IF2G - SULSO - GREMLIN Contacts

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IF2G - Translation initiation factor 2 subunit gamma

UniProt:	Q980A5	Sequences: MAWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	415 (359)
Sequences:	17655 (7894)
Seq/√Len:	416.6

ECOLI - LEPA TYPA EFG RF3 EFTU2 CYSN EFTU1 SELB IF2
BACSU - LEPA TYPA EFG EFTU IF2
HALSA - IF2G EF2 EF1A IF2P Q9HPE4
SULSO - IF2G EF2 IF2P EF1A Q97W17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_V	183_V	5.198	1.00
275_K	281_F	5.048	1.00
181_I	197_G	3.877	1.00
157_E	161_S	3.792	1.00
214_V	244_Q	3.205	1.00
121_N	153_V	3.062	1.00
251_Q	297_I	2.768	1.00
172_G	176_E	2.697	1.00
130_R	169_F	2.695	1.00
374_K	379_E	2.664	1.00
248_K	274_T	2.652	1.00
196_E	200_E	2.607	1.00
183_V	194_L	2.549	1.00
208_D	211_Q	2.541	1.00
213_P	242_I	2.496	1.00
248_K	251_Q	2.488	1.00
350_P	353_A	2.429	1.00
252_E	261_V	2.323	1.00
113_G	202_I	2.290	1.00
211_Q	244_Q	2.283	1.00
163_Y	180_I	2.255	1.00
163_Y	182_P	2.247	1.00
28_A	188_K	2.160	1.00
52_A	55_N	2.150	1.00
13_G	111_M	2.132	1.00
164_R	168_Q	2.111	1.00
371_T	375_K	2.099	1.00
197_G	201_Y	2.038	1.00
115_I	147_V	2.012	1.00
254_K	261_V	2.008	1.00
65_P	69_V	2.008	1.00
213_P	253_I	2.004	1.00
26_V	91_F	1.983	1.00
221_F	239_G	1.971	1.00
120_A	148_Q	1.943	1.00
12_I	89_I	1.908	1.00
161_S	165_Q	1.904	1.00
32_I	192_D	1.860	1.00
276_I	279_I	1.849	1.00
213_P	247_F	1.839	1.00
66_E	74_C	1.833	1.00
14_V	26_V	1.823	1.00
314_S	320_D	1.806	1.00
118_V	129_T	1.791	1.00
215_M	240_G	1.784	1.00
82_E	86_L	1.762	1.00
217_V	238_I	1.748	1.00
236_G	340_V	1.742	1.00
246_L	274_T	1.740	1.00
28_A	31_G	1.699	1.00
149_N	185_A	1.689	1.00
160_L	164_R	1.686	1.00
278_S	281_F	1.665	1.00
192_D	196_E	1.642	1.00
179_P	197_G	1.640	1.00
47_I	52_A	1.638	1.00
44_G	48_K	1.637	1.00
119_A	122_E	1.633	1.00
46_T	50_G	1.602	1.00
147_V	185_A	1.594	1.00
163_Y	167_K	1.594	1.00
87_R	199_E	1.593	1.00
151_V	189_I	1.588	1.00
370_V	374_K	1.582	1.00
52_A	56_I	1.569	1.00
133_F	166_I	1.564	1.00
278_S	282_G	1.558	1.00
92_I	111_M	1.550	1.00
54_T	79_S	1.546	1.00
29_I	191_I	1.528	1.00
25_L	117_V	1.511	1.00
190_N	193_S	1.503	1.00
162_Q	165_Q	1.490	1.00
286_F	289_A	1.481	1.00
155_S	158_E	1.466	1.00
371_T	374_K	1.462	1.00
183_V	190_N	1.461	1.00
82_E	88_R	1.460	1.00
116_L	146_I	1.450	1.00
46_T	49_L	1.449	1.00
179_P	201_Y	1.436	1.00
323_V	381_E	1.434	1.00
370_V	382_L	1.432	1.00
172_G	175_A	1.427	1.00
240_G	283_D	1.421	1.00
8_P	87_R	1.397	1.00
36_K	53_E	1.396	1.00
146_I	180_I	1.396	1.00
33_W	195_I	1.392	1.00
136_L	144_L	1.381	1.00
64_K	75_K	1.377	1.00
349_D	352_R	1.377	1.00
80_D	88_R	1.371	1.00
348_V	359_L	1.371	1.00
25_L	185_A	1.369	1.00
114_A	141_V	1.365	1.00
247_F	264_Q	1.360	1.00
85_F	196_E	1.359	1.00
266_K	271_P	1.343	1.00
344_E	347_K	1.341	1.00
28_A	191_I	1.338	1.00
334_N	338_R	1.335	1.00
44_G	47_I	1.335	1.00
249_V	273_F	1.333	1.00
146_I	166_I	1.332	1.00
309_D	312_L	1.320	1.00
105_L	135_A	1.312	1.00
47_I	51_Y	1.307	1.00
165_Q	168_Q	1.304	1.00
89_I	199_E	1.302	1.00
345_M	358_M	1.299	1.00
275_K	279_I	1.296	1.00
132_H	135_A	1.294	1.00
122_E	126_Q	1.291	1.00
87_R	203_K	1.282	1.00
349_D	353_A	1.280	1.00
271_P	274_T	1.274	1.00
184_S	187_H	1.273	1.00
29_I	81_D	1.273	1.00
289_A	295_V	1.272	1.00
347_K	352_R	1.272	1.00
249_V	271_P	1.271	1.00
358_M	369_I	1.270	1.00
334_N	373_V	1.268	1.00
373_V	380_V	1.262	1.00
8_P	86_L	1.258	1.00
84_K	196_E	1.257	1.00
309_D	315_I	1.254	1.00
345_M	348_V	1.254	1.00
15_V	114_A	1.244	1.00
69_V	375_K	1.227	1.00
81_D	89_I	1.224	1.00
327_W	330_R	1.222	1.00
254_K	298_G	1.221	1.00
252_E	263_K	1.214	1.00
215_M	242_I	1.212	1.00
33_W	81_D	1.209	1.00
148_Q	182_P	1.199	1.00
145_I	197_G	1.196	1.00
47_I	50_G	1.193	1.00
278_S	283_D	1.191	1.00
254_K	259_L	1.185	1.00
164_R	167_K	1.175	1.00
315_I	318_L	1.172	1.00
25_L	194_L	1.159	1.00
324_P	327_W	1.155	1.00
114_A	136_L	1.154	1.00
15_V	136_L	1.154	1.00
11_N	90_S	1.140	1.00
84_K	87_R	1.140	1.00
332_K	336_L	1.137	1.00
53_E	56_I	1.130	1.00
15_V	116_L	1.128	1.00
65_P	68_Y	1.120	1.00
115_I	198_I	1.117	1.00
273_F	278_S	1.116	1.00
28_A	32_I	1.115	1.00
46_T	51_Y	1.114	1.00
313_G	320_D	1.110	1.00
338_R	341_G	1.109	1.00
238_I	289_A	1.100	1.00
253_I	264_Q	1.100	1.00
275_K	278_S	1.099	1.00
209_L	246_L	1.099	1.00
81_D	91_F	1.087	1.00
277_S	281_F	1.087	1.00
339_V	345_M	1.082	1.00
306_T	309_D	1.082	1.00
258_G	288_E	1.067	1.00
280_R	294_L	1.059	1.00
256_L	296_A	1.052	1.00
347_K	351_I	1.043	1.00
318_L	321_A	1.034	1.00
313_G	317_T	1.028	1.00
323_V	379_E	1.026	1.00
354_K	357_L	1.025	1.00
314_S	322_E	1.019	1.00
305_L	309_D	1.017	1.00
272_I	275_K	1.017	1.00
345_M	350_P	1.016	1.00
330_R	333_Y	1.008	1.00
317_T	359_L	0.997	1.00
316_I	320_D	0.996	1.00
130_R	134_V	0.994	1.00
48_K	51_Y	0.987	1.00
315_I	320_D	0.987	1.00
66_E	70_T	0.983	1.00
167_K	171_K	0.982	1.00
25_L	191_I	0.975	1.00
329_I	333_Y	0.971	1.00
30_T	35_S	0.970	1.00
290_K	293_G	0.964	1.00
29_I	195_I	0.963	1.00
146_I	178_V	0.960	1.00
120_A	151_V	0.959	1.00
118_V	166_I	0.958	1.00
372_S	376_D	0.958	1.00
242_I	281_F	0.958	1.00
278_S	285_E	0.955	1.00
113_G	145_I	0.953	1.00
347_K	350_P	0.952	1.00
278_S	284_E	0.949	1.00
297_I	300_Y	0.949	1.00
262_E	285_E	0.938	1.00
32_I	188_K	0.935	1.00
317_T	322_E	0.933	1.00
336_L	349_D	0.928	1.00
319_A	322_E	0.925	1.00
151_V	182_P	0.921	1.00
13_G	114_A	0.921	1.00
280_R	283_D	0.918	1.00
333_Y	336_L	0.916	1.00
225_K	235_G	0.916	1.00
260_R	288_E	0.914	1.00
49_L	52_A	0.913	1.00
325_V	328_N	0.908	1.00
25_L	147_V	0.907	1.00
145_I	202_I	0.905	1.00
13_G	108_A	0.902	1.00
257_P	261_V	0.902	1.00
207_R	244_Q	0.901	1.00
85_F	199_E	0.901	1.00
24_T	185_A	0.899	1.00
14_V	115_I	0.898	1.00
314_S	317_T	0.896	1.00
317_T	320_D	0.896	1.00
76_S	92_I	0.889	1.00
210_S	246_L	0.887	1.00
51_Y	54_T	0.886	1.00
167_K	170_T	0.886	1.00
31_G	188_K	0.886	1.00
277_S	280_R	0.883	1.00
313_G	346_L	0.882	1.00
17_H	20_H	0.882	1.00
347_K	353_A	0.878	1.00
12_I	198_I	0.876	1.00
145_I	181_I	0.876	1.00
249_V	267_V	0.873	1.00
271_P	277_S	0.868	1.00
313_G	316_I	0.866	1.00
37_H	48_K	0.865	1.00
338_R	342_A	0.865	1.00
277_S	286_F	0.864	1.00
276_I	283_D	0.864	1.00
125_P	129_T	0.853	1.00
349_D	354_K	0.852	1.00
271_P	275_K	0.850	1.00
162_Q	166_I	0.843	1.00
157_E	162_Q	0.842	1.00
367_L	370_V	0.841	1.00
147_V	194_L	0.840	1.00
331_I	342_A	0.840	1.00
116_L	129_T	0.840	1.00
7_Q	87_R	0.838	1.00
270_E	276_I	0.838	1.00
344_E	350_P	0.835	1.00
318_L	389_W	0.832	1.00
316_I	321_A	0.832	1.00
309_D	313_G	0.831	1.00
336_L	339_V	0.830	1.00
279_I	283_D	0.829	1.00
133_F	144_L	0.829	1.00
273_F	279_I	0.828	1.00
156_K	162_Q	0.827	1.00
152_D	184_S	0.823	1.00
344_E	349_D	0.823	1.00
343_K	360_S	0.820	1.00
314_S	318_L	0.816	1.00
113_G	203_K	0.815	1.00
157_E	160_L	0.815	1.00
160_L	182_P	0.814	1.00
321_A	381_E	0.808	1.00
347_K	354_K	0.805	1.00
123_P	165_Q	0.804	1.00
19_D	72_P	0.797	1.00
345_M	349_D	0.797	1.00
280_R	285_E	0.796	1.00
348_V	357_L	0.795	1.00
307_K	310_N	0.794	1.00
273_F	276_I	0.791	1.00
66_E	371_T	0.791	1.00
44_G	51_Y	0.791	1.00
160_L	163_Y	0.789	1.00
13_G	94_A	0.788	1.00
9_E	90_S	0.785	1.00
346_L	350_P	0.785	1.00
388_V	391_N	0.784	1.00
309_D	316_I	0.781	1.00
65_P	375_K	0.779	1.00
120_A	156_K	0.776	1.00
342_A	365_T	0.776	1.00
26_V	54_T	0.776	1.00
265_G	268_S	0.772	1.00
277_S	283_D	0.771	1.00
115_I	194_L	0.770	1.00
213_P	264_Q	0.769	1.00
44_G	49_L	0.768	1.00
204_T	207_R	0.766	1.00
116_L	132_H	0.765	1.00
165_Q	169_F	0.764	1.00
360_S	382_L	0.764	1.00
32_I	191_I	0.763	1.00
246_L	288_E	0.762	1.00
193_S	196_E	0.761	1.00
315_I	319_A	0.761	1.00
311_L	314_S	0.760	1.00
268_S	271_P	0.757	1.00
264_Q	267_V	0.755	1.00
166_I	170_T	0.755	1.00
116_L	136_L	0.753	1.00
240_G	281_F	0.750	1.00
240_G	295_V	0.750	1.00
274_T	278_S	0.746	1.00
56_I	75_K	0.744	1.00
133_F	137_G	0.740	1.00
345_M	353_A	0.738	1.00
390_S	393_I	0.737	1.00
196_E	199_E	0.733	1.00
274_T	285_E	0.731	1.00
276_I	280_R	0.729	1.00
350_P	355_E	0.729	1.00
350_P	354_K	0.727	1.00
345_M	351_I	0.725	1.00
329_I	332_K	0.725	1.00
156_K	160_L	0.723	1.00
335_L	342_A	0.722	1.00
248_K	288_E	0.721	1.00
121_N	155_S	0.720	1.00
280_R	291_P	0.717	1.00
55_N	88_R	0.716	1.00
19_D	97_H	0.715	1.00
352_R	356_T	0.712	1.00
316_I	322_E	0.712	1.00
334_N	340_V	0.711	1.00
285_E	288_E	0.708	1.00
182_P	189_I	0.706	1.00
279_I	282_G	0.706	1.00
156_K	161_S	0.704	1.00
270_E	273_F	0.701	1.00
44_G	50_G	0.700	1.00
35_S	81_D	0.700	1.00
20_H	122_E	0.699	1.00
15_V	108_A	0.696	1.00
167_K	180_I	0.696	1.00
31_G	38_S	0.692	1.00
318_L	322_E	0.692	1.00
312_L	315_I	0.691	1.00
166_I	169_F	0.690	1.00
281_F	284_E	0.689	1.00
16_G	20_H	0.687	1.00
50_G	68_Y	0.686	1.00
84_K	199_E	0.685	1.00
347_K	356_T	0.685	1.00
317_T	321_A	0.683	1.00
265_G	269_Y	0.683	1.00
66_E	372_S	0.681	1.00
291_P	294_L	0.678	1.00
314_S	319_A	0.676	1.00
346_L	349_D	0.676	1.00
325_V	330_R	0.675	1.00
104_M	132_H	0.673	1.00
255_V	262_E	0.672	1.00
18_V	97_H	0.670	0.99
313_G	318_L	0.668	0.99
69_V	371_T	0.662	0.99
348_V	353_A	0.661	0.99
49_L	54_T	0.661	0.99
10_V	205_P	0.661	0.99
326_L	333_Y	0.660	0.99
334_N	342_A	0.660	0.99
209_L	212_K	0.659	0.99
269_Y	272_I	0.659	0.99
54_T	77_C	0.659	0.99
271_P	276_I	0.658	0.99
119_A	153_V	0.653	0.99
85_F	200_E	0.652	0.99
70_T	371_T	0.652	0.99
17_H	126_Q	0.651	0.99
383_R	392_N	0.650	0.99
257_P	260_R	0.649	0.99
296_A	303_P	0.648	0.99
305_L	308_A	0.648	0.99
197_G	200_E	0.646	0.99
224_N	235_G	0.642	0.99
276_I	285_E	0.642	0.99
218_I	239_G	0.641	0.99
75_K	79_S	0.641	0.99
35_S	82_E	0.639	0.99
118_V	146_I	0.639	0.99
47_I	54_T	0.637	0.99
328_N	332_K	0.636	0.99
253_I	295_V	0.635	0.99
29_I	33_W	0.635	0.99
51_Y	68_Y	0.634	0.99
275_K	280_R	0.631	0.99
262_E	268_S	0.629	0.99
274_T	279_I	0.628	0.99
339_V	342_A	0.627	0.99
278_S	294_L	0.626	0.99
134_V	138_I	0.625	0.99
332_K	337_E	0.624	0.99
252_E	298_G	0.624	0.99
313_G	321_A	0.624	0.99
113_G	198_I	0.623	0.99
246_L	276_I	0.620	0.99
241_S	278_S	0.618	0.99
280_R	297_I	0.617	0.99
305_L	313_G	0.617	0.99
145_I	198_I	0.616	0.99
115_I	145_I	0.616	0.99
307_K	312_L	0.615	0.99
330_R	334_N	0.613	0.99
217_V	240_G	0.612	0.99
329_I	340_V	0.612	0.99
331_I	338_R	0.612	0.99
217_V	289_A	0.611	0.99
273_F	281_F	0.610	0.99
279_I	284_E	0.609	0.99
329_I	337_E	0.607	0.99
213_P	246_L	0.606	0.99
223_V	237_V	0.606	0.99
242_I	275_K	0.605	0.99
344_E	353_A	0.605	0.99
309_D	317_T	0.601	0.99
255_V	258_G	0.601	0.99
317_T	357_L	0.600	0.99
313_G	322_E	0.599	0.99
167_K	177_N	0.598	0.99
261_V	298_G	0.598	0.99
105_L	132_H	0.597	0.99
54_T	73_S	0.596	0.99
125_P	165_Q	0.596	0.99
262_E	289_A	0.594	0.99
255_V	289_A	0.594	0.99
214_V	243_I	0.594	0.99
134_V	337_E	0.591	0.99
337_E	342_A	0.589	0.99
9_E	88_R	0.588	0.99
215_M	247_F	0.585	0.99
273_F	277_S	0.585	0.99
256_L	302_D	0.584	0.99
280_R	284_E	0.584	0.99
101_M	135_A	0.584	0.99
352_R	355_E	0.584	0.99
275_K	283_D	0.583	0.99
129_T	146_I	0.581	0.99
346_L	352_R	0.581	0.99
258_G	290_K	0.580	0.99
194_L	198_I	0.579	0.99
365_T	382_L	0.577	0.99
216_L	243_I	0.577	0.99
320_D	323_V	0.576	0.98
272_I	279_I	0.576	0.98
237_V	282_G	0.575	0.98
255_V	295_V	0.575	0.98
215_M	295_V	0.574	0.98
212_K	297_I	0.574	0.98
225_K	234_K	0.574	0.98
137_G	140_G	0.574	0.98
264_Q	268_S	0.573	0.98
331_I	335_L	0.573	0.98
118_V	162_Q	0.571	0.98
272_I	276_I	0.567	0.98
18_V	73_S	0.566	0.98
359_L	389_W	0.565	0.98
331_I	373_V	0.564	0.98
67_A	71_E	0.563	0.98
348_V	358_M	0.562	0.98
109_A	243_I	0.560	0.98
117_V	149_N	0.559	0.98
223_V	234_K	0.557	0.98
182_P	190_N	0.557	0.98
17_H	129_T	0.556	0.98
330_R	335_L	0.556	0.98
161_S	164_R	0.556	0.98
134_V	137_G	0.555	0.98
285_E	299_T	0.555	0.98
8_P	85_F	0.555	0.98
329_I	341_G	0.554	0.98
198_I	202_I	0.553	0.98
105_L	138_I	0.553	0.98
48_K	52_A	0.552	0.98
19_D	150_K	0.551	0.98
281_F	285_E	0.551	0.98
315_I	321_A	0.550	0.98
309_D	318_L	0.549	0.98
353_A	357_L	0.548	0.98
89_I	198_I	0.547	0.98
94_A	104_M	0.545	0.98
312_L	320_D	0.544	0.98
36_K	44_G	0.541	0.98
276_I	284_E	0.540	0.98
309_D	314_S	0.540	0.98
98_E	127_P	0.539	0.98
50_G	54_T	0.539	0.98
48_K	54_T	0.538	0.98
74_C	368_G	0.538	0.98
207_R	211_Q	0.537	0.98
329_I	338_R	0.536	0.98
98_E	131_E	0.535	0.98
122_E	153_V	0.535	0.98
181_I	190_N	0.535	0.98
46_T	52_A	0.534	0.98
110_L	216_L	0.530	0.97
263_K	284_E	0.529	0.97
28_A	187_H	0.529	0.97
177_N	180_I	0.529	0.97
112_D	241_S	0.528	0.97
88_R	279_I	0.528	0.97
107_G	111_M	0.528	0.97
191_I	195_I	0.528	0.97
326_L	329_I	0.527	0.97
247_F	253_I	0.525	0.97
135_A	139_I	0.525	0.97
330_R	337_E	0.524	0.97
270_E	274_T	0.523	0.97
329_I	342_A	0.521	0.97
316_I	319_A	0.520	0.97
330_R	336_L	0.519	0.97
64_K	69_V	0.518	0.97
345_M	369_I	0.517	0.97
34_T	37_H	0.517	0.97
50_G	53_E	0.517	0.97
133_F	170_T	0.514	0.97
242_I	247_F	0.513	0.97
325_V	329_I	0.511	0.97
330_R	342_A	0.510	0.97
130_R	133_F	0.510	0.97
336_L	341_G	0.510	0.97
339_V	347_K	0.509	0.97
281_F	294_L	0.507	0.97
116_L	133_F	0.504	0.97
328_N	336_L	0.502	0.96
30_T	79_S	0.502	0.96
314_S	321_A	0.502	0.96
315_I	322_E	0.502	0.96
203_K	206_Y	0.501	0.96
44_G	188_K	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kiyV	1	0.9157	100	0.308	Contact Map
1darA	1	0.7614	100	0.322	Contact Map
3j25A	1	0.9157	100	0.324	Contact Map
2xexA	1	0.9036	100	0.329	Contact Map
2dy1A	1	0.9229	100	0.334	Contact Map
4fn5A	1	0.8675	100	0.338	Contact Map
4zciA	1	0.8627	100	0.346	Contact Map
2yweA	1	0.8217	100	0.346	Contact Map
3cb4D	1	0.8386	100	0.349	Contact Map
3vqtA	2	0.8892	100	0.373	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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