GREMLIN Database
CBIX - Sirohydrochlorin cobaltochelatase
UniProt: Q980A7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (111)
Sequences: 3643 (2445)
Seq/√Len: 232.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_K99_E3.6141.00
45_T48_E3.4591.00
11_S16_W2.9091.00
5_L49_A2.8921.00
35_E52_N2.7291.00
60_K101_T2.6421.00
6_L24_A2.4851.00
21_I38_F2.4281.00
67_L74_F2.1141.00
3_G53_L2.0041.00
40_E73_H1.9641.00
74_F105_P1.9581.00
9_H73_H1.9411.00
62_V103_A1.9101.00
117_V121_N1.8851.00
24_A36_F1.8041.00
43_K48_E1.7761.00
3_G58_A1.6981.00
50_L100_I1.6811.00
83_G86_N1.6761.00
115_V118_K1.5591.00
17_K42_N1.5431.00
39_L67_L1.5351.00
64_V103_A1.5351.00
62_V101_T1.4741.00
67_L71_G1.4721.00
7_V63_V1.4711.00
25_E28_S1.4661.00
50_L85_D1.3871.00
70_T104_D1.3821.00
37_G49_A1.3401.00
35_E56_K1.3061.00
72_T76_R1.2821.00
73_H79_P1.2811.00
8_L20_G1.2671.00
5_L61_I1.2121.00
8_L38_F1.1881.00
26_Y30_Y1.1841.00
82_L102_I1.1651.00
114_E117_V1.1571.00
51_S55_A1.1491.00
14_P18_D1.1411.00
6_L34_V1.1231.00
7_V46_L1.1111.00
26_Y29_K1.1101.00
9_H40_E1.0991.00
15_E18_D1.0931.00
5_L37_G1.0751.00
47_S81_L1.0731.00
38_F44_P1.0731.00
28_S34_V1.0671.00
65_P74_F1.0561.00
86_N99_E1.0181.00
24_A28_S1.0151.00
25_E29_K1.0121.00
5_L53_L1.0111.00
18_D21_I1.0011.00
70_T75_R0.9881.00
33_L56_K0.9781.00
54_L98_I0.9751.00
47_S84_I0.9671.00
20_G36_F0.9631.00
22_K25_E0.9541.00
53_L58_A0.9441.00
102_I105_P0.9421.00
21_I36_F0.9411.00
20_G38_F0.9381.00
81_L84_I0.9381.00
27_L31_F0.9341.00
119_R122_E0.9291.00
23_Y66_L0.9271.00
63_V82_L0.9171.00
17_K38_F0.9141.00
3_G33_L0.9010.99
7_V37_G0.8930.99
118_K122_E0.8640.99
5_L50_L0.8610.99
28_S31_F0.8370.99
21_I25_E0.8280.99
27_L34_V0.8240.99
79_P82_L0.8170.99
7_V78_I0.8110.99
22_K26_Y0.8000.99
3_G49_A0.7990.99
35_E53_L0.7940.99
80_R84_I0.7670.98
49_A53_L0.7590.98
65_P103_A0.7510.98
49_A52_N0.7490.98
24_A34_V0.7470.98
9_H12_K0.7430.98
33_L58_A0.7290.98
82_L100_I0.7270.98
11_S78_I0.7240.98
19_V22_K0.7230.98
39_L73_H0.7210.98
54_L100_I0.7090.97
118_K121_N0.7090.97
9_H67_L0.7060.97
106_L119_R0.6990.97
115_V119_R0.6990.97
52_N56_K0.6990.97
6_L67_L0.6970.97
41_F71_G0.6950.97
13_I17_K0.6870.97
18_D22_K0.6850.97
12_K41_F0.6820.97
7_V39_L0.6810.97
6_L27_L0.6800.97
59_D97_E0.6790.96
17_K21_I0.6780.96
113_G117_V0.6710.96
24_A27_L0.6690.96
5_L46_L0.6640.96
57_G60_K0.6560.96
5_L63_V0.6540.96
22_K29_K0.6530.96
47_S51_S0.6430.95
37_G102_I0.6370.95
8_L69_A0.6350.95
9_H66_L0.6350.95
37_G63_V0.6310.95
59_D101_T0.6210.94
33_L53_L0.6170.94
9_H23_Y0.6140.94
61_I100_I0.6030.93
4_V62_V0.6010.93
39_L46_L0.5940.93
16_W112_I0.5920.93
9_H41_F0.5920.93
45_T49_A0.5860.92
38_F42_N0.5830.92
6_L20_G0.5820.92
40_E74_F0.5770.92
86_N97_E0.5690.91
84_I87_D0.5640.91
71_G74_F0.5560.90
40_E72_T0.5560.90
54_L58_A0.5530.90
73_H107_G0.5520.90
35_E103_A0.5520.90
66_L71_G0.5460.89
39_L72_T0.5460.89
74_F102_I0.5450.89
70_T108_F0.5450.89
12_K73_H0.5440.89
56_K110_E0.5430.89
57_G98_I0.5420.89
81_L85_D0.5330.88
70_T74_F0.5330.88
27_L64_V0.5320.88
9_H72_T0.5320.88
17_K72_T0.5290.88
41_F73_H0.5260.88
28_S32_S0.5220.87
110_E114_E0.5210.87
46_L81_L0.5110.86
40_E46_L0.5110.86
23_Y39_L0.5070.86
40_E65_P0.5050.85
66_L112_I0.5030.85
16_W38_F0.5030.85
47_S50_L0.5030.85
80_R83_G0.5020.85
67_L72_T0.5010.85
40_E76_R0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jh3A 2 0.9688 99.9 0.255 Contact Map
1tjnA 4 0.9375 99.9 0.266 Contact Map
2xwsA 2 0.9453 99.9 0.268 Contact Map
3lyhA 2 0.9297 99.9 0.293 Contact Map
4ccsA 1 0.8516 99.8 0.338 Contact Map
2xvyA 3 0.9531 99.8 0.371 Contact Map
2xwpA 5 0.9375 99.8 0.391 Contact Map
2h1vA 1 0.9297 99.4 0.53 Contact Map
3hcnA 2 0.9453 99.2 0.583 Contact Map
1lbqA 2 0.9219 99.2 0.59 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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