GREMLIN Database
Q980C9 - Uncharacterized protein
UniProt: Q980C9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (224)
Sequences: 139 (96)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_G225_I4.3090.97
116_D189_I4.0000.95
126_L175_V3.1180.83
39_R47_V2.9900.80
116_D163_E2.9780.80
127_I132_G2.8960.78
27_D37_S2.8930.78
135_V209_L2.8650.77
185_R210_D2.7790.75
22_K227_S2.7220.73
148_V169_S2.4860.66
20_I27_D2.3580.62
215_M218_E2.2950.59
126_L130_V2.1650.55
117_F147_Y2.1580.54
216_L220_E2.1490.54
130_V227_S2.1220.53
113_D240_R2.0820.52
177_V182_S1.9940.48
33_D209_L1.9830.48
68_R73_A1.8900.45
64_A169_S1.8770.44
229_K238_G1.8630.44
53_A216_L1.8480.43
38_L81_Y1.8400.43
53_A82_V1.8360.43
126_L202_V1.8150.42
64_A148_V1.7890.41
81_Y100_L1.7860.41
33_D116_D1.7450.39
192_K213_A1.7420.39
49_Q132_G1.7420.39
192_K197_R1.7130.38
204_H227_S1.6950.38
116_D195_P1.6730.37
114_M215_M1.6670.37
27_D86_I1.6660.37
80_R154_R1.6600.37
54_R100_L1.6510.36
99_E158_S1.6500.36
54_R81_Y1.6500.36
131_D153_I1.6090.35
123_I200_V1.5400.33
60_Q175_V1.4930.31
130_V175_V1.4790.31
22_K30_W1.4690.30
23_R171_M1.4480.30
28_I82_V1.4460.30
127_I225_I1.4280.29
88_I200_V1.3930.28
164_F203_F1.3860.28
150_T180_R1.3800.28
39_R182_S1.3760.27
23_R227_S1.3630.27
157_L215_M1.3620.27
155_A159_L1.3580.27
144_V180_R1.3580.27
30_W192_K1.3160.26
130_V168_L1.3050.25
95_K111_I1.3040.25
97_V112_V1.2770.25
20_I214_L1.2570.24
38_L172_V1.2540.24
100_L121_I1.2530.24
73_A166_Q1.2500.24
78_I180_R1.2470.24
58_I86_I1.2380.24
111_I129_A1.2350.24
37_S224_I1.2200.23
196_I199_Q1.2170.23
28_I79_K1.2170.23
23_R81_Y1.2150.23
46_N96_V1.1960.23
131_D238_G1.1950.23
43_E206_P1.1930.22
64_A224_I1.1890.22
68_R168_L1.1850.22
143_K202_V1.1810.22
23_R73_A1.1800.22
110_F154_R1.1750.22
56_M227_S1.1630.22
117_F167_V1.1630.22
75_S100_L1.1620.22
68_R231_T1.1570.22
126_L200_V1.1540.21
195_P206_P1.1490.21
21_G117_F1.1490.21
82_V94_Y1.1360.21
191_L222_I1.1290.21
135_V215_M1.1250.21
62_V190_A1.1190.21
22_K100_L1.1080.20
39_R96_V1.1060.20
77_F114_M1.1060.20
111_I222_I1.1050.20
103_M221_G1.1000.20
62_V179_T1.0980.20
60_Q209_L1.0950.20
78_I217_S1.0860.20
33_D80_R1.0730.20
121_I166_Q1.0600.19
73_A147_Y1.0560.19
109_P117_F1.0490.19
209_L226_V1.0460.19
164_F183_S1.0440.19
73_A109_P1.0430.19
20_I100_L1.0420.19
79_K82_V1.0410.19
193_V205_R1.0370.19
28_I51_E1.0250.18
25_S147_Y1.0180.18
99_E173_N1.0170.18
70_R174_R1.0140.18
88_I92_R1.0070.18
28_I230_P0.9930.18
19_T125_K0.9920.18
150_T159_L0.9830.18
23_R39_R0.9780.17
169_S205_R0.9770.17
160_S163_E0.9700.17
40_K188_M0.9680.17
27_D52_L0.9680.17
65_D71_R0.9680.17
167_V211_P0.9630.17
128_R135_V0.9610.17
72_Q154_R0.9590.17
117_F172_V0.9570.17
159_L220_E0.9520.17
102_K212_L0.9460.17
99_E192_K0.9350.17
24_I85_L0.9340.17
120_P237_K0.9320.16
39_R200_V0.9230.16
57_G209_L0.9200.16
83_S135_V0.9170.16
94_Y170_M0.9120.16
49_Q151_D0.9120.16
185_R220_E0.9110.16
99_E120_P0.9070.16
122_C166_Q0.8990.16
189_I237_K0.8970.16
132_G201_V0.8940.16
81_Y121_I0.8930.16
28_I87_S0.8920.16
21_G164_F0.8870.16
81_Y199_Q0.8830.16
46_N212_L0.8820.15
47_V121_I0.8750.15
202_V218_E0.8730.15
84_A167_V0.8720.15
131_D229_K0.8680.15
58_I160_S0.8650.15
51_E57_G0.8640.15
169_S174_R0.8630.15
150_T235_L0.8590.15
47_V204_H0.8560.15
111_I225_I0.8530.15
23_R48_S0.8480.15
76_E135_V0.8420.15
55_E221_G0.8380.15
151_D202_V0.8350.15
159_L164_F0.8310.15
39_R54_R0.8300.15
53_A225_I0.8300.15
183_S193_V0.8280.14
58_I123_I0.8280.14
151_D210_D0.8270.14
73_A135_V0.8270.14
28_I135_V0.8260.14
63_I191_L0.8240.14
29_V171_M0.8220.14
29_V81_Y0.8190.14
40_K45_F0.8180.14
27_D40_K0.8140.14
56_M111_I0.8100.14
33_D98_K0.8090.14
56_M195_P0.8090.14
128_R230_P0.8040.14
124_D139_V0.7980.14
68_R122_C0.7980.14
64_A205_R0.7950.14
71_R74_G0.7940.14
65_D74_G0.7940.14
59_K168_L0.7890.14
69_G174_R0.7880.14
46_N104_F0.7850.14
22_K27_D0.7790.14
85_L92_R0.7760.14
84_A213_A0.7760.14
98_K101_A0.7760.14
60_Q72_Q0.7750.14
60_Q64_A0.7700.13
23_R130_V0.7700.13
84_A101_A0.7690.13
51_E219_V0.7590.13
43_E212_L0.7550.13
155_A176_V0.7550.13
121_I125_K0.7540.13
20_I23_R0.7540.13
111_I137_S0.7510.13
57_G154_R0.7500.13
28_I38_L0.7480.13
192_K224_I0.7480.13
80_R119_S0.7450.13
60_Q168_L0.7400.13
32_K113_D0.7300.13
51_E151_D0.7280.13
19_T226_V0.7250.13
133_V216_L0.7240.13
179_T190_A0.7240.13
39_R127_I0.7220.13
48_S57_G0.7220.13
180_R232_E0.7190.13
114_M124_D0.7180.13
148_V173_N0.7160.13
45_F93_G0.7130.13
166_Q235_L0.7130.13
156_I176_V0.7080.12
171_M207_V0.7060.12
78_I223_N0.7050.12
56_M179_T0.7040.12
195_P212_L0.7030.12
121_I129_A0.7030.12
92_R179_T0.7010.12
108_F163_E0.6980.12
164_F194_A0.6980.12
149_V224_I0.6960.12
117_F123_I0.6960.12
221_G240_R0.6960.12
191_L227_S0.6920.12
112_V116_D0.6900.12
38_L228_M0.6880.12
56_M62_V0.6860.12
17_I171_M0.6850.12
232_E236_I0.6810.12
25_S46_N0.6750.12
189_I212_L0.6740.12
29_V160_S0.6720.12
114_M236_I0.6670.12
37_S192_K0.6670.12
28_I63_I0.6650.12
20_I171_M0.6630.12
43_E141_D0.6630.12
25_S171_M0.6620.12
152_S217_S0.6610.12
75_S159_L0.6600.12
34_I44_M0.6600.12
212_L216_L0.6510.12
18_E209_L0.6460.11
117_F171_M0.6420.11
47_V127_I0.6380.11
48_S63_I0.6370.11
46_N144_V0.6360.11
73_A100_L0.6360.11
151_D240_R0.6360.11
169_S172_V0.6350.11
20_I37_S0.6310.11
159_L204_H0.6300.11
199_Q220_E0.6280.11
117_F131_D0.6260.11
38_L240_R0.6250.11
68_R150_T0.6240.11
20_I86_I0.6230.11
155_A164_F0.6230.11
173_N221_G0.6210.11
151_D185_R0.6200.11
164_F205_R0.6160.11
30_W234_D0.6140.11
144_V167_V0.6130.11
97_V241_S0.6110.11
159_L188_M0.6100.11
172_V225_I0.6090.11
121_I126_L0.6060.11
56_M182_S0.6040.11
155_A216_L0.6020.11
147_Y167_V0.6020.11
132_G168_L0.6020.11
161_G166_Q0.6020.11
18_E22_K0.6000.11
202_V237_K0.5990.11
58_I104_F0.5990.11
152_S239_L0.5980.11
130_V215_M0.5950.11
210_D223_N0.5940.11
51_E238_G0.5920.11
86_I163_E0.5870.11
91_R219_V0.5860.11
169_S224_I0.5840.11
50_G172_V0.5820.11
168_L227_S0.5810.11
113_D203_F0.5800.11
153_I165_Y0.5800.11
148_V205_R0.5790.10
72_Q218_E0.5740.10
94_Y168_L0.5710.10
225_I240_R0.5680.10
206_P212_L0.5660.10
91_R216_L0.5640.10
78_I122_C0.5630.10
88_I220_E0.5620.10
18_E51_E0.5610.10
98_K236_I0.5590.10
21_G56_M0.5500.10
102_K142_K0.5410.10
44_M120_P0.5380.10
114_M147_Y0.5380.10
53_A208_K0.5350.10
22_K171_M0.5340.10
173_N177_V0.5310.10
46_N232_E0.5300.10
91_R104_F0.5290.10
117_F229_K0.5280.10
49_Q189_I0.5280.10
196_I223_N0.5270.10
167_V206_P0.5260.10
159_L206_P0.5250.10
47_V230_P0.5210.10
177_V204_H0.5200.10
215_M240_R0.5200.10
132_G200_V0.5190.10
86_I214_L0.5180.10
170_M188_M0.5160.10
88_I113_D0.5130.10
156_I192_K0.5130.10
57_G234_D0.5120.10
38_L46_N0.5110.10
194_A203_F0.5090.10
194_A205_R0.5080.10
85_L158_S0.5070.10
135_V157_L0.5070.10
46_N82_V0.5060.10
79_K87_S0.5060.10
34_I113_D0.5030.09
148_V224_I0.5030.09
110_F165_Y0.5020.09
23_R27_D0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mctA 2 0.3211 98.5 0.909 Contact Map
2auwA 2 0.378 98.4 0.909 Contact Map
2l49A 2 0.3984 98.4 0.909 Contact Map
3cecA 1 0.3659 98.4 0.91 Contact Map
2mqkA 1 0.2602 98.4 0.911 Contact Map
2b5aA 2 0.313 98.3 0.912 Contact Map
3fmyA 2 0.2642 98.3 0.912 Contact Map
3op9A 4 0.4309 98.3 0.912 Contact Map
1s4kA 2 0.4593 98.3 0.913 Contact Map
3mlfA 2 0.3821 98.3 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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