Q980C9 - SULSO - GREMLIN Contacts

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Q980C9 - Uncharacterized protein

UniProt:	Q980C9	Sequences: MFITLMAVDELFDSYIIETIGKRISGDIVWSKDISGSLRKWREMFNVSQGELAREMGIKQSVIADYERGRRQAGSEFIKRYVSALISIDARRGYKVVKELAKMFGINFPFIVDMRDFNSPICIDKLIRAVDGVVVNSFVTDKKVYGYVVTDSIRAILSLSGLEFYQVLSMMVNRVVVFTRVSSGRSPMIALKVAPIRPQVVVFHRPVKLDPLALMLSEVEGINIIVSMKPTEEDLIKGLRSLLAES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	246 (224)
Sequences:	139 (96)
Seq/√Len:	6.4

HALSA - Q9HPI8
SULSO - Q980C9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_G	225_I	4.309	0.97
116_D	189_I	4.000	0.95
126_L	175_V	3.118	0.83
39_R	47_V	2.990	0.80
116_D	163_E	2.978	0.80
127_I	132_G	2.896	0.78
27_D	37_S	2.893	0.78
135_V	209_L	2.865	0.77
185_R	210_D	2.779	0.75
22_K	227_S	2.722	0.73
148_V	169_S	2.486	0.66
20_I	27_D	2.358	0.62
215_M	218_E	2.295	0.59
126_L	130_V	2.165	0.55
117_F	147_Y	2.158	0.54
216_L	220_E	2.149	0.54
130_V	227_S	2.122	0.53
113_D	240_R	2.082	0.52
177_V	182_S	1.994	0.48
33_D	209_L	1.983	0.48
68_R	73_A	1.890	0.45
64_A	169_S	1.877	0.44
229_K	238_G	1.863	0.44
53_A	216_L	1.848	0.43
38_L	81_Y	1.840	0.43
53_A	82_V	1.836	0.43
126_L	202_V	1.815	0.42
64_A	148_V	1.789	0.41
81_Y	100_L	1.786	0.41
33_D	116_D	1.745	0.39
192_K	213_A	1.742	0.39
49_Q	132_G	1.742	0.39
192_K	197_R	1.713	0.38
204_H	227_S	1.695	0.38
116_D	195_P	1.673	0.37
114_M	215_M	1.667	0.37
27_D	86_I	1.666	0.37
80_R	154_R	1.660	0.37
54_R	100_L	1.651	0.36
99_E	158_S	1.650	0.36
54_R	81_Y	1.650	0.36
131_D	153_I	1.609	0.35
123_I	200_V	1.540	0.33
60_Q	175_V	1.493	0.31
130_V	175_V	1.479	0.31
22_K	30_W	1.469	0.30
23_R	171_M	1.448	0.30
28_I	82_V	1.446	0.30
127_I	225_I	1.428	0.29
88_I	200_V	1.393	0.28
164_F	203_F	1.386	0.28
150_T	180_R	1.380	0.28
39_R	182_S	1.376	0.27
23_R	227_S	1.363	0.27
157_L	215_M	1.362	0.27
155_A	159_L	1.358	0.27
144_V	180_R	1.358	0.27
30_W	192_K	1.316	0.26
130_V	168_L	1.305	0.25
95_K	111_I	1.304	0.25
97_V	112_V	1.277	0.25
20_I	214_L	1.257	0.24
38_L	172_V	1.254	0.24
100_L	121_I	1.253	0.24
73_A	166_Q	1.250	0.24
78_I	180_R	1.247	0.24
58_I	86_I	1.238	0.24
111_I	129_A	1.235	0.24
37_S	224_I	1.220	0.23
196_I	199_Q	1.217	0.23
28_I	79_K	1.217	0.23
23_R	81_Y	1.215	0.23
46_N	96_V	1.196	0.23
131_D	238_G	1.195	0.23
43_E	206_P	1.193	0.22
64_A	224_I	1.189	0.22
68_R	168_L	1.185	0.22
143_K	202_V	1.181	0.22
23_R	73_A	1.180	0.22
110_F	154_R	1.175	0.22
56_M	227_S	1.163	0.22
117_F	167_V	1.163	0.22
75_S	100_L	1.162	0.22
68_R	231_T	1.157	0.22
126_L	200_V	1.154	0.21
195_P	206_P	1.149	0.21
21_G	117_F	1.149	0.21
82_V	94_Y	1.136	0.21
191_L	222_I	1.129	0.21
135_V	215_M	1.125	0.21
62_V	190_A	1.119	0.21
22_K	100_L	1.108	0.20
39_R	96_V	1.106	0.20
77_F	114_M	1.106	0.20
111_I	222_I	1.105	0.20
103_M	221_G	1.100	0.20
62_V	179_T	1.098	0.20
60_Q	209_L	1.095	0.20
78_I	217_S	1.086	0.20
33_D	80_R	1.073	0.20
121_I	166_Q	1.060	0.19
73_A	147_Y	1.056	0.19
109_P	117_F	1.049	0.19
209_L	226_V	1.046	0.19
164_F	183_S	1.044	0.19
73_A	109_P	1.043	0.19
20_I	100_L	1.042	0.19
79_K	82_V	1.041	0.19
193_V	205_R	1.037	0.19
28_I	51_E	1.025	0.18
25_S	147_Y	1.018	0.18
99_E	173_N	1.017	0.18
70_R	174_R	1.014	0.18
88_I	92_R	1.007	0.18
28_I	230_P	0.993	0.18
19_T	125_K	0.992	0.18
150_T	159_L	0.983	0.18
23_R	39_R	0.978	0.17
169_S	205_R	0.977	0.17
160_S	163_E	0.970	0.17
40_K	188_M	0.968	0.17
27_D	52_L	0.968	0.17
65_D	71_R	0.968	0.17
167_V	211_P	0.963	0.17
128_R	135_V	0.961	0.17
72_Q	154_R	0.959	0.17
117_F	172_V	0.957	0.17
159_L	220_E	0.952	0.17
102_K	212_L	0.946	0.17
99_E	192_K	0.935	0.17
24_I	85_L	0.934	0.17
120_P	237_K	0.932	0.16
39_R	200_V	0.923	0.16
57_G	209_L	0.920	0.16
83_S	135_V	0.917	0.16
94_Y	170_M	0.912	0.16
49_Q	151_D	0.912	0.16
185_R	220_E	0.911	0.16
99_E	120_P	0.907	0.16
122_C	166_Q	0.899	0.16
189_I	237_K	0.897	0.16
132_G	201_V	0.894	0.16
81_Y	121_I	0.893	0.16
28_I	87_S	0.892	0.16
21_G	164_F	0.887	0.16
81_Y	199_Q	0.883	0.16
46_N	212_L	0.882	0.15
47_V	121_I	0.875	0.15
202_V	218_E	0.873	0.15
84_A	167_V	0.872	0.15
131_D	229_K	0.868	0.15
58_I	160_S	0.865	0.15
51_E	57_G	0.864	0.15
169_S	174_R	0.863	0.15
150_T	235_L	0.859	0.15
47_V	204_H	0.856	0.15
111_I	225_I	0.853	0.15
23_R	48_S	0.848	0.15
76_E	135_V	0.842	0.15
55_E	221_G	0.838	0.15
151_D	202_V	0.835	0.15
159_L	164_F	0.831	0.15
39_R	54_R	0.830	0.15
53_A	225_I	0.830	0.15
183_S	193_V	0.828	0.14
58_I	123_I	0.828	0.14
151_D	210_D	0.827	0.14
73_A	135_V	0.827	0.14
28_I	135_V	0.826	0.14
63_I	191_L	0.824	0.14
29_V	171_M	0.822	0.14
29_V	81_Y	0.819	0.14
40_K	45_F	0.818	0.14
27_D	40_K	0.814	0.14
56_M	111_I	0.810	0.14
33_D	98_K	0.809	0.14
56_M	195_P	0.809	0.14
128_R	230_P	0.804	0.14
124_D	139_V	0.798	0.14
68_R	122_C	0.798	0.14
64_A	205_R	0.795	0.14
71_R	74_G	0.794	0.14
65_D	74_G	0.794	0.14
59_K	168_L	0.789	0.14
69_G	174_R	0.788	0.14
46_N	104_F	0.785	0.14
22_K	27_D	0.779	0.14
85_L	92_R	0.776	0.14
84_A	213_A	0.776	0.14
98_K	101_A	0.776	0.14
60_Q	72_Q	0.775	0.14
60_Q	64_A	0.770	0.13
23_R	130_V	0.770	0.13
84_A	101_A	0.769	0.13
51_E	219_V	0.759	0.13
43_E	212_L	0.755	0.13
155_A	176_V	0.755	0.13
121_I	125_K	0.754	0.13
20_I	23_R	0.754	0.13
111_I	137_S	0.751	0.13
57_G	154_R	0.750	0.13
28_I	38_L	0.748	0.13
192_K	224_I	0.748	0.13
80_R	119_S	0.745	0.13
60_Q	168_L	0.740	0.13
32_K	113_D	0.730	0.13
51_E	151_D	0.728	0.13
19_T	226_V	0.725	0.13
133_V	216_L	0.724	0.13
179_T	190_A	0.724	0.13
39_R	127_I	0.722	0.13
48_S	57_G	0.722	0.13
180_R	232_E	0.719	0.13
114_M	124_D	0.718	0.13
148_V	173_N	0.716	0.13
45_F	93_G	0.713	0.13
166_Q	235_L	0.713	0.13
156_I	176_V	0.708	0.12
171_M	207_V	0.706	0.12
78_I	223_N	0.705	0.12
56_M	179_T	0.704	0.12
195_P	212_L	0.703	0.12
121_I	129_A	0.703	0.12
92_R	179_T	0.701	0.12
108_F	163_E	0.698	0.12
164_F	194_A	0.698	0.12
149_V	224_I	0.696	0.12
117_F	123_I	0.696	0.12
221_G	240_R	0.696	0.12
191_L	227_S	0.692	0.12
112_V	116_D	0.690	0.12
38_L	228_M	0.688	0.12
56_M	62_V	0.686	0.12
17_I	171_M	0.685	0.12
232_E	236_I	0.681	0.12
25_S	46_N	0.675	0.12
189_I	212_L	0.674	0.12
29_V	160_S	0.672	0.12
114_M	236_I	0.667	0.12
37_S	192_K	0.667	0.12
28_I	63_I	0.665	0.12
20_I	171_M	0.663	0.12
43_E	141_D	0.663	0.12
25_S	171_M	0.662	0.12
152_S	217_S	0.661	0.12
75_S	159_L	0.660	0.12
34_I	44_M	0.660	0.12
212_L	216_L	0.651	0.12
18_E	209_L	0.646	0.11
117_F	171_M	0.642	0.11
47_V	127_I	0.638	0.11
48_S	63_I	0.637	0.11
46_N	144_V	0.636	0.11
73_A	100_L	0.636	0.11
151_D	240_R	0.636	0.11
169_S	172_V	0.635	0.11
20_I	37_S	0.631	0.11
159_L	204_H	0.630	0.11
199_Q	220_E	0.628	0.11
117_F	131_D	0.626	0.11
38_L	240_R	0.625	0.11
68_R	150_T	0.624	0.11
20_I	86_I	0.623	0.11
155_A	164_F	0.623	0.11
173_N	221_G	0.621	0.11
151_D	185_R	0.620	0.11
164_F	205_R	0.616	0.11
30_W	234_D	0.614	0.11
144_V	167_V	0.613	0.11
97_V	241_S	0.611	0.11
159_L	188_M	0.610	0.11
172_V	225_I	0.609	0.11
121_I	126_L	0.606	0.11
56_M	182_S	0.604	0.11
155_A	216_L	0.602	0.11
147_Y	167_V	0.602	0.11
132_G	168_L	0.602	0.11
161_G	166_Q	0.602	0.11
18_E	22_K	0.600	0.11
202_V	237_K	0.599	0.11
58_I	104_F	0.599	0.11
152_S	239_L	0.598	0.11
130_V	215_M	0.595	0.11
210_D	223_N	0.594	0.11
51_E	238_G	0.592	0.11
86_I	163_E	0.587	0.11
91_R	219_V	0.586	0.11
169_S	224_I	0.584	0.11
50_G	172_V	0.582	0.11
168_L	227_S	0.581	0.11
113_D	203_F	0.580	0.11
153_I	165_Y	0.580	0.11
148_V	205_R	0.579	0.10
72_Q	218_E	0.574	0.10
94_Y	168_L	0.571	0.10
225_I	240_R	0.568	0.10
206_P	212_L	0.566	0.10
91_R	216_L	0.564	0.10
78_I	122_C	0.563	0.10
88_I	220_E	0.562	0.10
18_E	51_E	0.561	0.10
98_K	236_I	0.559	0.10
21_G	56_M	0.550	0.10
102_K	142_K	0.541	0.10
44_M	120_P	0.538	0.10
114_M	147_Y	0.538	0.10
53_A	208_K	0.535	0.10
22_K	171_M	0.534	0.10
173_N	177_V	0.531	0.10
46_N	232_E	0.530	0.10
91_R	104_F	0.529	0.10
117_F	229_K	0.528	0.10
49_Q	189_I	0.528	0.10
196_I	223_N	0.527	0.10
167_V	206_P	0.526	0.10
159_L	206_P	0.525	0.10
47_V	230_P	0.521	0.10
177_V	204_H	0.520	0.10
215_M	240_R	0.520	0.10
132_G	200_V	0.519	0.10
86_I	214_L	0.518	0.10
170_M	188_M	0.516	0.10
88_I	113_D	0.513	0.10
156_I	192_K	0.513	0.10
57_G	234_D	0.512	0.10
38_L	46_N	0.511	0.10
194_A	203_F	0.509	0.10
194_A	205_R	0.508	0.10
85_L	158_S	0.507	0.10
135_V	157_L	0.507	0.10
46_N	82_V	0.506	0.10
79_K	87_S	0.506	0.10
34_I	113_D	0.503	0.09
148_V	224_I	0.503	0.09
110_F	165_Y	0.502	0.09
23_R	27_D	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mctA	2	0.3211	98.5	0.909	Contact Map
2auwA	2	0.378	98.4	0.909	Contact Map
2l49A	2	0.3984	98.4	0.909	Contact Map
3cecA	1	0.3659	98.4	0.91	Contact Map
2mqkA	1	0.2602	98.4	0.911	Contact Map
2b5aA	2	0.313	98.3	0.912	Contact Map
3fmyA	2	0.2642	98.3	0.912	Contact Map
3op9A	4	0.4309	98.3	0.912	Contact Map
1s4kA	2	0.4593	98.3	0.913	Contact Map
3mlfA	2	0.3821	98.3	0.913	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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