3481.00
181_L191_R1.3431.00
112_F115_Y1.3431.00
107_I291_F1.3311.00
294_L298_S1.3261.00
107_I110_I1.3261.00
395_Y399_E1.3171.00
221_I239_L1.3061.00
370_I374_I1.3051.00
197_L201_E1.3051.00
198_E202_Y1.2981.00
401_N406_I1.2971.00
189_F193_L1.2941.00
173_L176_I1.2891.00
194_A201_E1.2791.00
441_E444_E1.2791.00
269_F326_G1.2791.00
26_F36_G1.2721.00
199_K203_Y1.2691.00
442_L449_C1.2671.00
295_I352_A1.2661.00
292_F356_S1.2511.00
443_Y447_K1.2481.00
420_V436_L1.2481.00
348_F352_A1.2481.00
101_S105_V1.2421.00
182_V198_E1.2421.00
446_T449_C1.2411.00
188_M191_R1.2281.00
103_I107_I1.2261.00
429_Y432_I1.2241.00
425_K429_Y1.2231.00
341_I344_F1.2201.00
89_F92_V1.2171.00
250_R258_H1.2131.00
308_K311_N1.2041.00
442_L446_T1.1971.00
398_C402_L1.1951.00
118_L349_S1.1941.00
91_A303_G1.1941.00
175_T186_T1.1921.00
194_A200_I1.1871.00
390_Q393_P1.1841.00
398_C403_R1.1801.00
323_V360_V1.1761.00
410_S413_G1.1711.00
192_T198_E1.1681.00
22_S43_L1.1651.00
435_L438_I1.1641.00
67_V222_G1.1571.00
119_I123_A1.1541.00
421_N427_L1.1491.00
253_L257_L1.1401.00
101_S104_L1.1401.00
111_G115_Y1.1271.00
278_T347_S1.1261.00
194_A199_K1.1131.00
417_I420_V1.1111.00
217_I239_L1.1091.00
108_Y115_Y1.1011.00
288_S348_F1.0971.00
438_I445_S1.0921.00
102_V302_A1.0911.00
420_V427_L1.0911.00
307_S314_G1.0901.00
246_Y250_R1.0851.00
419_V424_N1.0781.00
125_S130_L1.0781.00
402_L406_I1.0751.00
437_E442_L1.0741.00
389_L392_K1.0731.00
172_I178_E1.0721.00
220_I224_L1.0721.00
441_E448_A1.0611.00
284_I287_F1.0601.00
403_R406_I1.0551.00
174_I177_I1.0551.00
256_R259_A1.0531.00
428_G431_S1.0501.00
435_L443_Y1.0501.00
96_S158_I1.0431.00
190_G194_A1.0411.00
411_E415_R1.0401.00
445_S448_A1.0381.00
22_S26_F1.0351.00
175_T185_F1.0351.00
298_S302_A1.0251.00
441_E445_S1.0231.00
328_D353_I1.0231.00
387_I391_I1.0211.00
378_K381_K1.0171.00
193_L198_E1.0171.00
442_L445_S1.0161.00
434_T438_I1.0141.00
43_L48_V1.0131.00
87_N147_L1.0081.00
72_L76_E1.0071.00
410_S433_Q1.0061.00
288_S292_F1.0041.00
188_M192_T1.0021.00
79_N82_N1.0011.00
92_V95_E0.9971.00
10_L13_G0.9961.00
57_I60_F0.9921.00
226_E232_S0.9911.00
395_Y398_C0.9891.00
41_G45_G0.9851.00
423_E430_V0.9771.00
250_R257_L0.9721.00
20_K23_E0.9701.00
121_P331_L0.9681.00
399_E406_I0.9641.00
419_V432_I0.9641.00
118_L122_L0.9631.00
429_Y433_Q0.9601.00
193_L197_L0.9591.00
251_P257_L0.9571.00
414_V417_I0.9551.00
401_N405_V0.9471.00
397_S406_I0.9451.00
401_N404_S0.9401.00
89_F93_I0.9361.00
197_L200_I0.9361.00
27_R30_G0.9341.00
173_L191_R0.9331.00
256_R260_F0.9281.00
427_L437_E0.9191.00
98_I302_A0.9181.00
441_E449_C0.9181.00
304_F316_I0.9181.00
189_F192_T0.9171.00
369_K373_K0.9161.00
85_N89_F0.9161.00
402_L405_V0.9151.00
127_A152_V0.9141.00
195_K200_I0.9121.00
134_L145_S0.9121.00
440_P447_K0.9111.00
398_C405_V0.9071.00
358_L362_L0.9031.00
436_L445_S0.9021.00
87_N90_L0.9011.00
438_I442_L0.9001.00
186_T190_G0.8991.00
125_S326_G0.8961.00
148_I317_N0.8951.00
19_A23_E0.8921.00
84_P87_N0.8911.00
412_R415_R0.8901.00
43_L46_N0.8891.00
223_Y227_L0.8891.00
388_K391_I0.8871.00
181_L184_A0.8861.00
383_S386_V0.8851.00
324_K328_D0.8841.00
186_T191_R0.8831.00
153_I237_F0.8831.00
409_I412_R0.8811.00
117_I335_G0.8811.00
80_V83_R0.8791.00
419_V422_Y0.8791.00
99_P103_I0.8781.00
283_S286_L0.8771.00
443_Y449_C0.8771.00
419_V426_P0.8761.00
126_S155_I0.8751.00
175_T181_L0.8751.00
295_I324_K0.8721.00
314_G318_G0.8701.00
181_L230_F0.8691.00
424_N430_V0.8691.00
93_I97_I0.8691.00
419_V423_E0.8661.00
46_N278_T0.8641.00
124_M159_F0.8621.00
44_L275_L0.8581.00
213_S217_I0.8581.00
249_D254_L0.8561.00
336_L343_E0.8561.00
50_G53_Q0.8521.00
130_L133_M0.8461.00
396_A402_L0.8451.00
222_G236_A0.8441.00
134_L140_S0.8431.00
370_I373_K0.8421.00
386_V391_I0.8411.00
175_T194_A0.8411.00
388_K392_K0.8401.00
26_F30_G0.8361.00
422_Y426_P0.8361.00
179_I194_A0.8361.00
399_E403_R0.8321.00
172_I190_G0.8321.00
404_S407_S0.8301.00
289_L292_F0.8291.00
357_A360_V0.8291.00
402_L421_N0.8261.00
426_P431_S0.8241.00
252_E255_E0.8241.00
343_E347_S0.8241.00
249_D252_E0.8231.00
417_I426_P0.8211.00
437_E445_S0.8211.00
100_F123_A0.8171.00
427_L435_L0.8151.00
438_I448_A0.8120.99
194_A197_L0.8100.99
181_L190_G0.8080.99
273_I326_G0.8070.99
386_V389_L0.8050.99
417_I434_T0.8050.99
152_V155_I0.8040.99
106_A109_I0.8020.99
424_N428_G0.8010.99
289_L355_L0.8000.99
395_Y403_R0.8000.99
441_E447_K0.8000.99
344_F348_F0.7930.99
437_E448_A0.7910.99
88_V107_I0.7870.99
324_K353_I0.7850.99
129_P357_A0.7840.99
421_N426_P0.7820.99
117_I121_P0.7810.99
291_F348_F0.7800.99
193_L196_I0.7750.99
179_I190_G0.7750.99
284_I344_F0.7740.99
278_T281_N0.7730.99
187_I190_G0.7720.99
292_F296_I0.7660.99
425_K428_G0.7660.99
13_G17_I0.7600.99
427_L431_S0.7550.99
402_L413_G0.7550.99
196_I202_Y0.7550.99
407_S411_E0.7540.99
107_I119_I0.7540.99
304_F308_K0.7540.99
430_V435_L0.7520.99
439_D443_Y0.7510.99
434_T437_E0.7510.99
94_L97_I0.7510.99
97_I101_S0.7490.99
296_I359_I0.7490.99
402_L407_S0.7470.99
177_I182_V0.7470.99
59_S272_G0.7460.99
253_L256_R0.7450.99
293_S297_A0.7450.99
440_P449_C0.7420.99
255_E258_H0.7400.99
98_I101_S0.7380.99
425_K432_I0.7360.99
439_D442_L0.7360.99
300_F304_F0.7340.99
417_I423_E0.7330.99
177_I180_F0.7320.99
196_I199_K0.7320.99
419_V435_L0.7310.99
215_I260_F0.7300.99
424_N432_I0.7290.99
195_K202_Y0.7270.99
21_I24_E0.7260.99
112_F116_L0.7240.99
435_L440_P0.7240.99
175_T190_G0.7240.99
183_F187_I0.7240.99
180_F191_R0.7230.99
434_T441_E0.7200.99
124_M127_A0.7200.99
130_L323_V0.7200.99
115_Y119_I0.7190.99
15_M23_E0.7170.99
417_I428_G0.7150.99
71_F240_G0.7150.99
418_V424_N0.7140.99
434_T449_C0.7130.99
438_I449_C0.7120.99
406_I417_I0.7120.99
385_E388_K0.7120.99
185_F191_R0.7110.99
37_P267_P0.7110.99
236_A269_F0.7100.99
386_V390_Q0.7060.99
107_I118_L0.7060.99
301_L305_I0.7050.99
122_L324_K0.7040.99
182_V191_R0.7040.99
179_I191_R0.7040.99
251_P254_L0.7040.99
13_G216_A0.7030.99
422_Y430_V0.7030.99
144_I316_I0.7020.99
221_I235_S0.7010.98
415_R423_E0.7000.98
419_V430_V0.7000.98
58_I272_G0.6990.98
185_F189_F0.6990.98
102_V105_V0.6980.98
410_S414_V0.6980.98
406_I415_R0.6950.98
194_A202_Y0.6940.98
185_F188_M0.6940.98
420_V430_V0.6930.98
384_Q389_L0.6930.98
424_N433_Q0.6910.98
418_V423_E0.6890.98
87_N150_Q0.6870.98
246_Y249_D0.6860.98
147_L312_I0.6850.98
412_R426_P0.6840.98
442_L447_K0.6840.98
404_S408_K0.6830.98
110_I345_M0.6820.98
424_N431_S0.6810.98
391_I394_L0.6810.98
418_V428_G0.6800.98
431_S435_L0.6800.98
71_F218_I0.6790.98
399_E405_V0.6790.98
440_P444_E0.6760.98
437_E441_E0.6760.98
398_C401_N0.6750.98
316_I367_N0.6750.98
95_E99_P0.6730.98
250_R254_L0.6720.98
22_S28_R0.6680.98
142_N145_S0.6680.98
307_S312_I0.6680.98
397_S401_N0.6670.98
420_V424_N0.6670.98
18_A22_S0.6660.98
406_I420_V0.6660.98
190_G198_E0.6650.98
410_S417_I0.6640.98
420_V437_E0.6630.98
85_N88_V0.6620.98
254_L257_L0.6620.98
422_Y428_G0.6600.98
79_N245_D0.6600.98
320_A323_V0.6600.98
381_K384_Q0.6600.98
366_I371_S0.6600.98
420_V428_G0.6600.98
217_I220_I0.6590.98
248_K252_E0.6580.98
411_E432_I0.6560.98
189_F197_L0.6510.98
189_F221_I0.6500.98
379_K382_L0.6500.98
402_L409_I0.6490.98
133_M320_A0.6490.98
359_I363_L0.6450.97
410_S415_R0.6450.97
284_I348_F0.6420.97
18_A44_L0.6410.97
440_P448_A0.6410.97
147_L150_Q0.6400.97
436_L439_D0.6400.97
96_S99_P0.6400.97
253_L258_H0.6380.97
304_F315_K0.6380.97
110_I114_N0.6370.97
381_K386_V0.6370.97
420_V438_I0.6360.97
409_I421_N0.6360.97
434_T442_L0.6340.97
396_A399_E0.6320.97
384_Q387_I0.6320.97
417_I421_N0.6300.97
408_K412_R0.6280.97
183_F191_R0.6280.97
127_A148_I0.6230.97
423_E442_L0.6230.97
95_E303_G0.6220.97
319_F363_L0.6220.97
90_L310_L0.6210.97
127_A275_L0.6210.97
410_S426_P0.6210.97
91_A306_S0.6180.97
182_V201_E0.6180.97
175_T197_L0.6160.97
285_I332_L0.6150.97
172_I180_F0.6130.97
390_Q394_L0.6110.96
246_Y253_L0.6100.96
125_S321_T0.6100.96
214_L241_I0.6090.96
372_N376_E0.6090.96
397_S400_E0.6080.96
151_Q155_I0.6070.96
48_V51_V0.6050.96
42_I279_K0.6040.96
423_E435_L0.6000.96
177_I185_F0.6000.96
269_F361_P0.5990.96
397_S403_R0.5990.96
191_R201_E0.5990.96
435_L439_D0.5980.96
45_G52_I0.5970.96
287_F291_F0.5970.96
434_T445_S0.5970.96
278_T343_E0.5970.96
353_I357_A0.5970.96
362_L366_I0.5970.96
405_V419_V0.5950.96
415_R431_S0.5940.96
329_S353_I0.5940.96
106_A290_L0.5920.96
144_I318_G0.5900.96
398_C419_V0.5900.96
423_E434_T0.5890.96
151_Q317_N0.5890.96
326_G329_S0.5890.96
408_K415_R0.5880.96
24_E28_R0.5870.96
373_K376_E0.5850.95
405_V411_E0.5840.95
409_I414_V0.5820.95
438_I441_E0.5810.95
175_T191_R0.5780.95
121_P349_S0.5780.95
369_K374_I0.5780.95
191_R242_L0.5770.95
438_I446_T0.5770.95
78_F245_D0.5760.95
378_K382_L0.5750.95
23_E28_R0.5740.95
411_E423_E0.5740.95
299_K321_T0.5730.95
408_K411_E0.5730.95
411_E417_I0.5730.95
421_N430_V0.5720.95
178_E193_L0.5720.95
395_Y407_S0.5710.95
422_Y429_Y0.5710.95
84_P88_V0.5690.95
152_V327_V0.5670.95
349_S353_I0.5670.95
32_V132_R0.5670.95
395_Y409_I0.5660.95
172_I182_V0.5640.94
417_I427_L0.5630.94
400_E404_S0.5620.94
156_E231_N0.5590.94
88_V150_Q0.5590.94
407_S410_S0.5590.94
180_F183_F0.5590.94
70_L233_A0.5590.94
290_L294_L0.5580.94
70_L124_M0.5570.94
370_I389_L0.5560.94
236_A240_G0.5550.94
397_S408_K0.5550.94
175_T198_E0.5550.94
226_E229_K0.5530.94
333_L337_T0.5530.94
428_G433_Q0.5530.94
19_A354_S0.5530.94
65_G269_F0.5520.94
131_S149_F0.5520.94
281_N343_E0.5500.94
412_R423_E0.5490.94
160_V330_S0.5490.94
283_S287_F0.5490.94
303_G318_G0.5460.93
195_K201_E0.5460.93
189_F224_L0.5450.93
427_L432_I0.5430.93
421_N424_N0.5420.93
426_P443_Y0.5410.93
287_F290_L0.5410.93
321_T326_G0.5400.93
15_M271_L0.5390.93
225_A230_F0.5390.93
337_T340_Y0.5380.93
70_L237_F0.5370.93
436_L444_E0.5370.93
418_V433_Q0.5360.93
69_L236_A0.5360.93
179_I201_E0.5360.93
124_M328_D0.5330.93
23_E214_L0.5330.93
433_Q443_Y0.5330.93
110_I118_L0.5330.93
299_K303_G0.5320.93
74_G241_I0.5310.93
379_K384_Q0.5300.92
420_V432_I0.5280.92
250_R253_L0.5280.92
149_F329_S0.5280.92
325_G329_S0.5280.92
126_S152_V0.5270.92
19_A22_S0.5260.92
395_Y413_G0.5250.92
395_Y421_N0.5240.92
436_L448_A0.5240.92
86_A89_F0.5230.92
395_Y414_V0.5230.92
295_I356_S0.5230.92
222_G226_E0.5220.92
424_N437_E0.5210.92
252_E258_H0.5210.92
418_V425_K0.5210.92
252_E257_L0.5190.92
45_G48_V0.5190.92
305_I308_K0.5180.92
399_E404_S0.5180.92
129_P132_R0.5180.92
144_I314_G0.5170.92
400_E405_V0.5170.92
409_I418_V0.5170.92
417_I425_K0.5160.91
414_V418_V0.5160.91
96_S154_L0.5150.91
409_I417_I0.5150.91
172_I181_L0.5150.91
138_K291_F0.5140.91
430_V445_S0.5140.91
397_S409_I0.5130.91
196_I201_E0.5130.91
113_K170_S0.5130.91
260_F265_F0.5120.91
186_T238_F0.5120.91
401_N414_V0.5110.91
152_V323_V0.5100.91
191_R198_E0.5100.91
46_N49_F0.5090.91
398_C414_V0.5080.91
420_V429_Y0.5060.91
401_N417_I0.5050.91
408_K418_V0.5020.90
401_N407_S0.5010.90
117_I170_S0.5010.90
404_S412_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.7327 100 0.424 Contact Map
4czbA 2 0.7366 100 0.447 Contact Map
4cz8A 2 0.7248 100 0.449 Contact Map
1zcdA 1 0.6733 99.9 0.705 Contact Map
4gx0A 3 0.4297 99.4 0.831 Contact Map
1lnqA 6 0.3782 99.1 0.855 Contact Map
3l9wA 2 0.2277 99 0.859 Contact Map
3nafA 3 0.2495 98.8 0.866 Contact Map
2aefA 2 0.2218 98.7 0.874 Contact Map
2mdfA 1 0.1129 98.7 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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