GREMLIN Database
Y416 - UPF0218 protein SSO0416
UniProt: Q980A1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (158)
Sequences: 208 (171)
Seq/√Len: 13.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_I131_L7.9491.00
78_K151_N7.0561.00
52_T61_L5.2351.00
149_Q155_V4.0821.00
56_Y77_T2.8920.96
98_E103_R2.7480.95
25_P149_Q2.7430.95
150_P153_G2.2050.86
70_L135_V2.2010.86
149_Q152_A2.1720.85
132_V135_V2.1720.85
26_Y100_G2.1000.83
23_S149_Q2.0280.80
66_I102_I2.0260.80
23_S26_Y2.0150.80
57_V136_T1.9960.79
141_H164_R1.9550.78
21_E173_K1.8140.72
15_F19_R1.8120.72
22_L174_A1.7510.69
99_A142_G1.6360.64
53_V113_I1.6260.63
30_F56_Y1.6150.63
25_P155_V1.6080.63
92_E123_F1.5640.60
134_P149_Q1.5490.60
72_V122_V1.5300.59
72_V110_M1.5200.58
73_I93_Y1.4660.55
23_S152_A1.4390.54
22_L62_E1.4060.52
27_G149_Q1.4050.52
146_I154_A1.3980.52
136_T167_V1.3900.51
141_H159_V1.3550.49
35_I164_R1.3350.48
133_I157_I1.3210.47
163_I167_V1.3080.47
152_A155_V1.3010.46
57_V77_T1.2920.46
113_I138_S1.2850.46
106_I109_I1.2490.44
102_I111_E1.2360.43
120_G174_A1.2300.43
107_F138_S1.2290.43
52_T58_S1.2240.42
171_L174_A1.2000.41
15_F155_V1.1940.41
16_D133_I1.1790.40
77_T95_V1.1650.39
105_E174_A1.1390.38
122_V139_A1.1250.37
101_K171_L1.1190.37
18_L98_E1.1160.37
19_R99_A1.1120.37
26_Y149_Q1.1060.36
34_K38_E1.0910.36
53_V73_I1.0890.35
84_N102_I1.0810.35
62_E141_H1.0770.35
16_D19_R1.0720.35
23_S155_V1.0600.34
110_M122_V1.0400.33
79_R147_Y1.0380.33
50_I105_E1.0370.33
58_S95_V1.0310.33
51_I135_V1.0290.33
96_T125_D1.0190.32
29_L103_R1.0140.32
75_G80_T1.0050.31
90_N121_V1.0030.31
99_A167_V0.9980.31
22_L170_I0.9890.31
94_K99_A0.9810.30
16_D174_A0.9790.30
133_I136_T0.9790.30
76_K96_T0.9780.30
140_N152_A0.9780.30
49_R69_F0.9680.30
122_V151_N0.9660.30
50_I61_L0.9640.30
15_F152_A0.9480.29
19_R58_S0.9450.29
53_V145_V0.9370.28
23_S162_M0.9220.28
37_L119_G0.8960.27
87_I107_F0.8960.27
32_N164_R0.8910.26
14_S111_E0.8890.26
20_N144_I0.8710.26
13_F171_L0.8710.26
95_V118_E0.8700.26
160_N163_I0.8680.26
80_T115_K0.8610.25
49_R52_T0.8600.25
70_L89_R0.8600.25
157_I163_I0.8600.25
57_V171_L0.8530.25
38_E164_R0.8520.25
80_T103_R0.8500.25
75_G146_I0.8460.25
102_I175_I0.8440.25
169_D173_K0.8340.24
58_S71_E0.8190.24
50_I66_I0.8170.23
112_N120_G0.8100.23
67_V71_E0.8090.23
119_G164_R0.8090.23
139_A160_N0.8030.23
140_N160_N0.7990.23
57_V146_I0.7970.23
111_E138_S0.7970.23
19_R57_V0.7940.23
111_E133_I0.7930.23
140_N143_D0.7910.23
31_I105_E0.7800.22
134_P152_A0.7760.22
98_E140_N0.7660.22
21_E29_L0.7600.21
161_E173_K0.7560.21
99_A111_E0.7530.21
80_T137_L0.7500.21
72_V166_R0.7450.21
27_G130_L0.7330.20
76_K81_I0.7310.20
52_T72_V0.7290.20
72_V94_K0.7250.20
75_G113_I0.7220.20
93_Y125_D0.7210.20
22_L133_I0.7170.20
21_E146_I0.7160.20
73_I167_V0.7160.20
37_L75_G0.7150.20
126_G129_D0.7090.20
55_D129_D0.7090.20
129_D148_G0.7090.20
127_E148_G0.7090.20
74_D148_G0.7090.20
74_D129_D0.7090.20
126_G148_G0.7090.20
74_D127_E0.7090.20
55_D126_G0.7090.20
55_D148_G0.7090.20
54_G129_D0.7090.20
54_G148_G0.7090.20
55_D74_D0.7090.20
54_G126_G0.7090.20
74_D126_G0.7090.20
54_G127_E0.7090.20
54_G74_D0.7090.20
55_D127_E0.7090.20
105_E108_E0.7060.19
27_G153_G0.7000.19
118_E164_R0.6850.19
38_E73_I0.6820.19
63_E94_K0.6740.18
81_I143_D0.6720.18
103_R139_A0.6720.18
66_I69_F0.6710.18
100_G162_M0.6690.18
103_R131_L0.6690.18
103_R106_I0.6570.18
30_F64_N0.6550.18
36_F57_V0.6510.18
144_I156_V0.6510.18
63_E133_I0.6410.17
68_P140_N0.6340.17
158_I175_I0.6260.17
13_F142_G0.6230.17
73_I121_V0.6180.17
159_V170_I0.6150.17
104_F144_I0.6130.17
132_V145_V0.6120.17
22_L171_L0.6110.17
50_I115_K0.6100.16
29_L110_M0.6090.16
132_V136_T0.6030.16
80_T93_Y0.5970.16
29_L156_V0.5960.16
103_R152_A0.5950.16
67_V70_L0.5940.16
29_L144_I0.5930.16
26_Y131_L0.5920.16
28_I65_G0.5910.16
165_W169_D0.5900.16
141_H160_N0.5890.16
162_M174_A0.5860.16
68_P95_V0.5830.16
40_I73_I0.5800.16
104_F157_I0.5790.16
99_A104_F0.5770.16
111_E115_K0.5760.15
81_I122_V0.5720.15
108_E115_K0.5650.15
63_E138_S0.5650.15
130_L153_G0.5630.15
95_V124_V0.5620.15
119_G160_N0.5610.15
100_G151_N0.5590.15
63_E114_L0.5570.15
77_T107_F0.5530.15
107_F134_P0.5520.15
34_K105_E0.5500.15
93_Y122_V0.5480.15
28_I70_L0.5470.15
46_R130_L0.5460.15
14_S167_V0.5440.15
145_V168_R0.5420.15
137_L161_E0.5410.15
92_E157_I0.5370.14
133_I137_L0.5370.14
17_N70_L0.5360.14
70_L93_Y0.5360.14
40_I66_I0.5350.14
113_I119_G0.5300.14
50_I139_A0.5290.14
15_F153_G0.5280.14
136_T156_V0.5270.14
16_D20_N0.5260.14
149_Q153_G0.5240.14
28_I50_I0.5240.14
38_E64_N0.5190.14
53_V71_E0.5160.14
81_I174_A0.5110.14
79_R129_D0.5090.14
79_R148_G0.5090.14
79_R126_G0.5090.14
79_R127_E0.5090.14
54_G79_R0.5090.14
74_D79_R0.5090.14
55_D79_R0.5090.14
58_S108_E0.5080.14
93_Y109_I0.5070.14
21_E53_V0.5050.14
17_N24_R0.5050.14
63_E96_T0.5010.14
72_V114_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wa8A 1 0.8156 31.8 0.948 Contact Map
2izoA 1 0.7821 26 0.95 Contact Map
1rxwA 1 0.8939 20.4 0.953 Contact Map
1pe9A 1 0.5363 18.4 0.954 Contact Map
3oryA 3 0.8939 17.6 0.954 Contact Map
1jr2A 1 0.4972 16.9 0.954 Contact Map
4ffjA 2 0.3966 13.1 0.957 Contact Map
3mw8A 1 0.7877 12.9 0.957 Contact Map
2yvqA 2 0.2626 11.3 0.958 Contact Map
3re1A 1 0.8156 10 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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