GREMLIN Database
Q980C4 - Uncharacterized protein
UniProt: Q980C4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (168)
Sequences: 9856 (7366)
Seq/√Len: 568.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L87_K3.8071.00
10_V17_T3.4521.00
60_G74_M2.9421.00
50_A115_F2.8051.00
73_Y101_V2.8001.00
116_T143_V2.6311.00
73_Y115_F2.5081.00
79_Y102_K2.4351.00
23_G80_I2.4301.00
138_A148_I2.2491.00
103_S108_N2.1831.00
60_G72_V2.1751.00
48_T71_K2.1641.00
14_I66_K2.1011.00
19_L91_L2.0541.00
89_A100_I1.9651.00
54_C85_A1.9491.00
21_S84_L1.9371.00
16_L65_L1.9071.00
12_N17_T1.8931.00
142_L146_G1.8291.00
63_L119_Y1.7761.00
40_N172_I1.7331.00
135_E163_F1.7321.00
133_K137_E1.6951.00
33_G36_I1.6601.00
106_F141_R1.6501.00
150_L163_F1.5891.00
61_I89_A1.5431.00
64_A72_V1.5351.00
82_I102_K1.4921.00
161_K165_K1.4841.00
82_I100_I1.4751.00
105_I130_F1.4521.00
104_D133_K1.4461.00
67_N70_L1.4441.00
48_T73_Y1.4421.00
114_K143_V1.4421.00
61_I94_V1.4231.00
9_E19_L1.4001.00
54_C60_G1.3871.00
104_D107_D1.3741.00
76_D82_I1.3731.00
74_M100_I1.3531.00
154_K178_Y1.3531.00
16_L66_K1.3371.00
54_C76_D1.3311.00
16_L62_Y1.3291.00
137_E140_D1.3281.00
37_L149_Q1.3231.00
106_F137_E1.3121.00
156_E171_S1.2941.00
41_I149_Q1.2931.00
36_I175_K1.2871.00
48_T143_V1.2851.00
120_S150_L1.2811.00
48_T113_V1.2791.00
17_T91_L1.2721.00
24_I56_Y1.2671.00
12_N15_P1.2651.00
48_T116_T1.2591.00
34_T59_I1.2551.00
14_I39_E1.2441.00
87_K91_L1.2361.00
136_A166_R1.2271.00
18_L62_Y1.2171.00
49_V63_L1.2141.00
160_E164_S1.1951.00
85_A100_I1.1891.00
86_K90_K1.1791.00
64_A96_N1.1611.00
78_N81_A1.1601.00
156_E160_E1.1601.00
59_I119_Y1.1581.00
49_V117_A1.1481.00
18_L61_I1.1441.00
48_T115_F1.1371.00
131_L150_L1.1311.00
49_V70_L1.1281.00
75_V109_I1.1221.00
41_I117_A1.1211.00
52_V105_I1.1071.00
49_V72_V1.1061.00
160_E171_S1.0971.00
105_I133_K1.0861.00
47_G116_T1.0361.00
38_L62_Y1.0291.00
41_I119_Y1.0281.00
155_G159_I1.0211.00
62_Y66_K1.0121.00
135_E162_I0.9981.00
36_I180_L0.9931.00
174_R179_S0.9541.00
34_T38_L0.9481.00
14_I65_L0.9481.00
87_K90_K0.9451.00
51_D60_G0.9431.00
73_Y113_V0.9371.00
40_N180_L0.9311.00
21_S87_K0.9271.00
23_G84_L0.9251.00
61_I92_N0.9251.00
75_V103_S0.9201.00
155_G158_N0.9161.00
14_I62_Y0.9111.00
115_F118_I0.9091.00
117_A149_Q0.8961.00
89_A94_V0.8951.00
131_L152_A0.8881.00
82_I86_K0.8811.00
52_V134_L0.8751.00
16_L92_N0.8731.00
42_K45_E0.8671.00
157_E161_K0.8641.00
152_A156_E0.8631.00
20_S84_L0.8571.00
129_D132_K0.8551.00
64_A97_R0.8521.00
47_G70_L0.8521.00
90_K95_E0.8461.00
162_I166_R0.8431.00
83_K86_K0.8381.00
37_L41_I0.8341.00
65_L92_N0.8301.00
24_I84_L0.8301.00
53_G130_F0.8281.00
172_I180_L0.8221.00
161_K164_S0.8201.00
120_S134_L0.8191.00
36_I40_N0.8171.00
29_E33_G0.8141.00
152_A159_I0.8111.00
20_S24_I0.7991.00
52_V75_V0.7981.00
18_L58_P0.7861.00
60_G64_A0.7841.00
173_K177_G0.7801.00
158_N161_K0.7791.00
48_T114_K0.7781.00
38_L59_I0.7681.00
131_L159_I0.7671.00
171_S174_R0.7661.00
89_A96_N0.7621.00
86_K100_I0.7571.00
35_R39_E0.7541.00
86_K89_A0.7521.00
51_D54_C0.7511.00
130_F133_K0.7491.00
132_K162_I0.7431.00
79_Y83_K0.7431.00
74_M85_A0.7391.00
20_S56_Y0.7251.00
47_G67_N0.7201.00
132_K136_A0.7111.00
118_I141_R0.7081.00
117_A147_F0.7081.00
103_S109_I0.7031.00
40_N149_Q0.6991.00
135_E150_L0.6991.00
50_A75_V0.6981.00
157_E160_E0.6891.00
64_A95_E0.6871.00
149_Q172_I0.6841.00
18_L56_Y0.6831.00
80_I83_K0.6831.00
36_I39_E0.6821.00
129_D133_K0.6771.00
63_L70_L0.6731.00
106_F118_I0.6711.00
61_I88_N0.6701.00
41_I63_L0.6701.00
94_V97_R0.6651.00
133_K136_A0.6641.00
152_A171_S0.6581.00
158_N162_I0.6571.00
54_C74_M0.6531.00
118_I138_A0.6491.00
132_K165_K0.6471.00
15_P65_L0.6431.00
37_L119_Y0.6431.00
54_C100_I0.6411.00
75_V101_V0.6401.00
159_I162_I0.6391.00
126_K153_Y0.6331.00
44_A47_G0.6321.00
131_L135_E0.6301.00
8_F11_I0.6261.00
63_L67_N0.6251.00
10_V19_L0.6131.00
110_P141_R0.6111.00
106_F109_I0.6031.00
65_L94_V0.6021.00
136_A139_Y0.6021.00
64_A94_V0.5981.00
136_A162_I0.5971.00
46_N69_N0.5961.00
164_S167_F0.5951.00
137_E141_R0.5941.00
103_S106_F0.5861.00
135_E159_I0.5851.00
70_L116_T0.5841.00
10_V91_L0.5831.00
53_G105_I0.5811.00
55_G121_N0.5791.00
156_E178_Y0.5781.00
126_K154_K0.5781.00
101_V108_N0.5781.00
134_L148_I0.5741.00
20_S27_K0.5680.99
97_R101_V0.5660.99
20_S26_S0.5630.99
38_L58_P0.5590.99
52_V106_F0.5590.99
168_K171_S0.5570.99
15_P66_K0.5560.99
152_A160_E0.5540.99
83_K87_K0.5530.99
135_E166_R0.5530.99
103_S107_D0.5520.99
142_L148_I0.5510.99
46_N71_K0.5510.99
8_F17_T0.5490.99
77_V102_K0.5490.99
39_E175_K0.5480.99
38_L63_L0.5470.99
139_Y166_R0.5410.99
110_P113_V0.5410.99
112_D140_D0.5390.99
62_Y65_L0.5360.99
159_I179_S0.5350.99
60_G100_I0.5340.99
64_A89_A0.5310.99
76_D85_A0.5280.99
105_I137_E0.5280.99
8_F15_P0.5280.99
21_S83_K0.5260.99
33_G180_L0.5250.99
174_R177_G0.5230.99
122_P159_I0.5180.99
47_G69_N0.5180.99
138_A142_L0.5170.99
64_A68_P0.5160.99
101_V113_V0.5140.99
56_Y84_L0.5110.99
21_S80_I0.5110.99
105_I134_L0.5100.99
50_A109_I0.5100.99
13_G62_Y0.5080.99
49_V67_N0.5020.99
37_L59_I0.5020.99
8_F12_N0.5000.99
143_V146_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dcmA 1 0.957 100 0.389 Contact Map
2b3tA 1 0.9731 100 0.402 Contact Map
1nv8A 1 0.9301 100 0.414 Contact Map
3dmgA 1 0.9731 100 0.439 Contact Map
2pjdA 1 0.9731 100 0.443 Contact Map
1dusA 1 0.9839 99.9 0.481 Contact Map
3evzA 1 0.9032 99.9 0.513 Contact Map
3lpmA 2 0.957 99.9 0.52 Contact Map
3c6kA 2 0.9624 99.9 0.523 Contact Map
4dzrA 2 0.7581 99.9 0.528 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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