GREMLIN Database
RISB - 6,7-dimethyl-8-ribityllumazine synthase
UniProt: Q980B5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (138)
Sequences: 3210 (1664)
Seq/√Len: 141.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_D97_E3.6351.00
9_G57_L3.3611.00
12_V24_L2.5261.00
54_I68_T2.1401.00
59_E99_N2.1251.00
55_K97_E2.1101.00
74_K110_G2.0411.00
65_A134_L2.0201.00
18_D117_V1.9881.00
28_L32_R1.9681.00
68_T91_I1.9601.00
24_L41_V1.9151.00
30_H128_V1.9121.00
31_A36_V1.9041.00
50_M106_I1.9001.00
40_V63_I1.8871.00
86_Q89_R1.8851.00
17_Y21_Q1.8661.00
55_K59_E1.8591.00
89_R93_D1.8191.00
76_E118_E1.7901.00
114_E118_E1.7231.00
65_A131_A1.6861.00
87_T106_I1.5791.00
18_D113_H1.5461.00
78_K81_E1.5431.00
56_K99_N1.5371.00
22_L25_Q1.5281.00
55_K96_T1.5161.00
9_G63_I1.5151.00
72_V83_V1.5101.00
123_Y126_R1.5081.00
52_L95_S1.4831.00
42_I57_L1.4601.00
48_F104_L1.4391.00
32_R38_V1.3831.00
21_Q43_K1.3821.00
11_V54_I1.3761.00
58_L98_F1.3551.00
78_K82_L1.3381.00
44_V53_A1.3341.00
19_I71_A1.3051.00
110_G115_Q1.2961.00
81_E84_A1.2951.00
8_L138_T1.2731.00
8_L31_A1.2351.00
58_L66_V1.2321.00
6_I138_T1.2211.00
80_D84_A1.2151.00
72_V84_A1.2111.00
30_H129_E1.1971.00
52_L141_L1.1941.00
13_A20_T1.1851.00
31_A67_V1.1721.00
30_H33_F1.1701.00
126_R129_E1.1560.99
53_A141_L1.1560.99
58_L100_K1.1530.99
11_V50_M1.1510.99
85_S89_R1.1400.99
78_K110_G1.1300.99
12_V20_T1.1250.99
55_K99_N1.1020.99
103_T130_A1.0820.99
51_P90_K1.0760.99
54_I66_V1.0640.99
87_T104_L1.0620.99
29_S33_F1.0570.99
69_L105_G1.0520.99
24_L43_K1.0290.99
55_K98_F1.0160.99
82_L85_S1.0150.99
137_R140_K0.9990.98
30_H132_I0.9900.98
19_I117_V0.9860.98
30_H34_L0.9820.98
125_T129_E0.9650.98
28_L38_V0.9640.98
24_L28_L0.9580.98
59_E98_F0.9580.98
25_Q29_S0.9550.98
92_V95_S0.9520.98
16_N71_A0.9520.98
103_T133_K0.9450.98
6_I142_D0.9450.98
73_I113_H0.9410.98
58_L94_L0.9400.98
54_I91_I0.9380.98
113_H121_E0.9210.97
25_Q28_L0.9120.97
94_L102_V0.9080.97
74_K78_K0.9080.97
17_Y43_K0.9080.97
61_D100_K0.9060.97
6_I135_V0.9050.97
21_Q25_Q0.9020.97
12_V43_K0.8910.97
60_K63_I0.8870.97
34_L132_I0.8830.97
65_A103_T0.8730.96
28_L41_V0.8680.96
51_P92_V0.8620.96
10_I24_L0.8540.96
113_H117_V0.8510.96
80_D110_G0.8480.96
4_K37_E0.8360.95
88_A104_L0.8330.95
14_E133_K0.8180.95
16_N20_T0.8070.94
8_L36_V0.8040.94
50_M68_T0.8020.94
134_L138_T0.8020.94
12_V41_V0.7960.94
7_R37_E0.7950.94
23_M26_K0.7910.94
105_G127_A0.7910.94
66_V100_K0.7880.94
112_T115_Q0.7830.94
79_H119_R0.7820.94
56_K59_E0.7780.93
90_K94_L0.7750.93
113_H118_E0.7610.93
52_L55_K0.7560.92
19_I113_H0.7550.92
48_F88_A0.7490.92
23_M124_A0.7470.92
52_L56_K0.7430.92
118_E121_E0.7390.91
93_D96_T0.7370.91
123_Y127_A0.7230.91
52_L94_L0.7220.90
20_T71_A0.7190.90
59_E97_E0.7140.90
52_L96_T0.7080.90
116_A119_R0.7070.90
50_M91_I0.7050.89
6_I9_G0.6990.89
109_H116_A0.6960.89
133_K137_R0.6950.89
57_L63_I0.6920.89
128_V132_I0.6850.88
53_A137_R0.6820.88
13_A50_M0.6770.87
50_M87_T0.6720.87
56_K142_D0.6720.87
134_L137_R0.6710.87
10_I27_A0.6690.87
12_V69_L0.6630.86
129_E133_K0.6620.86
86_Q90_K0.6600.86
60_K100_K0.6540.86
33_F125_T0.6540.86
9_G42_I0.6540.86
5_S40_V0.6530.86
6_I139_R0.6500.85
14_E136_Q0.6450.85
131_A135_V0.6420.85
82_L104_L0.6410.84
8_L65_A0.6390.84
26_K124_A0.6350.84
48_F82_L0.6340.84
78_K84_A0.6270.83
90_K96_T0.6260.83
77_T119_R0.6230.83
26_K122_E0.6180.82
30_H125_T0.6130.82
19_I120_I0.6120.82
76_E88_A0.6100.81
26_K120_I0.6080.81
22_L120_I0.6060.81
116_A120_I0.6030.81
11_V66_V0.6030.81
13_A44_V0.6030.81
31_A128_V0.5930.80
122_E134_L0.5920.80
26_K105_G0.5910.79
85_S88_A0.5890.79
45_P134_L0.5880.79
8_L67_V0.5860.79
47_T72_V0.5830.78
54_I94_L0.5820.78
48_F83_V0.5810.78
66_V101_P0.5790.78
7_R61_D0.5680.77
14_E21_Q0.5640.76
11_V57_L0.5630.76
6_I64_D0.5600.76
127_A137_R0.5530.75
122_E125_T0.5530.75
80_D107_I0.5520.75
95_S98_F0.5470.74
38_V41_V0.5450.74
40_V62_F0.5440.74
4_K35_N0.5430.73
56_K138_T0.5420.73
103_T134_L0.5350.72
122_E126_R0.5340.72
117_V120_I0.5290.72
13_A109_H0.5280.71
4_K39_K0.5250.71
76_E121_E0.5170.70
36_V135_V0.5140.69
136_Q140_K0.5100.69
138_T141_L0.5100.69
105_G116_A0.5060.68
94_L98_F0.5000.67
11_V53_A0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rvvA 6 0.9156 100 0.125 Contact Map
1hqkA 6 0.9156 100 0.125 Contact Map
3nq4A 6 0.9091 100 0.128 Contact Map
2i0fA 3 0.8961 100 0.13 Contact Map
2obxA 4 0.9156 100 0.131 Contact Map
1kz1A 5 0.9026 100 0.131 Contact Map
1c41A 6 0.9416 100 0.133 Contact Map
2c92A 3 0.9156 100 0.136 Contact Map
1ejbA 3 0.9221 100 0.136 Contact Map
1c2yA 6 0.9221 100 0.138 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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