GREMLIN Database
CBIA - Cobyrinate a,c-diamide synthase
UniProt: Q980B1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 434 (426)
Sequences: 2252 (1676)
Seq/√Len: 81.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_L100_T4.5571.00
129_K133_Y4.1381.00
310_S316_I4.0701.00
241_A279_A4.0591.00
123_T131_L3.9801.00
28_K203_E3.9281.00
239_K264_E3.8661.00
309_M314_V3.5971.00
384_S420_Y3.1721.00
84_I109_T3.1701.00
116_N147_K2.9751.00
171_P208_Y2.9671.00
251_Y285_G2.9211.00
29_K206_E2.8711.00
282_I306_L2.8661.00
329_N347_D2.7561.00
72_L107_T2.6991.00
246_P272_N2.6711.00
154_Y158_R2.6641.00
34_G51_T2.5171.00
105_K135_R2.4981.00
8_S13_S2.4841.00
310_S416_T2.4701.00
19_T23_M2.4261.00
256_L265_L2.3991.00
328_K345_D2.3861.00
302_T305_W2.3851.00
3_R109_T2.3791.00
29_K212_D2.3591.00
329_N337_N2.3351.00
28_K199_R2.2721.00
105_K137_D2.2701.00
303_K307_K2.2631.00
28_K206_E2.2381.00
23_M51_T2.1991.00
205_V209_V2.1791.00
371_N374_N2.1431.00
76_G82_G2.0561.00
294_N298_K2.0541.00
154_Y169_Y2.0401.00
21_A205_V2.0371.00
242_I267_F2.0321.00
276_V305_W2.0291.00
115_I128_V2.0291.00
328_K347_D2.0201.00
145_F161_V1.9761.00
310_S343_I1.9201.00
167_L217_M1.9091.00
300_T303_K1.9081.00
275_Y305_W1.8861.00
360_E375_V1.8861.00
112_I214_I1.8861.00
23_M34_G1.8771.00
306_L341_T1.8451.00
240_M263_Y1.8381.00
366_E371_N1.8291.00
37_A103_L1.8131.00
24_R199_R1.8131.00
128_V164_V1.7801.00
64_G67_N1.7741.00
239_K266_E1.7741.00
47_H55_S1.7711.00
18_I170_V1.7671.00
244_Y267_F1.7581.00
165_E213_K1.7281.00
360_E377_R1.7181.00
6_L114_I1.7091.00
28_K202_S1.7011.00
331_I337_N1.6951.00
128_V161_V1.6941.00
243_A268_F1.6851.00
61_W377_R1.6601.00
33_R53_F1.6601.00
23_M47_H1.6541.00
145_F166_V1.6411.00
304_K308_N1.6271.00
74_K261_N1.6261.00
307_K311_Y1.6211.00
366_E372_K1.6141.00
26_L81_I1.6091.00
260_K267_F1.6041.00
151_E171_P1.6031.00
253_Q260_K1.6011.00
24_R28_K1.5991.00
25_A211_L1.5911.00
327_S346_I1.5811.00
125_G160_A1.5801.00
361_L421_S1.5781.00
292_H295_E1.5781.00
282_I314_V1.5671.00
242_I265_L1.5641.00
276_V279_A1.5631.00
9_D13_S1.5611.00
324_M348_I1.5571.00
327_S348_I1.5511.00
297_E339_S1.5481.00
344_F416_T1.5420.99
24_R195_Q1.5350.99
253_Q257_D1.5320.99
5_L109_T1.5310.99
303_K341_T1.5300.99
311_Y414_N1.5280.99
120_I127_I1.5180.99
18_I144_I1.5100.99
297_E303_K1.5070.99
363_A370_V1.5010.99
362_E375_V1.4900.99
151_E155_N1.4820.99
209_V214_I1.4800.99
213_K216_E1.4760.99
187_T249_S1.4730.99
108_K139_S1.4570.99
257_D260_K1.4550.99
301_R305_W1.4500.99
65_K102_E1.4400.99
30_Y80_D1.4380.99
293_L338_H1.4250.99
112_I144_I1.4240.99
81_I215_Y1.4100.99
362_E397_K1.4100.99
273_N302_T1.3990.99
299_S302_T1.3950.99
350_T420_Y1.3910.99
112_I167_L1.3890.99
23_M83_I1.3770.99
37_A87_V1.3700.99
221_E224_E1.3690.99
350_T384_S1.3490.99
242_I256_L1.3470.99
4_I83_I1.3450.99
316_I416_T1.3410.99
118_S147_K1.3360.99
351_K385_K1.3360.99
24_R202_S1.3270.98
4_I218_A1.3200.98
240_M281_A1.3180.98
56_I257_D1.3150.98
3_R224_E1.3130.98
337_N347_D1.3050.98
23_M55_S1.3030.98
299_S325_Y1.2990.98
111_I138_V1.2630.98
117_C157_C1.2620.98
305_W309_M1.2620.98
30_Y215_Y1.2480.98
324_M384_S1.2450.98
243_A270_P1.2390.98
241_A282_I1.2340.98
115_I124_V1.2290.97
170_V204_L1.2250.97
31_K80_D1.2240.97
276_V302_T1.2220.97
203_E207_K1.2160.97
284_I306_L1.2140.97
60_L106_V1.2120.97
7_S111_I1.2090.97
87_V100_T1.2080.97
132_K140_I1.2030.97
293_L330_L1.1990.97
72_L109_T1.1960.97
60_L103_L1.1900.97
187_T288_Y1.1900.97
169_Y208_Y1.1790.97
3_R221_E1.1770.97
18_I114_I1.1730.97
129_K134_Y1.1730.97
135_R138_V1.1710.97
260_K264_E1.1670.97
174_K177_E1.1570.96
81_I218_A1.1450.96
255_N425_F1.1440.96
4_I112_I1.1440.96
97_L102_E1.1330.96
245_D269_S1.1270.96
326_L416_T1.1240.96
3_R72_L1.1130.95
48_K56_I1.1090.95
239_K279_A1.1050.95
238_R263_Y1.1040.95
176_L204_L1.1030.95
361_L398_V1.1030.95
31_K78_E1.1010.95
318_A418_A1.0990.95
296_L325_Y1.0960.95
90_L138_V1.0950.95
70_R74_K1.0870.95
324_M330_L1.0850.95
273_N299_S1.0800.95
26_L215_Y1.0760.95
302_T325_Y1.0750.94
331_I349_K1.0740.94
3_R108_K1.0690.94
396_F417_V1.0670.94
266_E279_A1.0640.94
288_Y291_L1.0640.94
117_C148_I1.0620.94
68_V103_L1.0620.94
349_K385_K1.0610.94
175_N200_Y1.0550.94
149_A172_F1.0450.94
331_I347_D1.0430.94
67_N71_S1.0400.93
302_T306_L1.0390.93
167_L214_I1.0330.93
364_V397_K1.0270.93
69_K106_V1.0210.93
34_G55_S1.0210.93
31_K53_F1.0200.93
173_D204_L1.0170.93
2_K221_E1.0110.92
56_I75_Y1.0080.92
274_E299_S1.0050.92
120_I124_V0.9970.92
53_F79_F0.9950.92
65_K106_V0.9860.92
316_I343_I0.9860.92
202_S206_E0.9840.91
6_L112_I0.9800.91
105_K138_V0.9800.91
113_L123_T0.9720.91
346_I386_P0.9680.91
155_N159_N0.9630.91
239_K278_D0.9630.91
400_I404_I0.9580.90
282_I316_I0.9580.90
33_R79_F0.9530.90
327_S386_P0.9520.90
122_S134_Y0.9450.90
101_Y138_V0.9440.90
26_L30_Y0.9440.90
98_Y103_L0.9440.90
9_D131_L0.9400.89
283_Y317_Y0.9350.89
46_Y194_V0.9340.89
282_I309_M0.9310.89
328_K346_I0.9300.89
199_R202_S0.9250.89
60_L68_V0.9240.89
117_C145_F0.9230.89
8_S131_L0.9210.88
204_L208_Y0.9170.88
324_M340_M0.9100.88
29_K215_Y0.9090.88
309_M316_I0.9070.88
10_R13_S0.9040.88
254_E257_D0.9040.88
45_G187_T0.9040.88
309_M312_A0.9030.87
303_K325_Y0.8990.87
347_D387_I0.8990.87
148_I157_C0.8980.87
274_E301_R0.8980.87
370_V374_N0.8970.87
210_D213_K0.8970.87
152_T155_N0.8960.87
96_T105_K0.8870.87
53_F78_E0.8830.86
49_I194_V0.8820.86
25_A29_K0.8800.86
158_R162_E0.8790.86
147_K172_F0.8780.86
297_E338_H0.8720.86
180_S383_V0.8710.86
173_D176_L0.8710.86
239_K280_E0.8690.85
367_N370_V0.8670.85
327_S344_F0.8670.85
173_D200_Y0.8660.85
281_A315_K0.8630.85
35_F82_G0.8620.85
10_R116_N0.8620.85
359_T400_I0.8600.85
273_N325_Y0.8580.85
90_L111_I0.8570.85
317_Y417_V0.8540.84
68_V106_V0.8530.84
33_R48_K0.8500.84
63_M71_S0.8490.84
258_I262_K0.8470.84
22_I205_V0.8460.84
349_K387_I0.8430.84
145_F169_Y0.8420.84
237_K264_E0.8420.84
303_K340_M0.8410.83
91_Y138_V0.8410.83
127_I131_L0.8410.83
3_R84_I0.8390.83
17_L47_H0.8370.83
304_K307_K0.8330.83
88_M121_G0.8310.83
255_N259_L0.8210.82
48_K54_P0.8130.81
113_L131_L0.8130.81
193_E196_N0.8120.81
198_I201_A0.8060.81
300_T304_K0.8050.81
75_Y254_E0.8050.81
167_L213_K0.8040.81
100_T109_T0.8040.81
24_R50_A0.8030.81
141_R217_M0.8020.80
328_K342_G0.8000.80
104_A111_I0.7880.79
129_K132_K0.7830.79
2_K218_A0.7820.79
276_V299_S0.7810.79
47_H51_T0.7760.78
84_I107_T0.7750.78
203_E206_E0.7740.78
161_V166_V0.7700.78
25_A206_E0.7700.78
303_K339_S0.7670.77
61_W268_F0.7670.77
363_A367_N0.7660.77
60_L102_E0.7650.77
212_D215_Y0.7650.77
96_T122_S0.7540.76
45_G188_V0.7530.76
88_M92_D0.7470.76
274_E302_T0.7460.75
125_G134_Y0.7450.75
2_K219_S0.7450.75
235_G238_R0.7400.75
42_I46_Y0.7400.75
66_N294_N0.7400.75
42_I182_H0.7390.75
26_L83_I0.7380.75
102_E106_V0.7380.75
308_N311_Y0.7380.75
355_T385_K0.7360.74
115_I131_L0.7340.74
294_N336_K0.7330.74
37_A100_T0.7320.74
246_P295_E0.7300.74
409_D421_S0.7300.74
238_R241_A0.7270.74
9_D123_T0.7260.73
90_L135_R0.7250.73
204_L207_K0.7230.73
310_S341_T0.7200.73
7_S87_V0.7180.73
356_I359_T0.7170.73
41_F249_S0.7160.72
63_M68_V0.7120.72
24_R27_S0.7120.72
56_I424_H0.7120.72
343_I416_T0.7120.72
255_N283_Y0.7110.72
72_L82_G0.7090.72
362_E399_R0.7090.72
154_Y171_P0.7090.72
86_G100_T0.7080.72
16_T185_L0.7080.72
117_C166_V0.7080.72
276_V309_M0.7080.72
88_M180_S0.7070.71
191_N197_L0.7060.71
308_N312_A0.7060.71
213_K217_M0.7050.71
327_S330_L0.7050.71
187_T291_L0.7040.71
27_S50_A0.7040.71
293_L297_E0.7040.71
306_L325_Y0.7040.71
187_T190_D0.7040.71
243_A269_S0.7020.71
279_A314_V0.7010.71
145_F157_C0.6960.70
121_G156_Y0.6950.70
22_I26_L0.6950.70
295_E307_K0.6950.70
275_Y302_T0.6930.70
320_C422_H0.6920.70
239_K267_F0.6920.70
6_L125_G0.6920.70
92_D357_G0.6910.70
3_R222_D0.6910.70
398_V421_S0.6900.70
189_E244_Y0.6890.70
30_Y81_I0.6880.69
364_V408_L0.6880.69
217_M220_D0.6870.69
411_V418_A0.6820.69
401_G404_I0.6810.69
193_E197_L0.6790.68
61_W360_E0.6780.68
25_A205_V0.6780.68
323_L418_A0.6770.68
61_W98_Y0.6760.68
90_L101_Y0.6760.68
356_I407_K0.6760.68
62_M424_H0.6750.68
62_M255_N0.6750.68
183_L379_H0.6740.68
150_S172_F0.6740.68
10_R120_I0.6720.68
323_L386_P0.6700.67
23_M32_V0.6670.67
157_C161_V0.6670.67
178_I191_N0.6660.67
249_S288_Y0.6630.67
200_Y203_E0.6620.66
5_L84_I0.6610.66
273_N301_R0.6610.66
22_I214_I0.6600.66
313_G415_N0.6600.66
179_K202_S0.6590.66
142_G167_L0.6560.66
268_F302_T0.6550.66
363_A373_N0.6530.65
363_A374_N0.6530.65
124_V145_F0.6490.65
26_L211_L0.6490.65
64_G68_V0.6490.65
45_G249_S0.6480.65
294_N338_H0.6480.65
56_I254_E0.6480.65
218_A221_E0.6470.65
143_V161_V0.6460.65
46_Y191_N0.6450.64
331_I335_N0.6390.64
284_I321_G0.6380.64
149_A355_T0.6370.63
151_E207_K0.6370.63
323_L419_S0.6360.63
195_Q199_R0.6330.63
317_Y423_L0.6310.63
241_A266_E0.6300.63
329_N339_S0.6300.63
291_L383_V0.6280.62
108_K222_D0.6280.62
256_L267_F0.6280.62
65_K69_K0.6270.62
251_Y265_L0.6270.62
360_E399_R0.6250.62
4_I214_I0.6250.62
365_K393_E0.6230.62
35_F75_Y0.6220.62
123_T127_I0.6210.62
101_Y135_R0.6200.61
158_R210_D0.6200.61
214_I218_A0.6190.61
115_I123_T0.6180.61
6_L18_I0.6170.61
330_L340_M0.6160.61
182_H320_C0.6150.61
22_I211_L0.6130.61
225_I230_D0.6120.60
359_T380_E0.6110.60
311_Y413_S0.6110.60
109_T221_E0.6100.60
41_F324_M0.6080.60
331_I387_I0.6080.60
102_E135_R0.6070.60
18_I205_V0.6070.60
140_I164_V0.6060.60
88_M183_L0.6050.60
158_R166_V0.6050.60
162_E209_V0.6030.59
170_V201_A0.6020.59
373_N378_G0.6020.59
71_S103_L0.5990.59
48_K76_G0.5980.59
333_E336_K0.5980.59
48_K51_T0.5980.59
49_I195_Q0.5970.59
363_A396_F0.5970.59
34_G420_Y0.5970.59
183_L320_C0.5950.58
178_I186_V0.5950.58
105_K139_S0.5940.58
124_V157_C0.5940.58
390_N413_S0.5920.58
307_K316_I0.5920.58
324_M327_S0.5920.58
5_L103_L0.5910.58
378_G421_S0.5900.58
60_L64_G0.5900.58
184_G250_F0.5870.57
272_N302_T0.5860.57
141_R165_E0.5860.57
412_K415_N0.5860.57
232_E304_K0.5840.57
62_M378_G0.5830.57
88_M156_Y0.5830.57
181_R250_F0.5810.56
91_Y152_T0.5810.56
269_S302_T0.5800.56
149_A356_I0.5790.56
153_H356_I0.5780.56
310_S344_F0.5780.56
118_S172_F0.5780.56
76_G79_F0.5780.56
214_I219_S0.5740.56
21_A25_A0.5740.56
396_F400_I0.5730.55
279_A282_I0.5730.55
54_P253_Q0.5710.55
363_A412_K0.5710.55
188_V194_V0.5710.55
27_S51_T0.5710.55
400_I403_G0.5700.55
363_A366_E0.5690.55
369_I373_N0.5690.55
91_Y197_L0.5690.55
266_E281_A0.5680.55
264_E336_K0.5680.55
66_N69_K0.5680.55
165_E168_G0.5680.55
271_L357_G0.5680.55
27_S53_F0.5670.55
33_R56_I0.5660.55
334_N352_D0.5660.55
4_I81_I0.5650.54
25_A202_S0.5650.54
88_M357_G0.5630.54
11_S88_M0.5630.54
234_N295_E0.5630.54
171_P204_L0.5630.54
57_N358_Y0.5620.54
400_I407_K0.5620.54
81_I212_D0.5600.54
214_I217_M0.5600.54
217_M221_E0.5600.54
22_I83_I0.5590.54
172_F356_I0.5590.54
87_V354_L0.5580.54
20_S50_A0.5580.54
51_T55_S0.5570.53
250_F381_F0.5570.53
141_R167_L0.5570.53
303_K343_I0.5540.53
250_F320_C0.5540.53
63_M67_N0.5530.53
181_R289_P0.5530.53
7_S90_L0.5530.53
39_P92_D0.5530.53
17_L350_T0.5500.52
140_I144_I0.5500.52
395_V400_I0.5500.52
166_V169_Y0.5490.52
180_S324_M0.5490.52
88_M354_L0.5480.52
361_L396_F0.5480.52
104_A138_V0.5480.52
153_H378_G0.5480.52
275_Y301_R0.5450.52
250_F379_H0.5450.52
257_D261_N0.5440.52
108_K224_E0.5440.52
67_N424_H0.5440.52
60_L98_Y0.5440.52
273_N305_W0.5430.52
398_V401_G0.5420.51
284_I314_V0.5410.51
103_L106_V0.5400.51
241_A284_I0.5400.51
234_N237_K0.5390.51
244_Y256_L0.5380.51
251_Y283_Y0.5380.51
317_Y410_G0.5380.51
306_L343_I0.5380.51
344_F411_V0.5380.51
91_Y98_Y0.5380.51
154_Y166_V0.5370.51
359_T421_S0.5370.51
20_S55_S0.5360.51
90_L104_A0.5360.51
183_L381_F0.5360.51
13_S17_L0.5360.51
187_T191_N0.5350.51
396_F409_D0.5350.51
271_L295_E0.5340.50
196_N199_R0.5340.50
397_K406_N0.5330.50
122_S285_G0.5330.50
41_F217_M0.5330.50
397_K408_L0.5320.50
62_M427_N0.5320.50
348_I386_P0.5320.50
11_S87_V0.5320.50
259_L318_A0.5310.50
21_A170_V0.5310.50
75_Y257_D0.5300.50
19_T47_H0.5300.50
120_I131_L0.5300.50
321_G324_M0.5270.49
96_T135_R0.5250.49
108_K137_D0.5240.49
248_F273_N0.5230.49
144_I166_V0.5230.49
3_R218_A0.5220.49
20_S46_Y0.5210.49
196_N200_Y0.5210.49
241_A268_F0.5210.49
320_C379_H0.5210.49
148_I154_Y0.5200.49
32_V80_D0.5200.49
44_P188_V0.5200.49
149_A153_H0.5190.48
283_Y344_F0.5190.48
63_M424_H0.5180.48
11_S15_K0.5170.48
323_L409_D0.5170.48
182_H381_F0.5160.48
394_F404_I0.5160.48
186_V190_D0.5150.48
387_I391_E0.5150.48
323_L383_V0.5140.48
213_K219_S0.5130.48
283_Y425_F0.5130.48
88_M425_F0.5120.48
102_E105_K0.5120.48
187_T194_V0.5120.48
203_E242_I0.5120.48
238_R264_E0.5110.47
324_M331_I0.5110.47
58_L68_V0.5110.47
71_S426_S0.5110.47
352_D385_K0.5110.47
317_Y425_F0.5100.47
366_E369_I0.5100.47
19_T34_G0.5100.47
98_Y123_T0.5100.47
162_E166_V0.5100.47
394_F409_D0.5090.47
67_N426_S0.5080.47
398_V409_D0.5070.47
281_A314_V0.5070.47
27_S81_I0.5070.47
324_M420_Y0.5060.47
250_F290_E0.5040.46
307_K341_T0.5030.46
45_G189_E0.5030.46
145_F154_Y0.5020.46
320_C381_F0.5020.46
258_I429_Q0.5010.46
66_N216_E0.5000.46
288_Y333_E0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s1mA 4 0.9286 100 0.681 Contact Map
1vcoA 4 0.9309 100 0.693 Contact Map
3nvaA 2 0.9332 100 0.709 Contact Map
4zdjA 4 0.9101 100 0.714 Contact Map
4a0gA 2 0.8687 100 0.822 Contact Map
3fgnA 2 0.4562 99.9 0.86 Contact Map
3fijA 4 0.4263 99.9 0.864 Contact Map
2issD 1 0.4101 99.9 0.866 Contact Map
1ka9H 1 0.4217 99.9 0.868 Contact Map
3ug7A 4 0.4309 99.9 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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