GREMLIN Database
APGM - 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
UniProt: Q980A0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (389)
Sequences: 741 (585)
Seq/√Len: 29.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E382_N6.1861.00
29_E384_K5.7471.00
16_D27_P4.8311.00
39_L366_L4.2081.00
90_L154_V3.7721.00
35_A330_G3.6461.00
214_R218_Q3.6261.00
313_G356_K3.6031.00
281_N284_A3.5041.00
216_I222_P3.4751.00
41_K379_G3.3821.00
74_Y238_P3.1781.00
283_N327_R3.0521.00
249_A296_N3.0001.00
314_L317_E2.9951.00
267_N296_N2.9481.00
128_E205_V2.9061.00
291_E295_E2.8391.00
45_I386_A2.8211.00
241_S247_K2.6731.00
118_K121_E2.6241.00
248_A266_M2.6071.00
250_A261_C2.5871.00
250_A257_I2.5780.99
382_N385_E2.5550.99
287_K291_E2.4940.99
90_L96_A2.4880.99
33_K37_T2.4840.99
213_K216_I2.4790.99
43_S366_L2.4750.99
38_D42_N2.4730.99
267_N295_E2.4230.99
249_A292_L2.3250.99
344_M402_L2.2510.99
128_E209_S2.2310.99
342_I369_V2.2060.98
142_K156_S2.1900.98
214_R217_E2.1800.98
17_R361_D2.1700.98
91_S156_S2.1690.98
125_L223_A2.1410.98
269_I292_L2.0910.98
36_I345_F2.0840.98
143_F198_L2.0330.97
17_R354_E2.0030.97
355_I359_T1.9600.97
33_K322_I1.9290.96
376_D389_G1.9120.96
394_R397_D1.9100.96
49_D53_P1.9060.96
286_A332_I1.8610.95
310_S352_P1.8600.95
272_S281_N1.8290.95
345_F366_L1.8280.95
45_I378_V1.8190.95
11_A325_I1.8030.94
104_V225_I1.7900.94
60_D75_Y1.7820.94
315_V319_V1.7730.94
167_T179_S1.7590.94
33_K36_I1.7400.93
240_F248_A1.7190.93
18_P24_G1.7140.93
11_A14_L1.6900.92
102_A110_V1.6770.92
15_G350_V1.6590.92
10_V66_I1.6470.91
42_N368_Y1.6400.91
7_L301_L1.6150.90
88_A152_A1.6090.90
76_R80_A1.6070.90
202_V225_I1.6020.90
93_G157_G1.5800.89
291_E294_K1.5660.89
199_T228_L1.5220.88
110_V172_E1.5090.87
303_I328_V1.5080.87
14_L322_I1.5080.87
344_M398_V1.4930.86
30_A319_V1.4910.86
244_T399_T1.4890.86
141_I153_V1.4750.86
271_P288_A1.4670.85
253_A285_K1.4590.85
84_L263_E1.4560.85
47_L387_R1.4560.85
348_D358_H1.4470.85
309_A317_E1.4430.85
58_G230_G1.4390.84
143_F153_V1.4320.84
238_P242_S1.4290.84
29_E385_E1.4020.83
290_I335_N1.3970.83
179_S196_N1.3880.82
286_A328_V1.3670.81
105_N111_V1.3400.80
249_A269_I1.3300.79
336_I341_L1.3270.79
20_S23_N1.3260.79
243_Y400_N1.3220.79
9_I325_I1.3200.79
54_G360_G1.3140.78
123_E127_K1.3070.78
49_D392_R1.3050.78
114_R117_R1.3030.78
280_T285_K1.3030.78
9_I303_I1.2960.77
286_A331_A1.2930.77
212_N215_R1.2910.77
25_L30_A1.2890.77
380_D385_E1.2860.77
141_I194_I1.2840.77
123_E145_K1.2830.77
79_G228_L1.2830.77
247_K296_N1.2710.76
100_N150_R1.2680.76
45_I389_G1.2530.75
320_K324_R1.2350.74
149_H227_L1.2340.74
117_R312_D1.2150.73
189_I193_E1.2150.73
70_D73_V1.2090.72
197_I201_K1.2070.72
66_I346_T1.2060.72
214_R220_E1.1920.71
143_F226_V1.1880.71
238_P243_Y1.1810.70
6_I402_L1.1750.70
43_S368_Y1.1700.70
369_V372_P1.1700.70
240_F246_L1.1610.69
10_V300_F1.1540.69
258_K270_T1.1400.68
348_D351_T1.1350.67
45_I376_D1.1350.67
351_T358_H1.1320.67
8_L298_F1.1320.67
127_K131_E1.1250.67
369_V373_I1.1170.66
290_I331_A1.1060.65
149_H229_R1.1000.65
67_F257_I1.0940.64
113_R117_R1.0930.64
272_S288_A1.0910.64
94_D156_S1.0830.64
282_Y321_A1.0810.64
35_A333_I1.0800.63
331_A335_N1.0790.63
102_A227_L1.0770.63
201_K204_D1.0740.63
54_G362_P1.0710.63
276_G280_T1.0680.63
133_I198_L1.0540.62
198_L202_V1.0530.61
174_L179_S1.0500.61
124_Q211_I1.0500.61
275_T281_N1.0420.61
5_K297_D1.0420.61
15_G66_I1.0380.60
168_D229_R1.0330.60
292_L296_N1.0320.60
198_L226_V1.0310.60
208_S213_K1.0300.60
121_E211_I1.0280.60
311_H348_D1.0270.59
15_G346_T1.0240.59
67_F381_F1.0240.59
177_L180_K1.0230.59
378_V385_E1.0230.59
257_I261_C1.0180.59
170_H254_T1.0130.58
42_N201_K1.0080.58
311_H358_H1.0060.58
78_R351_T1.0060.58
67_F228_L1.0030.58
60_D80_A1.0000.57
163_K183_E0.9980.57
256_L308_A0.9900.57
38_D337_G0.9890.57
105_N108_L0.9810.56
94_D154_V0.9800.56
204_D207_N0.9800.56
275_T280_T0.9800.56
211_I218_Q0.9780.56
254_T257_I0.9760.56
99_G151_I0.9750.55
281_N287_K0.9710.55
239_P242_S0.9690.55
38_D333_I0.9680.55
62_S302_H0.9610.54
249_A299_V0.9600.54
124_Q127_K0.9590.54
306_T321_A0.9570.54
30_A33_K0.9560.54
22_L30_A0.9510.54
67_F250_A0.9500.54
399_T402_L0.9490.53
301_L329_I0.9430.53
271_P284_A0.9420.53
110_V113_R0.9410.53
39_L343_L0.9390.53
170_H256_L0.9380.53
35_A334_D0.9360.52
203_F225_I0.9330.52
244_T251_V0.9320.52
45_I366_L0.9320.52
96_A156_S0.9310.52
64_L69_L0.9300.52
352_P362_P0.9300.52
168_D227_L0.9270.52
258_K274_A0.9250.52
215_R219_G0.9240.51
251_V269_I0.9190.51
215_R220_E0.9180.51
78_R348_D0.9170.51
114_R312_D0.9170.51
283_N287_K0.9160.51
350_V359_T0.9150.51
275_T279_D0.9140.51
260_I332_I0.9070.50
141_I219_G0.9040.50
276_G285_K0.9040.50
179_S195_I0.9010.50
121_E215_R0.9010.50
284_A288_A0.8980.49
329_I345_F0.8960.49
346_T350_V0.8870.49
78_R358_H0.8870.49
10_V195_I0.8830.48
113_R168_D0.8780.48
205_V241_S0.8770.48
117_R277_G0.8770.48
132_K205_V0.8730.47
342_I402_L0.8710.47
365_V391_L0.8660.47
19_V353_V0.8620.47
70_D242_S0.8590.46
328_V331_A0.8560.46
9_I97_F0.8530.46
57_P313_G0.8510.46
87_G262_R0.8500.46
200_R203_F0.8490.46
82_E311_H0.8480.45
314_L353_V0.8430.45
17_R20_S0.8420.45
335_N338_R0.8410.45
122_G399_T0.8400.45
103_T221_K0.8370.45
6_I342_I0.8360.45
195_I228_L0.8310.44
316_E320_K0.8300.44
130_N142_K0.8240.44
112_D117_R0.8230.44
78_R311_H0.8230.44
80_A232_A0.8220.43
204_D363_V0.8210.43
208_S266_M0.8190.43
133_I143_F0.8180.43
78_R307_D0.8160.43
43_S369_V0.8150.43
307_D348_D0.8110.43
39_L367_L0.8100.43
199_T226_V0.8090.42
287_K331_A0.8080.42
148_E308_A0.8080.42
128_E210_E0.8080.42
51_I65_S0.8070.42
320_K323_E0.8040.42
114_R229_R0.8030.42
113_R229_R0.8000.42
60_D76_R0.8000.42
137_N143_F0.7980.42
7_L220_E0.7980.42
149_H168_D0.7980.42
330_G334_D0.7950.41
107_D175_K0.7950.41
57_P360_G0.7930.41
92_H234_Y0.7880.41
317_E320_K0.7840.41
71_P74_Y0.7840.41
129_L202_V0.7830.40
133_I205_V0.7800.40
173_G333_I0.7770.40
98_R150_R0.7770.40
287_K314_L0.7730.40
261_C367_L0.7720.40
281_N288_A0.7720.40
44_M401_I0.7710.40
98_R170_H0.7680.39
23_N43_S0.7680.39
307_D358_H0.7680.39
39_L73_V0.7680.39
237_L263_E0.7670.39
360_G367_L0.7580.39
113_R227_L0.7570.38
171_H254_T0.7570.38
102_A172_E0.7550.38
247_K267_N0.7550.38
347_G350_V0.7540.38
238_P241_S0.7520.38
14_L347_G0.7520.38
137_N197_I0.7520.38
211_I215_R0.7500.38
172_E179_S0.7500.38
64_L260_I0.7480.38
7_L336_I0.7460.38
80_A90_L0.7460.38
207_N224_N0.7450.38
310_S355_I0.7450.38
272_S284_A0.7440.38
307_D311_H0.7440.38
82_E307_D0.7430.37
7_L343_L0.7430.37
58_G63_H0.7420.37
51_I57_P0.7420.37
39_L329_I0.7410.37
333_I343_L0.7410.37
101_F113_R0.7400.37
20_S393_I0.7370.37
378_V389_G0.7350.37
98_R112_D0.7350.37
286_A290_I0.7340.37
311_H351_T0.7330.37
241_S294_K0.7320.37
82_E146_G0.7310.37
349_H358_H0.7290.36
32_N323_E0.7290.36
164_V191_T0.7280.36
202_V347_G0.7260.36
125_L209_S0.7240.36
11_A96_A0.7180.36
84_L333_I0.7180.36
211_I216_I0.7130.35
267_N391_L0.7110.35
13_G31_A0.7090.35
292_L295_E0.7080.35
250_A367_L0.7080.35
255_A357_E0.7070.35
129_L133_I0.7060.35
7_L244_T0.7050.35
111_V221_K0.7040.35
106_N251_V0.7020.34
96_A235_V0.7010.34
209_S212_N0.6990.34
141_I155_L0.6990.34
212_N219_G0.6980.34
93_G161_S0.6960.34
80_A231_A0.6950.34
239_P269_I0.6940.34
132_K201_K0.6910.34
286_A301_L0.6910.34
99_G153_V0.6890.34
228_L277_G0.6890.34
65_S71_P0.6880.33
114_R227_L0.6870.33
165_S182_L0.6860.33
21_K386_A0.6860.33
80_A112_D0.6850.33
307_D351_T0.6840.33
79_G117_R0.6830.33
35_A38_D0.6800.33
44_M390_S0.6780.33
65_S329_I0.6770.33
117_R149_H0.6770.33
117_R229_R0.6770.33
62_S308_A0.6740.32
352_P359_T0.6740.32
212_N220_E0.6730.32
146_G255_A0.6700.32
102_A229_R0.6700.32
209_S215_R0.6680.32
102_A149_H0.6640.32
310_S359_T0.6620.32
97_F164_V0.6620.32
64_L74_Y0.6610.32
284_A324_R0.6590.31
33_K73_V0.6570.31
101_F153_V0.6560.31
192_A376_D0.6520.31
9_I329_I0.6520.31
227_L304_K0.6510.31
249_A267_N0.6510.31
274_A280_T0.6500.31
37_T323_E0.6490.31
285_K305_A0.6470.31
164_V197_I0.6440.30
325_I329_I0.6400.30
63_H257_I0.6400.30
4_Y271_P0.6390.30
55_I72_H0.6380.30
33_K325_I0.6380.30
123_E154_V0.6370.30
11_A329_I0.6370.30
100_N229_R0.6370.30
252_S261_C0.6370.30
73_V238_P0.6360.30
324_R327_R0.6360.30
63_H304_K0.6350.30
208_S387_R0.6340.30
15_G359_T0.6340.30
201_K205_V0.6330.30
69_L235_V0.6300.30
150_R229_R0.6290.29
283_N331_A0.6280.29
82_E348_D0.6260.29
281_N285_K0.6230.29
101_F145_K0.6220.29
266_M298_F0.6210.29
86_A146_G0.6180.29
367_L402_L0.6180.29
114_R304_K0.6170.29
76_R235_V0.6160.29
151_I255_A0.6160.29
82_E145_K0.6150.29
16_D26_T0.6150.29
57_P62_S0.6140.28
164_V291_E0.6130.28
112_D116_G0.6130.28
116_G221_K0.6120.28
196_N224_N0.6100.28
44_M365_V0.6100.28
78_R349_H0.6080.28
104_V111_V0.6040.28
30_A386_A0.6000.28
273_G288_A0.5990.28
59_S256_L0.5980.27
323_E326_D0.5970.27
170_H253_A0.5960.27
113_R149_H0.5960.27
22_L315_V0.5960.27
146_G280_T0.5950.27
170_H230_G0.5940.27
96_A154_V0.5930.27
36_I303_I0.5930.27
210_E219_G0.5930.27
78_R82_E0.5920.27
319_V323_E0.5920.27
16_D50_P0.5910.27
119_L151_I0.5910.27
122_G206_L0.5900.27
63_H255_A0.5900.27
152_A309_A0.5890.27
161_S191_T0.5870.27
47_L392_R0.5860.27
61_T230_G0.5850.27
124_Q128_E0.5850.27
267_N270_T0.5850.27
60_D305_A0.5840.27
248_A298_F0.5830.27
278_I321_A0.5830.27
57_P355_I0.5830.27
226_V238_P0.5820.26
30_A388_K0.5820.26
343_L370_P0.5810.26
102_A304_K0.5810.26
349_H363_V0.5810.26
230_G254_T0.5800.26
251_V305_A0.5790.26
301_L306_T0.5780.26
195_I369_V0.5780.26
217_E220_E0.5770.26
15_G347_G0.5770.26
75_Y80_A0.5750.26
125_L128_E0.5730.26
229_R304_K0.5720.26
101_F158_K0.5690.26
88_A114_R0.5690.26
271_P274_A0.5680.26
59_S254_T0.5680.26
15_G148_E0.5680.26
243_Y320_K0.5670.26
289_A299_V0.5660.25
162_D233_H0.5660.25
129_L226_V0.5650.25
257_I277_G0.5640.25
360_G404_N0.5640.25
133_I201_K0.5630.25
258_K379_G0.5620.25
63_H350_V0.5610.25
13_G26_T0.5610.25
102_A114_R0.5600.25
130_N137_N0.5600.25
271_P281_N0.5590.25
270_T397_D0.5590.25
211_I221_K0.5590.25
170_H229_R0.5570.25
82_E358_H0.5560.25
273_G285_K0.5520.25
96_A263_E0.5490.24
140_K294_K0.5490.24
144_Y154_V0.5480.24
63_H171_H0.5460.24
95_V301_L0.5460.24
155_L389_G0.5450.24
63_H85_G0.5450.24
99_G228_L0.5450.24
32_N320_K0.5450.24
33_K352_P0.5440.24
253_A308_A0.5440.24
10_V350_V0.5440.24
342_I367_L0.5410.24
241_S245_K0.5410.24
336_I382_N0.5410.24
253_A356_K0.5380.24
10_V15_G0.5370.24
147_T381_F0.5370.24
57_P98_R0.5370.24
302_H307_D0.5370.24
51_I61_T0.5360.24
344_M367_L0.5360.24
349_H364_P0.5360.24
267_N287_K0.5350.24
31_A326_D0.5350.24
8_L174_L0.5350.24
69_L96_A0.5350.24
229_R312_D0.5350.24
210_E214_R0.5340.24
50_P346_T0.5330.24
173_G177_L0.5330.24
143_F382_N0.5330.24
128_E294_K0.5320.24
28_L69_L0.5320.24
275_T285_K0.5310.23
146_G170_H0.5310.23
42_N294_K0.5300.23
85_G152_A0.5300.23
153_V228_L0.5300.23
330_G341_L0.5290.23
18_P34_P0.5290.23
52_S284_A0.5270.23
307_D349_H0.5270.23
365_V369_V0.5250.23
133_I137_N0.5240.23
254_T308_A0.5240.23
114_R148_E0.5230.23
61_T75_Y0.5230.23
245_K386_A0.5220.23
48_M344_M0.5220.23
88_A167_T0.5220.23
38_D368_Y0.5220.23
373_I376_D0.5210.23
33_K310_S0.5210.23
23_N376_D0.5210.23
40_L46_G0.5210.23
20_S24_G0.5210.23
253_A305_A0.5210.23
36_I269_I0.5210.23
43_S385_E0.5210.23
305_A321_A0.5200.23
51_I168_D0.5200.23
110_V255_A0.5200.23
62_S351_T0.5190.23
97_F231_A0.5180.23
18_P216_I0.5180.23
75_Y231_A0.5180.23
127_K295_E0.5180.23
93_G389_G0.5160.23
24_G236_K0.5160.23
335_N345_F0.5160.23
141_I389_G0.5140.22
124_Q214_R0.5140.22
43_S84_L0.5140.22
25_L32_N0.5140.22
74_Y260_I0.5130.22
277_G312_D0.5130.22
103_T212_N0.5130.22
79_G191_T0.5130.22
254_T357_E0.5120.22
4_Y308_A0.5120.22
334_D338_R0.5120.22
28_L381_F0.5110.22
67_F302_H0.5100.22
121_E220_E0.5090.22
53_P92_H0.5090.22
164_V361_D0.5080.22
219_G222_P0.5060.22
98_R253_A0.5060.22
193_E197_I0.5060.22
266_M386_A0.5040.22
57_P352_P0.5030.22
59_S274_A0.5020.22
64_L71_P0.5020.22
63_H166_D0.5020.22
115_A192_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kd8A 1 0.8937 100 0.244 Contact Map
2zktA 3 0.93 100 0.271 Contact Map
1o98A 1 0.901 99.9 0.835 Contact Map
4my4A 1 0.8961 99.9 0.842 Contact Map
3igzB 1 0.901 99.9 0.856 Contact Map
3tg0A 2 0.7971 99.7 0.882 Contact Map
1zedA 2 0.8188 99.7 0.885 Contact Map
3m7vA 1 0.8068 99.6 0.888 Contact Map
2w5vA 2 0.7126 99.6 0.891 Contact Map
1k7hA 2 0.8116 99.6 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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