GREMLIN Database
IF2G - Translation initiation factor 2 subunit gamma
UniProt: Q980A5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (359)
Sequences: 17655 (7894)
Seq/√Len: 416.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_V183_V5.1981.00
275_K281_F5.0481.00
181_I197_G3.8771.00
157_E161_S3.7921.00
214_V244_Q3.2051.00
121_N153_V3.0621.00
251_Q297_I2.7681.00
172_G176_E2.6971.00
130_R169_F2.6951.00
374_K379_E2.6641.00
248_K274_T2.6521.00
196_E200_E2.6071.00
183_V194_L2.5491.00
208_D211_Q2.5411.00
213_P242_I2.4961.00
248_K251_Q2.4881.00
350_P353_A2.4291.00
252_E261_V2.3231.00
113_G202_I2.2901.00
211_Q244_Q2.2831.00
163_Y180_I2.2551.00
163_Y182_P2.2471.00
28_A188_K2.1601.00
52_A55_N2.1501.00
13_G111_M2.1321.00
164_R168_Q2.1111.00
371_T375_K2.0991.00
197_G201_Y2.0381.00
115_I147_V2.0121.00
254_K261_V2.0081.00
65_P69_V2.0081.00
213_P253_I2.0041.00
26_V91_F1.9831.00
221_F239_G1.9711.00
120_A148_Q1.9431.00
12_I89_I1.9081.00
161_S165_Q1.9041.00
32_I192_D1.8601.00
276_I279_I1.8491.00
213_P247_F1.8391.00
66_E74_C1.8331.00
14_V26_V1.8231.00
314_S320_D1.8061.00
118_V129_T1.7911.00
215_M240_G1.7841.00
82_E86_L1.7621.00
217_V238_I1.7481.00
236_G340_V1.7421.00
246_L274_T1.7401.00
28_A31_G1.6991.00
149_N185_A1.6891.00
160_L164_R1.6861.00
278_S281_F1.6651.00
192_D196_E1.6421.00
179_P197_G1.6401.00
47_I52_A1.6381.00
44_G48_K1.6371.00
119_A122_E1.6331.00
46_T50_G1.6021.00
147_V185_A1.5941.00
163_Y167_K1.5941.00
87_R199_E1.5931.00
151_V189_I1.5881.00
370_V374_K1.5821.00
52_A56_I1.5691.00
133_F166_I1.5641.00
278_S282_G1.5581.00
92_I111_M1.5501.00
54_T79_S1.5461.00
29_I191_I1.5281.00
25_L117_V1.5111.00
190_N193_S1.5031.00
162_Q165_Q1.4901.00
286_F289_A1.4811.00
155_S158_E1.4661.00
371_T374_K1.4621.00
183_V190_N1.4611.00
82_E88_R1.4601.00
116_L146_I1.4501.00
46_T49_L1.4491.00
179_P201_Y1.4361.00
323_V381_E1.4341.00
370_V382_L1.4321.00
172_G175_A1.4271.00
240_G283_D1.4211.00
8_P87_R1.3971.00
36_K53_E1.3961.00
146_I180_I1.3961.00
33_W195_I1.3921.00
136_L144_L1.3811.00
64_K75_K1.3771.00
349_D352_R1.3771.00
80_D88_R1.3711.00
348_V359_L1.3711.00
25_L185_A1.3691.00
114_A141_V1.3651.00
247_F264_Q1.3601.00
85_F196_E1.3591.00
266_K271_P1.3431.00
344_E347_K1.3411.00
28_A191_I1.3381.00
334_N338_R1.3351.00
44_G47_I1.3351.00
249_V273_F1.3331.00
146_I166_I1.3321.00
309_D312_L1.3201.00
105_L135_A1.3121.00
47_I51_Y1.3071.00
165_Q168_Q1.3041.00
89_I199_E1.3021.00
345_M358_M1.2991.00
275_K279_I1.2961.00
132_H135_A1.2941.00
122_E126_Q1.2911.00
87_R203_K1.2821.00
349_D353_A1.2801.00
271_P274_T1.2741.00
184_S187_H1.2731.00
29_I81_D1.2731.00
289_A295_V1.2721.00
347_K352_R1.2721.00
249_V271_P1.2711.00
358_M369_I1.2701.00
334_N373_V1.2681.00
373_V380_V1.2621.00
8_P86_L1.2581.00
84_K196_E1.2571.00
309_D315_I1.2541.00
345_M348_V1.2541.00
15_V114_A1.2441.00
69_V375_K1.2271.00
81_D89_I1.2241.00
327_W330_R1.2221.00
254_K298_G1.2211.00
252_E263_K1.2141.00
215_M242_I1.2121.00
33_W81_D1.2091.00
148_Q182_P1.1991.00
145_I197_G1.1961.00
47_I50_G1.1931.00
278_S283_D1.1911.00
254_K259_L1.1851.00
164_R167_K1.1751.00
315_I318_L1.1721.00
25_L194_L1.1591.00
324_P327_W1.1551.00
114_A136_L1.1541.00
15_V136_L1.1541.00
11_N90_S1.1401.00
84_K87_R1.1401.00
332_K336_L1.1371.00
53_E56_I1.1301.00
15_V116_L1.1281.00
65_P68_Y1.1201.00
115_I198_I1.1171.00
273_F278_S1.1161.00
28_A32_I1.1151.00
46_T51_Y1.1141.00
313_G320_D1.1101.00
338_R341_G1.1091.00
238_I289_A1.1001.00
253_I264_Q1.1001.00
275_K278_S1.0991.00
209_L246_L1.0991.00
81_D91_F1.0871.00
277_S281_F1.0871.00
339_V345_M1.0821.00
306_T309_D1.0821.00
258_G288_E1.0671.00
280_R294_L1.0591.00
256_L296_A1.0521.00
347_K351_I1.0431.00
318_L321_A1.0341.00
313_G317_T1.0281.00
323_V379_E1.0261.00
354_K357_L1.0251.00
314_S322_E1.0191.00
305_L309_D1.0171.00
272_I275_K1.0171.00
345_M350_P1.0161.00
330_R333_Y1.0081.00
317_T359_L0.9971.00
316_I320_D0.9961.00
130_R134_V0.9941.00
48_K51_Y0.9871.00
315_I320_D0.9871.00
66_E70_T0.9831.00
167_K171_K0.9821.00
25_L191_I0.9751.00
329_I333_Y0.9711.00
30_T35_S0.9701.00
290_K293_G0.9641.00
29_I195_I0.9631.00
146_I178_V0.9601.00
120_A151_V0.9591.00
118_V166_I0.9581.00
372_S376_D0.9581.00
242_I281_F0.9581.00
278_S285_E0.9551.00
113_G145_I0.9531.00
347_K350_P0.9521.00
278_S284_E0.9491.00
297_I300_Y0.9491.00
262_E285_E0.9381.00
32_I188_K0.9351.00
317_T322_E0.9331.00
336_L349_D0.9281.00
319_A322_E0.9251.00
151_V182_P0.9211.00
13_G114_A0.9211.00
280_R283_D0.9181.00
333_Y336_L0.9161.00
225_K235_G0.9161.00
260_R288_E0.9141.00
49_L52_A0.9131.00
325_V328_N0.9081.00
25_L147_V0.9071.00
145_I202_I0.9051.00
13_G108_A0.9021.00
257_P261_V0.9021.00
207_R244_Q0.9011.00
85_F199_E0.9011.00
24_T185_A0.8991.00
14_V115_I0.8981.00
314_S317_T0.8961.00
317_T320_D0.8961.00
76_S92_I0.8891.00
210_S246_L0.8871.00
51_Y54_T0.8861.00
167_K170_T0.8861.00
31_G188_K0.8861.00
277_S280_R0.8831.00
313_G346_L0.8821.00
17_H20_H0.8821.00
347_K353_A0.8781.00
12_I198_I0.8761.00
145_I181_I0.8761.00
249_V267_V0.8731.00
271_P277_S0.8681.00
313_G316_I0.8661.00
37_H48_K0.8651.00
338_R342_A0.8651.00
277_S286_F0.8641.00
276_I283_D0.8641.00
125_P129_T0.8531.00
349_D354_K0.8521.00
271_P275_K0.8501.00
162_Q166_I0.8431.00
157_E162_Q0.8421.00
367_L370_V0.8411.00
147_V194_L0.8401.00
331_I342_A0.8401.00
116_L129_T0.8401.00
7_Q87_R0.8381.00
270_E276_I0.8381.00
344_E350_P0.8351.00
318_L389_W0.8321.00
316_I321_A0.8321.00
309_D313_G0.8311.00
336_L339_V0.8301.00
279_I283_D0.8291.00
133_F144_L0.8291.00
273_F279_I0.8281.00
156_K162_Q0.8271.00
152_D184_S0.8231.00
344_E349_D0.8231.00
343_K360_S0.8201.00
314_S318_L0.8161.00
113_G203_K0.8151.00
157_E160_L0.8151.00
160_L182_P0.8141.00
321_A381_E0.8081.00
347_K354_K0.8051.00
123_P165_Q0.8041.00
19_D72_P0.7971.00
345_M349_D0.7971.00
280_R285_E0.7961.00
348_V357_L0.7951.00
307_K310_N0.7941.00
273_F276_I0.7911.00
66_E371_T0.7911.00
44_G51_Y0.7911.00
160_L163_Y0.7891.00
13_G94_A0.7881.00
9_E90_S0.7851.00
346_L350_P0.7851.00
388_V391_N0.7841.00
309_D316_I0.7811.00
65_P375_K0.7791.00
120_A156_K0.7761.00
342_A365_T0.7761.00
26_V54_T0.7761.00
265_G268_S0.7721.00
277_S283_D0.7711.00
115_I194_L0.7701.00
213_P264_Q0.7691.00
44_G49_L0.7681.00
204_T207_R0.7661.00
116_L132_H0.7651.00
165_Q169_F0.7641.00
360_S382_L0.7641.00
32_I191_I0.7631.00
246_L288_E0.7621.00
193_S196_E0.7611.00
315_I319_A0.7611.00
311_L314_S0.7601.00
268_S271_P0.7571.00
264_Q267_V0.7551.00
166_I170_T0.7551.00
116_L136_L0.7531.00
240_G281_F0.7501.00
240_G295_V0.7501.00
274_T278_S0.7461.00
56_I75_K0.7441.00
133_F137_G0.7401.00
345_M353_A0.7381.00
390_S393_I0.7371.00
196_E199_E0.7331.00
274_T285_E0.7311.00
276_I280_R0.7291.00
350_P355_E0.7291.00
350_P354_K0.7271.00
345_M351_I0.7251.00
329_I332_K0.7251.00
156_K160_L0.7231.00
335_L342_A0.7221.00
248_K288_E0.7211.00
121_N155_S0.7201.00
280_R291_P0.7171.00
55_N88_R0.7161.00
19_D97_H0.7151.00
352_R356_T0.7121.00
316_I322_E0.7121.00
334_N340_V0.7111.00
285_E288_E0.7081.00
182_P189_I0.7061.00
279_I282_G0.7061.00
156_K161_S0.7041.00
270_E273_F0.7011.00
44_G50_G0.7001.00
35_S81_D0.7001.00
20_H122_E0.6991.00
15_V108_A0.6961.00
167_K180_I0.6961.00
31_G38_S0.6921.00
318_L322_E0.6921.00
312_L315_I0.6911.00
166_I169_F0.6901.00
281_F284_E0.6891.00
16_G20_H0.6871.00
50_G68_Y0.6861.00
84_K199_E0.6851.00
347_K356_T0.6851.00
317_T321_A0.6831.00
265_G269_Y0.6831.00
66_E372_S0.6811.00
291_P294_L0.6781.00
314_S319_A0.6761.00
346_L349_D0.6761.00
325_V330_R0.6751.00
104_M132_H0.6731.00
255_V262_E0.6721.00
18_V97_H0.6700.99
313_G318_L0.6680.99
69_V371_T0.6620.99
348_V353_A0.6610.99
49_L54_T0.6610.99
10_V205_P0.6610.99
326_L333_Y0.6600.99
334_N342_A0.6600.99
209_L212_K0.6590.99
269_Y272_I0.6590.99
54_T77_C0.6590.99
271_P276_I0.6580.99
119_A153_V0.6530.99
85_F200_E0.6520.99
70_T371_T0.6520.99
17_H126_Q0.6510.99
383_R392_N0.6500.99
257_P260_R0.6490.99
296_A303_P0.6480.99
305_L308_A0.6480.99
197_G200_E0.6460.99
224_N235_G0.6420.99
276_I285_E0.6420.99
218_I239_G0.6410.99
75_K79_S0.6410.99
35_S82_E0.6390.99
118_V146_I0.6390.99
47_I54_T0.6370.99
328_N332_K0.6360.99
253_I295_V0.6350.99
29_I33_W0.6350.99
51_Y68_Y0.6340.99
275_K280_R0.6310.99
262_E268_S0.6290.99
274_T279_I0.6280.99
339_V342_A0.6270.99
278_S294_L0.6260.99
134_V138_I0.6250.99
332_K337_E0.6240.99
252_E298_G0.6240.99
313_G321_A0.6240.99
113_G198_I0.6230.99
246_L276_I0.6200.99
241_S278_S0.6180.99
280_R297_I0.6170.99
305_L313_G0.6170.99
145_I198_I0.6160.99
115_I145_I0.6160.99
307_K312_L0.6150.99
330_R334_N0.6130.99
217_V240_G0.6120.99
329_I340_V0.6120.99
331_I338_R0.6120.99
217_V289_A0.6110.99
273_F281_F0.6100.99
279_I284_E0.6090.99
329_I337_E0.6070.99
213_P246_L0.6060.99
223_V237_V0.6060.99
242_I275_K0.6050.99
344_E353_A0.6050.99
309_D317_T0.6010.99
255_V258_G0.6010.99
317_T357_L0.6000.99
313_G322_E0.5990.99
167_K177_N0.5980.99
261_V298_G0.5980.99
105_L132_H0.5970.99
54_T73_S0.5960.99
125_P165_Q0.5960.99
262_E289_A0.5940.99
255_V289_A0.5940.99
214_V243_I0.5940.99
134_V337_E0.5910.99
337_E342_A0.5890.99
9_E88_R0.5880.99
215_M247_F0.5850.99
273_F277_S0.5850.99
256_L302_D0.5840.99
280_R284_E0.5840.99
101_M135_A0.5840.99
352_R355_E0.5840.99
275_K283_D0.5830.99
129_T146_I0.5810.99
346_L352_R0.5810.99
258_G290_K0.5800.99
194_L198_I0.5790.99
365_T382_L0.5770.99
216_L243_I0.5770.99
320_D323_V0.5760.98
272_I279_I0.5760.98
237_V282_G0.5750.98
255_V295_V0.5750.98
215_M295_V0.5740.98
212_K297_I0.5740.98
225_K234_K0.5740.98
137_G140_G0.5740.98
264_Q268_S0.5730.98
331_I335_L0.5730.98
118_V162_Q0.5710.98
272_I276_I0.5670.98
18_V73_S0.5660.98
359_L389_W0.5650.98
331_I373_V0.5640.98
67_A71_E0.5630.98
348_V358_M0.5620.98
109_A243_I0.5600.98
117_V149_N0.5590.98
223_V234_K0.5570.98
182_P190_N0.5570.98
17_H129_T0.5560.98
330_R335_L0.5560.98
161_S164_R0.5560.98
134_V137_G0.5550.98
285_E299_T0.5550.98
8_P85_F0.5550.98
329_I341_G0.5540.98
198_I202_I0.5530.98
105_L138_I0.5530.98
48_K52_A0.5520.98
19_D150_K0.5510.98
281_F285_E0.5510.98
315_I321_A0.5500.98
309_D318_L0.5490.98
353_A357_L0.5480.98
89_I198_I0.5470.98
94_A104_M0.5450.98
312_L320_D0.5440.98
36_K44_G0.5410.98
276_I284_E0.5400.98
309_D314_S0.5400.98
98_E127_P0.5390.98
50_G54_T0.5390.98
48_K54_T0.5380.98
74_C368_G0.5380.98
207_R211_Q0.5370.98
329_I338_R0.5360.98
98_E131_E0.5350.98
122_E153_V0.5350.98
181_I190_N0.5350.98
46_T52_A0.5340.98
110_L216_L0.5300.97
263_K284_E0.5290.97
28_A187_H0.5290.97
177_N180_I0.5290.97
112_D241_S0.5280.97
88_R279_I0.5280.97
107_G111_M0.5280.97
191_I195_I0.5280.97
326_L329_I0.5270.97
247_F253_I0.5250.97
135_A139_I0.5250.97
330_R337_E0.5240.97
270_E274_T0.5230.97
329_I342_A0.5210.97
316_I319_A0.5200.97
330_R336_L0.5190.97
64_K69_V0.5180.97
345_M369_I0.5170.97
34_T37_H0.5170.97
50_G53_E0.5170.97
133_F170_T0.5140.97
242_I247_F0.5130.97
325_V329_I0.5110.97
330_R342_A0.5100.97
130_R133_F0.5100.97
336_L341_G0.5100.97
339_V347_K0.5090.97
281_F294_L0.5070.97
116_L133_F0.5040.97
328_N336_L0.5020.96
30_T79_S0.5020.96
314_S321_A0.5020.96
315_I322_E0.5020.96
203_K206_Y0.5010.96
44_G188_K0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kiyV 1 0.9157 100 0.308 Contact Map
1darA 1 0.7614 100 0.322 Contact Map
3j25A 1 0.9157 100 0.324 Contact Map
2xexA 1 0.9036 100 0.329 Contact Map
2dy1A 1 0.9229 100 0.334 Contact Map
4fn5A 1 0.8675 100 0.338 Contact Map
4zciA 1 0.8627 100 0.346 Contact Map
2yweA 1 0.8217 100 0.346 Contact Map
3cb4D 1 0.8386 100 0.349 Contact Map
3vqtA 2 0.8892 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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