GREMLIN Database
Q980B0 - 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (MetE-1)
UniProt: Q980B0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (301)
Sequences: 4933 (2900)
Seq/√Len: 167.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_N35_K4.8621.00
277_E282_I3.5241.00
25_W30_K3.3961.00
74_F144_Y3.2581.00
49_E53_N3.0381.00
118_L178_V2.9891.00
43_N46_K2.9571.00
45_K49_E2.8661.00
119_E177_V2.8441.00
100_I148_S2.8001.00
26_Y33_K2.7351.00
21_K25_W2.6391.00
286_Y299_I2.4621.00
33_K37_E2.4521.00
154_N159_L2.4271.00
155_S158_E2.4111.00
61_N134_L2.3671.00
70_V139_P2.3351.00
48_F134_L2.2521.00
168_N211_N2.2451.00
278_R281_T2.2441.00
78_S105_N2.2301.00
22_V39_H2.1661.00
161_M203_E2.1461.00
112_N116_Q2.1461.00
37_E116_Q2.1341.00
161_M207_S2.1301.00
38_K42_E2.0741.00
45_K120_F2.0371.00
44_I120_F2.0221.00
172_Q176_S2.0151.00
106_V173_E1.9881.00
35_K38_K1.9791.00
113_S117_D1.9681.00
275_K281_T1.9581.00
115_L177_V1.9461.00
171_S181_I1.9341.00
77_I166_V1.8841.00
179_D215_E1.8761.00
42_E46_K1.8711.00
259_F262_R1.8611.00
9_L301_N1.8381.00
49_E52_G1.8141.00
65_R72_V1.7791.00
80_T144_Y1.7771.00
311_V315_K1.7531.00
18_K42_E1.7461.00
40_I66_W1.7071.00
165_S207_S1.6981.00
31_I35_K1.6931.00
225_N233_L1.6841.00
17_P21_K1.6831.00
183_I209_L1.6661.00
283_I287_N1.6641.00
133_K179_D1.6631.00
199_E203_E1.6531.00
118_L133_K1.6491.00
139_P143_T1.6351.00
103_K162_D1.5911.00
50_L314_V1.5801.00
207_S210_D1.5671.00
266_L289_V1.5211.00
81_E99_I1.5181.00
18_K43_N1.5141.00
116_Q119_E1.5031.00
160_M204_I1.4891.00
104_I166_V1.4691.00
280_T284_R1.4601.00
42_E45_K1.4541.00
69_I139_P1.4471.00
38_K41_S1.4381.00
202_P206_K1.4351.00
241_F262_R1.4121.00
269_L277_E1.3941.00
175_S213_K1.3891.00
43_N47_L1.3861.00
115_L170_L1.3821.00
58_Y135_K1.3771.00
50_L53_N1.3741.00
312_V315_K1.3651.00
160_M200_K1.3641.00
279_I283_I1.3451.00
78_S107_K1.3411.00
41_S120_F1.3411.00
120_F123_K1.3401.00
279_I319_L1.3351.00
206_K237_P1.3331.00
293_G296_D1.3311.00
112_N173_E1.3181.00
162_D165_S1.3171.00
290_K297_V1.3171.00
195_R199_E1.3101.00
22_V31_I1.3101.00
293_G297_V1.3071.00
48_F121_S1.3071.00
173_E176_S1.3011.00
287_N291_R1.3001.00
25_W31_I1.2991.00
171_S183_I1.2981.00
164_A208_M1.2851.00
157_I161_M1.2831.00
263_K298_I1.2811.00
7_K56_L1.2741.00
118_L134_L1.2721.00
62_G113_S1.2671.00
115_L173_E1.2621.00
261_S296_D1.2591.00
150_N154_N1.2551.00
13_F50_L1.2531.00
157_I200_K1.2301.00
76_F113_S1.2121.00
39_H42_E1.2111.00
248_N251_K1.2051.00
202_P235_S1.1901.00
314_V318_K1.1881.00
52_G132_S1.1811.00
138_I170_L1.1781.00
46_K50_L1.1771.00
315_K318_K1.1741.00
13_F47_L1.1661.00
100_I159_L1.1621.00
90_D247_E1.1561.00
164_A207_S1.1541.00
119_E122_R1.1541.00
24_S28_T1.1461.00
84_P149_D1.1411.00
240_Y263_K1.1211.00
34_E38_K1.1201.00
83_G96_R1.1161.00
198_L229_R1.1041.00
269_L282_I1.1021.00
79_G144_Y1.1021.00
194_K197_I1.1001.00
203_E207_S1.0961.00
265_Y300_G1.0961.00
172_Q212_V1.0911.00
106_V169_S1.0761.00
168_N207_S1.0761.00
268_M286_Y1.0620.99
311_V314_V1.0560.99
9_L60_T1.0540.99
73_T77_I1.0470.99
9_L56_L1.0410.99
111_E116_Q1.0410.99
105_N162_D1.0390.99
265_Y298_I1.0380.99
37_E117_D1.0360.99
154_N158_E1.0350.99
196_D199_E1.0250.99
143_T187_A1.0190.99
173_E177_V1.0190.99
54_I318_K1.0140.99
16_N314_V1.0130.99
50_L54_I1.0100.99
180_A217_H1.0080.99
294_V297_V1.0050.99
198_L232_T1.0020.99
289_V297_V0.9900.99
168_N172_Q0.9840.99
157_I203_E0.9830.99
37_E66_W0.9810.99
268_M282_I0.9810.99
140_G185_E0.9810.99
37_E41_S0.9810.99
137_V184_H0.9810.99
256_Y292_K0.9790.99
285_V288_S0.9730.99
186_P236_L0.9680.99
39_H43_N0.9640.99
53_N318_K0.9590.99
172_Q211_N0.9570.99
166_V169_S0.9520.99
309_P315_K0.9520.99
170_L174_L0.9510.99
60_T137_V0.9460.99
164_A168_N0.9420.99
9_L51_A0.9380.99
167_V186_P0.9370.99
71_D96_R0.9270.99
287_N290_K0.9200.98
41_S65_R0.9120.98
146_V197_I0.9040.98
251_K254_R0.8960.98
212_V239_D0.8880.98
146_V190_T0.8880.98
150_N159_L0.8830.98
26_Y31_I0.8830.98
19_L64_F0.8780.98
245_V251_K0.8760.98
288_S291_R0.8760.98
233_L241_F0.8740.98
8_A135_K0.8730.98
74_F148_S0.8730.98
145_Y160_M0.8720.98
122_R133_K0.8710.98
105_N169_S0.8690.98
77_I170_L0.8680.98
219_I242_G0.8670.98
187_A190_T0.8630.98
119_E123_K0.8610.98
35_K39_H0.8610.98
159_L162_D0.8600.98
281_T284_R0.8590.98
256_Y288_S0.8530.98
258_Y262_R0.8530.98
247_E270_N0.8500.97
280_T283_I0.8450.97
282_I285_V0.8440.97
19_L40_I0.8430.97
59_T132_S0.8420.97
118_L122_R0.8410.97
253_G257_T0.8410.97
181_I214_I0.8360.97
168_N208_M0.8350.97
249_L285_V0.8270.97
146_V187_A0.8250.97
285_V289_V0.8200.97
157_I196_D0.8190.97
135_K298_I0.8160.97
143_T186_P0.8160.97
118_L177_V0.8130.97
47_L64_F0.8120.97
46_K310_E0.8120.97
189_Y220_T0.8030.96
55_K132_S0.8020.96
95_Y98_P0.8010.96
299_I320_L0.7980.96
245_V266_L0.7880.96
87_R92_N0.7880.96
145_Y201_L0.7870.96
77_I163_Y0.7830.96
234_F261_S0.7830.96
102_E152_Y0.7820.96
86_Q93_F0.7770.96
276_M309_P0.7730.96
81_E101_K0.7700.96
92_N95_Y0.7690.95
210_D237_P0.7650.95
135_K182_E0.7600.95
22_V40_I0.7590.95
41_S116_Q0.7540.95
237_P262_R0.7530.95
115_L119_E0.7520.95
310_E314_V0.7500.95
230_L255_V0.7490.95
58_Y298_I0.7480.95
231_D235_S0.7480.95
85_L88_F0.7420.95
5_V290_K0.7410.94
150_N155_S0.7390.94
165_S169_S0.7350.94
47_L50_L0.7340.94
82_K85_L0.7270.94
282_I299_I0.7250.94
206_K210_D0.7250.94
31_I39_H0.7240.94
45_K48_F0.7200.94
101_K104_I0.7170.93
79_G106_V0.7170.93
36_L40_I0.7150.93
47_L51_A0.7140.93
85_L93_F0.7130.93
41_S123_K0.7110.93
258_Y261_S0.7090.93
178_V181_I0.7090.93
161_M165_S0.7080.93
84_P87_R0.7030.93
172_Q175_S0.7020.93
76_F114_F0.6990.93
253_G256_Y0.6990.93
193_I196_D0.6970.92
292_K297_V0.6950.92
175_S212_V0.6950.92
111_E115_L0.6920.92
50_L310_E0.6900.92
25_W35_K0.6870.92
170_L173_E0.6870.92
7_K299_I0.6850.92
146_V156_P0.6830.92
270_N273_N0.6830.92
251_K255_V0.6830.92
72_V117_D0.6810.92
169_S172_Q0.6810.92
85_L89_F0.6760.91
58_Y180_A0.6740.91
122_R134_L0.6730.91
89_F92_N0.6730.91
86_Q92_N0.6720.91
229_R233_L0.6690.91
193_I197_I0.6670.91
175_S214_I0.6660.91
217_H240_Y0.6650.91
40_I44_I0.6650.91
54_I317_L0.6630.91
199_E202_P0.6620.90
142_L187_A0.6600.90
219_I240_Y0.6590.90
24_S27_N0.6580.90
74_F83_G0.6580.90
86_Q149_D0.6550.90
45_K123_K0.6550.90
142_L193_I0.6530.90
114_F117_D0.6530.90
142_L200_K0.6520.90
21_K24_S0.6520.90
225_N243_I0.6510.90
248_N252_L0.6510.90
150_N153_Y0.6490.90
142_L201_L0.6470.89
89_F93_F0.6460.89
151_R154_N0.6440.89
100_I104_I0.6440.89
188_I218_L0.6430.89
107_K169_S0.6410.89
256_Y291_R0.6370.89
189_Y223_E0.6350.89
7_K57_E0.6350.89
17_P24_S0.6320.88
85_L91_N0.6310.88
269_L320_L0.6290.88
53_N314_V0.6270.88
175_S215_E0.6240.88
76_F111_E0.6240.88
135_K180_A0.6210.87
34_E37_E0.6210.87
250_K253_G0.6190.87
143_T146_V0.6170.87
115_L174_L0.6170.87
243_I255_V0.6150.87
48_F52_G0.6130.87
258_Y264_V0.6110.87
232_T235_S0.6100.87
188_I201_L0.6090.86
37_E40_I0.6090.86
60_T136_A0.6070.86
88_F91_N0.6060.86
48_F59_T0.6060.86
66_W243_I0.6040.86
231_D234_F0.6040.86
242_G300_G0.6030.86
41_S45_K0.6020.86
241_F264_V0.6010.86
102_E151_R0.6010.86
202_P232_T0.5970.85
213_K239_D0.5950.85
93_F96_R0.5940.85
88_F92_N0.5940.85
180_A240_Y0.5920.85
209_L212_V0.5920.85
168_N210_D0.5890.85
146_V186_P0.5890.85
184_H303_T0.5890.85
140_G205_Y0.5880.84
156_P160_M0.5860.84
73_T139_P0.5840.84
234_F262_R0.5830.84
104_I162_D0.5820.84
199_E235_S0.5820.84
175_S216_K0.5820.84
84_P92_N0.5770.83
231_D257_T0.5750.83
218_L233_L0.5740.83
56_L59_T0.5740.83
88_F93_F0.5730.83
252_L256_Y0.5700.83
41_S44_I0.5690.83
142_L160_M0.5690.83
223_E226_N0.5680.82
68_D96_R0.5680.82
47_L310_E0.5670.82
87_R91_N0.5660.82
82_K86_Q0.5640.82
242_G265_Y0.5640.82
201_L205_Y0.5640.82
111_E166_V0.5640.82
255_V289_V0.5630.82
188_I233_L0.5620.82
87_R90_D0.5610.82
86_Q91_N0.5610.82
135_K184_H0.5610.82
266_L286_Y0.5590.81
85_L92_N0.5590.81
73_T76_F0.5580.81
25_W39_H0.5580.81
5_V282_I0.5580.81
86_Q90_D0.5550.81
122_R177_V0.5550.81
240_Y298_I0.5540.81
87_R93_F0.5540.81
19_L43_N0.5540.81
8_A298_I0.5530.81
86_Q97_Q0.5520.81
84_P90_D0.5520.81
68_D93_F0.5510.80
27_N71_D0.5510.80
290_K294_V0.5480.80
122_R179_D0.5470.80
19_L39_H0.5460.80
63_L66_W0.5460.80
195_R198_L0.5440.80
168_N212_V0.5440.80
8_A58_Y0.5440.80
6_K58_Y0.5420.79
19_L24_S0.5410.79
18_K46_K0.5410.79
62_G114_F0.5400.79
91_N96_R0.5380.79
198_L233_L0.5360.79
194_K228_K0.5360.79
188_I222_F0.5340.78
9_L13_F0.5340.78
76_F117_D0.5340.78
164_A204_I0.5330.78
309_P313_V0.5330.78
174_L177_V0.5330.78
119_E173_E0.5330.78
74_F79_G0.5320.78
100_I144_Y0.5300.78
152_Y158_E0.5290.78
159_L163_Y0.5290.78
158_E161_M0.5290.78
161_M204_I0.5270.77
142_L197_I0.5270.77
223_E303_T0.5270.77
17_P309_P0.5260.77
281_T285_V0.5250.77
245_V289_V0.5250.77
84_P89_F0.5230.77
257_T292_K0.5230.77
249_L254_R0.5220.77
70_V144_Y0.5210.77
80_T163_Y0.5200.77
20_G24_S0.5200.77
246_I302_N0.5190.76
16_N43_N0.5160.76
6_K298_I0.5140.76
87_R95_Y0.5130.76
256_Y289_V0.5120.75
188_I225_N0.5120.75
13_F51_A0.5100.75
62_G117_D0.5100.75
65_R120_F0.5100.75
24_S275_K0.5080.75
48_F123_K0.5080.75
102_E162_D0.5070.75
60_T135_K0.5050.74
263_K296_D0.5050.74
26_Y36_L0.5040.74
181_I216_K0.5030.74
70_V73_T0.5030.74
210_D235_S0.5010.74
79_G100_I0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u1jA 1 0.9576 100 0.243 Contact Map
2nq5A 1 0.9455 100 0.255 Contact Map
1ypxA 1 0.9091 100 0.262 Contact Map
3rpdA 1 0.9636 100 0.268 Contact Map
1t7lA 1 0.9667 100 0.269 Contact Map
4l6hA 1 0.9485 100 0.286 Contact Map
4exqA 2 0.9152 99.7 0.787 Contact Map
1j93A 2 0.9091 99.7 0.79 Contact Map
2ejaA 2 0.9061 99.7 0.792 Contact Map
4ay7A 1 0.9182 99.7 0.795 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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