GREMLIN Database
Q97ZZ5 - Uncharacterized protein
UniProt: Q97ZZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (222)
Sequences: 2208 (1829)
Seq/√Len: 122.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E61_K3.5161.00
140_Y202_T3.4481.00
26_E65_R3.4121.00
33_L68_V3.0501.00
25_S51_P2.8651.00
54_K57_N2.8151.00
30_Y34_L2.7951.00
140_Y144_Y2.7141.00
157_D161_I2.5961.00
143_M204_D2.5461.00
25_S54_K2.4791.00
67_W86_V2.4491.00
172_K235_N2.4471.00
158_I161_I2.3871.00
23_S61_K2.3071.00
59_L68_V2.2991.00
36_Y39_A2.2891.00
59_L78_Y2.2531.00
40_T43_E2.2411.00
147_A237_L2.2311.00
145_L204_D2.1491.00
23_S26_E2.1391.00
135_R139_D2.0611.00
136_L206_I1.9951.00
29_V55_V1.9831.00
129_I218_G1.8891.00
30_Y83_L1.8751.00
69_I79_E1.8391.00
24_K28_K1.8341.00
25_S48_L1.8101.00
83_L113_F1.7981.00
29_V58_V1.7941.00
158_I162_L1.7741.00
32_Y47_K1.7741.00
29_V44_V1.7291.00
95_Q99_D1.7211.00
109_I113_F1.6901.00
144_Y202_T1.6851.00
25_S50_L1.6731.00
170_E188_Q1.6621.00
42_R46_N1.6611.00
51_P54_K1.6471.00
180_N191_R1.6461.00
190_K238_W1.5881.00
174_I237_L1.5871.00
204_D231_T1.5871.00
136_L208_L1.5761.00
89_K93_T1.5681.00
22_I67_W1.5661.00
145_L231_T1.5501.00
163_R166_S1.5451.00
164_A167_L1.5421.00
137_L144_Y1.5361.00
224_K228_D1.4811.00
231_T235_N1.4621.00
132_N220_F1.4511.00
63_E70_K1.4431.00
38_R77_V1.4311.00
29_V50_L1.4171.00
27_L31_S1.4121.00
160_D164_A1.4001.00
146_V200_I1.3921.00
94_F97_K1.3901.00
44_V55_V1.3831.00
159_I162_L1.3771.00
147_A174_I1.3731.00
35_I47_K1.3651.00
157_D164_A1.3631.00
52_Y56_Y1.3501.00
25_S58_V1.3331.00
132_N135_R1.3291.00
51_P58_V1.3181.00
124_I220_F1.3111.00
18_S24_K1.2831.00
39_A47_K1.2801.00
25_S57_N1.2781.00
96_E100_E1.2511.00
36_Y47_K1.2490.99
172_K238_W1.2330.99
175_V189_V1.2260.99
201_I231_T1.2190.99
108_P111_S1.2170.99
137_L202_T1.2150.99
86_V91_K1.2140.99
48_L55_V1.2040.99
150_Y176_D1.2010.99
147_A195_L1.1930.99
67_W90_I1.1900.99
146_V173_I1.1620.99
55_V68_V1.1390.99
122_V132_N1.1380.99
147_A196_F1.1290.99
32_Y48_L1.1190.99
43_E46_N1.1190.99
32_Y44_V1.1150.99
137_L171_T1.1110.99
122_V222_N1.0940.99
65_R93_T1.0920.99
158_I164_A1.0870.99
205_S222_N1.0830.99
96_E99_D1.0800.99
45_S68_V1.0770.98
71_I79_E1.0760.98
141_S205_S1.0720.98
159_I164_A1.0640.98
195_L198_S1.0420.98
187_A198_S1.0210.98
34_L83_L1.0210.98
41_A52_Y1.0210.98
91_K101_F1.0130.98
35_I112_I0.9950.97
159_I163_R0.9830.97
112_I116_N0.9820.97
50_L55_V0.9820.97
25_S29_V0.9750.97
187_A191_R0.9730.97
161_I164_A0.9720.97
145_L201_I0.9690.97
42_R53_T0.9660.97
144_Y171_T0.9630.97
145_L235_N0.9610.97
227_I231_T0.9430.97
41_A56_Y0.9420.96
26_E58_V0.9370.96
84_R110_S0.9320.96
87_W90_I0.9240.96
105_F110_S0.9220.96
60_S64_G0.9210.96
129_I217_T0.9200.96
95_Q103_K0.9200.96
94_F98_L0.9020.96
121_I226_L0.9010.95
147_A233_Y0.8970.95
70_K76_A0.8940.95
33_L59_L0.8940.95
103_K107_E0.8930.95
120_N222_N0.8890.95
140_Y203_S0.8840.95
177_K191_R0.8830.95
66_G126_R0.8760.95
103_K112_I0.8760.95
17_A27_L0.8740.95
192_A237_L0.8680.94
133_A137_L0.8660.94
219_L226_L0.8610.94
87_W94_F0.8610.94
53_T57_N0.8500.94
31_S112_I0.8460.94
18_S27_L0.8350.93
51_P55_V0.8270.93
70_K75_P0.8220.93
197_G229_I0.8210.93
151_Q198_S0.8180.93
40_T78_Y0.8120.92
132_N136_L0.8110.92
48_L58_V0.8100.92
142_K170_E0.8080.92
172_K190_K0.8060.92
106_I113_F0.8030.92
201_I207_L0.8030.92
234_F238_W0.8030.92
124_I128_N0.8010.92
122_V220_F0.8000.92
136_L202_T0.7980.92
111_S114_S0.7920.91
177_K193_Q0.7910.91
181_L196_F0.7860.91
133_A198_S0.7710.90
82_P110_S0.7700.90
223_H228_D0.7690.90
201_I227_I0.7690.90
55_V155_R0.7660.90
221_S230_G0.7640.90
30_Y81_I0.7620.90
31_S35_I0.7610.90
91_K94_F0.7600.90
206_I222_N0.7600.90
63_E68_V0.7590.89
32_Y39_A0.7570.89
19_I97_K0.7550.89
45_S55_V0.7530.89
40_T77_V0.7510.89
150_Y198_S0.7500.89
133_A149_S0.7460.89
110_S113_F0.7450.89
137_L187_A0.7440.88
90_I94_F0.7440.88
147_A199_G0.7430.88
177_K180_N0.7400.88
50_L56_Y0.7270.87
99_D151_Q0.7260.87
61_K64_G0.7250.87
114_S118_A0.7230.87
135_R202_T0.7220.87
229_I233_Y0.7140.86
120_N223_H0.7120.86
181_L215_I0.7060.86
41_A78_Y0.7050.86
92_I117_M0.6980.85
22_I27_L0.6960.85
105_F111_S0.6910.85
46_N52_Y0.6910.85
140_Y164_A0.6880.84
65_R136_L0.6810.84
219_L223_H0.6800.84
55_V233_Y0.6790.84
32_Y35_I0.6760.83
77_V208_L0.6740.83
156_S161_I0.6730.83
145_L172_K0.6720.83
133_A200_I0.6660.82
163_R167_L0.6650.82
182_P185_S0.6620.82
148_I151_Q0.6610.82
128_N151_Q0.6600.82
40_T56_Y0.6580.82
33_L44_V0.6580.82
97_K101_F0.6530.81
139_D206_I0.6490.81
136_L220_F0.6470.80
68_V78_Y0.6430.80
131_D134_L0.6410.80
146_V171_T0.6400.80
31_S34_L0.6390.80
36_Y213_N0.6390.80
154_V164_A0.6390.80
185_S201_I0.6360.79
134_L138_K0.6340.79
104_Q108_P0.6340.79
86_V123_V0.6320.79
43_E98_L0.6310.79
147_A223_H0.6290.79
100_E152_E0.6260.78
165_N171_T0.6250.78
156_S160_D0.6230.78
186_S190_K0.6230.78
93_T97_K0.6160.77
74_R131_D0.6150.77
168_K203_S0.6120.77
131_D135_R0.6120.77
149_S189_V0.6060.76
175_V187_A0.6050.76
49_S73_K0.6050.76
107_E206_I0.6050.76
38_R138_K0.6030.76
224_K227_I0.6030.76
188_Q191_R0.6020.76
143_M203_S0.6020.76
85_D100_E0.5990.75
188_Q192_A0.5980.75
60_S201_I0.5970.75
130_M137_L0.5950.75
44_V48_L0.5940.75
51_P57_N0.5930.74
151_Q187_A0.5920.74
27_L56_Y0.5900.74
33_L78_Y0.5900.74
42_R45_S0.5890.74
90_I201_I0.5890.74
189_V192_A0.5880.74
210_I215_I0.5870.74
34_L80_A0.5870.74
173_I187_A0.5860.74
149_S198_S0.5860.74
69_I81_I0.5850.73
41_A59_L0.5800.73
29_V83_L0.5800.73
45_S52_Y0.5780.73
107_E170_E0.5780.73
166_S205_S0.5740.72
145_L223_H0.5740.72
105_F113_F0.5730.72
40_T52_Y0.5720.72
33_L41_A0.5710.72
135_R138_K0.5690.71
80_A174_I0.5680.71
94_F101_F0.5680.71
60_S76_A0.5650.71
165_N175_V0.5640.71
119_Y223_H0.5630.71
57_N60_S0.5610.70
124_I132_N0.5570.70
20_F94_F0.5570.70
124_I218_G0.5550.70
49_S85_D0.5550.70
81_I85_D0.5540.69
208_L220_F0.5540.69
154_V181_L0.5520.69
29_V68_V0.5520.69
85_D114_S0.5490.69
148_I198_S0.5470.68
107_E110_S0.5450.68
44_V94_F0.5440.68
54_K58_V0.5430.68
206_I220_F0.5430.68
171_T187_A0.5430.68
45_S53_T0.5410.68
112_I118_A0.5400.67
69_I223_H0.5400.67
25_S28_K0.5400.67
22_I144_Y0.5380.67
158_I183_D0.5370.67
36_Y92_I0.5330.66
60_S63_E0.5320.66
78_Y144_Y0.5310.66
232_V236_H0.5300.66
147_A229_I0.5270.66
138_K142_K0.5260.65
132_N218_G0.5250.65
83_L87_W0.5240.65
43_E47_K0.5240.65
191_R194_S0.5240.65
110_S239_S0.5240.65
111_S115_S0.5240.65
52_Y217_T0.5230.65
92_I96_E0.5210.65
105_F109_I0.5210.65
85_D210_I0.5190.64
107_E212_N0.5190.64
39_A46_N0.5180.64
50_L54_K0.5170.64
133_A208_L0.5160.64
181_L186_S0.5160.64
51_P121_I0.5150.64
230_G233_Y0.5150.64
31_S108_P0.5140.64
169_A203_S0.5120.63
221_S227_I0.5100.63
80_A220_F0.5030.62
25_S41_A0.5030.62
48_L56_Y0.5030.62
91_K95_Q0.5000.62
117_M151_Q0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.9095 100 0.394 Contact Map
1byrA 2 0.5226 99 0.773 Contact Map
2f5tX 2 0.4897 98.9 0.781 Contact Map
4ggjA 2 0.6091 98.8 0.791 Contact Map
1sfxA 3 0.428 98.6 0.804 Contact Map
3r0aA 2 0.4609 98.5 0.811 Contact Map
4nb5A 4 0.5802 98.4 0.814 Contact Map
1qgpA 1 0.2963 98.4 0.816 Contact Map
3pqkA 2 0.4156 98.4 0.816 Contact Map
1q1hA 1 0.3333 98.4 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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