GREMLIN Database
MVK - Mevalonate kinase
UniProt: Q980D2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (293)
Sequences: 5146 (3842)
Seq/√Len: 224.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_K33_S4.9951.00
238_Y262_K4.8331.00
47_I91_K3.8741.00
39_S91_K3.6951.00
229_N232_E3.5981.00
127_S130_E3.4771.00
36_V113_G3.3731.00
221_A233_L3.1451.00
170_E226_V3.0721.00
34_L109_A3.0361.00
269_C282_C3.0181.00
161_Y222_K2.9641.00
216_E220_R2.8801.00
234_G268_G2.8431.00
244_L249_I2.7021.00
177_E286_V2.6531.00
38_V117_A2.5601.00
41_N91_K2.4651.00
232_E235_L2.4621.00
254_A280_I2.3511.00
293_R297_A2.2161.00
224_L232_E2.2041.00
119_S125_D2.1781.00
223_S227_E2.1211.00
14_F221_A2.1001.00
112_V155_T2.0911.00
220_R232_E2.0781.00
224_L229_N2.0111.00
7_V113_G1.9771.00
222_K226_V1.9611.00
181_G282_C1.8821.00
115_V131_I1.8641.00
259_S263_Q1.8581.00
187_M274_G1.8411.00
40_E88_K1.8161.00
175_N286_V1.7531.00
73_V76_Y1.7361.00
242_G262_K1.7361.00
5_A120_K1.7331.00
242_G245_F1.7211.00
260_R264_L1.6621.00
256_E260_R1.6571.00
129_D133_K1.6421.00
94_I110_V1.6181.00
250_T255_D1.6021.00
258_V269_C1.6011.00
285_S288_A1.5981.00
132_A155_T1.5941.00
137_N141_K1.5881.00
291_L295_Y1.5741.00
24_P219_N1.5561.00
112_V135_S1.5401.00
44_F61_N1.5321.00
4_E37_K1.5281.00
52_N95_N1.5271.00
188_S191_D1.5131.00
119_S124_I1.5111.00
185_R251_S1.5051.00
88_K122_L1.4671.00
263_Q298_R1.4591.00
45_L59_D1.4571.00
235_L239_V1.4431.00
260_R298_R1.4271.00
284_K291_L1.4251.00
220_R223_S1.4221.00
241_H258_V1.4131.00
38_V90_V1.3971.00
292_L296_N1.3911.00
24_P161_Y1.3771.00
17_H20_V1.3761.00
72_K76_Y1.3691.00
38_V121_Y1.3541.00
37_K93_E1.3511.00
181_G280_I1.3461.00
47_I57_K1.3381.00
116_A128_R1.3301.00
294_S298_R1.3221.00
128_R155_T1.3101.00
82_N86_M1.3011.00
46_I90_V1.2871.00
119_S131_I1.2841.00
192_V276_A1.2841.00
290_V294_S1.2761.00
18_A215_G1.2701.00
81_L118_Y1.2601.00
179_T291_L1.2481.00
209_N243_L1.2371.00
231_E285_S1.2331.00
193_L200_K1.2321.00
196_V200_K1.2261.00
239_V242_G1.2211.00
189_T192_V1.2211.00
250_T271_I1.2171.00
292_L295_Y1.2151.00
119_S126_L1.2131.00
45_L57_K1.2011.00
50_S53_I1.2011.00
83_Y137_N1.1971.00
10_K19_V1.1931.00
290_V293_R1.1831.00
177_E289_E1.1741.00
40_E121_Y1.1731.00
41_N89_P1.1701.00
254_A271_I1.1701.00
92_I114_T1.1631.00
213_V239_V1.1601.00
224_L236_L1.1591.00
223_S226_V1.1591.00
167_K170_E1.1581.00
129_D156_Y1.1581.00
27_A153_T1.1551.00
183_I257_I1.1521.00
12_T27_A1.1501.00
94_I114_T1.1421.00
269_C280_I1.1381.00
87_K137_N1.1371.00
161_Y219_N1.1361.00
291_L296_N1.1361.00
233_L283_I1.1281.00
216_E219_N1.1251.00
209_N213_V1.1201.00
16_E244_L1.1111.00
257_I280_I1.1001.00
46_I89_P1.0991.00
112_V154_E1.0821.00
252_P256_E1.0811.00
38_V92_I1.0781.00
36_V92_I1.0761.00
143_Q147_S1.0751.00
201_E204_K1.0741.00
195_R198_T1.0741.00
208_E212_D1.0711.00
24_P215_G1.0631.00
139_E278_G1.0571.00
18_A21_Y1.0491.00
7_V154_E1.0481.00
49_P93_E1.0481.00
76_Y79_E1.0451.00
255_D259_S1.0431.00
264_L294_S1.0391.00
51_L93_E1.0321.00
80_V115_V1.0301.00
109_A154_E1.0291.00
251_S254_A1.0291.00
194_W197_R1.0231.00
206_V248_G1.0191.00
43_K89_P1.0171.00
231_E235_L1.0161.00
25_A149_M1.0141.00
185_R253_E1.0141.00
36_V94_I1.0101.00
201_E205_E0.9981.00
9_L98_V0.9971.00
260_R263_Q0.9971.00
237_M268_G0.9941.00
77_V114_T0.9911.00
12_T16_E0.9811.00
197_R200_K0.9801.00
294_S297_A0.9791.00
11_L281_I0.9601.00
115_V134_I0.9501.00
6_K35_K0.9501.00
128_R131_I0.9481.00
83_Y87_K0.9461.00
181_G261_A0.9391.00
116_A131_I0.9381.00
47_I59_D0.9381.00
23_R215_G0.9371.00
59_D62_E0.9341.00
87_K130_E0.9341.00
75_R78_F0.9291.00
80_V138_I0.9241.00
11_L28_M0.9231.00
35_K95_N0.9201.00
109_A113_G0.9190.99
83_Y86_M0.9180.99
115_V135_S0.9110.99
221_A225_I0.9090.99
145_I189_T0.9080.99
181_G257_I0.9080.99
267_K285_S0.9050.99
18_A23_R0.9020.99
36_V117_A0.9010.99
132_A136_H0.8940.99
217_I236_L0.8910.99
218_T221_A0.8880.99
198_T202_S0.8880.99
96_S109_A0.8860.99
291_L294_S0.8850.99
183_I277_G0.8750.99
143_Q146_A0.8670.99
11_L272_S0.8660.99
27_A149_M0.8640.99
195_R199_L0.8610.99
237_M281_I0.8600.99
48_S77_V0.8600.99
209_N212_D0.8580.99
14_F236_L0.8540.99
238_Y242_G0.8540.99
258_V262_K0.8470.99
80_V84_F0.8430.99
10_K105_G0.8420.99
145_I274_G0.8390.99
245_F255_D0.8390.99
152_Y156_Y0.8350.99
22_D165_G0.8330.99
19_V23_R0.8310.99
240_N243_L0.8290.99
293_R296_N0.8260.99
26_I218_T0.8250.99
131_I155_T0.8230.99
12_T149_M0.8220.99
220_R236_L0.8210.99
289_E292_L0.8160.99
70_A75_R0.8150.99
111_I138_I0.8130.99
202_S205_E0.8080.99
205_E248_G0.8050.99
139_E151_T0.8030.99
12_T17_H0.8030.99
39_S93_E0.8010.99
37_K95_N0.7930.99
194_W198_T0.7890.98
255_D258_V0.7890.98
236_L240_N0.7860.98
272_S279_S0.7860.98
67_S70_A0.7830.98
10_K147_S0.7830.98
136_H147_S0.7810.98
34_L113_G0.7810.98
130_E133_K0.7780.98
242_G246_S0.7730.98
41_N44_F0.7680.98
24_P218_T0.7660.98
110_V114_T0.7630.98
261_A269_C0.7630.98
229_N235_L0.7570.98
44_F59_D0.7560.98
28_M159_L0.7550.98
136_H140_L0.7530.98
26_I222_K0.7500.98
5_A113_G0.7500.98
181_G269_C0.7450.98
213_V216_E0.7410.98
219_N223_S0.7390.98
232_E236_L0.7360.98
206_V209_N0.7320.98
108_A147_S0.7320.98
41_N46_I0.7310.97
10_K151_T0.7280.97
111_I135_S0.7270.97
161_Y218_T0.7260.97
204_K208_E0.7240.97
220_R239_V0.7200.97
241_H250_T0.7180.97
212_D245_F0.7160.97
135_S155_T0.7150.97
264_L291_L0.7140.97
26_I221_A0.7110.97
241_H245_F0.7100.97
132_A151_T0.7100.97
29_T154_E0.7070.97
76_Y84_F0.7070.97
130_E134_I0.7060.97
112_V131_I0.7050.97
252_P255_D0.7030.97
11_L30_I0.7030.97
253_E256_E0.7030.97
79_E83_Y0.6990.97
206_V213_V0.6980.97
243_L246_S0.6950.97
8_P29_T0.6950.97
19_V151_T0.6940.97
19_V25_A0.6850.96
133_K136_H0.6810.96
179_T284_K0.6810.96
12_T19_V0.6790.96
152_Y162_F0.6780.96
261_A282_C0.6770.96
203_N206_V0.6740.96
10_K25_A0.6730.96
132_A152_Y0.6720.96
108_A144_G0.6700.96
234_G238_Y0.6680.96
241_H271_I0.6680.96
217_I243_L0.6670.96
12_T272_S0.6670.96
76_Y80_V0.6650.96
236_L239_V0.6640.96
286_V289_E0.6620.96
193_L198_T0.6610.95
119_S122_L0.6600.95
72_K77_V0.6600.95
147_S189_T0.6600.95
140_L143_Q0.6580.95
72_K78_F0.6570.95
116_A119_S0.6550.95
119_S130_E0.6540.95
183_I280_I0.6500.95
210_I243_L0.6480.95
266_I288_A0.6480.95
145_I148_R0.6470.95
237_M283_I0.6460.95
205_E209_N0.6460.95
176_F267_K0.6440.95
33_S98_V0.6430.95
234_G237_M0.6420.95
49_P91_K0.6410.95
179_T261_A0.6390.95
13_L159_L0.6390.95
138_I143_Q0.6370.94
142_V147_S0.6370.94
208_E246_S0.6350.94
261_A291_L0.6340.94
56_V60_L0.6330.94
272_S281_I0.6310.94
12_T105_G0.6290.94
183_I254_A0.6250.94
19_V147_S0.6240.94
151_T278_G0.6240.94
74_L78_F0.6230.94
102_V182_Y0.6230.94
48_S51_L0.6230.94
153_T160_I0.6220.94
83_Y134_I0.6180.94
238_Y268_G0.6170.94
34_L98_V0.6100.93
82_N85_E0.6090.93
23_R212_D0.6080.93
51_L95_N0.6070.93
175_N287_E0.6060.93
143_Q148_R0.6060.93
108_A135_S0.6040.93
256_E298_R0.6040.93
18_A24_P0.6010.93
189_T193_L0.6010.93
221_A237_M0.6010.93
241_H255_D0.5990.93
133_K137_N0.5990.93
90_V122_L0.5980.92
12_T25_A0.5980.92
113_G117_A0.5960.92
261_A280_I0.5950.92
259_S262_K0.5950.92
25_A147_S0.5900.92
212_D216_E0.5890.92
266_I285_S0.5870.92
69_E72_K0.5870.92
9_L17_H0.5870.92
256_E259_S0.5850.92
71_K74_L0.5850.92
92_I117_A0.5840.92
116_A155_T0.5830.91
238_Y258_V0.5830.91
250_T254_A0.5830.91
147_S151_T0.5830.91
218_T222_K0.5810.91
196_V199_L0.5790.91
41_N47_I0.5770.91
187_M279_S0.5760.91
139_E144_G0.5760.91
251_S276_A0.5730.91
66_E70_A0.5720.91
119_S134_I0.5720.91
175_N285_S0.5710.91
68_D71_K0.5710.91
261_A295_Y0.5700.91
69_E75_R0.5700.91
220_R224_L0.5670.90
17_H149_M0.5660.90
170_E222_K0.5650.90
17_H244_L0.5600.90
11_L279_S0.5590.90
255_D261_A0.5580.90
114_T118_Y0.5570.90
83_Y141_K0.5570.90
28_M178_L0.5570.90
181_G281_I0.5570.90
76_Y83_Y0.5540.89
75_R142_V0.5530.89
84_F87_K0.5520.89
168_G171_K0.5520.89
10_K149_M0.5510.89
178_L281_I0.5510.89
119_S128_R0.5510.89
19_V105_G0.5500.89
14_F233_L0.5500.89
132_A149_M0.5480.89
167_K171_K0.5440.88
79_E82_N0.5440.88
249_I271_I0.5440.88
16_E281_I0.5430.88
211_L215_G0.5420.88
19_V149_M0.5410.88
5_A116_A0.5400.88
264_L295_Y0.5380.88
139_E150_D0.5380.88
136_H151_T0.5370.88
255_D271_I0.5360.88
77_V94_I0.5350.88
244_L254_A0.5350.88
177_E287_E0.5340.88
115_V138_I0.5330.87
101_S278_G0.5330.87
241_H244_L0.5320.87
18_A218_T0.5320.87
143_Q189_T0.5290.87
12_T244_L0.5280.87
30_I104_L0.5280.87
208_E245_F0.5250.87
179_T292_L0.5210.86
256_E262_K0.5210.86
197_R201_E0.5210.86
111_I151_T0.5210.86
217_I240_N0.5200.86
148_R151_T0.5200.86
284_K289_E0.5200.86
13_L237_M0.5180.86
44_F48_S0.5180.86
249_I254_A0.5180.86
76_Y81_L0.5170.86
20_V105_G0.5160.86
9_L34_L0.5120.85
99_E278_G0.5120.85
156_Y169_F0.5110.85
152_Y169_F0.5100.85
258_V280_I0.5080.85
102_V278_G0.5080.85
24_P163_P0.5070.85
5_A36_V0.5070.85
25_A108_A0.5060.85
239_V243_L0.5060.85
180_A272_S0.5060.85
10_K20_V0.5040.84
213_V217_I0.5030.84
187_M192_V0.5020.84
11_L27_A0.5020.84
108_A274_G0.5020.84
208_E247_L0.5010.84
118_Y122_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pieA 1 0.9904 100 0.293 Contact Map
2a2cA 1 0.9777 100 0.312 Contact Map
1kvkA 2 0.9904 100 0.312 Contact Map
3v2uC 2 0.9904 100 0.321 Contact Map
1wuuA 2 0.9936 100 0.327 Contact Map
2cz9A 1 0.9618 100 0.336 Contact Map
4hacA 2 0.9363 100 0.337 Contact Map
3k85A 3 0.8726 100 0.337 Contact Map
3k17A 3 0.9713 100 0.338 Contact Map
2hfsA 1 0.9745 100 0.343 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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