GREMLIN Database
Q980D0 - mRNA 3'-end processing factor, putative
UniProt: Q980D0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (387)
Sequences: 5233 (3231)
Seq/√Len: 164.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_F139_L4.2611.00
96_G124_K3.7791.00
127_V220_I3.6451.00
100_L129_S3.4591.00
223_S228_V3.4551.00
112_P115_P3.2171.00
128_V161_T3.1431.00
198_E205_K3.1391.00
74_F92_G3.0061.00
154_T218_S2.9181.00
470_A474_K2.8541.00
153_G158_R2.7101.00
221_K228_V2.6601.00
448_K476_E2.6021.00
127_V206_V2.5571.00
92_G97_S2.5331.00
256_V457_V2.5171.00
76_K489_E2.5081.00
200_E205_K2.4551.00
440_R472_L2.4441.00
205_K223_S2.4141.00
410_R414_E2.3761.00
89_I459_V2.2611.00
198_E207_S2.1781.00
206_V222_V2.1451.00
150_K191_M2.1411.00
259_M458_L2.1221.00
117_Q145_G2.0911.00
91_V100_L2.0881.00
152_Y193_I2.0871.00
356_G359_D2.0631.00
119_M122_K2.0221.00
98_I125_G2.0201.00
159_I334_F2.0051.00
457_V490_I1.9611.00
195_Y218_S1.9421.00
75_L258_V1.9401.00
466_E483_T1.9241.00
97_S122_K1.8991.00
100_L231_F1.8741.00
96_G203_S1.8551.00
286_V292_V1.8231.00
158_R190_F1.8121.00
159_I333_G1.8001.00
194_G197_E1.7941.00
267_N441_R1.7791.00
161_T190_F1.7761.00
196_G247_E1.7761.00
484_P490_I1.7471.00
206_V220_I1.7361.00
193_I208_L1.7281.00
126_F142_Y1.7251.00
285_V396_A1.7161.00
261_S469_L1.7111.00
126_F149_T1.7081.00
91_V222_V1.7021.00
455_K480_E1.6921.00
223_S252_G1.6881.00
208_L220_I1.6861.00
288_S428_R1.6851.00
474_K478_G1.6781.00
207_S223_S1.6771.00
209_Y219_I1.6741.00
162_E166_K1.6551.00
284_E428_R1.6281.00
74_F489_E1.6191.00
396_A430_E1.6181.00
255_N454_E1.6141.00
98_I204_L1.5871.00
230_A254_A1.5711.00
455_K482_I1.5701.00
392_N395_N1.5611.00
257_L450_V1.5601.00
153_G161_T1.5471.00
309_L318_V1.5291.00
73_Y229_I1.5281.00
158_R192_A1.5191.00
309_L369_V1.5161.00
447_V473_I1.5151.00
156_A337_F1.5121.00
97_S123_V1.5121.00
219_I230_A1.5071.00
258_V459_V1.5051.00
294_V305_V1.5051.00
355_K363_A1.5021.00
207_S221_K1.4951.00
363_A368_G1.4851.00
292_V398_F1.4811.00
471_D474_K1.4721.00
293_L382_A1.4501.00
470_A481_V1.4471.00
75_L91_V1.4281.00
320_Y328_T1.4271.00
99_I123_V1.4251.00
76_K92_G1.4211.00
280_D284_E1.4211.00
283_M311_E1.4161.00
75_L256_V1.4061.00
267_N440_R1.4031.00
155_V194_G1.3961.00
482_I490_I1.3921.00
319_Y360_R1.3871.00
458_L466_E1.3851.00
403_Q409_G1.3841.00
90_E97_S1.3831.00
139_L186_T1.3811.00
282_V309_L1.3721.00
125_G152_Y1.3691.00
290_G396_A1.3671.00
468_S471_D1.3511.00
214_I436_S1.3421.00
283_M287_E1.3381.00
284_E288_S1.3371.00
257_L447_V1.3361.00
88_A99_I1.3291.00
299_L327_I1.3281.00
259_M469_L1.3271.00
136_I161_T1.3211.00
251_I450_V1.3191.00
286_V369_V1.3151.00
230_A450_V1.3121.00
193_I199_V1.3111.00
456_V473_I1.3091.00
261_S461_G1.3051.00
200_E203_S1.2861.00
114_F142_Y1.2831.00
456_V469_L1.2811.00
329_E333_G1.2761.00
272_K439_G1.2721.00
129_S231_F1.2611.00
230_A257_L1.2591.00
389_L395_N1.2451.00
135_H460_H1.2401.00
221_K230_A1.2371.00
128_V153_G1.2311.00
259_M447_V1.2211.00
128_V157_T1.2191.00
305_V369_V1.2181.00
235_I259_M1.2131.00
399_L412_L1.2081.00
485_E488_Q1.2071.00
360_R363_A1.2051.00
238_T445_E1.2041.00
127_V208_L1.2011.00
195_Y217_S1.1981.00
141_I145_G1.1901.00
291_T368_G1.1901.00
93_N203_S1.1811.00
277_D280_D1.1811.00
195_Y210_N1.1751.00
125_G201_I1.1741.00
100_L220_I1.1731.00
286_V316_Y1.1731.00
438_A442_Q1.1711.00
440_R468_S1.1701.00
155_V192_A1.1631.00
78_L90_E1.1631.00
93_N96_G1.1601.00
252_G451_K1.1531.00
265_K464_D1.1501.00
473_I477_I1.1461.00
163_T330_I1.1431.00
90_E99_I1.1401.00
441_R444_L1.1371.00
386_F397_V1.1291.00
82_R463_P1.1261.00
133_L164_M1.1241.00
421_Y485_E1.1191.00
359_D362_R1.1151.00
444_L472_L1.1061.00
127_V222_V1.1061.00
209_Y221_K1.1031.00
458_L481_V1.0971.00
474_K480_E1.0821.00
74_F491_S1.0801.00
127_V201_I1.0720.99
302_S320_Y1.0700.99
81_G484_P1.0630.99
310_A340_R1.0590.99
92_G122_K1.0580.99
154_T157_T1.0560.99
75_L89_I1.0380.99
393_S426_K1.0370.99
100_L258_V1.0370.99
467_S470_A1.0330.99
154_T208_L1.0310.99
82_R485_E1.0300.99
472_L476_E1.0290.99
98_I127_V1.0260.99
465_N469_L1.0250.99
143_Q186_T1.0250.99
94_S203_S1.0210.99
196_G209_Y1.0190.99
132_H437_H1.0160.99
98_I124_K1.0150.99
444_L476_E1.0090.99
262_T460_H1.0080.99
424_L427_A1.0070.99
128_V139_L1.0060.99
125_G150_K1.0040.99
93_N204_L1.0020.99
296_A302_S1.0020.99
296_A371_V0.9940.99
235_I443_L0.9930.99
211_A217_S0.9920.99
354_V363_A0.9920.99
291_T389_L0.9920.99
115_P118_E0.9840.99
232_T446_I0.9790.99
120_P147_L0.9780.99
129_S258_V0.9760.99
254_A257_L0.9710.99
293_L372_A0.9700.99
113_N116_L0.9670.99
265_K468_S0.9660.99
160_I327_I0.9640.99
281_K430_E0.9630.99
259_M456_V0.9580.99
471_D475_Q0.9550.99
135_H234_D0.9540.99
97_S116_L0.9520.99
397_V427_A0.9510.99
224_S227_G0.9510.99
447_V456_V0.9490.99
412_L425_L0.9490.99
237_L246_A0.9480.99
91_V98_I0.9430.99
425_L429_L0.9380.99
303_Q307_S0.9380.99
482_I488_Q0.9350.99
306_L318_V0.9340.99
463_P467_S0.9320.99
81_G486_N0.9290.99
232_T259_M0.9280.98
91_V231_F0.9260.98
339_N354_V0.9240.98
131_A214_I0.9230.98
164_M323_M0.9210.98
93_N225_E0.9160.98
404_A407_T0.9140.98
117_Q120_P0.9130.98
276_N280_D0.9130.98
234_D460_H0.9100.98
443_L472_L0.9100.98
84_V262_T0.9030.98
129_S220_I0.9020.98
308_V434_F0.8960.98
132_H213_H0.8930.98
390_S397_V0.8910.98
130_H213_H0.8870.98
228_V252_G0.8870.98
243_M300_A0.8830.98
354_V359_D0.8810.98
317_P367_K0.8790.98
285_V398_F0.8780.98
143_Q151_V0.8770.98
143_Q189_N0.8750.98
259_M443_L0.8730.98
445_E448_K0.8710.98
130_H135_H0.8700.98
307_S338_L0.8700.98
116_L120_P0.8670.98
273_D276_N0.8660.98
134_D437_H0.8660.98
153_G190_F0.8610.98
306_L371_V0.8590.98
257_L456_V0.8590.98
76_K90_E0.8590.98
99_I116_L0.8580.97
232_T257_L0.8570.97
398_F430_E0.8570.97
114_F117_Q0.8540.97
199_V206_V0.8540.97
275_E311_E0.8530.97
267_N439_G0.8500.97
207_S250_N0.8410.97
159_I330_I0.8410.97
237_L442_Q0.8380.97
387_K391_E0.8380.97
440_R443_L0.8370.97
261_S466_E0.8360.97
130_H437_H0.8330.97
134_D460_H0.8330.97
248_I251_I0.8270.97
143_Q148_N0.8230.97
136_I164_M0.8230.97
294_V400_V0.8230.97
288_S396_A0.8210.97
98_I201_I0.8190.97
292_V396_A0.8190.97
163_T326_E0.8180.97
120_P123_V0.8160.97
97_S124_K0.8160.97
144_I168_F0.8140.97
217_S233_G0.8140.97
441_R445_E0.8110.96
100_L222_V0.8110.96
264_G443_L0.8110.96
95_D122_K0.8100.96
198_E223_S0.8090.96
320_Y354_V0.8010.96
418_F424_L0.8000.96
193_I206_V0.7940.96
219_I251_I0.7930.96
230_A251_I0.7910.96
328_T371_V0.7870.96
96_G202_D0.7840.96
313_N367_K0.7820.96
219_I235_I0.7810.96
384_Y387_K0.7800.96
211_A219_I0.7790.96
89_I100_L0.7770.96
116_L123_V0.7760.95
390_S425_L0.7720.95
474_K481_V0.7690.95
308_V311_E0.7680.95
293_L389_L0.7620.95
98_I222_V0.7580.95
291_T367_K0.7580.95
318_V369_V0.7570.95
136_I160_I0.7540.95
470_A483_T0.7520.95
326_E329_E0.7520.95
270_N273_D0.7500.95
390_S418_F0.7460.94
402_Y412_L0.7460.94
132_H460_H0.7450.94
264_G468_S0.7440.94
399_L413_L0.7440.94
209_Y230_A0.7430.94
329_E332_L0.7420.94
364_W367_K0.7420.94
281_K398_F0.7400.94
448_K477_I0.7390.94
239_E448_K0.7380.94
274_V434_F0.7380.94
262_T297_F0.7380.94
157_T303_Q0.7360.94
269_P277_D0.7360.94
291_T395_N0.7350.94
282_V286_V0.7350.94
96_G122_K0.7340.94
282_V292_V0.7340.94
112_P116_L0.7330.94
279_Y313_N0.7310.94
164_M299_L0.7300.94
134_D262_T0.7290.94
159_I162_E0.7240.93
158_R162_E0.7230.93
254_A450_V0.7220.93
293_L395_N0.7200.93
204_L224_S0.7190.93
113_N117_Q0.7180.93
297_F460_H0.7160.93
92_G95_D0.7140.93
166_K169_L0.7110.93
152_Y191_M0.7070.93
271_R445_E0.7050.93
100_L459_V0.7040.93
403_Q412_L0.7020.92
323_M379_G0.6980.92
91_V229_I0.6950.92
444_L473_I0.6930.92
447_V479_V0.6930.92
241_K275_E0.6920.92
88_A102_Y0.6900.92
447_V469_L0.6890.92
132_H135_H0.6890.92
139_L149_T0.6870.92
210_N216_G0.6860.92
320_Y325_R0.6850.91
130_H134_D0.6810.91
168_F171_L0.6810.91
284_E287_E0.6810.91
297_F401_S0.6810.91
134_D213_H0.6790.91
82_R466_E0.6780.91
81_G459_V0.6770.91
283_M308_V0.6760.91
73_Y226_K0.6750.91
370_I385_Y0.6750.91
279_Y308_V0.6730.91
211_A246_A0.6720.91
256_V454_E0.6710.91
458_L483_T0.6700.91
294_V369_V0.6690.91
238_T442_Q0.6650.90
276_N313_N0.6650.90
151_V186_T0.6620.90
77_I484_P0.6620.90
128_V136_I0.6620.90
301_R435_S0.6600.90
352_N359_D0.6590.90
417_K426_K0.6590.90
211_A446_I0.6570.90
213_H437_H0.6560.90
123_V126_F0.6510.89
166_K187_M0.6510.89
239_E445_E0.6510.89
469_L472_L0.6490.89
478_G481_V0.6480.89
91_V204_L0.6470.89
310_A353_Y0.6460.89
445_E449_S0.6450.89
147_L150_K0.6450.89
210_N244_K0.6450.89
283_M312_R0.6440.89
212_G300_A0.6440.89
280_D283_M0.6430.89
196_G207_S0.6430.89
99_I142_Y0.6430.89
73_Y93_N0.6410.89
405_I410_R0.6400.88
108_E405_I0.6380.88
154_T216_G0.6360.88
332_L341_P0.6350.88
424_L429_L0.6350.88
281_K285_V0.6340.88
308_V312_R0.6340.88
100_L229_I0.6340.88
99_I126_F0.6320.88
310_A318_V0.6310.88
265_K465_N0.6310.88
81_G89_I0.6290.88
253_D450_V0.6290.88
463_P483_T0.6290.88
264_G472_L0.6270.87
155_V334_F0.6250.87
281_K431_I0.6230.87
237_L446_I0.6230.87
437_H460_H0.6230.87
411_K416_G0.6210.87
278_F434_F0.6190.87
139_L151_V0.6180.87
247_E250_N0.6180.87
270_N441_R0.6170.87
201_I287_E0.6170.87
325_R354_V0.6150.86
229_I256_V0.6140.86
211_A251_I0.6130.86
156_A215_P0.6120.86
96_G125_G0.6110.86
246_A251_I0.6100.86
302_S328_T0.6100.86
289_G366_E0.6100.86
240_T243_M0.6080.86
204_L222_V0.6070.86
135_H213_H0.6070.86
266_F439_G0.6060.86
467_S471_D0.6050.86
469_L473_I0.6040.85
305_V371_V0.6030.85
373_S378_K0.6030.85
143_Q165_L0.6020.85
235_I438_A0.6000.85
132_H260_E0.6000.85
359_D363_A0.5970.85
131_A136_I0.5970.85
75_L457_V0.5970.85
77_I81_G0.5950.85
91_V258_V0.5920.84
126_F151_V0.5920.84
456_V479_V0.5910.84
360_R368_G0.5910.84
424_L428_R0.5900.84
379_G407_T0.5900.84
229_I258_V0.5870.84
321_D357_W0.5860.84
156_A334_F0.5850.84
261_S458_L0.5850.84
365_K368_G0.5850.84
389_L394_K0.5840.84
231_F258_V0.5830.83
213_H460_H0.5830.83
136_I299_L0.5830.83
97_S119_M0.5820.83
333_G336_E0.5820.83
130_H460_H0.5800.83
135_H262_T0.5790.83
77_I89_I0.5780.83
443_L469_L0.5780.83
325_R356_G0.5770.83
201_I206_V0.5750.83
426_K429_L0.5750.83
210_N217_S0.5750.83
139_L152_Y0.5750.83
202_D225_E0.5750.83
307_S310_A0.5750.83
132_H234_D0.5730.82
126_F147_L0.5730.82
162_E188_D0.5720.82
279_Y283_M0.5720.82
83_E105_N0.5720.82
325_R353_Y0.5700.82
277_D430_E0.5680.82
96_G204_L0.5680.82
138_A141_I0.5670.82
279_Y304_E0.5670.82
262_T437_H0.5640.81
458_L470_A0.5600.81
102_Y126_F0.5600.81
187_M190_F0.5590.81
391_E424_L0.5570.81
301_R436_S0.5570.81
127_V202_D0.5560.80
98_I206_V0.5560.80
285_V292_V0.5560.80
133_L323_M0.5560.80
484_P488_Q0.5550.80
440_R444_L0.5540.80
291_T365_K0.5530.80
274_V308_V0.5530.80
253_D454_E0.5530.80
86_R403_Q0.5510.80
253_D452_D0.5510.80
358_E361_H0.5500.80
271_R441_R0.5500.80
139_L165_L0.5490.80
89_I231_F0.5490.80
305_V309_L0.5490.80
426_K430_E0.5480.80
228_V253_D0.5470.79
233_G262_T0.5470.79
281_K284_E0.5470.79
283_M313_N0.5470.79
163_T166_K0.5460.79
232_T262_T0.5460.79
442_Q445_E0.5450.79
319_Y368_G0.5450.79
300_A331_M0.5440.79
466_E469_L0.5440.79
387_K422_S0.5440.79
381_P385_Y0.5400.79
260_E437_H0.5390.78
378_K407_T0.5380.78
86_R402_Y0.5380.78
289_G292_V0.5370.78
135_H437_H0.5370.78
341_P353_Y0.5360.78
115_P119_M0.5360.78
285_V290_G0.5360.78
272_K434_F0.5360.78
189_N192_A0.5350.78
360_R385_Y0.5350.78
132_H262_T0.5340.78
454_E480_E0.5340.78
234_D437_H0.5330.78
457_V484_P0.5320.78
332_L352_N0.5300.77
341_P352_N0.5300.77
135_H297_F0.5280.77
390_S395_N0.5280.77
328_T332_L0.5280.77
209_Y251_I0.5270.77
219_I257_L0.5250.77
221_K252_G0.5240.76
387_K419_D0.5230.76
364_W368_G0.5220.76
306_L310_A0.5200.76
141_I144_I0.5170.76
171_L188_D0.5170.76
99_I102_Y0.5170.76
77_I457_V0.5170.76
201_I204_L0.5160.75
321_D370_I0.5160.75
143_Q147_L0.5150.75
193_I218_S0.5150.75
88_A138_A0.5120.75
155_V159_I0.5110.75
213_H301_R0.5100.75
379_G383_V0.5090.74
153_G157_T0.5070.74
207_S252_G0.5060.74
373_S381_P0.5060.74
427_A430_E0.5050.74
78_L117_Q0.5030.74
150_K189_N0.5030.74
386_F390_S0.5020.73
157_T193_I0.5020.73
132_H233_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ycbA 2 0.9959 100 0.326 Contact Map
3af5A 1 0.9959 100 0.335 Contact Map
2xr1A 2 0.9858 100 0.337 Contact Map
2i7tA 1 0.7744 100 0.365 Contact Map
3iekA 3 0.8394 100 0.37 Contact Map
3bk2A 2 0.7927 100 0.417 Contact Map
3zq4A 3 0.7907 100 0.421 Contact Map
2i7xA 1 0.8354 100 0.449 Contact Map
2az4A 1 0.7724 100 0.515 Contact Map
5ahoA 1 0.6179 100 0.589 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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