GREMLIN Database
Q980D4 - Sugar phosphate nucleotydyl transferase
UniProt: Q980D4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (312)
Sequences: 8617 (5657)
Seq/√Len: 320.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
273_V277_S3.7551.00
134_P160_T3.3591.00
121_Y129_V3.2581.00
275_D293_H2.8601.00
274_R292_A2.8581.00
291_I294_S2.7801.00
148_V151_K2.7271.00
308_L311_S2.6501.00
34_K42_E2.5921.00
264_N282_G2.5811.00
134_P196_I2.5571.00
119_D123_M2.4891.00
146_K159_S2.4611.00
263_K281_E2.3931.00
6_A49_V2.3521.00
256_K274_R2.3341.00
292_A309_T2.3231.00
296_I302_V2.3071.00
286_G304_S2.2681.00
99_V122_I2.2261.00
279_I285_I2.2171.00
127_Q170_P2.1971.00
146_K154_V2.1631.00
6_A44_L2.1371.00
117_L131_P2.1161.00
277_S291_I2.0971.00
120_T124_T2.0901.00
126_S193_N2.0611.00
266_Y284_K2.0561.00
262_G281_E2.0371.00
38_N66_E2.0271.00
255_I259_A2.0271.00
244_E263_K2.0241.00
269_S287_A2.0211.00
287_A304_S2.0131.00
247_A265_A1.9871.00
100_F171_K1.9781.00
99_V170_P1.9671.00
24_V30_T1.9571.00
148_V153_K1.9251.00
152_L194_Y1.9081.00
137_E140_E1.8961.00
279_I283_A1.8781.00
272_L290_E1.8531.00
132_L194_Y1.8171.00
268_G287_A1.8061.00
245_D263_K1.7841.00
293_H310_Y1.7831.00
242_I260_Y1.7801.00
289_C306_S1.7791.00
282_G299_F1.7651.00
281_E298_P1.7391.00
117_L168_I1.7271.00
140_E158_S1.7101.00
41_I52_F1.6831.00
23_K264_N1.6771.00
248_I266_Y1.6761.00
270_F288_Y1.6181.00
204_I213_A1.6101.00
252_Y270_F1.6061.00
151_K191_R1.6061.00
82_Q86_G1.5961.00
268_G286_G1.5911.00
51_E75_E1.5781.00
44_L103_A1.5381.00
224_V227_D1.5211.00
124_T193_N1.5111.00
37_I67_V1.5031.00
280_E298_P1.4881.00
53_E77_I1.4811.00
120_T195_F1.4801.00
38_N42_E1.4741.00
115_K119_D1.4631.00
60_G78_V1.4451.00
261_I265_A1.4341.00
117_L129_V1.4291.00
151_K193_N1.4211.00
265_A283_A1.4091.00
146_K156_K1.4041.00
286_G303_G1.4001.00
118_M168_I1.3901.00
284_K301_E1.3731.00
127_Q191_R1.3691.00
86_G89_L1.3621.00
5_K51_E1.3601.00
247_A281_E1.3511.00
102_L169_L1.3501.00
290_E307_Y1.3501.00
301_E318_K1.3491.00
60_G64_E1.3391.00
128_A186_L1.3391.00
296_I300_A1.3181.00
300_A317_A1.3041.00
99_V168_I1.3011.00
265_A279_I1.3001.00
101_V168_I1.2951.00
257_G275_D1.2841.00
36_I204_I1.2661.00
260_Y278_S1.2651.00
71_D74_F1.2491.00
86_G90_E1.2271.00
238_G256_K1.2211.00
31_V214_L1.2161.00
28_A66_E1.2081.00
56_V60_G1.2081.00
313_V317_A1.2061.00
147_I161_L1.2041.00
254_I272_L1.2011.00
132_L145_V1.1971.00
51_E73_S1.1871.00
112_E115_K1.1861.00
53_E94_S1.1781.00
184_D188_S1.1771.00
141_T158_S1.1741.00
271_S289_C1.1731.00
250_E269_S1.1681.00
185_L189_Q1.1591.00
283_A300_A1.1501.00
116_S119_D1.1491.00
103_A114_Y1.1481.00
288_Y305_K1.1471.00
104_F107_I1.1431.00
32_L217_L1.1421.00
224_V243_I1.1361.00
202_V216_T1.1331.00
243_I247_A1.1301.00
206_Y226_S1.1261.00
200_S216_T1.1221.00
163_L167_Y1.1211.00
313_V319_I1.1171.00
250_E253_A1.1051.00
232_S248_I1.1031.00
71_D75_E1.1001.00
132_L161_L1.0991.00
43_G111_A1.0931.00
112_E116_S1.0881.00
61_N65_E1.0791.00
250_E266_Y1.0771.00
147_I194_Y1.0741.00
176_F181_D1.0741.00
300_A313_V1.0691.00
24_V62_Q1.0671.00
39_Y217_L1.0651.00
202_V212_F1.0631.00
265_A280_E1.0591.00
152_L192_L1.0561.00
27_E105_G1.0541.00
268_G284_K1.0531.00
120_T193_N1.0491.00
89_L92_I1.0471.00
169_L182_Y1.0441.00
25_Q62_Q1.0401.00
291_I296_I1.0321.00
232_S251_D1.0271.00
98_D171_K1.0241.00
225_I228_K1.0221.00
286_G301_E1.0221.00
72_V76_T1.0221.00
62_Q65_E1.0211.00
144_L162_A1.0171.00
280_E297_E1.0151.00
299_F316_G1.0131.00
45_K73_S1.0101.00
75_E78_V1.0031.00
241_V255_I1.0031.00
244_E247_A0.9931.00
264_N281_E0.9841.00
283_A296_I0.9841.00
208_E212_F0.9831.00
97_D172_P0.9821.00
30_T35_A0.9761.00
303_G318_K0.9761.00
143_G157_E0.9701.00
82_Q177_T0.9661.00
14_G26_K0.9651.00
259_A273_V0.9621.00
128_A169_L0.9511.00
256_K272_L0.9481.00
120_T123_M0.9451.00
247_A261_I0.9441.00
206_Y209_D0.9441.00
71_D77_I0.9391.00
98_D170_P0.9361.00
130_I152_L0.9351.00
226_S229_A0.9351.00
225_I229_A0.9341.00
46_K111_A0.9331.00
41_I74_F0.9201.00
35_A38_N0.9151.00
135_I162_A0.9131.00
150_N196_I0.9121.00
237_I241_V0.9121.00
208_E226_S0.9081.00
57_N86_G0.9061.00
222_E226_S0.9061.00
64_E78_V0.9041.00
101_V118_M0.9011.00
70_L75_E0.9001.00
297_E312_I0.8991.00
244_E262_G0.8921.00
223_S227_D0.8891.00
37_I54_I0.8821.00
37_I63_I0.8811.00
273_V279_I0.8791.00
262_G265_A0.8771.00
253_A269_S0.8761.00
261_I267_V0.8751.00
271_S287_A0.8701.00
47_A114_Y0.8691.00
5_K95_I0.8691.00
255_I261_I0.8681.00
249_I253_A0.8681.00
118_M122_I0.8671.00
110_P200_S0.8601.00
52_F72_V0.8551.00
314_G317_A0.8541.00
136_S160_T0.8541.00
187_S192_L0.8521.00
8_V44_L0.8521.00
223_S226_S0.8511.00
70_L73_S0.8511.00
38_N67_V0.8471.00
243_I249_I0.8471.00
250_E268_G0.8461.00
185_L188_S0.8401.00
137_E158_S0.8361.00
232_S235_A0.8321.00
28_A62_Q0.8301.00
289_C303_G0.8281.00
238_G241_V0.8281.00
247_A262_G0.8271.00
308_L313_V0.8271.00
40_T103_A0.8271.00
215_E218_L0.8261.00
306_S319_I0.8231.00
130_I145_V0.8211.00
280_E283_A0.8211.00
72_V75_E0.8181.00
133_I201_W0.8151.00
71_D76_T0.8141.00
88_V102_L0.8141.00
146_K153_K0.8131.00
54_I67_V0.8131.00
224_V229_A0.8101.00
125_G170_P0.8081.00
244_E281_E0.8051.00
16_G26_K0.8051.00
285_I291_I0.8041.00
133_I162_A0.8031.00
252_Y255_I0.7991.00
244_E260_Y0.7951.00
222_E225_I0.7951.00
230_E248_I0.7921.00
71_D78_V0.7871.00
289_C305_K0.7861.00
61_N64_E0.7841.00
161_L196_I0.7831.00
288_Y304_S0.7831.00
25_Q59_K0.7781.00
7_I53_E0.7761.00
116_S120_T0.7751.00
251_D269_S0.7741.00
56_V76_T0.7731.00
7_I100_F0.7671.00
265_A281_E0.7671.00
216_T219_R0.7671.00
282_G298_P0.7671.00
109_A166_A0.7660.99
26_K106_D0.7660.99
289_C304_S0.7610.99
304_S307_Y0.7570.99
291_I308_L0.7550.99
53_E95_I0.7550.99
73_S76_T0.7540.99
35_A66_E0.7500.99
35_A39_Y0.7500.99
101_V114_Y0.7440.99
45_K52_F0.7440.99
32_L214_L0.7400.99
286_G289_C0.7360.99
240_G257_G0.7360.99
44_L49_V0.7340.99
271_S285_I0.7340.99
49_V118_M0.7300.99
59_K62_Q0.7270.99
135_I160_T0.7260.99
86_G177_T0.7230.99
289_C302_V0.7220.99
302_V308_L0.7220.99
249_I255_I0.7180.99
56_V64_E0.7170.99
177_T181_D0.7160.99
76_T79_Q0.7130.99
92_I96_D0.7110.99
247_A263_K0.7100.99
8_V41_I0.7090.99
128_A183_I0.7080.99
298_P315_K0.7080.99
41_I67_V0.7050.99
283_A297_E0.7010.99
12_G26_K0.7000.99
5_K100_F0.6990.99
45_K72_V0.6950.99
246_Y264_N0.6950.99
9_L104_F0.6950.99
293_H309_T0.6890.99
91_G94_S0.6880.99
131_P166_A0.6870.99
154_V184_D0.6860.99
137_E141_T0.6850.99
175_N181_D0.6850.99
246_Y263_K0.6840.99
7_I88_V0.6800.99
250_E254_I0.6730.99
283_A298_P0.6720.99
55_I87_A0.6710.99
88_V179_L0.6710.99
43_G47_A0.6700.99
294_S311_S0.6680.99
54_I74_F0.6660.99
202_V213_A0.6650.99
119_D122_I0.6640.99
43_G114_Y0.6620.99
274_R277_S0.6620.99
31_V36_I0.6570.98
250_E256_K0.6570.98
70_L74_F0.6520.98
232_S250_E0.6520.98
39_Y42_E0.6520.98
273_V285_I0.6450.98
95_I98_D0.6420.98
216_T220_R0.6390.98
278_S295_L0.6370.98
104_F165_G0.6360.98
5_K53_E0.6350.98
130_I192_L0.6340.98
242_I245_D0.6340.98
56_V63_I0.6340.98
250_E257_G0.6330.98
226_S245_D0.6330.98
8_V40_T0.6330.98
42_E46_K0.6320.98
133_I164_G0.6310.98
212_F215_E0.6300.98
256_K259_A0.6300.98
73_S77_I0.6290.98
53_E91_G0.6280.98
126_S129_V0.6280.98
243_I261_I0.6250.98
75_E94_S0.6240.98
224_V228_K0.6230.98
152_L155_V0.6220.98
121_Y170_P0.6210.98
145_V152_L0.6180.98
53_E75_E0.6180.98
230_E233_K0.6160.98
57_N60_G0.6160.98
240_G243_I0.6150.98
21_T29_I0.6070.97
212_F216_T0.6070.97
234_N237_I0.6060.97
9_L87_A0.6060.97
228_K234_N0.6040.97
141_T209_D0.6010.97
106_D203_D0.5960.97
75_E79_Q0.5960.97
103_A166_A0.5940.97
99_V118_M0.5940.97
9_L55_I0.5940.97
27_E63_I0.5890.97
214_L218_L0.5870.97
179_L182_Y0.5870.97
18_L22_E0.5870.97
164_G201_W0.5860.97
294_S308_L0.5860.97
131_P164_G0.5860.97
267_V271_S0.5850.97
11_G55_I0.5840.97
32_L39_Y0.5820.97
132_L196_I0.5810.97
294_S297_E0.5770.97
64_E76_T0.5750.96
23_K245_D0.5740.96
43_G46_K0.5710.96
301_E304_S0.5710.96
45_K71_D0.5710.96
151_K187_S0.5690.96
182_Y185_L0.5670.96
207_P211_L0.5670.96
225_I230_E0.5670.96
126_S191_R0.5640.96
81_K86_G0.5640.96
116_S195_F0.5630.96
161_L194_Y0.5630.96
17_L29_I0.5620.96
169_L179_L0.5620.96
132_L152_L0.5620.96
129_V168_I0.5610.96
227_D230_E0.5610.96
176_F180_L0.5600.96
311_S314_G0.5600.96
128_A192_L0.5600.96
252_Y256_K0.5590.96
297_E315_K0.5580.96
4_M118_M0.5570.96
70_L76_T0.5570.96
145_V161_L0.5560.96
47_A115_K0.5550.96
36_I40_T0.5550.96
252_Y257_G0.5550.96
292_A307_Y0.5530.96
98_D172_P0.5520.96
302_V306_S0.5460.95
42_E70_L0.5460.95
296_I313_V0.5460.95
227_D245_D0.5460.95
280_E295_L0.5450.95
238_G257_G0.5440.95
285_I289_C0.5430.95
153_K187_S0.5420.95
271_S304_S0.5410.95
124_T191_R0.5410.95
34_K39_Y0.5410.95
253_A267_V0.5400.95
275_D292_A0.5380.95
272_L292_A0.5380.95
102_L179_L0.5370.95
272_L287_A0.5370.95
31_V213_A0.5350.95
84_I88_V0.5340.95
252_Y269_S0.5320.95
132_L135_I0.5320.95
297_E314_G0.5310.95
224_V230_E0.5310.95
28_A37_I0.5310.95
228_K246_Y0.5300.94
157_E163_L0.5290.94
135_I139_T0.5280.94
129_V195_F0.5270.94
244_E265_A0.5260.94
5_K96_D0.5260.94
74_F77_I0.5260.94
284_K287_A0.5220.94
309_T318_K0.5210.94
268_G289_C0.5190.94
209_D212_F0.5190.94
217_L221_K0.5180.94
236_I254_I0.5170.94
254_I257_G0.5150.94
4_M99_V0.5140.94
14_G203_D0.5130.93
93_E96_D0.5130.93
12_G16_G0.5120.93
238_G254_I0.5120.93
50_K73_S0.5100.93
14_G27_E0.5100.93
122_I168_I0.5090.93
147_I150_N0.5090.93
89_L177_T0.5080.93
237_I243_I0.5080.93
67_V76_T0.5080.93
180_L184_D0.5080.93
303_G306_S0.5060.93
67_V74_F0.5050.93
263_K282_G0.5040.93
110_P220_R0.5040.93
197_W201_W0.5010.93
229_A243_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.9559 100 0.353 Contact Map
1yp2A 4 0.9642 100 0.367 Contact Map
1hm9A 3 0.9697 100 0.382 Contact Map
3brkX 2 0.9256 100 0.388 Contact Map
4g3qA 3 0.978 100 0.394 Contact Map
2v0hA 3 0.9614 100 0.407 Contact Map
4fceA 3 0.9477 100 0.416 Contact Map
2icyA 1 0.8209 100 0.548 Contact Map
2i5kA 5 0.7961 100 0.568 Contact Map
3jukA 3 0.6061 100 0.594 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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