GREMLIN Database
Q980D7 - Uncharacterized protein
UniProt: Q980D7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (167)
Sequences: 2414 (1524)
Seq/√Len: 117.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_L121_C4.0091.00
128_V145_L3.6641.00
25_D133_K3.0191.00
30_N127_S2.7831.00
15_K21_E2.6871.00
5_Y90_S2.6801.00
41_S116_L2.5881.00
46_S53_R2.4111.00
79_E83_K2.4021.00
42_L56_M2.3881.00
25_D130_K2.3791.00
45_I114_L2.3771.00
48_L109_V2.3191.00
41_S120_I2.2891.00
17_P71_A2.0911.00
55_I88_E2.0561.00
29_V32_I2.0451.00
62_D144_Y2.0161.00
55_I151_L1.9651.00
42_L152_L1.9071.00
158_Y162_Q1.8841.00
34_D127_S1.8801.00
23_W133_K1.8751.00
62_D81_K1.7981.00
79_E140_V1.7951.00
8_T15_K1.7841.00
151_L155_L1.7701.00
109_V113_F1.7431.00
120_I123_R1.7091.00
55_I92_F1.6621.00
111_A160_N1.6531.00
30_N34_D1.6481.00
84_W88_E1.6411.00
95_G162_Q1.6401.00
25_D129_V1.6381.00
64_F67_S1.5561.00
88_E91_S1.5461.00
69_E138_K1.5411.00
4_W154_V1.5181.00
92_F151_L1.4991.00
117_A152_L1.4771.00
114_L159_V1.4701.00
127_S130_K1.4671.00
41_S117_A1.4481.00
26_D135_S1.4121.00
83_K87_E1.3881.00
37_E123_R1.3781.00
70_I128_V1.3681.00
82_V140_V1.3461.00
5_Y86_E1.3291.00
14_T29_V1.3141.00
52_L159_V1.3091.00
40_A119_T1.2760.99
39_N64_F1.2680.99
52_L155_L1.2650.99
160_N167_E1.2590.99
93_S154_V1.2590.99
48_L113_F1.2520.99
44_V116_L1.2120.99
22_I26_D1.2070.99
131_I135_S1.1990.99
58_R84_W1.1840.99
44_V113_F1.1660.99
13_K23_W1.1640.99
77_F81_K1.1560.99
96_I154_V1.1380.99
47_S109_V1.1370.99
92_F158_Y1.1330.99
41_S113_F1.1300.99
108_H160_N1.1300.99
113_F116_L1.1110.99
79_E143_K1.1040.99
32_I70_I1.1020.99
51_Q91_S1.0830.98
5_Y89_I1.0670.98
110_A159_V1.0580.98
45_I117_A1.0510.98
23_W26_D1.0350.98
47_S112_S1.0350.98
132_L142_V1.0280.98
45_I159_V1.0280.98
88_E151_L1.0170.97
62_D84_W1.0160.97
69_E76_N1.0030.97
89_I154_V1.0010.97
51_Q162_Q1.0000.97
17_P72_G0.9970.97
31_A128_V0.9930.97
8_T21_E0.9800.97
8_T13_K0.9600.96
41_S45_I0.9350.96
46_S57_V0.9340.96
34_D123_R0.9320.96
140_V143_K0.9300.96
47_S113_F0.9270.96
101_N169_I0.9200.95
97_P161_K0.9160.95
39_N67_S0.9150.95
59_I144_Y0.9130.95
30_N130_K0.9000.95
50_P54_E0.8850.94
66_L141_H0.8830.94
53_R57_V0.8770.94
28_I135_S0.8630.94
102_F153_F0.8630.94
36_D118_R0.8510.93
16_L22_I0.8460.93
39_N60_Q0.8420.93
35_L63_I0.8410.93
130_K134_R0.8380.93
43_G60_Q0.8360.93
111_A167_E0.8340.92
100_R169_I0.8290.92
15_K19_V0.8260.92
61_S65_S0.8210.92
128_V141_H0.8210.92
55_I91_S0.8200.92
34_D124_S0.8160.92
161_K166_Q0.8100.91
92_F155_L0.8020.91
82_V143_K0.8020.91
91_S95_G0.7980.91
27_D127_S0.7950.91
57_V168_I0.7900.90
124_S145_L0.7880.90
56_M114_L0.7870.90
86_E90_S0.7820.90
26_D134_R0.7810.90
78_E81_K0.7790.90
121_C152_L0.7660.89
58_R62_D0.7640.89
14_T22_I0.7620.89
107_G160_N0.7590.88
44_V109_V0.7580.88
3_V7_G0.7580.88
38_L117_A0.7550.88
80_E83_K0.7480.88
28_I32_I0.7480.88
132_L137_A0.7400.87
32_I119_T0.7400.87
86_E89_I0.7280.86
88_E92_F0.7250.86
35_L66_L0.7230.86
8_T11_K0.7200.86
45_I113_F0.7170.85
55_I84_W0.7130.85
34_D120_I0.7050.84
116_L120_I0.7040.84
96_I99_L0.7000.84
44_V48_L0.7000.84
27_D134_R0.6980.84
11_K15_K0.6950.84
108_H165_V0.6930.83
49_Y162_Q0.6920.83
150_S157_L0.6900.83
93_S96_I0.6870.83
68_S72_G0.6870.83
105_P118_R0.6730.82
108_H111_A0.6710.81
7_G83_K0.6680.81
104_L107_G0.6670.81
129_V132_L0.6630.81
11_K139_D0.6550.80
22_I29_V0.6530.80
132_L136_K0.6510.80
106_G112_S0.6490.79
129_V142_V0.6490.79
31_A127_S0.6460.79
59_I148_L0.6420.79
58_R88_E0.6410.78
33_G36_D0.6410.78
31_A131_I0.6400.78
39_N107_G0.6370.78
103_I153_F0.6330.78
52_L158_Y0.6330.78
103_I156_A0.6320.77
3_V90_S0.6300.77
87_E91_S0.6300.77
115_H156_A0.6270.77
128_V142_V0.6260.77
111_A156_A0.6260.77
67_S107_G0.6240.77
95_G158_Y0.6240.77
31_A35_L0.6230.76
37_E120_I0.6180.76
3_V8_T0.6150.76
114_L155_L0.6130.75
52_L92_F0.6110.75
113_F117_A0.6110.75
108_H167_E0.6060.74
49_Y159_V0.6000.74
43_G67_S0.5960.73
65_S170_W0.5940.73
99_L153_F0.5930.73
14_T28_I0.5910.73
35_L145_L0.5890.72
16_L28_I0.5890.72
91_S94_K0.5870.72
161_K165_V0.5850.72
27_D31_A0.5820.72
69_E75_M0.5810.71
110_A113_F0.5790.71
121_C148_L0.5750.71
34_D126_R0.5730.70
23_W129_V0.5720.70
32_I90_S0.5710.70
7_G143_K0.5700.70
40_A156_A0.5690.70
11_K21_E0.5660.69
9_G12_G0.5640.69
27_D130_K0.5640.69
138_K141_H0.5610.69
74_D136_K0.5600.69
15_K20_G0.5580.68
60_Q67_S0.5570.68
35_L124_S0.5570.68
96_I101_N0.5550.68
38_L41_S0.5520.68
57_V61_S0.5500.67
17_P20_G0.5490.67
4_W150_S0.5480.67
4_W96_I0.5450.67
115_H157_L0.5450.67
18_S73_F0.5420.66
78_E84_W0.5350.65
77_F140_V0.5340.65
40_A44_V0.5340.65
84_W87_E0.5310.65
61_S170_W0.5290.64
54_E94_K0.5250.64
39_N105_P0.5240.64
38_L42_L0.5240.64
38_L45_I0.5230.63
109_V112_S0.5190.63
131_I137_A0.5170.63
103_I157_L0.5160.62
61_S75_M0.5150.62
139_D143_K0.5130.62
111_A114_L0.5130.62
58_R94_K0.5130.62
17_P93_S0.5120.62
64_F170_W0.5110.62
124_S131_I0.5110.62
97_P167_E0.5100.61
47_S108_H0.5090.61
58_R140_V0.5060.61
75_M78_E0.5040.61
7_G79_E0.5040.61
92_F170_W0.5020.60
33_G142_V0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nt8A 3 0.9884 100 0.06 Contact Map
3ci3A 3 0.9942 100 0.064 Contact Map
2idxA 3 0.9884 100 0.064 Contact Map
3ke4A 3 0.9302 100 0.065 Contact Map
2zhyA 3 0.9826 100 0.069 Contact Map
1rtyA 3 0.8953 100 0.071 Contact Map
2ah6A 3 0.8837 100 0.079 Contact Map
2g2dA 3 0.843 100 0.08 Contact Map
1wvtA 3 0.8605 100 0.089 Contact Map
1wy1A 3 0.8314 100 0.092 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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