GREMLIN Database
Q980D6 - Ornithine cyclodeaminase related protein (Ocd-like1)
UniProt: Q980D6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (290)
Sequences: 3904 (2810)
Seq/√Len: 165.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_G150_Q4.3391.00
23_K116_E4.2331.00
132_A156_A3.7211.00
137_Y166_R3.3711.00
126_I153_Y3.1821.00
175_E179_K2.9991.00
205_H276_S2.9441.00
200_L223_T2.9041.00
117_L266_I2.8661.00
175_E199_Y2.8631.00
5_T8_D2.8221.00
173_D176_T2.7331.00
141_K170_E2.5681.00
17_I297_E2.4681.00
128_G177_L2.4431.00
126_I151_K2.4291.00
129_I140_A2.3561.00
128_G181_S2.2971.00
228_K274_R2.2221.00
203_V274_R2.0821.00
292_H296_Q2.0791.00
140_A167_V2.0471.00
94_L295_Y1.9981.00
219_L277_L1.9871.00
4_L298_A1.9761.00
140_A152_L1.9671.00
61_V288_N1.9021.00
14_K17_I1.8731.00
197_G226_K1.8711.00
196_L199_Y1.8441.00
197_G220_D1.8421.00
115_T143_A1.8371.00
201_K204_F1.8111.00
23_K117_L1.7981.00
85_L295_Y1.7791.00
70_E73_E1.7671.00
224_I277_L1.6801.00
153_Y180_N1.6791.00
127_L149_V1.6681.00
20_S116_E1.6661.00
83_V291_A1.6641.00
23_K27_K1.6471.00
115_T207_S1.6311.00
161_F165_K1.6131.00
25_A289_I1.6091.00
196_L220_D1.5951.00
132_A154_I1.5811.00
87_S94_L1.5761.00
178_L199_Y1.5711.00
9_L294_A1.5391.00
121_G182_D1.5281.00
83_V102_L1.5181.00
127_L143_A1.5161.00
295_Y299_L1.5111.00
227_V277_L1.5001.00
222_D225_I1.4991.00
16_E145_E1.4741.00
212_H216_S1.4621.00
95_A295_Y1.4511.00
217_R221_D1.4491.00
270_I274_R1.4481.00
10_D101_T1.4471.00
116_E147_F1.4451.00
153_Y171_A1.4431.00
83_V99_G1.4411.00
22_V113_L1.4391.00
9_L97_I1.4381.00
27_K266_I1.4341.00
180_N201_K1.4211.00
149_V183_T1.4201.00
71_N76_L1.4181.00
271_K274_R1.4161.00
255_E258_M1.3971.00
202_D273_E1.3761.00
235_L264_E1.3681.00
18_A290_T1.3601.00
208_S219_L1.3551.00
46_G70_E1.3311.00
121_G124_I1.3231.00
74_R89_D1.3201.00
154_I163_L1.3141.00
87_S90_T1.3131.00
21_S293_I1.3131.00
8_D11_E1.3121.00
125_G182_D1.3111.00
111_S139_H1.2971.00
115_T205_H1.2961.00
158_K161_F1.2951.00
269_G274_R1.2921.00
122_R272_I1.2891.00
85_L291_A1.2781.00
231_I265_I1.2761.00
110_A286_E1.2731.00
59_S296_Q1.2581.00
226_K275_P1.2531.00
6_R98_D1.2501.00
163_L167_V1.2491.00
178_L184_I1.2491.00
130_I174_L1.2451.00
164_A168_G1.2411.00
127_L152_L1.2271.00
177_L181_S1.2211.00
130_I195_V1.2211.00
19_V146_Y1.2121.00
118_A231_I1.2091.00
4_L8_D1.2051.00
87_S92_E1.2041.00
12_L298_A1.2041.00
130_I155_S1.2001.00
151_K180_N1.1961.00
124_I183_T1.1811.00
182_D201_K1.1801.00
119_I124_I1.1731.00
124_I147_F1.1621.00
249_K254_L1.1581.00
235_L261_E1.1551.00
230_Y254_L1.1521.00
128_G153_Y1.1511.00
113_L117_L1.1391.00
162_E166_R1.1361.00
115_T183_T1.1191.00
26_F286_E1.1101.00
81_G99_G1.1061.00
112_I146_Y1.1011.00
186_A208_S1.0941.00
293_I297_E1.0931.00
234_S237_A1.0851.00
61_V85_L1.0851.00
165_K168_G1.0761.00
33_K57_D1.0750.99
65_V81_G1.0700.99
156_A159_S1.0690.99
108_A139_H1.0650.99
220_D223_T1.0630.99
235_L256_N1.0530.99
6_R10_D1.0510.99
124_I182_D1.0510.99
140_A163_L1.0500.99
15_A142_L1.0490.99
24_E27_K1.0470.99
161_F164_A1.0460.99
28_L33_K1.0430.99
24_E28_L1.0400.99
64_I84_I1.0390.99
185_F207_S1.0370.99
126_I180_N1.0290.99
165_K169_G1.0250.99
16_E20_S1.0230.99
231_I260_K1.0220.99
28_L58_Y1.0180.99
65_V79_V1.0150.99
76_L90_T1.0080.99
132_A163_L1.0050.99
112_I143_A0.9930.99
203_V269_G0.9900.99
135_E139_H0.9890.99
175_E196_L0.9870.99
244_D279_K0.9860.99
136_A156_A0.9790.99
27_K31_Q0.9790.99
200_L204_F0.9770.99
76_L92_E0.9750.99
19_V112_I0.9690.99
260_K264_E0.9660.99
254_L258_M0.9590.99
64_I86_M0.9590.99
221_D248_P0.9560.99
184_I200_L0.9540.99
59_S94_L0.9530.99
4_L97_I0.9480.99
160_H164_A0.9460.99
203_V275_P0.9420.99
139_H187_T0.9390.99
174_L178_L0.9380.99
176_T180_N0.9380.99
143_A185_F0.9360.99
31_Q267_E0.9330.99
84_I93_I0.9310.99
132_A136_A0.9250.98
97_I294_A0.9200.98
119_I147_F0.9170.98
26_F110_A0.9160.98
54_S284_A0.9160.98
81_G100_T0.9150.98
115_T147_F0.9100.98
232_V238_V0.9080.98
39_R52_M0.9060.98
269_G272_I0.9060.98
114_S280_T0.9050.98
127_L185_F0.9050.98
116_E146_Y0.9000.98
84_I96_I0.8970.98
110_A278_F0.8960.98
228_K231_I0.8940.98
27_K267_E0.8870.98
136_A163_L0.8860.98
80_Q92_E0.8750.98
128_G184_I0.8730.98
191_N215_D0.8680.98
138_Y141_K0.8680.98
217_R247_I0.8660.98
139_H209_I0.8650.98
20_S24_E0.8640.98
197_G223_T0.8590.98
128_G174_L0.8570.98
68_I91_G0.8560.97
115_T185_F0.8540.97
126_I182_D0.8530.97
59_S292_H0.8500.97
63_K287_D0.8500.97
232_V245_Y0.8490.97
144_L149_V0.8450.97
50_G65_V0.8450.97
207_S276_S0.8420.97
216_S279_K0.8340.97
102_L294_A0.8310.97
52_M65_V0.8280.97
112_I145_E0.8270.97
179_K199_Y0.8250.97
156_A160_H0.8250.97
234_S261_E0.8230.97
104_A134_T0.8190.97
249_K256_N0.8160.97
17_I20_S0.8160.97
172_T176_T0.8150.97
162_E165_K0.8120.97
50_G212_H0.8100.97
37_P42_M0.8100.97
29_H234_S0.8090.96
256_N259_I0.8060.96
97_I291_A0.8020.96
39_R241_E0.8000.96
61_V83_V0.8000.96
132_A159_S0.7980.96
21_S25_A0.7980.96
198_K222_D0.7970.96
23_K113_L0.7960.96
18_A105_I0.7960.96
117_L265_I0.7940.96
128_G173_D0.7890.96
71_N74_R0.7850.96
7_K11_E0.7840.96
71_N75_G0.7840.96
155_S195_V0.7830.96
12_L297_E0.7760.96
159_S162_E0.7750.96
121_G272_I0.7720.95
198_K226_K0.7700.95
15_A112_I0.7690.95
204_F275_P0.7660.95
130_I194_V0.7650.95
85_L288_N0.7620.95
114_S207_S0.7590.95
186_A195_V0.7560.95
52_M241_E0.7560.95
7_K10_D0.7540.95
50_G79_V0.7530.95
67_V79_V0.7510.95
101_T105_I0.7480.95
115_T119_I0.7460.94
79_V103_T0.7430.94
237_A281_V0.7340.94
212_H237_A0.7330.94
128_G155_S0.7320.94
221_D225_I0.7250.94
206_L223_T0.7250.94
26_F29_H0.7230.94
50_G216_S0.7220.93
111_S207_S0.7210.93
104_A138_Y0.7190.93
128_G171_A0.7080.93
112_I147_F0.7070.93
171_A177_L0.7030.93
50_G67_V0.7020.93
30_Y264_E0.7010.92
153_Y177_L0.6980.92
223_T277_L0.6970.92
149_V152_L0.6950.92
112_I127_L0.6950.92
212_H279_K0.6950.92
86_M93_I0.6940.92
177_L180_N0.6920.92
15_A108_A0.6890.92
115_T276_S0.6890.92
261_E264_E0.6880.92
9_L13_L0.6870.92
264_E268_K0.6840.92
245_Y259_I0.6830.91
203_V271_K0.6810.91
108_A138_Y0.6780.91
39_R281_V0.6740.91
41_V48_W0.6740.91
141_K167_V0.6740.91
175_E198_K0.6730.91
155_S174_L0.6730.91
195_V206_L0.6710.91
136_A187_T0.6710.91
68_I87_S0.6670.90
126_I181_S0.6670.90
237_A279_K0.6670.90
82_V96_I0.6660.90
147_F183_T0.6660.90
265_I268_K0.6650.90
63_K103_T0.6590.90
210_G218_E0.6570.90
137_Y167_V0.6540.90
230_Y257_K0.6530.90
78_L103_T0.6520.89
15_A145_E0.6500.89
111_S209_I0.6490.89
30_Y261_E0.6490.89
195_V220_D0.6470.89
119_I205_H0.6470.89
49_W66_N0.6410.89
154_I164_A0.6410.89
94_L299_L0.6400.89
123_N272_I0.6380.88
232_V235_L0.6340.88
167_V170_E0.6330.88
171_A176_T0.6330.88
213_T216_S0.6320.88
122_R147_F0.6300.88
119_I183_T0.6280.88
21_S289_I0.6270.88
200_L206_L0.6230.87
202_D275_P0.6230.87
59_S295_Y0.6220.87
93_I96_I0.6200.87
230_Y245_Y0.6170.87
81_G103_T0.6170.87
48_W213_T0.6140.87
163_L166_R0.6120.86
197_G222_D0.6100.86
174_L177_L0.6080.86
60_F68_I0.6080.86
200_L275_P0.6070.86
209_I280_T0.6020.85
41_V284_A0.6000.85
21_S290_T0.6000.85
51_L64_I0.5990.85
206_L219_L0.5970.85
67_V81_G0.5970.85
179_K201_K0.5930.85
242_S279_K0.5930.85
6_R99_G0.5930.85
48_W212_H0.5920.84
126_I150_Q0.5920.84
249_K255_E0.5920.84
38_Q237_A0.5880.84
293_I296_Q0.5880.84
114_S262_L0.5840.84
234_S283_I0.5830.84
203_V272_I0.5810.83
22_V109_A0.5800.83
82_V93_I0.5790.83
4_L294_A0.5780.83
33_K58_Y0.5740.83
166_R169_G0.5700.82
52_M281_V0.5700.82
114_S278_F0.5700.82
188_T218_E0.5700.82
184_I206_L0.5690.82
156_A280_T0.5670.82
34_V56_T0.5670.82
3_I96_I0.5660.82
37_P53_P0.5660.82
175_E178_L0.5630.81
190_S193_P0.5610.81
13_L294_A0.5610.81
41_V65_V0.5610.81
110_A283_I0.5590.81
67_V212_H0.5570.81
22_V286_E0.5570.81
245_Y254_L0.5560.81
28_L31_Q0.5550.81
263_G266_I0.5530.80
17_I293_I0.5520.80
187_T209_I0.5480.80
65_V103_T0.5470.80
184_I204_F0.5460.79
196_L222_D0.5450.79
12_L294_A0.5450.79
62_T84_I0.5440.79
129_I154_I0.5420.79
108_A142_L0.5410.79
212_H281_V0.5410.79
53_P65_V0.5400.79
296_Q299_L0.5400.79
230_Y258_M0.5400.79
241_E246_I0.5390.79
111_S143_A0.5380.78
184_I195_V0.5380.78
242_S281_V0.5370.78
246_I279_K0.5370.78
20_S23_K0.5360.78
118_A276_S0.5350.78
18_A22_V0.5350.78
19_V145_E0.5340.78
49_W60_F0.5330.78
135_E185_F0.5320.78
255_E259_I0.5310.78
41_V50_G0.5310.78
50_G237_A0.5300.77
126_I201_K0.5290.77
161_F168_G0.5280.77
127_L140_A0.5280.77
52_M67_V0.5250.77
59_S288_N0.5230.76
18_A142_L0.5220.76
30_Y267_E0.5210.76
99_G102_L0.5200.76
70_E74_R0.5190.76
106_R281_V0.5190.76
228_K276_S0.5170.76
157_R280_T0.5160.76
19_V109_A0.5160.76
128_G178_L0.5150.75
197_G275_P0.5140.75
22_V290_T0.5140.75
29_H285_V0.5130.75
238_V245_Y0.5130.75
195_V223_T0.5120.75
56_T289_I0.5110.75
8_D12_L0.5090.75
60_F88_P0.5090.75
48_W216_S0.5090.75
125_G151_K0.5070.74
153_Y181_S0.5050.74
173_D177_L0.5050.74
150_Q158_K0.5040.74
37_P44_V0.5040.74
14_K297_E0.5010.73
238_V281_V0.5010.73
218_E280_T0.5000.73
55_S60_F0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1omoA 2 0.9871 100 0.274 Contact Map
4mp8A 2 0.9806 100 0.295 Contact Map
3hdjA 2 0.9612 100 0.297 Contact Map
4bvaA 2 0.9256 100 0.31 Contact Map
1x7dA 2 0.9676 100 0.375 Contact Map
3oj0A 1 0.4304 99.2 0.847 Contact Map
4ppmA 2 0 99.1 0.857 Contact Map
3pwzA 1 0.7994 98.5 0.883 Contact Map
3obbA 4 0.5728 98.4 0.888 Contact Map
3g0oA 3 0.5793 98.3 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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