GREMLIN Database
GCH3 - GTP cyclohydrolase III
UniProt: Q980B6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (222)
Sequences: 110 (73)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_N195_K9.5681.00
40_I71_M4.7270.96
40_I86_C3.6720.85
83_I128_N3.3300.78
133_T146_I3.1730.74
4_L60_A3.1610.74
50_Q53_F3.1170.73
129_F193_K2.7540.63
148_N155_R2.7260.62
138_S141_D2.7240.62
201_G206_T2.7140.62
71_M86_C2.4670.54
138_S158_Y2.2850.48
12_R166_Y2.2520.47
13_E166_Y2.1490.44
12_R26_I2.0950.42
26_I166_Y2.0660.41
13_E26_I2.0180.40
90_G99_N2.0150.39
48_P68_L2.0070.39
92_T200_I1.9910.39
39_E150_Y1.9520.38
63_I183_K1.9420.37
161_G195_K1.9390.37
125_F208_I1.9210.37
24_W86_C1.8540.35
218_I222_R1.8470.34
33_F120_I1.8460.34
92_T162_G1.8210.34
24_W40_I1.7900.33
21_D205_R1.7600.32
6_I220_N1.7180.31
3_I183_K1.7120.31
24_W71_M1.7060.30
125_F196_V1.6760.30
122_A164_L1.6500.29
141_D158_Y1.6370.29
16_E26_I1.6310.28
7_K84_K1.6230.28
56_F214_S1.6220.28
34_M38_H1.5660.27
32_K73_N1.5640.27
21_D222_R1.5570.27
91_K190_D1.5470.26
6_I83_I1.5370.26
138_S164_L1.5140.26
193_K200_I1.4820.25
73_N133_T1.4670.24
60_A68_L1.4620.24
63_I90_G1.4300.24
16_E166_Y1.4250.23
75_M87_L1.4060.23
150_Y185_I1.3970.23
68_L194_I1.3920.23
63_I67_Q1.3890.23
180_S188_F1.3630.22
34_M139_V1.3600.22
4_L58_M1.3530.22
115_Y155_R1.3520.22
47_F208_I1.3510.22
69_A146_I1.3340.21
34_M113_K1.3280.21
15_T52_R1.3270.21
50_Q144_I1.3090.21
72_I194_I1.2870.20
39_E163_I1.2680.20
12_R16_E1.2540.20
13_E16_E1.2520.20
83_I202_K1.2330.19
24_W195_K1.2310.19
47_F173_L1.2290.19
53_F161_G1.2260.19
195_K205_R1.2230.19
58_M165_Q1.2220.19
32_K42_S1.2180.19
13_E49_L1.2140.19
4_L68_L1.2020.19
24_W205_R1.1870.18
120_I139_V1.1780.18
10_D33_F1.1730.18
8_L121_A1.1710.18
5_A75_M1.1710.18
2_K61_D1.1670.18
147_T151_V1.1560.18
6_I58_M1.1530.18
58_M68_L1.1480.18
145_E201_G1.1410.17
18_L212_T1.1400.17
72_I166_Y1.1340.17
65_T186_E1.1320.17
10_D216_E1.1300.17
31_N61_D1.1270.17
2_K165_Q1.1260.17
116_T136_Y1.1250.17
24_W162_G1.1170.17
149_I175_F1.1120.17
164_L172_Y1.1020.17
31_N57_L1.0860.16
146_I151_V1.0850.16
10_D74_D1.0840.16
114_E202_K1.0780.16
112_I117_D1.0700.16
20_Y58_M1.0650.16
101_S105_N1.0580.16
75_M157_L1.0540.16
60_A194_I1.0510.16
69_A116_T1.0400.16
86_C223_E1.0330.16
10_D101_S1.0330.16
38_H136_Y1.0270.15
66_T155_R1.0240.15
3_I92_T1.0200.15
36_K135_K1.0100.15
37_I58_M1.0020.15
66_T210_L1.0000.15
118_E179_E0.9980.15
15_T219_R0.9910.15
52_R219_R0.9910.15
52_R215_L0.9910.15
15_T215_L0.9910.15
37_I101_S0.9850.15
215_L219_R0.9830.15
66_T104_L0.9780.15
41_A173_L0.9740.15
67_Q95_E0.9730.15
37_I75_M0.9660.14
6_I185_I0.9560.14
46_T63_I0.9500.14
71_M162_G0.9490.14
155_R186_E0.9460.14
152_N162_G0.9430.14
118_E146_I0.9390.14
205_R222_R0.9380.14
21_D42_S0.9270.14
53_F121_A0.9220.14
2_K5_A0.9180.14
88_G114_E0.9180.14
212_T216_E0.9170.14
19_G205_R0.9150.14
140_Y144_I0.9110.14
86_C146_I0.9020.13
112_I220_N0.8950.13
88_G191_D0.8940.13
29_I121_A0.8930.13
24_W38_H0.8820.13
87_L113_K0.8810.13
41_A58_M0.8740.13
217_K220_N0.8730.13
9_L77_E0.8600.13
37_I48_P0.8550.13
162_G176_I0.8540.13
95_E103_C0.8510.13
17_R74_D0.8500.13
24_W34_M0.8470.13
70_Y144_I0.8460.13
118_E136_Y0.8450.13
125_F150_Y0.8420.13
49_L72_I0.8410.13
155_R164_L0.8270.12
106_N183_K0.8240.12
46_T203_N0.8240.12
2_K17_R0.8230.12
2_K68_L0.8200.12
5_A180_S0.8180.12
12_R72_I0.8140.12
92_T117_D0.8140.12
42_S123_L0.8070.12
144_I154_S0.8050.12
3_I71_M0.8040.12
174_G221_N0.7990.12
110_N114_E0.7940.12
8_L29_I0.7800.12
120_I162_G0.7790.12
110_N179_E0.7790.12
142_S148_N0.7780.12
148_N185_I0.7730.12
29_I166_Y0.7670.12
125_F185_I0.7650.12
40_I205_R0.7480.11
2_K58_M0.7450.11
101_S182_N0.7430.11
4_L165_Q0.7400.11
47_F212_T0.7370.11
61_D165_Q0.7350.11
6_I156_F0.7310.11
41_A142_S0.7220.11
2_K60_A0.7180.11
98_W179_E0.7160.11
65_T91_K0.7130.11
136_Y182_N0.7070.11
191_D204_A0.7070.11
106_N180_S0.7010.11
6_I140_Y0.7010.11
110_N222_R0.6980.11
13_E29_I0.6960.11
31_N128_N0.6950.11
162_G195_K0.6950.11
88_G106_N0.6920.11
115_Y151_V0.6920.11
88_G220_N0.6810.10
41_A200_I0.6800.10
43_Q145_E0.6800.10
55_N123_L0.6770.10
210_L218_I0.6760.10
38_H191_D0.6750.10
163_I185_I0.6740.10
97_Q218_I0.6720.10
65_T180_S0.6680.10
156_F159_K0.6680.10
71_M183_K0.6670.10
55_N216_E0.6660.10
132_E139_V0.6640.10
31_N122_A0.6600.10
24_W161_G0.6580.10
117_D202_K0.6450.10
110_N190_D0.6450.10
13_E79_L0.6440.10
90_G102_I0.6400.10
29_I49_L0.6370.10
18_L21_D0.6370.10
47_F188_F0.6370.10
121_A163_I0.6340.10
66_T132_E0.6310.10
18_L82_R0.6240.10
63_I181_V0.6220.10
108_D216_E0.6200.10
49_L166_Y0.6190.10
141_D144_I0.6140.10
106_N190_D0.6130.10
57_L129_F0.6120.10
72_I216_E0.6110.10
9_L55_N0.6090.10
83_I161_G0.6040.10
12_R49_L0.5940.09
17_R59_I0.5850.09
96_A199_G0.5840.09
28_K144_I0.5830.09
25_L77_E0.5820.09
91_K198_I0.5770.09
2_K166_Y0.5760.09
28_K140_Y0.5750.09
74_D121_A0.5720.09
195_K218_I0.5690.09
55_N153_L0.5660.09
144_I164_L0.5650.09
26_I49_L0.5630.09
12_R93_P0.5570.09
13_E72_I0.5540.09
79_L216_E0.5500.09
2_K48_P0.5460.09
105_N139_V0.5460.09
46_T93_P0.5420.09
48_P194_I0.5420.09
152_N161_G0.5390.09
18_L216_E0.5390.09
180_S201_G0.5370.09
38_H71_M0.5370.09
122_A145_E0.5370.09
112_I118_E0.5360.09
111_E122_A0.5350.09
62_G205_R0.5340.09
208_I218_I0.5340.09
8_L194_I0.5310.09
12_R29_I0.5300.09
31_N34_M0.5270.09
103_C158_Y0.5250.09
63_I92_T0.5250.09
42_S62_G0.5250.09
104_L202_K0.5220.09
37_I41_A0.5200.09
184_V188_F0.5170.09
92_T159_K0.5120.09
115_Y185_I0.5100.09
60_A201_G0.5100.09
129_F156_F0.5050.09
42_S213_T0.5020.09
126_D197_G0.5000.09
54_D169_G0.5000.09
54_D170_D0.5000.09
30_Q54_D0.5000.09
54_D171_N0.5000.09
54_D197_G0.5000.09
54_D211_A0.5000.09
30_Q168_G0.5000.09
30_Q126_D0.5000.09
30_Q124_H0.5000.09
11_Y27_Q0.5000.09
30_Q169_G0.5000.09
197_G211_A0.5000.09
30_Q211_A0.5000.09
30_Q197_G0.5000.09
30_Q171_N0.5000.09
54_D124_H0.5000.09
54_D126_D0.5000.09
171_N211_A0.5000.09
171_N197_G0.5000.09
170_D211_A0.5000.09
170_D197_G0.5000.09
169_G211_A0.5000.09
169_G197_G0.5000.09
168_G211_A0.5000.09
168_G197_G0.5000.09
168_G171_N0.5000.09
11_Y124_H0.5000.09
23_E27_Q0.5000.09
14_W54_D0.5000.09
124_H168_G0.5000.09
124_H169_G0.5000.09
124_H170_D0.5000.09
124_H171_N0.5000.09
124_H197_G0.5000.09
124_H211_A0.5000.09
23_E197_G0.5000.09
23_E171_N0.5000.09
23_E170_D0.5000.09
14_W124_H0.5000.09
23_E30_Q0.5000.09
23_E124_H0.5000.09
14_W211_A0.5000.09
14_W197_G0.5000.09
23_E168_G0.5000.09
23_E169_G0.5000.09
14_W171_N0.5000.09
14_W126_D0.5000.09
23_E211_A0.5000.09
14_W23_E0.5000.09
27_Q169_G0.5000.09
27_Q170_D0.5000.09
11_Y171_N0.5000.09
11_Y169_G0.5000.09
27_Q171_N0.5000.09
11_Y168_G0.5000.09
27_Q197_G0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qv6A 4 0.9957 100 0.132 Contact Map
3mtkA 2 0.632 97.3 0.921 Contact Map
3i5cA 2 0.7316 97 0.925 Contact Map
3hvaA 1 0.6017 96.9 0.926 Contact Map
3x1lA 1 0.7446 96.9 0.927 Contact Map
4uw2A 1 0.7446 96.8 0.928 Contact Map
4w8yA 1 0.8139 96.6 0.929 Contact Map
3pjxA 1 0.6883 96.6 0.929 Contact Map
4urgA 1 0.5844 96.5 0.93 Contact Map
3hvwA 1 0.5541 96.3 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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