GREMLIN Database
Q980B3 - GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase (DHBP synthase) (RibA))
UniProt: Q980B3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (190)
Sequences: 3294 (1673)
Seq/√Len: 121.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_E64_T3.7351.00
9_D14_I3.6281.00
160_R214_F3.0081.00
35_G176_E2.8321.00
46_R53_I2.6441.00
9_D206_H2.6431.00
166_S179_A2.4581.00
5_S206_H2.4461.00
6_L208_I2.4281.00
123_I176_E2.3601.00
34_A178_S2.3541.00
32_F41_S2.3061.00
55_Y120_L2.1981.00
154_R158_E2.1521.00
62_A152_I2.0881.00
63_K152_I2.0211.00
46_R185_L2.0111.00
59_I155_D1.9891.00
137_E142_F1.9631.00
57_T62_A1.9531.00
52_L108_I1.9441.00
115_I119_E1.9401.00
8_K12_S1.9381.00
199_I203_F1.9261.00
36_A175_L1.8921.00
117_I148_V1.8651.00
119_E142_F1.8591.00
99_V120_L1.8551.00
18_I165_L1.7881.00
59_I63_K1.7801.00
30_M199_I1.7541.00
33_Y175_L1.7511.00
42_I53_I1.7441.00
101_H119_E1.7291.00
197_K201_K1.6891.00
153_A167_I1.6831.00
197_K207_F1.6711.00
15_P32_F1.6311.00
62_A67_L1.6221.00
119_E122_K1.6141.00
16_I169_L1.6041.00
98_W149_P1.5751.00
59_I152_I1.5651.00
47_K50_G1.5591.00
17_L200_A1.5441.00
8_K11_E1.5431.00
60_N155_D1.4661.00
10_L33_Y1.4451.00
19_Y209_E1.4171.00
42_I117_I1.3961.00
30_M49_A1.3791.00
10_L16_I1.3781.00
19_Y193_K1.3681.00
28_T196_A1.3681.00
52_L149_P1.3621.00
169_L208_I1.2881.00
101_H104_T1.2611.00
18_I208_I1.2520.99
19_Y207_F1.2510.99
44_T203_F1.2490.99
35_G175_L1.2460.99
138_F141_N1.2430.99
10_L170_L1.2380.99
15_P41_S1.2350.99
37_I114_Y1.2220.99
30_M205_L1.2100.99
117_I180_V1.2010.99
37_I42_I1.1960.99
193_K207_F1.1900.99
69_F152_I1.1890.99
102_V143_M1.1870.99
17_L205_L1.1780.99
57_T178_S1.1750.99
39_W114_Y1.1520.99
166_S181_I1.1410.99
15_P30_M1.1400.99
200_A207_F1.1310.99
38_S41_S1.1150.99
184_I191_M1.1130.99
31_V181_I1.1080.99
115_I118_S1.1040.99
184_I196_A1.1030.99
53_I182_A1.0950.99
14_I206_H1.0880.99
58_A177_R1.0740.98
103_N115_I1.0660.98
195_K198_M1.0640.98
168_T217_V1.0600.98
105_K112_D1.0570.98
47_K186_D1.0500.98
114_Y118_S1.0490.98
121_H178_S1.0430.98
37_I41_S1.0400.98
55_Y117_I1.0350.98
43_Y50_G1.0290.98
155_D158_E1.0290.98
3_F208_I1.0270.98
17_L184_I1.0200.98
157_R217_V1.0000.97
62_A69_F0.9910.97
90_G143_M0.9910.97
55_Y99_V0.9760.97
48_E202_N0.9720.97
156_I168_T0.9690.97
66_G144_T0.9680.97
48_E199_I0.9660.97
57_T120_L0.9660.97
18_I31_V0.9560.97
61_E176_E0.9540.97
193_K197_K0.9450.96
157_R168_T0.9440.96
7_R172_K0.9410.96
89_Y143_M0.9270.96
170_L178_S0.9250.96
33_Y36_A0.9180.96
42_I180_V0.9120.96
212_D215_K0.9100.96
33_Y170_L0.9100.96
45_L53_I0.9090.96
3_F213_I0.8970.95
104_T112_D0.8920.95
56_A167_I0.8860.95
160_R211_K0.8830.95
39_W111_Y0.8670.94
31_V162_H0.8640.94
44_T205_L0.8610.94
15_P205_L0.8590.94
9_D12_S0.8590.94
119_E137_E0.8550.94
48_E186_D0.8540.94
56_A181_I0.8510.94
30_M44_T0.8470.94
55_Y148_V0.8460.93
50_G185_L0.8310.93
111_Y189_S0.8300.93
101_H142_F0.8290.93
58_A61_E0.8240.93
25_E29_D0.8060.92
165_L210_G0.8030.92
137_E141_N0.7950.91
7_R173_L0.7940.91
198_M202_N0.7910.91
191_M195_K0.7880.91
104_T142_F0.7880.91
27_E163_T0.7790.90
52_L182_A0.7730.90
100_N142_F0.7630.89
32_F45_L0.7610.89
104_T119_E0.7600.89
6_L18_I0.7560.89
32_F37_I0.7560.89
193_K209_E0.7540.89
211_K215_K0.7510.89
75_K144_T0.7510.89
211_K214_F0.7500.89
68_N72_E0.7500.89
194_D197_K0.7480.88
31_V166_S0.7440.88
198_M201_K0.7420.88
172_K213_I0.7310.87
17_L199_I0.7310.87
44_T199_I0.7290.87
89_Y100_N0.7290.87
200_A205_L0.7250.87
24_R29_D0.7230.87
67_L120_L0.7160.86
49_A182_A0.7140.86
44_T48_E0.7140.86
56_A166_S0.7120.86
60_N64_T0.7080.86
94_A154_R0.7060.85
104_T143_M0.7060.85
21_F160_R0.7060.85
170_L175_L0.7050.85
6_L16_I0.7030.85
101_H115_I0.7020.85
53_I185_L0.7000.85
47_K202_N0.7000.85
10_L173_L0.6980.85
89_Y92_Y0.6980.85
7_R10_L0.6960.85
55_Y121_H0.6940.84
196_A207_F0.6930.84
5_S8_K0.6930.84
42_I46_R0.6930.84
70_I98_W0.6900.84
52_L98_W0.6900.84
57_T61_E0.6840.84
165_L213_I0.6810.83
105_K192_N0.6800.83
100_N144_T0.6730.83
27_E162_H0.6720.83
122_K137_E0.6710.82
30_M203_F0.6710.82
28_T194_D0.6710.82
172_K216_E0.6700.82
66_G140_E0.6690.82
29_D183_E0.6670.82
46_R50_G0.6660.82
111_Y115_I0.6650.82
25_E183_E0.6640.82
19_Y196_A0.6610.81
24_R183_E0.6570.81
95_F149_P0.6560.81
124_I137_E0.6550.81
197_K200_A0.6480.80
52_L95_F0.6420.80
34_A180_V0.6420.80
59_I62_A0.6420.80
48_E203_F0.6400.79
29_D162_H0.6380.79
17_L196_A0.6370.79
30_M184_I0.6370.79
50_G108_I0.6320.79
33_Y173_L0.6300.78
163_T183_E0.6280.78
29_D163_T0.6270.78
42_I45_L0.6210.77
14_I204_G0.6170.77
46_R52_L0.6150.77
49_A185_L0.6110.76
166_S170_L0.6100.76
121_H176_E0.6060.76
43_Y49_A0.6060.76
29_D54_C0.5980.75
24_R27_E0.5960.74
69_F94_A0.5960.74
46_R49_A0.5920.74
7_R213_I0.5910.74
148_V180_V0.5900.74
43_Y110_D0.5890.74
100_N104_T0.5870.73
24_R163_T0.5840.73
189_S195_K0.5810.73
69_F74_L0.5780.72
60_N177_R0.5780.72
21_F211_K0.5740.72
58_A62_A0.5720.71
50_G184_I0.5670.71
49_A199_I0.5650.70
74_L89_Y0.5640.70
112_D115_I0.5640.70
91_D143_M0.5610.70
20_D27_E0.5580.69
14_I41_S0.5580.69
10_L169_L0.5550.69
49_A52_L0.5530.69
162_H210_G0.5520.69
151_L181_I0.5500.68
139_Y144_T0.5450.68
3_F7_R0.5450.68
27_E183_E0.5430.67
171_Q177_R0.5420.67
149_P187_E0.5420.67
58_A171_Q0.5380.67
107_G147_H0.5370.67
25_E162_H0.5370.67
201_K204_G0.5330.66
89_Y94_A0.5320.66
62_A96_S0.5310.66
5_S9_D0.5280.65
104_T115_I0.5280.65
97_V144_T0.5270.65
15_P33_Y0.5260.65
118_S121_H0.5260.65
64_T137_E0.5220.64
30_M45_L0.5220.64
64_T176_E0.5210.64
42_I49_A0.5190.64
25_E163_T0.5180.64
58_A155_D0.5180.64
66_G139_Y0.5160.64
56_A151_L0.5130.63
10_L179_A0.5120.63
103_N143_M0.5110.63
54_C95_F0.5100.63
91_D162_H0.5090.62
66_G138_F0.5070.62
43_Y47_K0.5070.62
22_D193_K0.5060.62
162_H165_L0.5050.62
102_V141_N0.5050.62
18_I179_A0.5040.62
7_R11_E0.5020.61
214_F217_V0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1snnA 2 0.968 100 0.124 Contact Map
1k4iA 2 0.8858 100 0.134 Contact Map
4ffjA 2 0.8447 100 0.138 Contact Map
3mioA 2 0.8356 100 0.139 Contact Map
4p6dA 2 0.8402 100 0.14 Contact Map
1tksA 2 0.8584 100 0.142 Contact Map
1g57A 2 0.8676 100 0.145 Contact Map
4i14A 2 0.8447 100 0.149 Contact Map
1y0nA 1 0.1872 58.5 0.949 Contact Map
4gimA 3 0.7854 31.9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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