Q980D4 - SULSO - GREMLIN Contacts

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Q980D4 - Sugar phosphate nucleotydyl transferase

UniProt:	Q980D4	Sequences: MSEMKAIVLAGGKGEGLLPYTEKVQKEAITVLGKAIINYTIEGLKKAGVKEFEIIVNEKGNQIEEEVEKLDVSFETIVQKKQGIDGAVLEGIESIDDDVFVLAFGDIIAPAEFYKSLMDTYIMTGSQAVIPLIPISEGTETYGLVKIVDNKLKVVKESSTLALGGAYILPKPKDNFTSLLDYIDLLSSQARLNYFIWSESWVDIGYPEDLLFALETLLRRKESVISDKAEISKNAIIGKGVIIEDYAIIEDYAIIKGPAYIGKNAYVGSFSLVRDYSSIEEGAKIGAYCEIAHSLIEPFAEVGSKSYLTYSIVGKGAKIGASVITASYPAHSLSRPRFNKLGALISPEKVIKHGSVIEAGTKV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (312)
Sequences:	8617 (5657)
Seq/√Len:	320.3

ECOLI - GLMU GLGC RMLA1 RMLA2
BACSU - GLMU GLGC GLGD
HALSA - Q9HSZ9 Q9HSZ8 Q9HS61
SULSO - Q980D4 Q7LXK9 Q980H9 Q97ZD1 Q7LXE7 Q97XG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
273_V	277_S	3.755	1.00
134_P	160_T	3.359	1.00
121_Y	129_V	3.258	1.00
275_D	293_H	2.860	1.00
274_R	292_A	2.858	1.00
291_I	294_S	2.780	1.00
148_V	151_K	2.727	1.00
308_L	311_S	2.650	1.00
34_K	42_E	2.592	1.00
264_N	282_G	2.581	1.00
134_P	196_I	2.557	1.00
119_D	123_M	2.489	1.00
146_K	159_S	2.461	1.00
263_K	281_E	2.393	1.00
6_A	49_V	2.352	1.00
256_K	274_R	2.334	1.00
292_A	309_T	2.323	1.00
296_I	302_V	2.307	1.00
286_G	304_S	2.268	1.00
99_V	122_I	2.226	1.00
279_I	285_I	2.217	1.00
127_Q	170_P	2.197	1.00
146_K	154_V	2.163	1.00
6_A	44_L	2.137	1.00
117_L	131_P	2.116	1.00
277_S	291_I	2.097	1.00
120_T	124_T	2.090	1.00
126_S	193_N	2.061	1.00
266_Y	284_K	2.056	1.00
262_G	281_E	2.037	1.00
38_N	66_E	2.027	1.00
255_I	259_A	2.027	1.00
244_E	263_K	2.024	1.00
269_S	287_A	2.021	1.00
287_A	304_S	2.013	1.00
247_A	265_A	1.987	1.00
100_F	171_K	1.978	1.00
99_V	170_P	1.967	1.00
24_V	30_T	1.957	1.00
148_V	153_K	1.925	1.00
152_L	194_Y	1.908	1.00
137_E	140_E	1.896	1.00
279_I	283_A	1.878	1.00
272_L	290_E	1.853	1.00
132_L	194_Y	1.817	1.00
268_G	287_A	1.806	1.00
245_D	263_K	1.784	1.00
293_H	310_Y	1.783	1.00
242_I	260_Y	1.780	1.00
289_C	306_S	1.779	1.00
282_G	299_F	1.765	1.00
281_E	298_P	1.739	1.00
117_L	168_I	1.727	1.00
140_E	158_S	1.710	1.00
41_I	52_F	1.683	1.00
23_K	264_N	1.677	1.00
248_I	266_Y	1.676	1.00
270_F	288_Y	1.618	1.00
204_I	213_A	1.610	1.00
252_Y	270_F	1.606	1.00
151_K	191_R	1.606	1.00
82_Q	86_G	1.596	1.00
268_G	286_G	1.591	1.00
51_E	75_E	1.578	1.00
44_L	103_A	1.538	1.00
224_V	227_D	1.521	1.00
124_T	193_N	1.511	1.00
37_I	67_V	1.503	1.00
280_E	298_P	1.488	1.00
53_E	77_I	1.481	1.00
120_T	195_F	1.480	1.00
38_N	42_E	1.474	1.00
115_K	119_D	1.463	1.00
60_G	78_V	1.445	1.00
261_I	265_A	1.434	1.00
117_L	129_V	1.429	1.00
151_K	193_N	1.421	1.00
265_A	283_A	1.409	1.00
146_K	156_K	1.404	1.00
286_G	303_G	1.400	1.00
118_M	168_I	1.390	1.00
284_K	301_E	1.373	1.00
127_Q	191_R	1.369	1.00
86_G	89_L	1.362	1.00
5_K	51_E	1.360	1.00
247_A	281_E	1.351	1.00
102_L	169_L	1.350	1.00
290_E	307_Y	1.350	1.00
301_E	318_K	1.349	1.00
60_G	64_E	1.339	1.00
128_A	186_L	1.339	1.00
296_I	300_A	1.318	1.00
300_A	317_A	1.304	1.00
99_V	168_I	1.301	1.00
265_A	279_I	1.300	1.00
101_V	168_I	1.295	1.00
257_G	275_D	1.284	1.00
36_I	204_I	1.266	1.00
260_Y	278_S	1.265	1.00
71_D	74_F	1.249	1.00
86_G	90_E	1.227	1.00
238_G	256_K	1.221	1.00
31_V	214_L	1.216	1.00
28_A	66_E	1.208	1.00
56_V	60_G	1.208	1.00
313_V	317_A	1.206	1.00
147_I	161_L	1.204	1.00
254_I	272_L	1.201	1.00
132_L	145_V	1.197	1.00
51_E	73_S	1.187	1.00
112_E	115_K	1.186	1.00
53_E	94_S	1.178	1.00
184_D	188_S	1.177	1.00
141_T	158_S	1.174	1.00
271_S	289_C	1.173	1.00
250_E	269_S	1.168	1.00
185_L	189_Q	1.159	1.00
283_A	300_A	1.150	1.00
116_S	119_D	1.149	1.00
103_A	114_Y	1.148	1.00
288_Y	305_K	1.147	1.00
104_F	107_I	1.143	1.00
32_L	217_L	1.142	1.00
224_V	243_I	1.136	1.00
202_V	216_T	1.133	1.00
243_I	247_A	1.130	1.00
206_Y	226_S	1.126	1.00
200_S	216_T	1.122	1.00
163_L	167_Y	1.121	1.00
313_V	319_I	1.117	1.00
250_E	253_A	1.105	1.00
232_S	248_I	1.103	1.00
71_D	75_E	1.100	1.00
132_L	161_L	1.099	1.00
43_G	111_A	1.093	1.00
112_E	116_S	1.088	1.00
61_N	65_E	1.079	1.00
250_E	266_Y	1.077	1.00
147_I	194_Y	1.074	1.00
176_F	181_D	1.074	1.00
300_A	313_V	1.069	1.00
24_V	62_Q	1.067	1.00
39_Y	217_L	1.065	1.00
202_V	212_F	1.063	1.00
265_A	280_E	1.059	1.00
152_L	192_L	1.056	1.00
27_E	105_G	1.054	1.00
268_G	284_K	1.053	1.00
120_T	193_N	1.049	1.00
89_L	92_I	1.047	1.00
169_L	182_Y	1.044	1.00
25_Q	62_Q	1.040	1.00
291_I	296_I	1.032	1.00
232_S	251_D	1.027	1.00
98_D	171_K	1.024	1.00
225_I	228_K	1.022	1.00
286_G	301_E	1.022	1.00
72_V	76_T	1.022	1.00
62_Q	65_E	1.021	1.00
144_L	162_A	1.017	1.00
280_E	297_E	1.015	1.00
299_F	316_G	1.013	1.00
45_K	73_S	1.010	1.00
75_E	78_V	1.003	1.00
241_V	255_I	1.003	1.00
244_E	247_A	0.993	1.00
264_N	281_E	0.984	1.00
283_A	296_I	0.984	1.00
208_E	212_F	0.983	1.00
97_D	172_P	0.982	1.00
30_T	35_A	0.976	1.00
303_G	318_K	0.976	1.00
143_G	157_E	0.970	1.00
82_Q	177_T	0.966	1.00
14_G	26_K	0.965	1.00
259_A	273_V	0.962	1.00
128_A	169_L	0.951	1.00
256_K	272_L	0.948	1.00
120_T	123_M	0.945	1.00
247_A	261_I	0.944	1.00
206_Y	209_D	0.944	1.00
71_D	77_I	0.939	1.00
98_D	170_P	0.936	1.00
130_I	152_L	0.935	1.00
226_S	229_A	0.935	1.00
225_I	229_A	0.934	1.00
46_K	111_A	0.933	1.00
41_I	74_F	0.920	1.00
35_A	38_N	0.915	1.00
135_I	162_A	0.913	1.00
150_N	196_I	0.912	1.00
237_I	241_V	0.912	1.00
208_E	226_S	0.908	1.00
57_N	86_G	0.906	1.00
222_E	226_S	0.906	1.00
64_E	78_V	0.904	1.00
101_V	118_M	0.901	1.00
70_L	75_E	0.900	1.00
297_E	312_I	0.899	1.00
244_E	262_G	0.892	1.00
223_S	227_D	0.889	1.00
37_I	54_I	0.882	1.00
37_I	63_I	0.881	1.00
273_V	279_I	0.879	1.00
262_G	265_A	0.877	1.00
253_A	269_S	0.876	1.00
261_I	267_V	0.875	1.00
271_S	287_A	0.870	1.00
47_A	114_Y	0.869	1.00
5_K	95_I	0.869	1.00
255_I	261_I	0.868	1.00
249_I	253_A	0.868	1.00
118_M	122_I	0.867	1.00
110_P	200_S	0.860	1.00
52_F	72_V	0.855	1.00
314_G	317_A	0.854	1.00
136_S	160_T	0.854	1.00
187_S	192_L	0.852	1.00
8_V	44_L	0.852	1.00
223_S	226_S	0.851	1.00
70_L	73_S	0.851	1.00
38_N	67_V	0.847	1.00
243_I	249_I	0.847	1.00
250_E	268_G	0.846	1.00
185_L	188_S	0.840	1.00
137_E	158_S	0.836	1.00
232_S	235_A	0.832	1.00
28_A	62_Q	0.830	1.00
289_C	303_G	0.828	1.00
238_G	241_V	0.828	1.00
247_A	262_G	0.827	1.00
308_L	313_V	0.827	1.00
40_T	103_A	0.827	1.00
215_E	218_L	0.826	1.00
306_S	319_I	0.823	1.00
130_I	145_V	0.821	1.00
280_E	283_A	0.821	1.00
72_V	75_E	0.818	1.00
133_I	201_W	0.815	1.00
71_D	76_T	0.814	1.00
88_V	102_L	0.814	1.00
146_K	153_K	0.813	1.00
54_I	67_V	0.813	1.00
224_V	229_A	0.810	1.00
125_G	170_P	0.808	1.00
244_E	281_E	0.805	1.00
16_G	26_K	0.805	1.00
285_I	291_I	0.804	1.00
133_I	162_A	0.803	1.00
252_Y	255_I	0.799	1.00
244_E	260_Y	0.795	1.00
222_E	225_I	0.795	1.00
230_E	248_I	0.792	1.00
71_D	78_V	0.787	1.00
289_C	305_K	0.786	1.00
61_N	64_E	0.784	1.00
161_L	196_I	0.783	1.00
288_Y	304_S	0.783	1.00
25_Q	59_K	0.778	1.00
7_I	53_E	0.776	1.00
116_S	120_T	0.775	1.00
251_D	269_S	0.774	1.00
56_V	76_T	0.773	1.00
7_I	100_F	0.767	1.00
265_A	281_E	0.767	1.00
216_T	219_R	0.767	1.00
282_G	298_P	0.767	1.00
109_A	166_A	0.766	0.99
26_K	106_D	0.766	0.99
289_C	304_S	0.761	0.99
304_S	307_Y	0.757	0.99
291_I	308_L	0.755	0.99
53_E	95_I	0.755	0.99
73_S	76_T	0.754	0.99
35_A	66_E	0.750	0.99
35_A	39_Y	0.750	0.99
101_V	114_Y	0.744	0.99
45_K	52_F	0.744	0.99
32_L	214_L	0.740	0.99
286_G	289_C	0.736	0.99
240_G	257_G	0.736	0.99
44_L	49_V	0.734	0.99
271_S	285_I	0.734	0.99
49_V	118_M	0.730	0.99
59_K	62_Q	0.727	0.99
135_I	160_T	0.726	0.99
86_G	177_T	0.723	0.99
289_C	302_V	0.722	0.99
302_V	308_L	0.722	0.99
249_I	255_I	0.718	0.99
56_V	64_E	0.717	0.99
177_T	181_D	0.716	0.99
76_T	79_Q	0.713	0.99
92_I	96_D	0.711	0.99
247_A	263_K	0.710	0.99
8_V	41_I	0.709	0.99
128_A	183_I	0.708	0.99
298_P	315_K	0.708	0.99
41_I	67_V	0.705	0.99
283_A	297_E	0.701	0.99
12_G	26_K	0.700	0.99
5_K	100_F	0.699	0.99
45_K	72_V	0.695	0.99
246_Y	264_N	0.695	0.99
9_L	104_F	0.695	0.99
293_H	309_T	0.689	0.99
91_G	94_S	0.688	0.99
131_P	166_A	0.687	0.99
154_V	184_D	0.686	0.99
137_E	141_T	0.685	0.99
175_N	181_D	0.685	0.99
246_Y	263_K	0.684	0.99
7_I	88_V	0.680	0.99
250_E	254_I	0.673	0.99
283_A	298_P	0.672	0.99
55_I	87_A	0.671	0.99
88_V	179_L	0.671	0.99
43_G	47_A	0.670	0.99
294_S	311_S	0.668	0.99
54_I	74_F	0.666	0.99
202_V	213_A	0.665	0.99
119_D	122_I	0.664	0.99
43_G	114_Y	0.662	0.99
274_R	277_S	0.662	0.99
31_V	36_I	0.657	0.98
250_E	256_K	0.657	0.98
70_L	74_F	0.652	0.98
232_S	250_E	0.652	0.98
39_Y	42_E	0.652	0.98
273_V	285_I	0.645	0.98
95_I	98_D	0.642	0.98
216_T	220_R	0.639	0.98
278_S	295_L	0.637	0.98
104_F	165_G	0.636	0.98
5_K	53_E	0.635	0.98
130_I	192_L	0.634	0.98
242_I	245_D	0.634	0.98
56_V	63_I	0.634	0.98
250_E	257_G	0.633	0.98
226_S	245_D	0.633	0.98
8_V	40_T	0.633	0.98
42_E	46_K	0.632	0.98
133_I	164_G	0.631	0.98
212_F	215_E	0.630	0.98
256_K	259_A	0.630	0.98
73_S	77_I	0.629	0.98
53_E	91_G	0.628	0.98
126_S	129_V	0.628	0.98
243_I	261_I	0.625	0.98
75_E	94_S	0.624	0.98
224_V	228_K	0.623	0.98
152_L	155_V	0.622	0.98
121_Y	170_P	0.621	0.98
145_V	152_L	0.618	0.98
53_E	75_E	0.618	0.98
230_E	233_K	0.616	0.98
57_N	60_G	0.616	0.98
240_G	243_I	0.615	0.98
21_T	29_I	0.607	0.97
212_F	216_T	0.607	0.97
234_N	237_I	0.606	0.97
9_L	87_A	0.606	0.97
228_K	234_N	0.604	0.97
141_T	209_D	0.601	0.97
106_D	203_D	0.596	0.97
75_E	79_Q	0.596	0.97
103_A	166_A	0.594	0.97
99_V	118_M	0.594	0.97
9_L	55_I	0.594	0.97
27_E	63_I	0.589	0.97
214_L	218_L	0.587	0.97
179_L	182_Y	0.587	0.97
18_L	22_E	0.587	0.97
164_G	201_W	0.586	0.97
294_S	308_L	0.586	0.97
131_P	164_G	0.586	0.97
267_V	271_S	0.585	0.97
11_G	55_I	0.584	0.97
32_L	39_Y	0.582	0.97
132_L	196_I	0.581	0.97
294_S	297_E	0.577	0.97
64_E	76_T	0.575	0.96
23_K	245_D	0.574	0.96
43_G	46_K	0.571	0.96
301_E	304_S	0.571	0.96
45_K	71_D	0.571	0.96
151_K	187_S	0.569	0.96
182_Y	185_L	0.567	0.96
207_P	211_L	0.567	0.96
225_I	230_E	0.567	0.96
126_S	191_R	0.564	0.96
81_K	86_G	0.564	0.96
116_S	195_F	0.563	0.96
161_L	194_Y	0.563	0.96
17_L	29_I	0.562	0.96
169_L	179_L	0.562	0.96
132_L	152_L	0.562	0.96
129_V	168_I	0.561	0.96
227_D	230_E	0.561	0.96
176_F	180_L	0.560	0.96
311_S	314_G	0.560	0.96
128_A	192_L	0.560	0.96
252_Y	256_K	0.559	0.96
297_E	315_K	0.558	0.96
4_M	118_M	0.557	0.96
70_L	76_T	0.557	0.96
145_V	161_L	0.556	0.96
47_A	115_K	0.555	0.96
36_I	40_T	0.555	0.96
252_Y	257_G	0.555	0.96
292_A	307_Y	0.553	0.96
98_D	172_P	0.552	0.96
302_V	306_S	0.546	0.95
42_E	70_L	0.546	0.95
296_I	313_V	0.546	0.95
227_D	245_D	0.546	0.95
280_E	295_L	0.545	0.95
238_G	257_G	0.544	0.95
285_I	289_C	0.543	0.95
153_K	187_S	0.542	0.95
271_S	304_S	0.541	0.95
124_T	191_R	0.541	0.95
34_K	39_Y	0.541	0.95
253_A	267_V	0.540	0.95
275_D	292_A	0.538	0.95
272_L	292_A	0.538	0.95
102_L	179_L	0.537	0.95
272_L	287_A	0.537	0.95
31_V	213_A	0.535	0.95
84_I	88_V	0.534	0.95
252_Y	269_S	0.532	0.95
132_L	135_I	0.532	0.95
297_E	314_G	0.531	0.95
224_V	230_E	0.531	0.95
28_A	37_I	0.531	0.95
228_K	246_Y	0.530	0.94
157_E	163_L	0.529	0.94
135_I	139_T	0.528	0.94
129_V	195_F	0.527	0.94
244_E	265_A	0.526	0.94
5_K	96_D	0.526	0.94
74_F	77_I	0.526	0.94
284_K	287_A	0.522	0.94
309_T	318_K	0.521	0.94
268_G	289_C	0.519	0.94
209_D	212_F	0.519	0.94
217_L	221_K	0.518	0.94
236_I	254_I	0.517	0.94
254_I	257_G	0.515	0.94
4_M	99_V	0.514	0.94
14_G	203_D	0.513	0.93
93_E	96_D	0.513	0.93
12_G	16_G	0.512	0.93
238_G	254_I	0.512	0.93
50_K	73_S	0.510	0.93
14_G	27_E	0.510	0.93
122_I	168_I	0.509	0.93
147_I	150_N	0.509	0.93
89_L	177_T	0.508	0.93
237_I	243_I	0.508	0.93
67_V	76_T	0.508	0.93
180_L	184_D	0.508	0.93
303_G	306_S	0.506	0.93
67_V	74_F	0.505	0.93
263_K	282_G	0.504	0.93
110_P	220_R	0.504	0.93
197_W	201_W	0.501	0.93
229_A	243_I	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ggoA	3	0.9559	100	0.353	Contact Map
1yp2A	4	0.9642	100	0.367	Contact Map
1hm9A	3	0.9697	100	0.382	Contact Map
3brkX	2	0.9256	100	0.388	Contact Map
4g3qA	3	0.978	100	0.394	Contact Map
2v0hA	3	0.9614	100	0.407	Contact Map
4fceA	3	0.9477	100	0.416	Contact Map
2icyA	1	0.8209	100	0.548	Contact Map
2i5kA	5	0.7961	100	0.568	Contact Map
3jukA	3	0.6061	100	0.594	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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