GREMLIN Database
METE - Methionine synthase
UniProt: Q980A9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (312)
Sequences: 4960 (2938)
Seq/√Len: 166.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_S37_D4.4361.00
304_K308_Q3.5401.00
27_L32_K3.3041.00
275_A319_V3.2221.00
269_E274_V3.1471.00
76_A138_I3.1261.00
52_D307_Y2.8291.00
51_Q55_K2.8261.00
116_F173_A2.8061.00
45_A48_A2.8021.00
47_I51_Q2.7631.00
101_V142_S2.6571.00
47_I122_V2.6061.00
271_S315_E2.5731.00
23_E27_L2.5561.00
117_T171_A2.5351.00
271_S319_V2.4321.00
28_H35_N2.4301.00
278_I292_I2.3451.00
278_I320_V2.2861.00
149_N152_D2.2831.00
148_R153_L2.2631.00
35_N39_Q2.2461.00
72_V133_T2.2041.00
80_K106_E2.2001.00
50_F128_L2.1581.00
63_D128_L2.1271.00
39_Q114_D2.1061.00
270_T273_E2.0761.00
162_N203_G2.0001.00
40_E44_D1.9881.00
24_S41_A1.9741.00
37_D40_E1.9401.00
110_P114_D1.9351.00
267_K273_E1.9301.00
107_Y167_N1.9171.00
166_K170_E1.9151.00
314_V318_K1.8911.00
46_V118_F1.8611.00
47_I118_F1.8501.00
274_V316_G1.8371.00
111_M115_E1.8251.00
44_D48_A1.7991.00
79_I160_A1.7991.00
50_F122_V1.7861.00
238_I241_Y1.7801.00
165_I176_I1.7481.00
113_V171_A1.7371.00
155_F196_A1.7281.00
195_E199_E1.6951.00
87_P90_V1.6731.00
51_Q54_Y1.6731.00
82_F138_I1.6661.00
67_R74_F1.6491.00
127_N174_K1.6421.00
178_I201_V1.6411.00
20_W44_D1.6391.00
19_K23_E1.6341.00
251_G254_K1.6111.00
42_F68_R1.5931.00
217_Y224_F1.5811.00
222_P249_K1.5751.00
116_F127_N1.5601.00
105_I160_A1.5531.00
33_M37_D1.5411.00
275_A279_R1.5321.00
104_K156_D1.5171.00
133_T137_T1.4861.00
83_K100_S1.4621.00
12_I294_P1.4611.00
20_W45_A1.4521.00
114_D117_T1.4391.00
198_N228_K1.4201.00
294_P313_M1.4151.00
71_M133_T1.4011.00
44_D47_I1.3991.00
88_V91_W1.3981.00
169_V205_N1.3871.00
282_L290_V1.3731.00
15_Y307_Y1.3691.00
113_V164_E1.3651.00
232_I254_K1.3521.00
191_S195_E1.3481.00
60_V129_K1.3421.00
258_A281_I1.3391.00
248_K284_Y1.3391.00
87_P91_W1.3361.00
272_E276_N1.3351.00
286_P289_K1.3201.00
54_Y124_Y1.3161.00
194_V198_N1.3121.00
271_S312_S1.3111.00
52_D55_K1.3001.00
155_F199_E1.2971.00
271_S316_G1.2921.00
27_L33_M1.2861.00
113_V167_N1.2811.00
176_I206_A1.2711.00
40_E43_N1.2681.00
144_N148_R1.2671.00
279_R283_E1.2651.00
86_G143_Y1.2641.00
305_I308_Q1.2611.00
199_E202_K1.2611.00
187_K190_V1.2581.00
56_A311_V1.2531.00
209_V231_Q1.2491.00
45_A49_V1.2491.00
110_P167_N1.2371.00
156_D159_K1.2301.00
315_E318_K1.2271.00
167_N170_E1.2241.00
261_V269_E1.2241.00
24_S33_M1.2111.00
78_R111_M1.2091.00
285_F289_K1.2061.00
165_I178_I1.2021.00
92_G238_I1.1961.00
307_Y311_V1.1921.00
43_N118_F1.1861.00
255_E291_W1.1781.00
12_I62_T1.1721.00
26_R30_A1.1711.00
175_I209_V1.1691.00
116_F128_L1.1661.00
253_D289_K1.1641.00
50_F119_A1.1631.00
64_G111_M1.1611.00
118_F121_S1.1591.00
117_T120_K1.1581.00
275_A320_V1.1571.00
80_K108_R1.1561.00
151_K155_F1.1331.00
271_S275_A1.1321.00
15_Y52_D1.1301.00
318_K322_E1.1291.00
285_F290_V1.1271.00
132_I164_E1.1071.00
48_A52_D1.0881.00
308_Q311_V1.0831.00
174_K207_K1.0771.00
101_V153_L1.0741.00
275_A316_G1.0731.00
58_V310_L1.0721.00
15_Y49_V1.0670.99
213_C296_C1.0620.99
41_A44_D1.0600.99
55_K311_V1.0550.99
166_K204_V1.0540.99
169_V206_A1.0540.99
197_V200_A1.0480.99
292_I313_M1.0370.99
261_V313_M1.0250.99
36_E40_E1.0130.99
75_F79_I1.0110.99
137_T182_A1.0100.99
231_Q255_E1.0090.99
81_G138_I1.0080.99
250_Y254_K1.0020.99
85_Y97_R1.0000.99
39_Q115_E0.9990.99
261_V274_V0.9990.99
191_S223_Y0.9980.99
148_R152_D0.9930.99
59_D317_T0.9920.99
107_Y163_Q0.9880.99
260_V278_I0.9850.99
282_L287_P0.9840.99
202_K228_K0.9820.99
315_E319_V0.9800.99
257_G293_N0.9790.99
167_N171_A0.9700.99
193_G197_V0.9700.99
118_F122_V0.9670.99
311_V315_E0.9660.99
257_G291_W0.9640.99
39_Q43_N0.9630.99
52_D56_A0.9620.99
239_Y242_K0.9620.99
39_Q68_R0.9600.99
160_A163_Q0.9570.99
166_K203_G0.9490.99
243_P246_L0.9340.99
164_E168_L0.9330.99
109_E114_D0.9320.99
195_E226_E0.9270.99
281_I290_V0.9270.99
277_D280_K0.9250.99
161_I181_P0.9180.98
92_G95_Y0.9160.98
96_Y99_P0.9140.98
131_T179_D0.9130.98
154_V192_W0.9120.98
158_A200_A0.9110.98
84_F87_P0.9080.98
73_E97_R0.9040.98
162_N166_K0.9030.98
260_V274_V0.9020.98
62_T131_T0.9020.98
83_K102_V0.9010.98
41_A45_A0.8990.98
211_H233_N0.8970.98
106_E163_Q0.8960.98
198_N201_V0.8950.98
158_A162_N0.8920.98
43_N67_R0.8890.98
140_E185_T0.8690.98
134_G180_E0.8610.98
117_T121_S0.8590.98
139_A154_V0.8570.98
144_N153_L0.8530.98
154_V196_A0.8520.97
302_S308_Q0.8480.97
218_S246_L0.8480.97
84_F88_V0.8480.97
181_P227_I0.8460.97
84_F90_V0.8390.97
21_L66_V0.8370.97
241_Y277_D0.8370.97
210_M224_F0.8340.97
49_V66_V0.8260.97
277_D281_I0.8260.97
28_H33_M0.8230.97
279_R282_L0.8190.97
182_A185_T0.8160.97
79_I164_E0.8120.97
116_F171_A0.8110.97
210_M229_V0.8100.97
224_F232_I0.8100.97
139_A193_G0.8070.97
86_G89_R0.8050.96
120_K127_N0.8040.96
151_K195_E0.8030.96
184_H212_I0.7950.96
317_T321_R0.7950.96
37_D41_A0.7940.96
196_A200_A0.7930.96
250_Y256_L0.7920.96
79_I157_L0.7890.96
316_G320_V0.7890.96
153_L156_D0.7870.96
313_M317_T0.7830.96
225_N253_D0.7810.96
140_E182_A0.7780.96
21_L42_F0.7770.96
303_R307_Y0.7760.96
187_K191_S0.7750.96
102_V105_I0.7750.96
162_N200_A0.7730.96
222_P226_E0.7720.96
84_F91_W0.7670.95
87_P95_Y0.7670.95
280_K283_E0.7640.95
236_L258_A0.7630.95
279_R320_V0.7630.95
60_V291_W0.7620.95
76_A142_S0.7590.95
274_V277_D0.7580.95
272_E275_A0.7550.95
85_Y90_V0.7530.95
158_A199_E0.7480.95
238_I262_D0.7470.95
273_E276_N0.7460.95
302_S306_A0.7450.95
268_V302_S0.7420.94
89_R92_G0.7410.94
85_Y88_V0.7370.94
137_T181_P0.7300.94
43_N114_D0.7280.94
243_P247_L0.7280.94
48_A303_R0.7270.94
129_K291_W0.7270.94
24_S42_F0.7260.94
106_E156_D0.7250.94
159_K199_E0.7230.94
11_V129_K0.7230.94
312_S316_G0.7210.94
285_F288_E0.7210.94
191_S198_N0.7180.93
129_K177_Q0.7180.93
159_K163_Q0.7160.93
55_K307_Y0.7130.93
248_K280_K0.7110.93
90_V95_Y0.7090.93
116_F120_K0.7080.93
91_W94_A0.7070.93
88_V92_G0.7050.93
113_V117_T0.7010.93
245_E249_K0.7010.93
49_V52_D0.6980.92
144_N149_N0.6950.92
13_G211_H0.6920.92
43_N122_V0.6920.92
174_K205_N0.6920.92
15_Y310_L0.6900.92
52_D303_R0.6860.92
166_K169_V0.6830.92
101_V105_I0.6820.92
228_K254_K0.6800.91
155_F159_K0.6740.91
88_V95_Y0.6710.91
123_S128_L0.6690.91
53_H310_L0.6690.91
240_N243_P0.6680.91
164_E167_N0.6660.91
43_N121_S0.6630.90
192_W195_E0.6620.90
27_L37_D0.6610.90
216_D242_K0.6590.90
60_V175_I0.6580.90
247_L281_I0.6550.90
89_R95_Y0.6550.90
225_N249_K0.6540.90
33_M41_A0.6540.90
49_V53_H0.6530.90
287_P320_V0.6530.90
163_Q166_K0.6530.90
262_D265_N0.6480.89
89_R93_T0.6480.89
38_L42_F0.6470.89
56_A314_V0.6460.89
74_F115_E0.6450.89
113_V168_L0.6440.89
90_V93_T0.6430.89
89_R94_A0.6420.89
173_A176_I0.6390.89
36_E39_Q0.6360.89
105_I157_L0.6350.88
221_A246_L0.6340.88
140_E150_K0.6340.88
220_V224_F0.6310.88
244_L280_K0.6270.88
78_R112_L0.6260.88
16_P306_A0.6240.88
245_E248_K0.6230.87
136_Y182_A0.6180.87
87_P93_T0.6150.87
136_Y193_G0.6150.87
54_Y123_S0.6150.87
261_V309_K0.6120.87
9_T58_V0.6100.86
57_G318_K0.6100.86
26_R29_K0.6080.86
150_K154_V0.6070.86
311_V314_V0.6050.86
76_A85_Y0.6020.86
78_R109_E0.6020.86
42_F46_V0.6010.86
12_I293_N0.6000.85
266_R300_L0.5990.85
270_T316_G0.5980.85
109_E113_V0.5960.85
188_E191_S0.5950.85
225_N254_K0.5950.85
233_N293_N0.5930.85
120_K128_L0.5920.85
304_K307_Y0.5910.85
103_S146_Y0.5910.85
278_I316_G0.5890.84
242_K245_E0.5880.84
194_V197_V0.5880.84
205_N230_D0.5870.84
145_E148_R0.5860.84
86_G91_W0.5860.84
232_I256_L0.5860.84
39_Q42_F0.5860.84
11_V310_L0.5850.84
162_N201_V0.5840.84
194_V200_A0.5840.84
294_P310_L0.5820.84
137_T140_E0.5820.84
112_L115_E0.5820.84
220_V223_Y0.5810.84
47_I50_F0.5790.83
65_E68_R0.5780.83
251_G289_K0.5770.83
43_N47_I0.5750.83
87_P94_A0.5740.83
58_V61_P0.5730.83
43_N46_V0.5730.83
236_L243_P0.5720.83
64_G112_L0.5710.83
155_F195_E0.5710.83
109_E160_A0.5700.82
191_S226_E0.5700.82
90_V94_A0.5690.82
75_F133_T0.5660.82
168_L171_A0.5660.82
183_L210_M0.5650.82
91_W95_Y0.5640.82
84_F95_Y0.5630.82
207_K230_D0.5630.82
49_V303_R0.5610.81
274_V292_I0.5610.81
248_K283_E0.5600.81
78_R115_E0.5590.81
214_Y297_G0.5580.81
129_K175_I0.5580.81
29_K73_E0.5580.81
88_V94_A0.5570.81
108_R113_V0.5560.81
88_V143_Y0.5560.81
22_R26_R0.5560.81
233_N257_G0.5560.81
21_L26_R0.5550.81
124_Y128_L0.5540.81
108_R167_N0.5530.81
19_K26_R0.5520.80
222_P225_N0.5510.80
61_P122_V0.5510.80
58_V314_V0.5500.80
204_V230_D0.5500.80
62_T130_I0.5490.80
75_F78_R0.5480.80
82_F157_L0.5480.80
194_V223_Y0.5470.80
192_W198_N0.5440.79
201_V204_V0.5440.79
151_K192_W0.5410.79
182_A194_V0.5410.79
119_A123_S0.5410.79
140_E181_P0.5400.79
231_Q291_W0.5390.79
140_E190_V0.5390.79
175_I231_Q0.5390.79
183_L212_I0.5380.79
70_E97_R0.5360.78
136_Y154_V0.5360.78
93_T97_R0.5360.78
50_F61_P0.5350.78
258_A278_I0.5340.78
21_L41_A0.5330.78
129_K179_D0.5310.78
88_V98_K0.5300.78
28_H38_L0.5270.77
68_R234_F0.5270.77
140_E187_K0.5260.77
76_A81_G0.5250.77
310_L314_V0.5220.77
56_A307_Y0.5220.77
179_D296_C0.5210.77
186_R189_D0.5190.76
183_L215_G0.5180.76
284_Y290_V0.5180.76
85_Y93_T0.5180.76
159_K200_A0.5150.76
241_Y244_L0.5140.76
21_L45_A0.5140.76
169_V204_V0.5140.76
64_G115_E0.5130.75
155_F158_A0.5120.75
263_V300_L0.5120.75
110_P113_V0.5090.75
70_E93_T0.5080.75
81_G101_V0.5070.75
236_L281_I0.5060.74
223_Y226_E0.5060.74
244_L284_Y0.5060.74
191_S220_V0.5060.74
179_D211_H0.5050.74
157_L185_T0.5050.74
70_E96_Y0.5030.74
85_Y89_R0.5030.74
194_V227_I0.5020.74
152_D155_F0.5020.74
103_S156_D0.5010.74
135_P178_I0.5010.74
40_E51_Q0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t7lA 1 0.9729 100 0.247 Contact Map
1ypxA 1 0.8946 100 0.251 Contact Map
2nq5A 1 0.8614 100 0.272 Contact Map
1u1jA 1 0.9217 100 0.277 Contact Map
3rpdA 1 0.9669 100 0.279 Contact Map
4l6hA 1 0.9488 100 0.279 Contact Map
2ejaA 2 0.8946 99.8 0.769 Contact Map
4ay7A 1 0.9006 99.8 0.776 Contact Map
1j93A 2 0.9036 99.8 0.778 Contact Map
4exqA 2 0.9187 99.8 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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